Conserved Protein Domain Family
LETM1_RBD

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pfam07766: LETM1_RBD (This model is not part of the current CDD release)
LETM1-like, RBD
Members of this entry are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans. This entry represents the ribosome-binding domain (RBD) of LETM1/MDM38 proteins.
Statistics
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PSSM-Id: 517881
Aligned: 116 rows
Threshold Bit Score: 177.293
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_004182708  75 MKRRELIQLRKTADDLFRLLPFSAFIIIPFAELLLPFCLKLFPN-LLPSTYETGDNKMLKL----IRLAENKSIISSLLR 149
Q28EM8       110 LPYREMEKLRQFRRDIIKAAPVVIISIPPFANYLVFVLMYFFPRqLLIRHFWTPKQREEFLdiyhRMRVEAYPEILDGLL 189 tropical clawed...
NP_001124088 121 LPYRDMEKIRQVRRDLIKAIPLVILSIPPFANYLVFMLMYLYPRqLLIRHFWTPQQLVDFQvayhNQRARHHWAVVKGLE 200
8_pfamImport   1 LPYRDMEKLRQVRRDLIKAAPLVLISLPPFANYLVFVLMYFFPRqILIPHFWNPRQRVEFRgvyhSLRARHHRPVIAGLQ 80 
5_pfamImport   1 LPYRDMEKLRQFRRDIMKAVPLMMISIPPFANYLVFVLMYFFPRqLLIPHFWTPKQQVEFRglyhSYRVRHHWPVLKGLE 80 
XP_005798965 119 LHYREMEKLRQFRRDLIKAIPLVIITIPPFANYLIFFLMYFFPRqLLIPHFWTPRQQLEFRkvyhSHRTRYHQPVLKELE 198
XP_004071023 123 LPYREMEKLRQFRRDLFKAIPLVVISIPPFANYLVFVLMYFFPRqLLIPHFWNPQQQVEFRslyhSIRTRNHRPILEELE 202
XP_007248372  99 LPYRDMERLLLFRRDMIKAIPLIVISLPPFAIGVVFTLMCLFPRqLLFRHFWTPQQQRKYQmiahVKRSKHQAEVLNNIL 178
XP_002129203 139 ISYREEMTIYNLNQDGIKAAPLLPIAVLPMGFFLILIPVYFFPRlVLPQTFWSKHQRYKFLsqihRSRILDYGVIIHHLN 218
XP_005991473 117 LPYREMESLRQFRRDIIKAAPLLLISIPPFANYLVFVLMYFFPRqLLIRHFWNPGQQEEYLgiyhLRRAHLYPEIVTHLL 196 coelacanth
XP_004182708 150 ---NTLndsklniplynnhSKQiatNKEIFNKFFYRLKilKRnGYsLAITklsfhfteHEVLQVAKLFKDD---TLLISL 223
Q28EM8       190 navPKL-------------SERn--LRNQMFQLCTQVQ--HG-TH-PQV---------ENLHAVCTAFSGPp--LGMKRL 239 tropical clawed...
NP_001124088 201 stsNSV-------------QDTr--LKRHLLELCSKVR--SG-VH-PVV---------SDVHAVRTLFSGPp--LGIKKM 250
8_pfamImport  81 qtsHRI-------------EDGp--LRGRLLDLCAKVQ--GG-QN-PKA---------SDILAVRGLFSRPp--LSIKGM 130
5_pfamImport  81 ktsQRV-------------KDGq--LQSHLKNLCAKVQ--SG-AN-PKV---------SEILAVRSLFSGPp--LGIRRM 130
XP_005798965 199 dvsHQV-------------KNGh--LQSLLKNLCTKVQ--RG-GN-PNV---------SEILAVRSLFSKAp--LAMNTM 248
XP_004071023 203 vasHRV-------------KNVq--AQACLKSLCDDVR--RG-AN-PQV---------SDILAVRSLFVGPp--LGIKRL 252
XP_007248372 179 ltiPRI-------------SEWp--RRTLLLNLCSKVQ--SG-VH-PSV---------SEICAVREAFSGPp--LELQTL 228
XP_002129203 219 yhkLN--------------SDQn--TKYALEGICNSLA--GG-NI-PSNS--------DMLNNLKPLCKLHdgpCNVDHM 270
XP_005991473 197 nsvPKT-------------ANP---MQRRMQRLCTKVK--QG-FH-PEA---------AELHAVRSLFTEPp--LRIKRL 245 coelacanth
XP_004182708 224 TKRQLSLLNQYMSlsLPSLGTMNLLKYRLRHTLNKIKKDDILIARE-GVTHLTDEELYEACMSRGIQIQhetdllthkSV 302
Q28EM8       240 DVQQMKALSRVMF--LTPHLPAFLLQHRLGSHICEIQNLDCALLKL-GVNELSEEELKRACYIRGLNST---------HL 307 tropical clawed...
NP_001124088 251 YANQMRHLCPLLF--LTPRLPAFWISGRLNSHALELMQLDRAIIRL-GLHQLNDSELREACFVRGLNPE---------RL 318
8_pfamImport 131 SAGHMRHISPLLF--LTPRLPAFLVARRLNSHALELLQLDRALARL-GPHQLTDSEIREACYLRGISPD---------GL 198
5_pfamImport 131 SVDQMRHASPLLF--LTPRLPGFLIGRRLNSHALELLQLDRALSRL-GPHQLSESELRQACYVRGLHSN---------AL 198
XP_005798965 249 SNNQIRHISPLLF--LTPRLPGFLIGRRLNSHAVELFQLDRALSQM-GPHQLSEWELKQACYVRGMNAD---------SL 316
XP_004071023 253 SVGQMRHISPLLF--LTPHLPGFLMGQRLNTHGLELLQLDRALSRL-GLHQLNESELRQACYVRGINSY---------CL 320
XP_007248372 229 KASHLRSLGSQIP--VIVWLPSFLVRRRLTTKALDLLYLDRALGTL-GLDQLSDEEMKRACDLRGLSPS---------RL 296
XP_002129203 271 VYVLLRAFCRTIM--VSTYQPPSWLKYRLRKNASLVISLDHKLRREgLLNNLSSLELSTASMMRGIDGA---------EL 339
XP_005991473 246 NKQRVKALSQVMM--LTPHLPSFFLRRRLWSHVSELHHLDQALSRL-GVSQLSEGELKTACYIRGLNST---------HL 313 coelacanth
XP_004182708 303 MRKEMIKALENWLLLRLKHHIPMVLLILATTAP 335
Q28EM8       308 SREDCETWLHCWLQLSSMLKVSEASLLLHCMVL 340 tropical clawed frog
NP_001124088 319 SPGQLREWLTQWLQFSAHLRESETSLYLHCMVL 351
8_pfamImport 199 QVSQCRAWLSQWLQVSSSLRDSEASLLLHSLVF 231
5_pfamImport 199 GISQSREWLSQWLQVSSALKDSEVSLLLHCIVF 231
XP_005798965 317 GTSQSREWLSQWLQVSSALKESELSLLLHCMVL 349
XP_004071023 321 GTNQCREWLFRWLQVSSSLKDSEVSLLLHCIVF 353
XP_007248372 297 TSSQCREWLQQWLQFSAQLKDSESSLLLHSMTI 329
XP_002129203 340 SREAQLYWLNNWLQITKTCDDDDAWFVLHAMVL 372
XP_005991473 314 STAACRNWLTQWLQLSTRLKGSEFSLLLHSMVL 346 coelacanth
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