Conserved Protein Domain Family
Cas1_AcylT

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pfam07779: Cas1_AcylT (This model is not part of the current CDD release)
10 TM Acyl Transferase domain found in Cas1p
Cas1p protein of Cryptococcus neoformans is required for the synthesis of O-acetylated glucuronoxylomannans, a consitutent of the capsule, and is critical for its virulence. The multi TM domain of the Cas1p was unified with the 10 TM Sugar Acyltransferase superfamily. This superfamily is comprised of members from the OatA, MdoC, OpgC, NolL and GumG families in addition to the Cas1p family. The Cas1p protein has a N terminal PC-Esterase domain with the opposing Acyl esterase activity.
Statistics
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PSSM-Id: 517887
Aligned: 17 rows
Threshold Bit Score: 586.969
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEC13668      303 MNYNDGTCCSSS-EPVTMLQIITFSAFGVisilALAMIVHRHLQLRRARAF---------RA--DDVQCLVNgefslhrp 370 
XP_002425523  297 MNFQDGSCCSSA-EQYTSLQIITFFVLFIcfllAVLAKFIETFKKSKNKTE---------KSthHQSEf----------- 355 
XP_009029734  252 MNFDDGSCCTSP-ENPTTVQIAMAAFFATslaaAVLIATCRRLNGRSNKNN---------KNnnKTNNNNNNqskn---- 317 
XP_004347694  462 DRPDDVTCCAPY-PALTGLQYVFFAV--------VLFALVCWLGGSYAARH---------HTggAVASGAESafgatara 523 
Q6CDI8        309 VYPFSDTCCIHYkQPRTMGQVLLLGVI-------CAILPIIYLGQRYTRSDyyprfvryvSWpvPSIQDE---------- 371  Yarrowia lipo...
5_pfamImport    1 TPTVDGTCCKKP-DPVTVVQIILATFGSLwfvyHFCFVVVNLVQKHVQRPS---------PGteEENKKNNIrtt----- 65  
XP_006636227  349 LKPIDGSCCHPR-PPLNIVQKLTAGVFAS----AIMSFLVLNLLCYSKHRR---------SRhvTDLENAEEkrpaaat- 413 
4_pfamImport    1 LRPIDGSCCQTF-ASPNLLQKLSACIFAG----SAAALLVFHLLGRNRHRR---------LVp-PDVESLEEkkpataa- 64  
XP_519208     431 LKPVDGSCCQPR-PPVTLIQKLAACFFTL----SIIGYLIFYIIHRNAHRK---------NKpcTDLESGEEkkniint- 495 
XP_006011687  162 LRPNDASCCLPK-PSFTVIQKLTACFFGI----SIIGFLIFSYLFRNNHKK---------SKpcTDVESGEEkpttatp- 226  coelacanth
EEC13668      371 aiifgklslfydltCFNFSTLQLGLIMGYFFLCDRTNFFMKENKYYTHLNFFLPVAYVFALGLFFTEE-TQHTQVLHRDQ 449 
XP_002425523  356 -------------tIIFSALAKLALIMTYFYICDRTNFFMKETKTFSQSAFWIPIVYILCVGLFFTED-SGNSKVLHRNQ 421 
XP_009029734  318 ----------mdcpTLISCIAKLGLILLYFFICDRTTFFMKENKYYTHVNFFLPFTYLMILGLFFTES-TKQVQVLNRCQ 386 
XP_004347694  524 r----hmlsspnllSVAMPVAQLGLVLVFAFLCDRTHIFPKERKIYTHFDLIASIGVMFVAGWCTLTHvKTAPTFLSRDQ 599 
Q6CDI8        372 --------------TLLTACVVIAASLAYSFFCDRTQFFGKSSKQFEASEFWVLILLFLVATGYSFEPqNDNS-FLNRHQ 436  Yarrowia lipo...
5_pfamImport   66 ------------ivELVSAAAKMSLILLYFYICDRTDVFMKANKHYTNTRFFLPLLYIVFLGVFGIDA-AEKPVFLNRNQ 132 
XP_006636227  414 --------smaslkVPFQSVCKLGLIMVYFYLCDRADIFMKEQKFYTHSTFFIPLIYIFVLGVFYTEN-GKETKVLNREQ 484 
4_pfamImport   65 --------appgltAPLQALCRMGLIMSYFYLCDRADVFMKEQKFYTHSTFFIPLIYIFVLGVFYNEN-TKESKLLNREQ 135 
XP_519208     496 --------pvssleILLQSFCKLGLIMAYFYMCDRANLFMKENKFYTHSSFFIPIIYILVLGVFYNEN-TKETKVLNREQ 566 
XP_006011687  227 --------apanteILLQSLCKLGLIMAYFYLCDRANLFMKEHKFYTNSTFFVPLIFILMLGVFCNEN-AKESKLLNRDQ 297  coelacanth
EEC13668      450 TNEWKGWMQLIILIYHTTGASQVLPIYMHVRVLVTSYLFLTGYGHFTYFWHNGDFGLYRLWQMLFRMNLLVVVLCLSMNR 529 
XP_002425523  422 TDEWKGWMQLVLLIYHWTGAQKVLPIFLLSRVIISAYVFLSGYGHFFYYWHSGDGSIVRFFRVLFRLNFMQFVVCLCMNR 501 
XP_009029734  387 TDEWKGWMQIVILIYHLTGASKVLSIYMHIRVMVSAYLFLSAYGHFVYFFNKNDFSFHRLCTVLVRFNLLVVLLCLSMNR 466 
XP_004347694  600 TDEWKGWMQIVFLIYHFLGGSSVLPLYMLVRVFVASYLFLTGFGHFTFFYTKKQFGITRIIQVLTRLNVLTIGLCMVMDK 679 
Q6CDI8        437 TEEWKGWMQIIILIYHITGASKILPIYKFVRVLVAAYLFMTGFGHATFFIKRGDFSLKRATSVLFRMNFLSILLAYVMDT 516  Yarrowia lipo...
5_pfamImport  133 TDEWKGWMQLIILIYHMTGASVNVPIYMHIRLLVSMYLFMTGYGHFSYFWNKGDFGLHRVFGVMFRLNFLTIMLCLTMDR 212 
XP_006636227  485 TDEWKGWMQLVILIYHISGASAFIPVYMHVRVLVAAYLFQTGYGHFSFFWLKGDFGLNRVCQVLFRLNFLVVVLCLVMDR 564 
4_pfamImport  136 TDEWKGWMQLVILIYHVSGASAFLPVYMHVRVLVAAYLFQTGYGHFSFFWLKGDFGLYRVCQVLFRLNFLVLVLCLVMDR 215 
XP_519208     567 TDEWKGWMQLVILIYHISGASTFLPVYMHIRVLVAAYLFQTGYGHFSYFWIKGDFGIHRVCQVLFRLNFLVVVLCIVMDR 646 
XP_006011687  298 TDEWKGWMQLVILLYHISGASSFLPVYMHVRVLVAAYLFQTGYGHFSYFWIKDDLGLYRLCQILFRLNFLVVVLCLVMDR 377  coelacanth
EEC13668      530 PYQFYYFVPLVSFWFVVVFVTMTSI--PQVVAASAEANPLQYLYIVLKFVGLFSVVTILYMSEV------------FFEK 595 
XP_002425523  502 PYQFYEFLPLVSFWFVMMEVFLIVP--PHITNQSSDNHPIQYLYLVFKFVVFFGVIATLYMSEV------------FFEK 567 
XP_009029734  467 PYQFYYFVPLVTFWFIVIFIVMALP--PR---SSSSMSISSFFWIFLKIVGLAVVVTLLYSSEV------------FFDQ 529 
XP_004347694  680 PYQFYYFVPLSSFWFLVVYAIMAFPsiPAVQKRF------PGLDAPARILALFTICSIVWLPFSgnykstsaddfpIFQF 753 
Q6CDI8        517 DYLFYYFAPLVSFWFCVVWITFRVL--PSWNSIDTSVGP-----VLAKISASAVILNILVRFQL------------PFQI 577  Yarrowia lipo...
5_pfamImport  213 PYQFYYFVPMCSFWYLVLYLTMAMW--PRAYISSPTNENTAVFKMILKLSFLFFLIVVVFISQN------------LFES 278 
XP_006636227  565 PYQFYYFVPLVTFWFAVIYVTLAIW--PQILQKKANGSGIWHLGLLLKLLALLLFICFLTYSRG------------VFNS 630 
4_pfamImport  216 PYQFYYFVPLVTFWFVVIYCSLAVW--PQILQKKANSSGLWHFGVLAKLLALLLFICIFAFSQG------------FFER 281 
XP_519208     647 PYQFYYFVPLVTVWFMVIYVTLALW--PQIIQKKANGNCFWHFGLLLKLGFLLLFICFLAYSQG------------AFEK 712 
XP_006011687  378 PYQFYYFVPLVTFWFVVIYVVFALW--PPIVNRTASGSCFWNLSLLLRLGLLLTCICILAYFQS------------TFEA 443  coelacanth
EEC13668      596 IFVTRPWKALFVTTDDSIKEWWFRWKIDRYSVASGMLFAFAHYLLKQYRVVDDNH----------------HGNLFSR-E 658 
XP_002425523  568 IFVTRPWKALFVTADDDISLWWESWKRERYSVLCGMIFSSILLLAQRYSLIDDNN----------------HNNLFSN-K 630 
XP_009029734  530 LFLSTSLKPLFVTSDESIHDWRFRWNLDRYSSIYGLLFALALVMAKRFKLIDDSV----------------SDLVASR-K 592 
XP_004347694  754 LFDWWPIKELF-SVSDSLYEWRFRSGLDCFIVAHGMLIAYAYQIAKSHGVIHDNQpavrpgttppppgpllSGLLFNT-A 831 
Q6CDI8        578 VFAV--LKYLF-NIQWNLREWRFRLILDIYIVYIGMFAAVATLRYKQGNFPLK-----------------------NLvT 631  Yarrowia lipo...
5_pfamImport  279 MFSWWPVIRLFELPSGMVREWWFRCHLDRFAVLHGSLFAFSYIMLKRLSVVDDSR----------------QGCLFST-K 341 
XP_006636227  631 IFSIWPISKLF-ELHGSSHEWWFRWKLDRFAVFHGMLFAFVYLVLQKCQVLSEGK----------------GEPLFSN-R 692 
4_pfamImport  282 VFSVWPISALF-ELNGSIHEWWFRWKLDRFAVIHGMLFALLYLVLQKRQVLSEGK----------------GEALFSA-K 343 
XP_519208     713 IFSLWPLSKCF-ELKGNVYEWWFRWRLDRYVVFHGMLFAFIYLALQKRQILSEGK----------------GEPLFSN-K 774 
XP_006011687  444 VFATWPVSKLF-ELQGSVHEWWFRWKLDRFAVFHGMMFAFLYLTLQKWQVFSEGN----------------GEPLFSH-M 505  coelacanth
EEC13668      659 NGSSCTAVAhgvLLAFQFYTTFALVCRAKPDCNEIHAYVSFVPIISYIILRNISGLLRTRYSTFFAWFGKISLELFIAQY 738 
XP_002425523  631 ISLLLSLVS---ILGIGCYVVFALLCTDWSECTEIHSYATFLTIISYIILRNISGVLRTKYSTFFAWFGKISLELCVGQF 707 
XP_009029734  593 VNMLSMALS---ICGLVGYAVFTSLCNSKEQCNNNNNK----KILSYICLRNMMGCARRKFSAFFAWFGKMSLELFIAQY 665 
XP_004347694  832 TSAILSIVS---IGIFCWYIMFTRSCTDKAYCNYIHTFSSPFLVAAFAFLRNLTGRSRAVYSRFFAYIGQLSLELFLLQF 908 
Q6CDI8        632 NRLVLGVVA---LITFIVYIAVAASFGIKQNYNQAHPYISWMPIVAFVILRNITVRFRSHYSTWMSFIGTCSLETFTLQF 708  Yarrowia lipo...
5_pfamImport  342 VSLIAVTTS---IICTLLYSIWAMHCTDKQSCNEVHSFASLIPISAFILIRNIPGYLRAGYSAFFAWFGKISLELFIGQY 418 
XP_006636227  693 VSNCLLFIS---VVSFLTYSIWASSCKDKTECNELHPYISVVQILAFVLIRNIPGYARSLYSSFFAWFGKISLELFICQY 769 
4_pfamImport  344 MSNLLLFLS---VVSFITYSIWASSCKTKTECNEMHPYISVVQILAFILIRNIPGYARSVYSSFFAWFGKISLELFICQY 420 
XP_519208     775 ISNFLLFIS---VVSFLTYSIWASSCKNKAECNELHPSVSVVQILAFILIRNIPGYARSVYSSFFAWFGKISLELFICQY 851 
XP_006011687  506 VSYCLLFVS---VVSFLSYSIWAANCKIKAECNEWHPYISVIQILAFVLIRNIPGYARSVYSTFFAWFGKISLELFICQY 582  coelacanth
EEC13668      739 HIWLAADTHGVLVLV-PG----Y-----PVLNVIVTSFIFVCISHEIHLLTGKLVVFAIPADWRYMVRNLS 799 
XP_002425523  708 HIWLAGDLNGILVLL-PK----Y-----SNLNVFLTSFIFVCAAHEVHEITNTLLPYAVPTNMFTLGRNIL 768 
XP_009029734  666 HIWLAADTHGILVLI-PS----Y-----PVMNLIVTSFVFVCVAHEIKLLTSLLTPVLVPRSRLKLARNVL 726 
XP_004347694  909 HIWLAADTKGILVLI-PGtsgfW-----RLLNAAFTTGLFVAVSEVASDSSALIVSLLAPGDNTRAVISRF 973 
Q6CDI8        709 HFFLAADTKGRLYILnTPtssgVlgmlqKYLNFGLVTVIFIIVSHAVAEQSNALTKLFVGNQDQQLPEHVT 779  Yarrowia lipolytica
5_pfamImport  419 HIWLAADTKGILVLTsPD----W-----PMLNLLITTFIFVCVAHEIFSLTGVFAKHLVGSPKSADSKTLC 480 
XP_006636227  770 HIWLAADTKGILVLV-PG----Y-----PMLNIVISTFIFVCVAHEISQITNDLAQVAIPKDSSALVKRLL 830 
4_pfamImport  421 HIWLAADTKGILVLI-PG----N-----PSLNIMVSTFIFVCVAHEISLITNDLAQVVIPKDSMALLKRLG 481 
XP_519208     852 HIWLAADTRGILVLI-PG----N-----PMLNIIVSTFIFVCVAHEISQITNDLAQIIIPKDNSSLLKRLA 912 
XP_006011687  583 HIWLAADTRGILVLI-PG----N-----PVLNIIISTFIFVCIAHEISKITNDLVQIAIPKDDTALLKRLL 643  coelacanth
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