6CNB


Conserved Protein Domain Family
BRF1
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pfam07741: BRF1 (This model is not part of the current CDD release)
Brf1-like TBP-binding domain
In budding yeasts, Brf1 forms the TFIIIB complex with TATA-binding protein (TBP) and Bdp1. The TFIIIB complex can be recruited to the Pol III promoters and form an exceptionally kinetically stable TFIIIB-DNA complex, which then recruits the Pol III enzymatic complex and helps maintain it for multiple transcription cycles in a process called facilitated recycling. This entry represents the TATA binding protein (TBP) binding domain of Brf1 that covers both the Brf homology II and III regions.
Links
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Statistics
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PSSM-Id: 517862
Aligned: 127 rows
Threshold Bit Score: 48.698
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6CNB_R       603 EDVDDE-ELNAHLLNEEASKLKERIWIGLNADFLL---E-QESKRLKQEADIAT--------GNTSvkkkrtrrrnntrs 669 Saccharomyces c...
XP_003376712 424 DDLDDD-ELDGYLLTPEEAALKTKLWIRVNGEFME---E-YEKRKLLKEQEK-----------EEG-------------- 473
KAF8361356   423 EDIDDD-EIDSYILTDQEAHVKEKFWMKCNGEHLE---EvARRKKIREEEEAKE--------GEEG-------------- 476
XP_004346369 434 TVIEDD-EIAAAVLSRDEIIVKSKLWHHANRDYLL---K-QKQKQLEIADNLARgvaikadpVKRK-------------- 494
A0E531       335 SEIDEQ----EYILNEQEKANKQIVWSALNKEYIYdieLkNQKKKAQQEKNLLSgn-----kQQTQ-------------- 391 Paramecium tetr...
A0DUG6       335 SESDEQ----EYILSEQEKACKQLVWQTMYKEYIYdkmN-RNQKQDKQQKNLQSgn-----kQQNQ-------------- 390 Paramecium tetr...
XP_018638504 693 DDSAEE-EIRAMFLSESEQRAKALIWDELTKDVMPlvhRrLKEKKLREREMMLN---------QSK-------------- 748
Q4UC65       427 DDEDDIaMFKEMILPENERKMKMILWDEVTKDIMPkvyRrQMERKRREQLGQNV-------------------------- 480 Theileria annulata
XP_001615897 719 SDFYDS-EIENIILSEKERKRKMLIWDDMMKSYFPqyyK-QLKKQKKKRSSYHPdrvg-aekSRKK-------------- 781 malaria parasit...
XP_002130866 439 TGIDDN-EIDKLLLSPHESEIKQRIWMKEYGEFVK---E-LEEKREIKRIEN------------EK-------------- 487 vase tunicate

6CNB_R       670 deptktvdaaaaiglmsdlqdKSGLHAALKAAE---ES---GDFTTAD----SVKNMLQKAs--FSKKINYDAIDGLF 735 Saccharomyces cer...
XP_003376712 474 ---------------------SKGRRNFRKRGE---EG---TAATPGE----AIKRMVFEKr--LSKKINYEVL--ME 516
KAF8361356   477 ---------------------KKKKKRNLKKRD---HT---EAATPAE----AIEKIIQEKk--LSNKVNYDILKEFS 521
XP_004346369 495 ---------------------KKREPRT---------------TEPTEshdlTLRPAAVPKk--SSNKINYDVLRGLG 534
A0E531       392 ---------------------KARKQAKVEKSF----------PTPQE----SVAKNYENDg------INPQAVKNLF 428 Paramecium tetrau...
A0DUG6       391 ---------------------KPKKQVNVKQSF----------ATPQE----SVTNNYQNDg------INPQAVQNLF 427 Paramecium tetrau...
XP_018638504 749 ---------------------RKRLQSTGRRSRfgsDAgsaPAASAAE----SVRLALQMSsrsIVGKINDDALNSLF 801
Q4UC65       481 ---------------------KKRKYVRRVYSEyp------eAQDAVE----SARMALERHakgFMNHVNKDVFKSLL 527 Theileria annulata
XP_001615897 782 ---------------------KKKE-----NDD---HPl--DEQTTGD----SVIMALEKSdksMSTKMNYDVLKSLF 824 malaria parasite ...
XP_002130866 488 ---------------------KNRRPRKFKQVRykeYYg--ESRTAGE----AIEKLVSRQr--LSNKINYEALKkat 536 vase tunicate
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