Conserved Protein Domain Family
TCTN_DUF1619

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pfam07773: TCTN_DUF1619 (This model is not part of the current CDD release)
Tectonic domain DUF1619
This is a conserved domain found in tectonic proteins (TCTN1/2/3) which contains a Cys rich N-terminal region. Although its function is currently unknown (this domain is also known as DUF1619), studies in TCTN2 suggest that it is indispensable for normal functions. These proteins form a complex required for hedgehog signalling transduction.
Statistics
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PSSM-Id: 517884
Aligned: 56 rows
Threshold Bit Score: 148.459
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002503963  75 CLCDLTEGTCDANCCCDPDCDSNEKAQFTECATCVYD-GAnaamngkvclpegrsppslEYCLPSSTVSRVNL---LSSS 150
EDS36993       9 YYENRRINICDVNCCCDIDCSDQILRTFS--------------------------------CSEER------LdvaEYHH 50 
Q9VMH0       117 CSCDLQAGRCDLNCCCDNDCPLETRQVFN--------------------------------CLPNSLLPQLESrleDFQY 164 fruit fly
XP_001962306 116 CSCDVQAGRCNLNCCCDHDCNSEVRKVFS--------------------------------CLSSTTSPEVQAkleDFQY 163
XP_002065315 129 CSCDLREGICDLNCCCDRDCPSEILVVFN--------------------------------CLGLEAPAELQTrleDFQY 176
XP_002002698 149 CSCDLRQDLCEVNCCCDRDCSQESLQVFS--------------------------------CLPEQ---HTRLe--DFQY 191
EDW03016     271 CACDLHSDVCELNCCCDRDCPPEALLVFS--------------------------------CAQPATEEQLRRrleDFQY 318
EGI68878     212 CECDLIKSSCNINCCCDIDCNHSHLSAFSYCQNYHVElYDs------------------RYCYNRNFIQRNNT------- 266
EEC12108      74 CFCDLKRNSCDVECCCDSDCTEDDAKSFSFCVDRVPEaPDl------------------RYCTKRDAIFASRT------- 128
EFX86661     116 CTCDLIGGQCDVNCCCDPDCSQDDLRLFNGCWSPPSSyFDr------------------YYCSPDP----DRYglvWNNT 173
XP_002503963 151 SLGVVeqrkadmsflsqqlCIKDD-NSAS-----LGKYFLDP-GFATDdi-lkSSVTLQS--ERFWNPVPAAASe----- 215
EDS36993      51 REGLQscevq-----gglfCLVGEhRPPEegedgGGVFYDP--NLKESss------kyKWseIFPVGDVPKRGP------ 111
Q9VMH0       165 THGLPtcqin-----dgwlCVFRSnTKAT--------------KTQPPdmnidTSQYRKWkdNLEYQESDYAQSrp---- 221 fruit fly
XP_001962306 164 NHGLPscqin-----dgwlCVFRSnLKPT--------------NVPALslnlnADSQKKWp-dLEAYDGNPIETrs---- 219
XP_002065315 177 THGLPtcqlh-----dgwlCVFRSnTKPV--------------KMQPIfrdfdSSKYRKWpdLLEAYETDNVPSt----- 232
XP_002002698 192 NHGLPtcqis-----dgwlCVFRShTKPA--------------KKQTPsqifdSKDYNRWpeQLDAFETALPAPp----- 247
EDW03016     319 NHGLStcqln-----dgwlCVFRSnSKPP--------------KIKAQsnnfdAEQYKKWpeLLVAYESQLPLAtq---- 375
EGI68878     267 --PFIfekla-----nnlfCILYDnLPSIy-------------STNNNlvlyeEELWKIIemNNYKWEIRHSKTlfk-yn 325
EEC12108     129 ---LFekrpv-----gdllCVVVDnVRKK-------DVFGEPpSVSSPad--vHKLVEESrhGWMADGAEQTT------- 184
EFX86661     174 PEFRVqwssr-----sgmfCIVTDnVPKK-------RLFQDQaPVTEDel--fKQISPKLsgRWNDPESQPASAgleqwi 239
XP_002503963 216 tQPKYRHNDTIGVVKAASEpllpGNKFVLPGATFSGVCGWTNVIGYnmplpasAA-SEDATCLVPIDDTlSKSCTTL--- 291
EDS36993     112 -VSTYRVNDRIKLYNETSEk---IETLTLPFSLTNSECQLAQPVRY-------LR-DQSTEC--------LRSLEDLelf 171
Q9VMH0       222 sAGHYKFGQTLQLWQPETKq---LATLELPAAYESPNCQLKQSVWH-------LQ-PIRHVCR-------MKDSAQLqes 283 fruit fly
XP_001962306 220 sSLYYKFGEPLQLWQPESNe---LTTLELPISYESSQCKLKQAVRH-------LQ-SVSSHCP-------MKDANQLqes 281
XP_002065315 233 -QSHYKLGQALQLWHPESKe---SSVFMLPTSYETAHCHIRQAIRH-------LQ-PTENNCL-------MNDINQLqen 293
XP_002002698 248 mTSHYKFGQALQLWQPESKs---LANWELPMAYESASCQLKQTLLY-------LQ-PMESSCL-------LADATQLqmn 309
EDW03016     376 fTAHYKYGEALQLWQPDSKt---VSYFELPIGYESASCQLKRTLLH-------LQ-PMHSSCL-------MSDASQLqln 437
EGI68878     326 lSKYYQHGDILWKLHDKS-----IEEIEFLQSGFTGICTFKKILRY-------LQ-NWKGACI-------QNKLTNInpy 385
EEC12108     185 -KVRFKAGDALLRLEDDGG----VGEWSECVGASFTACEATEAVTY-------LR-DQVFECTRGVGVL-DNWCTSDp-- 248
EFX86661     240 yQPYYKQGSPIFTLHINGI----VSVLKLPRSLNSASCNTAQTVHF-------LEsDNDYQCSLPG----EDRCRPT--- 301
XP_002503963 292 -L--NAKYLVNDLKLak-tPGSSAT-PTEAPTISSMKYRSRIGGKLTDLTGTVpaatftd---------gsggsgaAD-- 355
EDS36993     172 nL--ALLEQQAFVRYlrspKAEIMEhCLDE-------------------------------------------------- 199
Q9VMH0       284 iW--SLLNQTSNYEIlskpRDLEEP-EVNGLIVQ---------------------------------------------- 314 fruit fly
XP_001962306 282 lW--DIMNFTSTSQLlgkpRDPEET-EHDGITIQ---------------------------------------------- 312
XP_002065315 294 lA--LILNITSNYQVlgkpRDIEET-EVEGINMQ---------------------------------------------- 324
XP_002002698 310 lW--SLLNLTNSHQLl--sRPRELE-EQQVHGLNITICQQLLLQPKIQCLEhn--------------------------- 357
EDW03016     438 lW--TLLNLTNSHQLlskpRELDDQ-DLQGINIQ---------------------------------------------- 468
EGI68878     386 lFtvT----FSNFTV----------------------IKSLPSFNDTLTTNQMcqsniclpvrihyclksfsacnrTSis 439
EEC12108     249 aL--SAQTYYRGFAI-----------------------------------SSSaedrvqvlptlcsgdvcsdfppsAHva 291
EFX86661     302 -I--RLEEWLANLAV---------------FRLPSYSVSSNGNAGNSSARWGDmdklapvvvricensdsgcrsdlPApe 363
XP_002503963 356 ------TCNF------------------------------AVVEAHYVITHDGSgSISSFAVDL-VFADVMTSTrwsavy 398
EDS36993     200 ------DCFNssvrfcdlsgqncqktnqssvndpegsyswYCPEVKIRFVHNYT-HLTAMETRL-LCGSIDLEQd----- 266
Q9VMH0       315 ------VCLRganksmrcle-----------rgndtqldvIVDHVELQLIHNFT-NILEAKLFL-EEAKLAEDDn----- 370 fruit fly
XP_001962306 313 ------VCQRdvggktvcek-----------qgnetqldaLPEALELQFIHNFT-NILEAKLIIgPSASWTEDEn----- 369
XP_002065315 325 ------ICQLwqsvnltrklac-------fdqandtqldmIVDKIELEFLHNYT-NILGVKLLL-REAPTRQTEs----- 384
XP_002002698 358 ----etQSEL------------------------------LVDRIELQLLHNYT-NILEAKLLL-REASVEDDKt----- 396
EDW03016     469 ------VCQQlllkpkelcl-----------eanetevdiLVDSIELQLLHNYT-HILAAKLLL-REANQQDENe----- 524
EGI68878     440 gfcmnsTCTN------------------------------IVKGLKYVIRHNGSaGINSIDAYF-NIGNASH-------- 480
EEC12108     292 sytddgECRN------------------------------VVSQVTYRIVHNGVhGIINITARY-ETTTLQSGAt----- 335
EFX86661     364 -----pSCRN------------------------------SLAAVTLRIAHNGTeGIRSVLADL-LYTSASAGA------ 401
XP_002503963 399 nangaladpgnpsSVRVKYTVSW--------KLSaetvvpRSGAPGYVVGAP 442
EDS36993     267 -------------TIWQRISVEFkrkdeekfSRK------VSGNLGYLVGKP 299
Q9VMH0       371 ------------ePLWLRYNVEFvtln-eslTKP------TSGPLGYLSGAP 403 fruit fly
XP_001962306 370 ------------ePVWLTYEVTFisvn-epiAKP------TSGPLGYL---P 399
XP_002065315 385 ------------eELWLHYKVSFksvn-etaSKP------ISGPLGYLTGKP 417
XP_002002698 397 -------------MLWLTYALVYqsveelntKPS-------SGALGYELGAP 428
EDW03016     525 -------------EIWLTYQLSFesin-aikAKP------SSGPLGYVQGAP 556
EGI68878     481 -------------PFYQYFEVEYkwidsnntQIFi-----RSGNLGYEMGKP 514
EEC12108     336 -------------EFLQRFRTFYvwlsdgisPAAe-----RSGNPGYLPGLP 369
EFX86661     402 -------------VRFQTIHQSLgemnrpsgGANnpl-rtRSGNPGYLTGKP 439
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