8EOI,6WW7


Conserved Protein Domain Family
EMC1_C
?
pfam07774: EMC1_C (This model is not part of the current CDD release)
ER membrane protein complex subunit 1, C-terminal
This is the C-terminal domain of ER membrane protein complex subunit 1. ER membrane protein complex subunit 1 is a component of the ER membrane protein complex (EMC, composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6). In Saccharomyces cerevisiae, the EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).
Links
?
Statistics
?
PSSM-Id: 517885
Aligned: 141 rows
Threshold Bit Score: 111.832
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
8EOI_A        767 SENWVVYQYWNTKARRNEFTVLELYEGTEQYNATAFssld------------------rpqlPQV--LQQSYIF--PSSI 824  human
Q5CTP8        734 FQNIILITSFHSNYKVPVILILELFQFIKDETSTGInmldkfiflvssk--knvkeskiysekHVhvQETTFLYnyELPI 811  Cryptosporidi...
A0E6E8        116 DDHKVFVTYQNQAKMIFEIWTVEIYHMKRSVHLQKCqsiiislkiqqiniimkqntilfsnskyidfLQQVYGF--PLGI 193  Paramecium te...
A0CJK9        666 DEHQVFVTYYNKAQMMFEIWTVEIYHAKIEVSFIKMlenyyftktp-------iitnyykadfEAffLQQVYGY--PLGI 736  Paramecium te...
Q245W3        775 DENGVFVSYYNPVYSIFQIWTVELFSKKMENNFVSMlqnyyfsesgak----yedfnylnenmDIiaLEQKYGY--SLGI 848  Tetrahymena t...
XP_024364130  780 SENWVVYHYFNLRQHRYEMSVLEIYDQSRLPDKgviqlmlgqhns------svpissyspvnLEV--KQQSYFF--TFTV 849 
XP_002682358  698 DENTLVYQYTNAKQMRHELTTVELFNNGTDFQKKGFgsilmeklfgsk----eagvftsfgysKPtsRKNTYIL--PFGV 771 
Q57ZY7        598 VEHAVLYHFMDVEKMRHSLGVWEMFETEVG---------------------------------PVlfKDTGATP--PQVI 642  Trypanosoma b...
XP_001468753  594 VEHAIVYYYLDAKKMRYCFGVWELFEDENS---------------------------------PVvfKTAGATI--PQII 638 
XP_002367805 1076 YDNVVMAHYWNLQQARYELHFVELQDAQKDEGPlsiifsaarh---------ivprltgfelPPPtgISQTYIL--PTGV 1144 Toxoplasma go...

8EOI_A        825 SA---------------------------------MEATITERGITSRHLL-IGLPSGAILS-LPK--ALLDPRRPEi-- 865  human
Q5CTP8        812 DY---------------------------------SLLSKTSESLASKIIL-FGSEKSNVFEcIPE--RLFSTLRPN--- 852  Cryptosporidi...
A0E6E8        194 KY---------------------------------LGITRTRKSLTKKNLL-IITTFSQMYQ-LDR--NLVSARRREn-- 234  Paramecium te...
A0CJK9        737 KY---------------------------------LGMSRTQKSLTKKNLL-IITTSGQLHS-LDR--NLVSTRRREk-- 777  Paramecium te...
Q245W3        849 KK---------------------------------MAVVTTKLSLTKRNLM-IITPNNQIHS-LDR--DILSTRRAVk-- 889  Tetrahymena t...
XP_024364130  850 KT---------------------------------MTVTSTAKGITAKQLL-LGTVNDQVLA-LDK--RLFDPRRTLt-- 890 
XP_002682358  772 RS---------------------------------IGVTKTTIGVTNKQFI-LSLTNDQIYL-VDK--KIIDARRPRn-- 812 
Q57ZY7        643 SSffsrhkrvfssratwppvvvgsvlgmhgggvakMSVTTSFGAIARKSLL-FVFTSGRVAS-VGLnrLLAGGQVSL--- 717  Trypanosoma b...
XP_001468753  639 ASffvntkrefssratrppivvvstlgsfggpladMGVTTSYNAIARKSLV-LAYATGRVVV-VELrhLLAGNQMPL--- 713 
XP_002367805 1145 RA---------------------------------FGVTATLQGITTRAILlATSSSHQIYT-MST--RLANARRPRlvd 1188 Toxoplasma go...

8EOI_A        866 ---------PTEQS------RE-EN---LIPYSPDVQIHAERFINYNQTVSRMR--------GIYTAPS---------GL 909  human
Q5CTP8        853 --------------------KSkKK---NLIHNSNLPF-YQSILSE-----RIKfstkfnskKIFSFPHe--------TY 895  Cryptosporidi...
A0E6E8        235 --------sDLDHPf------------------vQLTYRLFNMNSLF-IF-KVC--------QLTIKHSiskgfqqnlQI 278  Paramecium te...
A0CJK9        778 ----------aDQPile-ysLQsAE---LPPYQYQLPINFLNMLSYHQTF-DIE--------KFSIEST---------NL 825  Paramecium te...
Q245W3        890 --------lPKDNQlqnafsFEsTT---LPPYNYMVPIDRLSIISYHANLNDIK--------EIYFSGS---------NL 941  Tetrahymena t...
XP_024364130  891 ---------PTPAE------QE-EG---ILPLTDSIPISPQSYLTHSYQVEGLR--------GLLTIPA---------RL 934 
XP_002682358  813 ---------PTAASde-----iaEG---LMPYNPYIPFVSLNVPTYNKPVSRVK--------HIQTSPS---------IL 858 
Q57ZY7        718 ------------GD------GAgQLthvIIP--------STAIVTHRYRAARPT--------LIATRPT---------NL 754  Trypanosoma b...
XP_001468753  714 -----------PGA------KDrQMshlLLP--------SFLFASHKYRVAFPR--------KITTEPT---------LL 751 
XP_002367805 1189 erglplkeaGPAQQ------QQeEG---VLPYHPLLPLLPHDCISYYNQVFHVR--------GIAAHHT---------LR 1242 Toxoplasma go...

8EOI_A        910 ESTCLVVAYGLDIYQTR-VYPSKQFDVLKDDYDYVLISSVLFGLVFATMITKRLAQVKLLNRAW 972  human
Q5CTP8        896 ESKSKLLSVGFNSLEVFeIYPNTSFDLLPYDFNYYNIINTVFLILTITAISIYFSKRNQLK-KW 958  Cryptosporidium parvum
A0E6E8        279 QNPMPFLSF---MVLTI-ITPYKSYDMVQKNFNYDAVILTTVLITLTIQVSQKLIKSSKQVKQF 338  Paramecium tetraurelia
A0CJK9        826 ESSALLLVYGSDIFFTR-IAPDKTYDMLLDNFNYNALIVTTVLIVVATKVLSKLVKSSKQVKQF 888  Paramecium tetraurelia
Q245W3        942 ESTILFVAYGNDVFMSS-IAPDRTYDMINEDFNYILVTLSIIICFVGVFIAKKYASQSNLH-RL 1003 Tetrahymena thermophila SB210
XP_024364130  935 ESTSLVFAYGLDLFYTH-TAPSKIYDSLTEDFSYALLLVTIVVLFLSIIVTYVLSERRELAEKW 997 
XP_002682358  859 ESTTLMASSGLDVFFTR-LSPSKKFDILNEDFSYAMLIISTSALFISVFVAKYLANKKEVQLKW 921 
Q57ZY7        755 ESSCHVLVSGMDLFYVR-TSSGKEFDLLNSDFNKTLLIALTCSFGVLSLVARYFAMRKGVRQLW 817  Trypanosoma brucei
XP_001468753  752 ESSCHVVVSGLDLFYVR-SSSGKPFDLLNSDFNKPLLITLVCGFAALSVMARYFVNRKALNSAW 814 
XP_002367805 1243 ESTSSTFAFGLDLFFSP-VQPAKGYDVLSSQFNYGLLAAAMVTLLVLVVLTRWRAKEADLAAKW 1305 Toxoplasma gondii ME49
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap