Conserved Protein Domain Family
FEZ

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pfam07763: FEZ 
FEZ-like protein
This is a family of eukaryotic proteins thought to be involved in axonal outgrowth and fasciculation. The N-terminal regions of these sequences are less conserved than the C-terminal regions, and are highly acidic. The C. elegans homolog, UNC-76, may play structural and signalling roles in the control of axonal extension and adhesion (particularly in the presence of adjacent neuronal cells) and these roles have also been postulated for other FEZ family proteins. Certain homologs have been definitively found to interact with the N-terminal variable region (V1) of PKC-zeta, and this interaction causes cytoplasmic translocation of the FEZ family protein in mammalian neuronal cells. The C-terminal region probably participates in the association with the regulatory domain of PKC-zeta. The members of this family are predicted to form coiled-coil structures, which may interact with members of the RhoA family of signalling proteins, but are not thought to contain other characteristic protein motifs. Certain members of this family are expressed almost exclusively in the brain, whereas others (such as FEZ2) are expressed in other tissues, and are thought to perform similar but unknown functions in these tissues.
Statistics
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PSSM-Id: 400220
View PSSM: pfam07763
Aligned: 25 rows
Threshold Bit Score: 224.89
Threshold Setting Gi: 1020966579
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7JL61        61 NFDEKIAACLkDHEVTTA-DIAPVQIRTQEEVMNESQTWWTLTGNFGNIQPLDFGTSSICKKMAAALDsd--------sL 131 Caenorhabditis ...
EEN66629      60 EFDETLNICFrNYNAKTD-SIAPVKVLSQEEIMENSELWQGLTDNFANVLPVDWNSSYTRQLYNKALN-----------L 127 Florida lancelet
EKC28615      68 SFDEKITKCFcNFEENVNdKIAPVQIRSQEEIVNDCQVWWTITGNFGNILPIDWSKSYARQLQSKVLN-----------L 136 Pacific oyster
XP_015787650  89 TFDEKITKCFhDYEESVE-KLAPVQVRAQEDIINDSQMWWTLTGNFGNILPVDWSQSYARKLQLPSLKakdqngtnincL 167 two-spotted spi...
XP_002427172 125 TFDERITKCFcDYEENVE-KLAPVQVRTQEEIMNECQMWWTITGNFGNILPIDWSKSYARKLHVPTLN-----------L 192 human body louse
XP_001950389 125 TFDDKITRCFcDYEESVE-KLAPVQIRTQEEIMNECQMWWTITGNFGNILPIDWSKSYARKVQLPVLN-----------L 192 pea aphid
XP_002040450 143 TFDEKITKCFgNYEENVE-ELAPVQVRSQEEIMNECQMWWTITGNFGNILPIDWSKSYTRQMHMPTLN-----------L 210 Drosophila sech...
Q7QD97        21 TFDEKITKCFgNYEQSVE-ELAPVQVRSQEEIMNECQMWWTITGNFGNILPIDWSKTYARQMHVPALN-----------L 88  Anopheles gambi...
XP_392877     85 TFDEKITSCFrDYGTNVE-SLAPVQVRTQEEIMNECQMWWTITGTFGNILPIDWSKSYARKMHMPALN-----------L 152 honey bee
XP_014340345  91 DFDEKLTVCFrNYNTATE-GIAPVKPITEENIMKDDEIWNALTDNYGNVMPVDWKTSHTRALHLPTLN-----------L 158 coelacanth
Q7JL61       132 KDD-----------------------------------ASTRRSMT-----NSDDEDlLRQQMDVHQMIghHHGSTDtg- 170 Caenorhabditis ...
EEN66629     128 NEQk---------------------------------vREEPMNLD-----LSDDEE-LRESFDAHSLI--ISSLTQ--- 163 Florida lancelet
EKC28615     137 KENq----------------------------------VPESPNLD-----LSDDEE-LSQQFDMHSLI--VSSLQShd- 173 Pacific oyster
XP_015787650 168 NSK-----------------------------------NSLNHGDNilgdtTLDEED-LAKDLDLHSLI--LSSLHQ--- 206 two-spotted spi...
XP_002427172 193 TEN-----------------------------------NGGNSNDDii-nlSDEDEQ-VANDLDMHSLI--LNGLRQd-- 231 human body louse
XP_001950389 193 NNN-----------------------------------IQDESSDDl----SSEDEA-VSNDLDLHTLI--LSGPSAd-- 228 pea aphid
XP_002040450 211 GQNhtkqqqqnrnqqqqlhtqshqayphtngagsgsglDAQTPGDEfn-dlTSEDEA-VANDLDMHALI--LNGLNGdm- 285 Drosophila sech...
Q7QD97        89 GMR-----------------------------------KPGTPDDEllqdlSSEDEA-VASDLDMHALI--LGGLHAd-- 128 Anopheles gambi...
XP_392877    153 NE------------------------------------APVSQERPeledlSSEDEA-VATDLDMHALI--LSSSTDths 193 honey bee
XP_014340345 159 TEKg----------------------------------GIDNLNLD-----LSDDEE-LREQLDMHSII--VSCIND--- 193 coelacanth
Q7JL61       171 geTPPQTADQVIEEIDEMLQSCDFTGsmm-tdrTMESVDSMYsSmrspfpsSIQSSDADIKLrSAQALVSNPD-NLQELS 248 Caenorhabditis ...
EEN66629     164 --EPIFTAEEVIEEIDEIMGETSM---------EEETPVSEDsL-------SVLSQEMLALReRSNTVTSYDE-SLKKLP 224 Florida lancelet
EKC28615     174 -aDHVATADEVISEIETMMQEHGT---------QEYTQDD-------------LEHEMALEKeKLPQIPTYTEtDLKGMN 230 Pacific oyster
XP_015787650 207 --EPIFTAEQVLEEIDKIMQETSPTDkdssepmEEEKESS--------------TNRTVNETdNGIRSLIYRE-KLEKLT 269 two-spotted spi...
XP_002427172 232 -cESVKTAEEVIREIDDMIQEDFTGD-------SEESPDC----------------QDYERPkQIVHSPLYEE-KLKQLS 286 human body louse
XP_001950389 229 -iEP-PTADEVIREIDDIMEEGTS---------NECTPDS--------------------EHpKEVHSPLLEE-KLKTLN 276 pea aphid
XP_002040450 286 ddQPIKTVEEVIKEIDDIMDEAESPLd------EPETCDS----------------EVIEKArEVLGAPLYAE-KLQYLT 342 Drosophila sech...
Q7QD97       129 -nEPIKTADEVIKEIDDIMDETGS---------EDGQLEN----------------EVIEKAkEVLGSPLYEE-KLRSLS 181 Anopheles gambi...
XP_392877    194 peEPLKTAEEVLREIDDIMQESPS---------MERSPDSDGsL--------LDSDEALERSrEVLGSPLHEK-KLKHLT 255 honey bee
XP_014340345 194 --EPLFTAEQVIEEIEEMMQESPDPE-------DDETPTQSDrL-------SILSQEIQTLK-QSSTNSSYEE-RVKRLS 255 coelacanth
Q7JL61       249 YSKLVTLCAEMEQLIRVYNESLVDELAHRDELDYEKEMKNSFISLLLAIQNKRRVYA----NDRKRKVGKAS 316 Caenorhabditis elegans
EEN66629     225 LQTLNEVLEELEATIKEYSEILIQQLALRDELVYEKEVKNQFISALVAVQNRQREHKqnkdNKKKRKKVKGg 296 Florida lancelet
EKC28615     231 CTQLNEVLNEYEVIIKELSEVLIRELALRDELEYDKELKNQFISLLLTIQKRRRDGN----LDKKKKKTKSV 298 Pacific oyster
XP_015787650 270 ITQLNELYIELERMIQGNSETLIQELALRDELEFEKELKNTFISLLLGIQNKRRKHH----LERKKGKSANe 337 two-spotted spider mite
XP_002427172 287 LSQLNEVYLEVEVLIQKYSETLISELALRDELEYEKELKNTFIDLLVSVQNRRRQYH----AERKRCNRNGN 354 human body louse
XP_001950389 277 VSQLNEVYMELELLIRDYSETLITELALRDELEFEKELKNSFISLLLAVQNRRRQYH----VEKKRNSRAGN 344 pea aphid
XP_002040450 343 TTQLNELYMEMEVLIQELSETLINELALRDELEFEKELKNSFISLLLAVQNKRRQYH----VEKKRGKFQGP 410 Drosophila sechellia
Q7QD97       182 ITQLNELYMEMEVLIREFSETLISELALRDELEYEKELKNTFISLLLAVQNRRRQYH----VEKKKGKAGGK 249 Anopheles gambiae str. ...
XP_392877    256 SSQLNELLGEMESLVGALSETLIAELALRDELEYEKELKNQFISLLLAVQNRRRQHH----VTKKRNQMQNG 323 honey bee
XP_014340345 256 VAELNELLEEIETAIKDYSEELIQQLALRDELEFEKEVKNSFISVLIEVQNKQKEHRe---MVKKKKKMKNG 324 coelacanth
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