4H2A,4LHN


Conserved Protein Domain Family
PA14

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pfam07691: PA14 
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PA14 domain
This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.
Statistics
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PSSM-Id: 400161
View PSSM: pfam07691
Aligned: 22 rows
Threshold Bit Score: 97.0527
Threshold Setting Gi: 81657820
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4H2A_A   15 SSQGL-LGYYFSDLNFQAPMVVt-------SSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATS-ADN 85   Bacillus anthracis
Q8CK54   42 QEPGVtLRVFDVQTPLNELCTLkpg---qtPNHDKLMPTVDWSTTADFGGIADNFVSQASGYLVAPRDGTYVFRLV-SDD 117  Streptomyces coelic...
Q8AAF9  630 LNSGLkAVWHKFRGNLCAD-----------IDAAPVNGEYVVESVSIPEEVKGDIGLIITGYLEVPADGIYTFALL-SDD 697  Bacteroides thetaio...
Q7URI2  387 LEPGLdYRMYLGKFKKLPEFET--------MEVERTGQVDSLNLEEIQGDQRDDFALSINAMFRVPEEGLYRFQIT-SDD 457  Pirellula sp.
Q9P6J6  398 GKHGYvAKFYLEPATSENRTLI--------DDYDLEDGVVRFYDYCNDKMKDGYFYIDIEGYLIPDEDAVYEFGIS-VFG 468  Schizosaccharomyces...
P49008  626 PKPGL--TIRTAYGDLYDVPDLqqvaswevGTVSSLEEIMHGKEKITSPEVLERRVVEATGYVLIPEDGVYEF----STE 699  Porphyromonas gingi...
Q7UF11  396 LRSGVlVETFEPVAPSPPLSSIaelr-ddeTFVANTPSTASDISSFSYSAAPGAKVSRIRGIVSPPVSGHYTFHLA-ASD 473  Pirellula sp.
4LHN_A   78 DSYGn-WGCKGMG-----------------ACSNSQGIAYWSTDLFGFYTTPTNVTLEMTGYFLPPQTGSYTFKFAtVDD 139  Saccharomyces cerev...
P36170  121 DNTTLsSKTEKRE-----------------NDDCDQGAAYWSSDLFGFYTTPTNVTVEMTGYFLPPKTGTYTFGFAtVDD 183  Saccharomyces cerev...
Q7UKT3  181 SKHGLsVSIYEGKGWKKENRKI--------ERVDSVVDFDFGKEGPGEGVPWDEFHAHWDGGLRVEQTGRYEIVVR-SKT 251  Pirellula sp.
4H2A_A   86 HVTMW--VDDQEVINKA--------------------------SNSNKIRLEKGRLYQIKIQYQRENPTEKGld--fKLY 135  Bacillus anthracis
Q8CK54  118 GSRLA--LDGATVIDHDglhg---------------------aepKDGTVELTAGAHPLRIDHFDRGGGQQV-----QLS 169  Streptomyces coelic...
Q8AAF9  698 GSTLK--LDGELLGDNDgah---------------------spVEIIVQKALKAGLHPIEVRYFDCNGGVL------QME 748  Bacteroides thetaio...
Q7URI2  458 GSRVF--LHDKLFLDHDgnh---------------------ppMTVSRLVRAGAGLHPIRIDYFEGGGAQTL-----TAA 509  Pirellula sp.
Q9P6J6  469 TALLF--IDDVLLIDNKtkqtptnh-----------tfefgtiEERNSIYLKKGRKYNVRVEYGSAATYTLS------TN 529  Schizosaccharomyces...
P49008  700 NNEFW--IDNVKLIDNVgev--------------------kkfSRRNSSRALQKGYHPIKTIWVGAIQGGWP------TY 751  Porphyromonas gingi...
Q7UF11  474 EAELW--LSQGVTSDTSrliasvatpt------lmegftdanaGLSASVYLVAGQDYYVETLQVHDDPVAKNh---lSVA 542  Pirellula sp.
4LHN_A  140 SAILS--VGGATAFNCCaqqqppitstnftidgikpwggslppNIEGTVYMYAGYYYPMKVVYSNAVSWGTL-----PIS 212  Saccharomyces cerev...
P36170  184 SAILS--VGGNVAFECCkqeqppitstdftingikpwnadaptDIKGSTYMYAGYYYPIKIVYSNAVSWGTL-----PVS 256  Saccharomyces cerev...
Q7UKT3  252 SFTMDfgHDSKQLIDNHvqse-------------------grnEFRRTLLLTGGRVYPLEIDLNQRKRKGETppasiSLS 312  Pirellula sp.
4H2A_A  136 WTDSQNKKEVISSDN 150  Bacillus anthracis
Q8CK54  170 WMPPGESGFTVVPTE 184  Streptomyces coelicolor
Q8AAF9  749 LVNEKGEKEVLPKEW 763  Bacteroides thetaiotaomicron
Q7URI2  510 LTRLDVAGDDDGDDS 524  Pirellula sp.
Q9P6J6  530 LSPSTGGRYSIGCVK 544  Schizosaccharomyces pombe 972h-
P49008  752 WNYSRVMIRLKGEEK 766  Porphyromonas gingivalis W83
Q7UF11  543 WTRPDQLASGPQLIG 557  Pirellula sp.
4LHN_A  213 VTLPDGTTVSDDFEG 227  Saccharomyces cerevisiae S288C
P36170  257 VVLPDGTEVNDDFEG 271  Saccharomyces cerevisiae S288C
Q7UKT3  313 WVPPGGIETIIPASA 327  Pirellula sp.
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