Conserved Protein Domain Family
Nop53

?
pfam07767: Nop53 
Nop53 (60S ribosomal biogenesis)
This nucleolar family of proteins are involved in 60S ribosomal biogenesis. They are specifically involved in the processing beyond the 27S stage of 25S rRNA maturation. This family contains sequences that bear similarity to the glioma tumor suppressor candidate region gene 2 protein (p60). This protein has been found to interact with herpes simplex type 1 regulatory proteins.
Statistics
?
PSSM-Id: 400223
View PSSM: pfam07767
Aligned: 134 rows
Threshold Bit Score: 150.906
Threshold Setting Gi: 326428866
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
EEH60085       6 KGKRAWRKNIQLGeadYVDKKREDAR----TGGAVDELPDDALFFTDTDGGGG---------------I-ANAAvltrke 65  Micromonas pusi...
Q29GS2        16 KNKSAWRK-TDIQ---DVEQFLEDQRqeerIGT-FTEKQDEDLFVLDSTPLKakptvls---ikqkrkLn---------- 77  Drosophila pseu...
XP_001947341  10 RLKKDWRRKIDVT---DVDTYLEGKRlqerIGDSFSQKKDEELFHIDTSGKKqksk---------kksL----------- 66  pea aphid
EEB18057      11 KNKRSWRKNVDIT---DVENFLEDQRleerLGVKFSDTKNEELFEIDVKGQDDsnelsdiktnkcprvLlSKPNnsssyr 87  human body louse
XP_001601212  14 KTKKSWRKHVDTK---DVDSFLDNERleerLGTPFAQRKDEELFAVDRTRDESalqessglskkqrreLl---------- 80  jewel wasp
XP_396143     14 KTKKAWRKYTDTK---DIEKFLENSQleerLGS-FAIHKDSELFSISIAPEIfskq--------krreLl---------- 71  honey bee
EFN85346      13 KTKKSWRKHIDTK---DVDAFLEDIRleerMGPPLSKQANSELFTIDRTAGKtktvvss---kraarlAl---------- 76  Jerdon's jumpin...
EGI70398      43 KTKRSWRKYIDIK---DVDTFLDNNRleerLGTPFSKRIDTQLFSIDKTADVtenvis----kraarlAl---------- 105 Panamanian leaf...
8_pfamImport   3 NKKIYWRKHADVK---DVEDFLSEKRsnerVGWSFKNKKNEELFVIDngtvgql--------tqkqkaLl---------- 61 
EEZ98070      12 KSKLAWRKHVNIN---DVEEFLEDQRleerLGPSLASLNNEELFQVDTKPSEpeslsi-----------------knrkk 71  red flour beetle
EEH60085      66 kARNKTLRVDSILTKTrTSC----PYpVPVPRGakgpptasratkgaetTSDRsLreaSSFskAVAKAGGAtREKINGaa 141 Micromonas pusi...
Q29GS2        78 -AK-KPMRTFQPMENT-SKV----QD-PIVKRNhvkq---------kknGRNIeMevcNPTkpRHRQANSDrGQYYVKme 140 Drosophila pseu...
XP_001947341  67 ---NAPLKCLSILQST-SAI-----P-PLAKRSvkky---------kknNKKd-DdfdKNIkpLKKKGGIVkKKEAKEln 126 pea aphid
EEB18057      88 lRETELPKCYEILEKR-SAAkikkPA-EATKKQrvee--------------------eeeKepVKK-------------- 131 human body louse
XP_001601212  81 -KNTEP-KCFAILKPH-TAV----PD-PIVKRNrvrt---------peeRKSii---rKQKeaERKLKGQLkLKERVAik 140 jewel wasp
XP_396143     72 -KLKEP-RCFNILKPH-TAV----PD-PITKRNrvrt---------kdeRKNal---vLKKeaIRKSQNILtLKEKLRlk 131 honey bee
EFN85346      77 -KEKEA-KCFASLKPH-TQV----PD-PISKRNrvrt---------keeRMNsi---lRQReaERKLKGILkLKEKEAlk 136 Jerdon's jumpin...
EGI70398     106 -KNKEP-RCFASLKSH-TCV----PD-PISKRNrvrt---------keeRMNsi---lRQRevERQVKGVLkLKEKEAlk 165 Panamanian leaf...
8_pfamImport  62 -----PPRCFEVLKPL-TAV----PD-PIVKRNrvrs---------keeRKSsi---rKAIeeKKRLSGYIpRKVLEArr 118
EEZ98070      72 lKLQKPLRCFSILEPH-TKV----PD-PIKKRNrvrs---------keeRKNel---iKKKeaENRAKGILkHRELQAlr 133 red flour beetle
EEH60085     142 lykpnrrftlDDV--LADDPDAPKKQktYDIWDGGlardaardatrekhkattkagakhAEAASYsKHRLGDAPGSSSAR 219 Micromonas pusi...
Q29GS2       141 qrl---adkkSKK---------TNFD--NDIWQDvdfrdkipglkd--ekgwisrdlalHIAGNV-GKKLVKTHASMHHK 203 Drosophila pseu...
XP_001947341 127 ki----lkakVKTleLKENSTKDLFD--KDLWTSYrepgqrkdkliknvikwlpsevlnHNAKIL--PKLSNKKMSHPSQ 198 pea aphid
EEB18057     132 ------------------------FS--YDIW-Sddgknnkikke----newiqietlrHNLQNI-GEHKKVIPKTIQSK 179 human body louse
XP_001601212 141 nrl---lakeKRAnqPK-RGE---FK--VDVWKKepiveaelks------ewltndtvrHTLANT-GKKRKRVPESLHKK 204 jewel wasp
XP_396143    132 nkm---iaakKKLnkPK-RDE---FN--INIWKEkntkdinid--------wmssdtirHTLTHF-GIKKKRIPSSLHKK 193 honey bee
EFN85346     137 nra---lakaAFKkrPK-RGE---FK--TDLWDVtknvlpet---------vtewmstdTv------------------- 179 Jerdon's jumpin...
EGI70398     166 nri---lakiASInrSK-SKE---IK--EDIWNSinvlipetit------ewmssnsirHTLKHL-GIKKRKLP-LLCKK 228 Panamanian leaf...
8_pfamImport 119 srm---itrrQKKlqPK-EHN---FQ--KDLWDStnadendiagn----lewlndntlkHNLTKL-GAFKFGIPIGVRKK 184
EEZ98070     134 dka---tnenKKQaiPK-RGD---FN--QNIWDQednlnekne--------wfsnsttkHNLVGT-GKSRKTVKTPKRPK 195 red flour beetle
EEH60085     220 gnkKKAYApkngvgavEVDAAGSSYNPPEDARQEVI--AYEVGKElRKKLKKQLDPVRAPVSNnEANQKLAEElyyaqen 297 Micromonas pusi...
Q29GS2       204 ---TIKGKk------fVPPHPGMSYNPPLDAHKQLLseVVEREEG-IIKKEQHLKRVTTSMFS-KVTPEQRDErrlmems 272 Drosophila pseu...
XP_001947341 199 ---TTCKAed-----mKCPHPGLSYNPTIEDHVSLLanIAEKETE-LIKHEAHMNRVTRNLFK-QVSKEKNEQmiieelt 268 pea aphid
EEB18057     180 ---TSKLPa------iDIPHPGLSYNPSLKDHKEILskAAEKEYA-LIKEKKHLNRVTKEMFS-SIPREEMEKnwieemc 248 human body louse
XP_001601212 205 ---PSVLPa------vNAPHPGTSYNPSFKDHQELLaqVAAEEVK-LMKEEEHLNRVTNKMFR-KVTAKQKDAdnltems 273 jewel wasp
XP_396143    194 ---PSNIPa------vEAPHPGTSYNPSFEDHQKLLleVAQKEME-LIKEEEHLNRVTTKMFK-KVSLKEKEDnlikems 262 honey bee
EFN85346     180 ----------------EAPHPGTSYNPSYTDHQKLLndIAQKELE-LMKEEAHLDRVTTKMFK-KVPLNKRDEnlmkems 241 Jerdon's jumpin...
EGI70398     229 ---PSVLPa------vETPHPGTSYNPSYNDHQELLhnIVQKELE-LMKQDEHLNRVTTQMFK-KISLQKRDEnmmkeml 297 Panamanian leaf...
8_pfamImport 185 ---KSVIPt------vEFPHPGSSYNPSFKDHQDLLkiVVDQELE-KQKEEAHLKRVTSDLFS-KITRSEKAFlwmeems 253
EEZ98070     196 ---SSVLPp------vEPPHPGMSYNPSYEDHQDLLktIVEKETK-IIKEEEHLNRVTRDMFS-KVSEKQKNSmwmeems 264 red flour beetle
EEH60085     298 lyedasddeagg---------gdggggasknknpatsrdGKMTKAQRNKQLRRREQEAEEEANRLAKRHRRDLSNLKHLD 368 Micromonas pusi...
Q29GS2       273 egvdedadekeeeseqeeddpndssdkayrtinaaverdSKKSKQARRKELKQKELQRKTELKKKLKQQTADLIRIKSIR 352 Drosophila pseu...
XP_001947341 269 eglpgftddtvk--------evnedtsefkainppttrdNQKTIKKRKIQRRLRNEERQRMNAKIEKKKVSDLYRLRYIR 340 pea aphid
EEB18057     249 vgltvsksds------------ddddgqeykalnppvrnKKKTLQKKRKKREALLLKEKLKNQKIEKKKISDLHKLTKFN 316 human body louse
XP_001601212 274 eglplpnqkqdd--------dsdedndpnvrsinppalnVKKTLVQRRKQKEQRKLQQQRLKQKIEKKKVADIYHLNHLG 345 jewel wasp
XP_396143    263 eglklednqdfn---------edenndpivksinppvknKKKTRVQRRKQKEQKNLVHKKQQEKVEKKKISDIYKLRVLD 333 honey bee
EFN85346     242 eglpikkqttenskpt-kegdveeedssvaianskpvknIKKTLVQKRKQREQKQAANERTLAKIEKRKVSDIYKLKMLK 320 Jerdon's jumpin...
EGI70398     298 eglpknqttssfksi---eedheeenssitiannkskknIKKTLVQKRKQREQKQAINERTLMKLEKKKISDIYKLKTLQ 374 Panamanian leaf...
8_pfamImport 254 qglpqaeeikvehd----gkeeneesseykainpavsflKKKTKKQRRKQKLEKEAEFKRKEAKVQKKKVADLYKLRFIS 329
EEZ98070     265 qglpqastqqs-----------dnesdgeyksinpptknRKKTQQQRRKLREQKKLELLKQIAKKEKKKISDIHRIKLLK 333 red flour beetle
EEH60085     369 ARLDAEAAEEEAKrerrkvareerkaAQPDRLGKHRFVEEHTPVMLKDELTGSLRTLAGTHTLLRDRLKSL 439 Micromonas pusilla CCMP1545
Q29GS2       353 HELDDEAEDLNDLkkrrkq-raekkkFEPKRLGRHKFEEPDLDVNMPEDLAGNLRNVKPESNLLKDRFHLL 422 Drosophila pseudoobscura
XP_001947341 341 EELDELENTTNKKklkrlq-krqlnnISTRRLGTNKFTESSDTFALPKDLKGTLRETEPQGNIFKDCFESL 410 pea aphid
EEB18057     317 ESILKKEQKIKEKmekkke-kqkkkpFTTRVLSQIKYQDADIDFQLPEELSGNLRNINSIGSILHDRFKSL 386 human body louse
XP_001601212 346 KQISKKEQKLGLLkekrek-ikakkeLEPKVLSRHKFEPLEQEFLMGDEIAGNLRNTTPAGNLLKDRYKSL 415 jewel wasp
XP_396143    334 RQLAAKEKKEKVLhekrlk-kkilktVGTKTLSKVKFEPLELDFKLGSELTGNLRNSEPTGNLLKDRFKSL 403 honey bee
EFN85346     321 KQIESKEKKEDFLrqkrmk-kheresTTPKILSKTKFEPLDPVFQLSEELSGNLRNCNPSKNLLKDRFKSL 390 Jerdon's jumping ant
EGI70398     375 KQIEAKERKQESLrqkrtk-kresesLMPKTLSKTKFEPIDPDFQLAEELTGNLRNFKPSNNLLKERYKSL 444 Panamanian leafcutter ant
8_pfamImport 330 NDIKNIESTQLKNserrqk-laafnvSRTKRLGGKPYEEQNLAFSRGCELKGNLRSIKNGGNILADRFYSL 399
EEZ98070     334 NQIEKREKTTQILrekrkk-vqelkkTEPKRLSAIKFEECDLEFNMGPDIAGNLRNMKKEGNLLTDRFKSL 403 red flour beetle
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap