Conserved Protein Domain Family

pfam07706: TAT_ubiq 
Aminotransferase ubiquitination site
This segment contains a probable site of ubiquitination that ensures rapid degradation of tyrosine aminotransferase in rats. The half life of the enzyme in vivo is about 2-4 hours. In addition, unpublished information identifies at least 2 phosphorylation sites including CAPK at Ser29 and, at the other end of the protein, a casein kinase II site at S*QEECDK. This region of TAT is probably primarily related to regulatory events. Most other transaminases are much more stable and are not phosphorylated.
PSSM-Id: 400173
View PSSM: pfam07706
Aligned: 22 rows
Threshold Bit Score: 63.971
Threshold Setting Gi: 55742474
Created: 21-May-2020
Updated: 7-Aug-2020
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
XP_003439428    7 TKSYMVQMNGNG-----------VCGKTTVngktlnengvnrngvhgngvhhvnikgalyPTKSKSRRQR 65   Nile tilapia
ELW63039       17 MDPYTIKMNGNGslpsvldvrvnIGGRSAS------------------------------SGKMKGRKAR 56   Chinese tree shrew
CAF98918        3 NQAYVVQMNGNA-----------VHGKGPAkcptpngtrvtgn-----gmhrvgangslyPAKGKSRRLG 56   spotted green pufferfish
XP_003967041    3 NKAYLVQMNGNG-----------VHGKNPVnsktpngtgvtgs-----glhrlsgngslyPTKVKSRRLR 56   torafugu
XP_026653414    1 MDSYLIQVNGHGdhapvldvhlkNTGNTIS------------------------------PGKVKGRKPR 40   white-throated sparrow
XP_003227448    1 MDSYLIQVTGKSafpsvmdvqlgRAGRGPC------------------------------CVAGKGKGHR 40   green anole
XP_004763504    2 MDPYVIQMNGNSslpsvldmhvnIGGRSSL------------------------------PEKRKSRKAR 41   domestic ferret
XP_005218713    1 MDPYVIQMQDHGslpsvldvhvnVAGRSSV------------------------------LGKVKSRKAR 40   cattle
XP_003126932    1 MDPYVIQMHGHGnlpsvldvhvnTAGRIPV------------------------------PGKMKGRKAR 40   pig
XP_031471156    1 MDSYLIQVNGQGdhvplldihlkTNGNSMS------------------------------LGKVKGRKPR 40   Ring-necked pheasant
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap