Conserved Protein Domain Family
CCDC90-like
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pfam07798: CCDC90-like (This model is not part of the current CDD release)
Coiled-coil domain-containing protein 90-like
This entry includes coiled-coil domain-containing proteins 90 (CCDC90) and related proteins. CCDC90A is a key regulator of the mitochondrial calcium uniporter (MCU) and hence was renamed MCUR1. A study in mammals and in yeast homologue fmp32 has reported that MCUR1 is a cytochrome c oxidase assembly factor and that it has an indirect role as a regulator of MCU, however, subsequent publications confirmed the function of MCUR1 as a regulator of MCU. The role of CCDC90B proteins is still not known.
Links
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Statistics
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PSSM-Id: 517895
Aligned: 83 rows
Threshold Bit Score: 119.555
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EPB85172      32 FDTFKFVERLEK----ANFTRQQSESIMKALRKVIGESMTELTKPMVTKAEQEKAIYMYKVDFAHLKSEIQLLEKNDFSI 107
EQB51179     193 FDSFSLVKQLGG----GGYTEAQSITAMKAIRAILAHNLDVAQESLVSKSDVENETYLFRAACSELSTEVKNNQKLADEE 268
XP_013939712  34 FDTYSLVKQLHE----GGYSSDQATTMMKAVRALLAHNLDMAQEKLVSKSDVENESYLFSAACSELSAEIKNNRRAQDEQ 109
4_pfamImport   1 FDSYSLVKQLEE----GGYSREQAVTSMKAIRKILGQNLDVAQKSLVSKSDVENETYLFQAACSELSTEIKNNRRLQEEE 76 
XP_006667070 229 FDSYSLVKHLEVe---GGYTTQQAIMSMKAIRKLLAKNLHVAQQSLVSKSDVENETYLFSAACSELNTEVKNNRRIAEEE 305
XP_001908096 244 FDSYSLVKHLSSpdqpPKYTLPQSIALMKAIRALLAHNLDSAQSGLVSRSDVDNETYLFRAACSELSTEVRKNRRVADEQ 323
XP_002143025 183 FNTYQVFDELKE----GGFDDEQAHQMVGIIGDMVKYKIGDILENYFPMLDSDNEAYLFEAACSELRTEVQKMREADVNE 258
XP_002617313 110 IDTYEVYKQLTR----AGFTAEQSNEIIDLLVYQLNTKLSKLSTKYSQIYELENEQYLFESAQQELRVDITRNREQHIND 185
XP_959022    198 FDSYSLVKQLSA----GGYTLTQAITAMKAVRGLLASNLDVAQAGLVSKSDVENETYLFRAACSELSTEVKNNRRVADEQ 273 Neurospora cras...
EWY97946     162 FDTYSLVKQLQE----GGYTQEQATTSMKAIRTLLAENLDIAQSTLVSKSDVENETYLFTAACSELSTEIKNNRRLEEEQ 237 Fusarium oxyspo...

EPB85172     108 MKAENERLQAQVEKLRQRLKEEIVRAQANVRLDLNLEKGRVRDEASGQEIKMKETDTRIESEI-AGLRTQMEAIKFQILQ 186
EQB51179     269 MRQKRTLLQHEVDILTQSLNQELLTLNDNVRGMFNDRKMAVREEQKAGESVIQQINYKISLHLsSDAKSDIEGLRWVLIR 348
XP_013939712 110 IRQQRTHLQHEVDILTQTLNQELLTLNDNVRGAFNDRKMTVREEQKGADSAIQQITYKISIMLsSDSKSEIEGVRWILIR 189
4_pfamImport  77 MRQQRTHLQHEVDILTQSLNQELLTLNDAVRGLFNDRNMAVREEQKSVESAIQKINYKMSILLsSDSKSEIEGVRWVLIR 156
XP_006667070 306 LRQQRTHLQHEVDILTQSLNQEVATLNDTVKGMYNDRKQAVREEQKAMDSAIQKISYKISIDLtSDAKTEIEGVRWVLIW 385
XP_001908096 324 LRQQRTHLQHEVDILTQRLNQDLLTLTDSVRGMFNDRKMAVREEQKAVESRIQQINYKISVMLnSDSKSEIEEVRWVLIR 403
XP_002143025 259 RQLEIDSFQKDMEEFEQDVNSLLIDMRNNIDILLSERKNENDEVLKHTDIRIQEVNNSIVVDAnHRMKPVIEEFRWVLMR 338
XP_002617313 186 AVTKINALETDYEVISDELNNHFIQMKNDVQVAINDQKSDNTLKSKKIMLRIQETNHKITTELnMAMRSEIESLRWHLSR 265
XP_959022    274 LRQQRTHLLHEVDILTQRLNQELLTLNDNVRGMFNDRKMAVREEQKAVESRIQQINYKISVMLnSDARSDIEALRWVLIR 353 Neurospora cras...
EWY97946     238 LRQQRTHLQHEVDILTQSLNQEVHTLNDNVRGSFNDRKMAVREEQKSVESSIQQINYKISIVLsSDAKSEIEAVRWILIR 317 Fusarium oxyspo...

EPB85172     187 YMV-GTmTGAGALFLAY-LRMF 206
EQB51179     349 RSV-IGiLFMAVVTLGTlRYGS 369
XP_013939712 190 RSV-VGiLFMAIVTLGT---IR 207
4_pfamImport 157 RSV-VGlVFLAILTLGM---IR 174
XP_006667070 386 RSV-LGiVVMAFLTLGT---LR 403
XP_001908096 404 RSV-LGiLFMAVLTLGT---LR 421
XP_002143025 339 NGL-FLiFSVAVMLLGT-LYLW 358
XP_002617313 266 WGLiAImASVCASSVTIyVYRI 287
XP_959022    354 RSV-VGiLFMAVATLGT---LR 371 Neurospora crassa OR74A
EWY97946     318 RSV-LGiLFMAVLTLGT---LR 335 Fusarium oxysporum NRRL 32931
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