2HDI,8THE,3M8D,5FR8,3FHH,6I96,6V81,5ODW,1BY3,8AA4,1KMO,6BPM,5T3R,6E4V,5FQ8,1XKW,6SML,4AIQ,4EPA,8BLW


Conserved Protein Domain Family
Plug
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pfam07715: Plug (This model is not part of the current CDD release)
TonB-dependent Receptor Plug Domain
The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.
Links
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Statistics
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PSSM-Id: 517841
Aligned: 605 rows
Threshold Bit Score: 34.5526
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2HDI_A  20 LKDAPASISVITQEDLQRKPVQNLKDVLKE-VPGVQl-TNE-G-DNRKGVSIRGLds-------sYTLILVDGKRVNS-- 86   Escherichia coli
Q8A5Z2  31 MKDIGVQQTRFDSLVLKENIALSMADILTF-NSSIFv-KSYgR-ATLSTVSFRGTsa-------sHTQVTWNGMRINN-- 98   Bacteroides thetaiot...
Q8P7Y6  87 KRDSTSIVEAISAEDIGRLPDVSIAESLAR-LPGLA--AQRvA-GRAQVISVRGLsp-------dFSTTLLNGREVVSt- 154  Xanthomonas campestr...
Q8P6M3  52 KRNNTGISEAITAEDIGKFPSTNVAEALSQ-IPGVT--LDRrF-GQGERVSIDGTdp-------sLNLSFLDGHPVAQai 120  Xanthomonas campestr...
Q7M977  37 ISKNP-SLEIVTQETIRETEAKSVVDALQS-VPGIYt-DYAgA-RGETKVRLRGFss-------tRVPLYIDGIPIYV-- 103  Wolinella succinogenes
Q8KBM4  42 TGKSANSSETVPAAEMEMLDKQNLSEAADL-LPGVTi-SNVgG-RNEGMIYVRGFdm-------rQVPLYLDGVPLYV-- 109  Chlorobaculum tepidum
Q89H12 103 VDKVPSAINAVDANQIKRTGSLNVTDALRDnIAGVNitEVTgN-PFQPDVEFRGFvaspvtgtpqGLAVYQNGVRINE-- 179  Bradyrhizobium japon...
Q8P569  59 AAQLPYMVQSANRAELSRGRSNNLGDLLQRrFVGVDgnDVQgS-AFQNDLTFHGFrasalpgasqGVSVYLDGVRFNE-- 135  Xanthomonas campestr...
Q8A7N5  51 EVRSASPLQVFNKEELKNLQALQVSDAVKH-FAGVTvkDYGgI-GGLKTVSIRSLga-------qHTAVSYDGITVSD-- 119  Bacteroides thetaiot...
8BLW_A  51 evrSASPLQVFNKEELKNLQALQVSDAVKH-FAGVTv-KDYgGiGGLKTVSIRSLga-------qHTAVSYDGITVSD-- 119  Bacteroides thetaiot...

2HDI_A  87 RNavfrHNDFDLNWIP-----VDSIERIEVVRgPMSSLYGSDALGGV 128  Escherichia coli
Q8A5Z2  99 PM----LGMTDFSMIP-----SYFIDDASLLHgTSSVNMAGGGLGGL 136  Bacteroides thetaiotaomicron
Q8P7Y6 155 GD----NRSVEFDQYP-----SELVSGVTVYKtPDAGLVGQGLSGTV 192  Xanthomonas campestris pv. campestris
Q8P6M3 121 WL----YGEQPSRGFDytllaPQILGRAEIIK-SSEARLTEGSLGGT 162  Xanthomonas campestris pv. campestris
Q7M977 104 PY----DHNIDLGRFK-----TYDIGEIDVSKgYVSPMYGANTMGGA 141  Wolinella succinogenes
Q8KBM4 110 PY----DGYVDPNRFL-----TMNLSEVSVSKgFTSVLYGPNTLGGA 147  Chlorobaculum tepidum
Q89H12 180 AF----SDAVNWDLIP-----TAAIRSVTLVTnNPA--FGLNALGGA 215  Bradyrhizobium japonicum
Q8P569 136 PF----ADIVSWDMLP-----EAAINAVTLMPgSNP-LFGPNTLGGA 172  Xanthomonas campestris pv. campestris
Q8A7N5 120 CQ----TGQVDIGRFS-----LNNVDRLSLNNgQSDNIFQPARFFAS 157  Bacteroides thetaiotaomicron
8BLW_A 120 CQ----TGQVDIGRFS-----LNNVDRLSLNNgQSDNIFqparffas 157  Bacteroides thetaiotaomicron VPI-5482
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