5ED8


Conserved Protein Domain Family
Sad1_UNC

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pfam07738: Sad1_UNC 
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Sad1 / UNC-like C-terminal
The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.
Statistics
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PSSM-Id: 400199
View PSSM: pfam07738
Aligned: 23 rows
Threshold Bit Score: 114.695
Threshold Setting Gi: 74883899
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5ED8_A  132 LWYHSQSPRVILQPD---VHPGNCWAFQGPQGFAVVRLSARIRPTAVTLEHVPKALspnstI-SSAPKDFAIFGFDEDLQ 207  house mouse
Q9SG79  310 rrVHSKAVKMLTPSF---GEPGQCFPLKGSNGYVLVRLRAPIIPEAVTLEHVSKAVay--dR-SSAPKDCRVSGWLGDID 383  thale cress
Q9ULT8 1107 RNLPYGRLEDILSRD---NSALNCHSNDDKNAWFAIDLGLWVIPSAYTLRHARG-------YgRSALRNWVFQVSKDGQN 1176 human
Q20924  302 MSYFGTFQEGYALLDrdvLSPGEAWCTYDKRATLTVKLARFVIPKSVSYQHVRWSGi---vP-NHAPKLYDVVACTDSCC 377  Caenorhabditis elegans
O94901  675 LWYFSQSPRVVIQPD---IYPGNCWAFKGSQGYLVVRLSMMIHPAAFTLEHIPKTLsptgnI-SSAPKDFAVYGLENEYQ 750  human
Q8TAQ9  219 FLNHEMPPDIILQPD---VYPGKCWAFPGSQGHTLIKLATKIIPTAVTMEHISEKVspsgnI-SSAPKEFSVYGITKKCE 294  human
O55034  293 FWNYARPPSVILEPD---VFPGNCWAFEGEQGQVVIRLPGHVQLSDITLQHPPPTVahtggA-SSAPRDFAVFGLQADDD 368  Norway rat
Q8TC36  231 LWNYAQPPDVILEPN---VTPGNCWAFEGDRGQVTIQLAQKVYLSNLTLQHIPKTIslsgsL-DTAPKDFVIYGMEGSPK 306  human
Q09825  353 LVVRGHEPSIALTPN---NAVAMCWSFQGSEGQLGISLSRPVYVTNVTIEHVQHKIah--dL-SSAPKDFELWVQGMSSK 426  Schizosaccharomyces...
Q8SQT0  141 GFRKHKDPATVFDEN---VGVGECLTFKGSSCRFSVDFDKEVEICKLGIYHPVTRD-----T-SSAVQEFEVFSQGPDG- 210  Encephalitozoon cun...
5ED8_A  208 QE---GTLLGTFAY-DQDGEPIQTFYFQASKMA----TYQVVELRILTNW----GHPEYTCIYRFRVHGEP 266  house mouse
Q9SG79  384 MEtetMPLLTEFSY-DLDRSNAQTFDIADSAHSg---LVNTVRLDFNSNH----GSSSHTCIYRFRVHGRe 446  thale cress
Q9ULT8 1177 WTs-lYTHVDDCSL-NEPGSTA-TWPLDPPKDEk--qGWRHV--RIKQMGknasGQTHYLSLSGFELYGTV 1240 human
Q20924  378 TKw--QPLVANCEYkERDGSYDEQEQFCSVPTIqnhsPINHVQFRFRENH----GDMPKTCAYLIRVYGEP 442  Caenorhabditis elegans
O94901  751 EE---GQLLGQFTY-DQDGESLQMFQALKRPDDt---AFQIVELRIFSNW----GHPEYTCLYRFRVHGEP 810  human
Q8TAQ9  295 GE---EIFLGQFIY-NKTGTTVQTFELQHAVSE----YLLCVKLNIFSNW----GHPKYTCLYRFRVHGTP 353  human
O55034  369 ET---EVFLGKFIF-EVQKSEIQTFHLQNDPPS----AFPKVKIQILSNW----GHPRFTCLYRVRAHGVR 427  Norway rat
Q8TC36  307 E----EVFLGAFQF--QPENIIQMFPLQNQPAR----AFSAVKVKISSNW----GNPGFTCLYRVRVHGSV 363  human
Q09825  427 M----FVLLGKARY-SLTEDSIQTFSFESSNYIva-ePIQNVILKIKSNW----GNPNYTCLYQVRVHGTV 487  Schizosaccharomyces pombe 972h-
Q8SQT0  211 -----HLLVGEFKY-DPDVCGFQTFEFEGR-------TVKSVEFVVKSNG----GNKKFTCIYKLYLFGNK 264  Encephalitozoon cuniculi
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