Conserved Protein Domain Family
LETM1

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pfam07766: LETM1 
LETM1-like protein
Members of this family are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans.
Statistics
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PSSM-Id: 400222
View PSSM: pfam07766
Aligned: 135 rows
Threshold Bit Score: 186.547
Threshold Setting Gi: 1752402204
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCH63189      37 LGRRIRKEITHYINGTKLLANELSDSVKLVVRMTQ-GDH----MKRRELIQLRKTADDLFRLLPFSAFII-IPFAELLLP 110 Tetrapisispora ...
XP_001605931  73 NFPKTMHVYRVFSIGSKEFYADLKRYMQVRKKIRNfGADt---LNREELQLTFTFPKDLIKISPVLLISA-VPFTNYIIF 148 jewel wasp
EFA01050      73 SFPGAMRVYRVFTVGIKDFAQDLKDYFRIVRILNSpTKDkfksLTRREIELYHQMPKDMRKVAPVLLISA-LPFANYVIF 151 red flour beetle
XP_002084149 148 NFPKAMQLYRVFFDGVKDFFGDMKRFLKIARIANDsPQGir-aLNRQELELYMQMPRDMMKVAPALIGCS-LPMVGYAFF 225 Drosophila simu...
Q0IG76        85 KFPSAMHVYRVFLVGVKEFFNDMKKLVKITKIVYThDNDlr-cLTRKEIELYYQMPRDMKKVAPVLLVSA-LPFANYVVF 162 yellow fever mo...
Q7Q6P8        96 KFPSAVHVYRVFLVGVRDFFNDMKKLVKITKIVYShDNDlr-cLTRKEIELYYQMPRDMRKVAPVLLISA-LPFANYVIF 173 Anopheles gambi...
XP_002431928  21 MFPTAVKIYQDFSVGLKFLKSDFITLFRAFKKITScGLNs---LTRKELEVYYELPKDILRTAPVIFIGAvVPFGG-IIF 96  human body louse
EDO43880      70 rIQHFRKVMNQFVVGSKSLGSDVKRMVGIRRKLKEhGYNwd-aLTADETLHMTQVRQDLIKTLPAVLVFC-IPFLGYAAP 147 starlet sea ane...
NP_001155942 120 WSPSTAKYARLSVFGCKYLYKDVLVLLSAYKKYYSsDLSs---LTYAELELKYRLPLQLVRLTPILIFWP-VPFTNLFLF 195 pea aphid
XP_789564    100 vsPKARVFYERFVDGATSFVQDFRFVYSLNKRLKNgEVKle-dVEWKDLYKKMQMKQDVAKVLPVLVIVN-IPFVYYVTL 177 purple sea urchin
CCH63189     111 FCLKLFPN-LLPSTYETGDNKMLKL----IRLAENKSIISSLL--RNTLNDsklniplynnhSKQiAT---NKEIFNKFF 180 Tetrapisispora ...
XP_001605931 149 PLAFYFPHvLLTSHYWSIEDKLNFMlkehKKRLQHNKPLLRCV--QSQV-------------KTIqDTe--SRATFKNII 211 jewel wasp
EFA01050     152 PLAYLFPRiFLSRHFWNLQQRAEFSiyylRGRLVNNRPLFRCV--QGEL-------------DKIrGHr--LYYKWAEVL 214 red flour beetle
XP_002084149 226 PLVFYYPRsFLTAHFWTPQQRSEFQsyymKRRLCNNKDVFRCL--QAKL-------------KATaSHp--KHSAFAEIL 288 Drosophila simu...
Q0IG76       163 PLAYMYPRtFLTPHFWSIQQKVDFAqqdlKHRLQYNRRVFRCM--QAKL-------------DVMrKNndpLCEQFGNIL 227 yellow fever mo...
Q7Q6P8       174 PLAYMYPRtLLTSHFWSAQQKLDFVqidlRNRLLYNRRVFRCM--QSKL-------------DALkKThdpAYEKFAYML 238 Anopheles gambi...
XP_002431928  97 ILGYYFPKhLLTHHFWSQQQQNEFSslkhKKTISSYTPVYNCL--ESRL-------------SVIkDTd--LCLKMCNLL 159 human body louse
EDO43880     148 LIAFMYPKhLLSHHYWLPCQEQQFRdhdaLKRSNHYLPLVREVgrQALQ-------------EKRkDR---DLEDLLDVS 211 starlet sea ane...
NP_001155942 196 PLAFMFPKyLLSEHFWTDEQLKEYWikdqQNNFEHNMRVFEHL--SLMA-------------EECsDD---MLLKWFRVI 257 pea aphid
XP_789564    178 PVVLYFQRiFLSDHFITPEDVSNNHqenqKKRRRLYPFILKKL--DKRLKK-----------NPTsD----LAESLQQRI 240 purple sea urchin
CCH63189     181 YRlkiLKRNGysLaitklsfhfTEHEVLQVAKLFKDD-TLLISLTKRQLSLLNQYMSlsLPSLGTMN-------LLKYRL 252 Tetrapisispora ...
XP_001605931 212 AC---LGSGTh----------pTIDDILYCKKLFSGPpYSLKCMKRKHVKELLKVHG--MSRF--SL-------GNRTRL 267 jewel wasp
EFA01050     215 GM---MGSGVq----------pKVEQILQCKDLFTCEpYHLFYLKGKHVKHLLKIHD--LHM---GW-------FRRSRL 269 red flour beetle
XP_002084149 289 GQ---LGSGTh----------pTPEMLIDVKDIFADGpYSLLGMSRKHVRNLVNLHG--LPS---SI-------FKRHRL 343 Drosophila simu...
Q0IG76       228 GL---LGSGLh----------pTSEEILNIRDLFSRPpLHLNNLSSVHLKYLCKLHD--LNA---GL-------MRRYRL 282 yellow fever mo...
Q7Q6P8       239 GL---LGSGLh----------pTSEEILDVKEVFQRPpFHLNSLSSSHLKYLCRLHD--IHA---GL-------LRRFRL 293 Anopheles gambi...
XP_002431928 160 EN---IKSNVh----------pNAKSILSVKSLFKGVpFGLNHMESYHISKLLNLYN--MHK---GW-------RRRERL 214 human body louse
EDO43880     212 LK---TINKKh----------pTNEELLKSSDKFSGV-LGFNSLPKYHLKRLSHAWL--LWPWLPRR-------LLRGNL 268 starlet sea ane...
NP_001155942 258 EC---LGAGGv----------sPVDDIIQAIPVFTMFpYHFSTLPRQHIKVLLKMYN--IHR---GW-------RRRVRL 312 pea aphid
XP_789564    241 GE---DQLEKqpF---------SAAELLSFQPLFSQQ-TSLKSLSSSHLKYLCKLHS--------QWvflaassSLRKRL 299 purple sea urchin
CCH63189     253 RHTLNKIKKDDILIARE-GVTHLTDEELYEACMSRGIQIQhetdllthkSVMRKEMIKALENWLLLRLKHHIPMVLLIL 330 Tetrapisispora b...
XP_001605931 268 LERGLLIKRMDTAIQREgGVTKLPYDAIRWALSFRGVNPV---------NMSTESMQAWLDQWLLISSQVDEGSISLLL 337 jewel wasp
EFA01050     270 IERAVILQEMDKAIVREgGVHNMPQDALKHACYIRGLNPM---------NMRNEDMINWLNNWIKISSVVDRESWSLLL 339 red flour beetle
XP_002084149 344 HEHAFLVHYMDQAITREgGVHNLTPDALRYSCYLRGLNPD---------SLSSEAMIEWLRKWVKVSTSIQGEHITLFL 413 Drosophila simulans
Q0IG76       283 SERSYIVHHMDLAIKREgGVHNMPVESLKHACFVRGLNAT---------NLSTESMIDWLNEWVKVSLVVNQDNISMFL 352 yellow fever mos...
Q7Q6P8       294 SERAYVVHHMDMAIKREgGVHNMPIESLKHACYLRGLNAN---------NLSAESMIEWLQEWVKVSLVVDEDCISMLL 363 Anopheles gambia...
XP_002431928 215 YMRANLVKLMDLAIIKEgGPEILNLHDMRWHCFFRGLNPI---------NMNNDELLFWLRMWLEISREIDKNSYSLLL 284 human body louse
EDO43880     269 RRKLASIKKEDAALKRD-GLDSLDEIQIKRLCHCRGLQVQ---------SLEHEALKAWLTEWVELASHSSDHDdsfla 337 starlet sea anemone
NP_001155942 313 KKLAQYIQLMDRAIESEgGPDKLNDRQLKWACLFRGLSPF---------SSSRETLVLYLKDWIKISSKIDNDSLSCIL 382 pea aphid
XP_789564    300 STHSTLMVAMDQAILKA-GIHSIDEDDLRKLCYQRGLNPV---------GSDRQTLTDWLTEWTHISTSLTDAEWSLLL 368 purple sea urchin
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