Conserved Protein Domain Family
RabGGT_insert
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pfam07711: RabGGT_insert (This model is not part of the current CDD release)
Rab geranylgeranyl transferase alpha-subunit, insert domain
Rab geranylgeranyl transferase (RabGGT) catalyzes the addition of two geranylgeranyl groups to the C-terminal cysteine residues of Rab proteins, which is crucial for membrane association and function of these proteins in intracellular vesicular trafficking. This domain is inserted between pfam01239 repeats. This domain adopts an Ig-like fold and is thought to be involved in protein-protein interactions and might be involved in the recognition and binding of REP.
Links
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Statistics
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PSSM-Id: 517837
Aligned: 7 rows
Threshold Bit Score: 173.844
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_007233482 265 LISCVYVSREGERVAVAFSKPVNAL---TE--GLMLVLDGqQQQRVEWRSAHPRFRHSPVWLCELPPGSVSDINNEHNLT 339
4_pfamImport   1 MISCVYVSREEGRVAVAFSRPVNVRkkmCV--NLLLVLDG-QPQRVEWRSVHPRLKHSPVWICDLPPGAISDAVNEHNLT 77 
2_pfamImport   1 MISCVLVSREEETVTVAFSRPVDAQ---PG--GLMLLLDG-QPQTVEWRSVHPRFKHSPVWICDLPPGTISDVTNEHNLT 74 
3_pfamImport   1 SITCLYASWDMGQLVVGFSRPVNVLl-eSS--ELVLFVDG-RPTPVKWQNPRKTQSYSCVWVSVLRTVGLQSGAPIMTFF 76 
XP_031810957 244 AIRCLHVSRNEACLTVCFSRPIIVGp-gIE--TVMLLVDE-SPLPVEWRTPDGKKRPNHVWLCDLPADSFNDQDSQHSFF 319
Q5EA80       244 ALRCLHVSRDEACLTVSFSRPLLVG---SGmeTLLLMVDE-SPLAVEWRTPEGRNRPSHIWLCDLPATSLNDQLPQHTFR 319 domestic cattle
XP_056719630 298 SIRCLYVNREDASLAVAFSHPMAVAp-aSH--DLVVFGDE-SPLVVRWRTPDGRNKPGLMWLCDLPATSLNDHWPQHTFR 373 tarantolino

XP_007233482 340 VHWMEKHTHRDCALYTGRPESWCRDSA 366
4_pfamImport  78 VHWTEKRTRRDCALYTGRSQSWCRDSA 104
2_pfamImport  75 VHWMERHAHRDCALYTGRTESWCRDSA 101
3_pfamImport  77 CVWGGGQYNKECILYPGRTETWCRDSA 103
XP_031810957 320 LMW--GDVQKECVLYKGRKESWCRDSA 344
Q5EA80       320 VIWTAGDAQKECVLLKGRQEGWCRDSA 346 domestic cattle
XP_056719630 374 VLWAEGQAQKECVLFKGHKDCWSQDSV 400 tarantolino
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