O94019 86 FFIVIFITAFTAATsNDAGSIQdSL------NEKy-------------------------------gISYDA-----MNT 123 Candida albicans Q9Y7E0 42 VSWMTLVVTFSSTC-LLPAAP--EI------ANEf-------------------------------dMTVET-----INI 76 Aspergillus terreus O59833 89 LFVATVYTFLEVYV-IWSSTACiNF------FDIy-----------------------------------------qTNW 120 Schizosaccharomyces p... Q9URI1 123 ISFLTTSVYMGSAV-YTPGIE--EL------MHDf-------------------------------gIGRVV-----ATL 157 Candida albicans O59699 141 LAYVALCSSFASSV---FAVPAeAI------TTVf-------------------------------hISLTV-----SLL 175 Schizosaccharomyces p... P0CU10 48 ISSMTFLNQYGDSV-FAPSIS--NI------AEQf-------------------------------hASRTL-----VTL 82 Schizosaccharomyces p... O93992 65 ISIGSVCVTCISSS-VALATP--QI------MEHl-------------------------------dVSHEV-----AIL 99 Candida albicans Q8X5A4 20 FLIVAFLTGIAGAL-QTPTLSI-FL------TDEv-------------------------------hARPAM-----VGF 55 Escherichia coli O157:H7 Q961H2 54 LEPAVFLIFFARNL-IGAVYQNqILyqtcitIEKfnatqcepllg------------idrgsdadkeVEVIV-----QTY 115 fruit fly Q9VY22 66 VANNVTVEPILAAY-IMPSVLSnLA------TQNlnlekacrvnmaygdevcdaltrrqtanytleeETVQQmvarmAAW 138 fruit fly
O94019 124 ----GAGV---LFL--GI---GWGTFFL-TPA--SSLYGRKI-TYFICIFLGLLG-AVWFA-----L---VkstSD---- 174 Candida albicans Q9Y7E0 77 ----SNAG---VLV--AM---GYSSLIW-GPM--NKLVGRRT-SYNLAISMLCAC-SAGTA---------AainEKm--- 127 Aspergillus terreus O59833 121 ----HCSIqvsYLVqsLFivgNAFGPMLlGPM--SDIFGRKW-VYVGSLILYIIF--QIPQa----L---A---YNlp-m 180 Schizosaccharomyces p... Q9URI1 158 ----PLTL---FVI--GY---GVGPLVF-SPMseNAIFGRTS-IYIITLFLFVIL---QIPt---aL---V---NNia-g 210 Candida albicans O59699 176 ----TMTV---FLL--GY---CSGPIIW-APL--SELSGRKP-PILIGMLGFGIF-NISVA-----V---GkdiQT---- 226 Schizosaccharomyces p... P0CU10 83 ----GATL---YTL--GI---LFGNLIF-APL--SEQFGRRP-IYLIGYSVFALL-QIPIA-----L-------SVnlam 133 Schizosaccharomyces p... O93992 100 ----NISF---FIL--GL---GTGGCFL-SPI--SEFHGRRI-VYIGGLTTMIAF-EFLTA-----F---T---SNig-a 150 Candida albicans Q8X5A4 56 ----FFTG---SAV--IG---VLVSQFLaGRS--DKR-GDRKsLIVFCCLLGVLA--CTLFa----W---N---RNyfvl 108 Escherichia coli O157:H7 Q961H2 116 saniMMTT---SLL--ESiipAFASLFL-GPW--SDKFGRRP-ILLTTFTGYLTGaLILIVi---tYitrStniSPwwfl 183 fruit fly Q9VY22 139 ----KTVI---QSL--FP---CLLILFW-GSW--SDRHRRRKpCILIPVVGEFLG--VVGLmlcvyFeqaPmeaAAlt-e 200 fruit fly
O94019 175 SIWSQLFVGISEsCAEAQVQLSLSELYFAH------NLGSVL--TSYIVATSVGTYLGPLIAAFIV-QNIG---FRWVGW 242 Candida albicans Q9Y7E0 128 FIAFRVLSGLTG-TSFMVSGQTVLADIFEPv-----YRGTAV--GFFMAGTLSGPAIA-CVGGVIV-TFTS---WRVIFW 194 Aspergillus terreus O59833 181 MAINSAIAGAFG-SSALANVASSMCDIFTPe-----TVGFGI--SLFVWGANAGASIGSPIGEALY-DH-----WRWFYW 246 Schizosaccharomyces p... Q9URI1 211 LCILRFLGGFFA-SPCLATGGASVADVVKFw-----NLPVGL--AAWSLGAVCGPSFGPFFGSILT-VKAS---WRWTFW 278 Candida albicans O59699 227 IMMCRFFAGFFA-SAPLTVVAAALADMYSNk-----YRGTAI--TLFSAMVFDGPLVSPIVGGFLTkSYLG---WRWTEY 295 Schizosaccharomyces p... P0CU10 134 FLVFRFFSGLFG-SVGLSNGSGSLADLFEKk-----DRGKYM--VIYFTVLSIGPGIAPIISGFISqSSIG---WQWEFW 202 Schizosaccharomyces p... O93992 151 MVFGRFMSGFCG-SSYMSVASGSFADLFKArkkegkDANKEL--SLALILYSVAPFLGPSLGSLISgFINThlyYRWTFY 227 Candida albicans Q8X5A4 109 LFVGVFLSSFG--STANPQMFALAREHADKt-----GREAVMfsSFLRAQVSLAWVIGPPLAYALA-MGFS---FTVMYL 177 Escherichia coli O157:H7 Q961H2 184 LSSVPSVVSGGT-CALITGIYCYISDVAKEr-----KKALRM--VLNEASLCAGIMVGNVASGYIY-AATN---ALVLFS 251 fruit fly Q9VY22 201 AIFPSLSGGWFT---MLMGVFSYIADITTEe-----DRTLRI--GILNVCFSVGVPIGMAFSGVLL-KQIG---FYGVFS 266 fruit fly
O94019 243 IAAIISGALlfvIVfcLDETYFdrakftkpfitGIAPFDSSYSNGKSDsknsipekqnsvkiesnveskeveqsdddian 322 Candida albicans Q9Y7E0 195 LQLGMSGLG---LV--LSLLFF-----------PKIEGTSEKVSTAFKpttlvsii------------------------ 234 Aspergillus terreus O59833 247 MNMIVGGFF---VI--L--CVLcp--------eTLPVINIMNYSSTTGektvqvstlakak------------------- 292 Schizosaccharomyces p... Q9URI1 279 FMCIISGFS---FV--M--LCF-----------TLPETFGKTLLYRKAkrlraitgndritsegei-------------- 326 Candida albicans O59699 296 ITSFMGFFA---LI--I--VYL-----------FCDETYSKAIIQGKAkeyraitgnyfvhakse--------------- 342 Schizosaccharomyces p... P0CU10 203 ILLILSGFN---LFwaF--LLL-----------KETYPPVLNRKKFEKygeigenepvalrltg---------------- 250 Schizosaccharomyces p... O93992 228 VFIIWSGVL---LLavV--LFV-----------PETHEPVNLQRKAKRlrkttgdnryyaaadk---------------- 275 Candida albicans Q8X5A4 178 SAAVAFIVC---GV--M--VWL-----------FLPSMQKELPLATGTveap---------------------------- 211 Escherichia coli O157:H7 Q961H2 252 IAGSLMMFA-------LMYVLL-----------FVPESLNPGDIHTGSrvreffrf------------------------ 289 fruit fly Q9VY22 267 ISAAFYVIA---FV--Y--GFF-----------FLEEPQSRPEKSAEQkslladffdkeh-------------------- 308 fruit fly
O94019 323 egendppisywkrtamitpatnlkgtgFKQYINQLk-------------lLLKVFLYPpviysGFCWGIqnalLTFYLTV 389 Candida albicans Q9Y7E0 235 -------------------skfsptdvLKQWVYPNvflavsaweicplhlLETKCSCRkqkdlCCGLLA----ITQYSIL 291 Aspergillus terreus O59833 293 --------------savvrtkfvlstaFKLLCTEPiim----------alGLYNGFAY-----GLIFLY----LDGLFPV 339 Schizosaccharomyces p... Q9URI1 327 ---------enskmtsheliidtlwrpLEITVMEPvvl----------liNIYIAMVY-----S-ILYL----FFEVFPI 377 Candida albicans O59699 343 ----------eevltlsdiaknyllvpMKLLFTEPi--------------CFLITLYS-----SFVYAI----LYLLLEA 389 Schizosaccharomyces p... P0CU10 251 -----------kqllikllillsmkkpISILLSQPi--------------LICVACTI-----GSIYGMinlvLIAFSEV 300 Schizosaccharomyces p... O93992 276 -----------qttslyesvltsskrpILLLLKDNmtalln----lytgfTLAVVYLF-----FVAFPY----IFSTVYH 331 Candida albicans Q8X5A4 212 ----------------------------rrnRRDTl-------------lLFVICTLM-----WGSNSL----YIINMPL 241 Escherichia coli O157:H7 Q961H2 290 --------------------dlvtdliRTCFKRRPnfdr-------tiiwLTMIALTI------AIFDMegesTVNYMFV 336 fruit fly Q9VY22 309 ----------------vvqtfrvafkkGENQRRKRvil----------lmIVVMVIIG-----PLHGEM----AVTYLFT 353 fruit fly
O94019 390 edd-qyyDPPYSYG--------NIAVGLMNIPCLIGAIIg--CFFAGTLS-DYftiylakRNKgiqeaEYRLWFLLPPAI 457 Candida albicans Q9Y7E0 292 tsaraifNSRFHLTtalv-sglFYLA--PGAGFLIG------SLVGGKLSdRTvrr--yiVKR-----GFRLPQDRLHSG 355 Aspergillus terreus O59833 340 f------VDNYKMGymg--anlTYLN--FLVGVTIVVMLqpiQNWLYRWD-KRrhg--gvARP-----EARFLISLLTVW 401 Schizosaccharomyces p... Q9URI1 378 y-----fVGVKHFTlvelgttyMSIV--IGIVIAAFIYI---PVIRQKFT-KP-------ILR-----QEQVFPEVFIPI 434 Candida albicans O59699 390 y------PIIFGEKrhf--smgVAELPYIGLLVGVFIGSginIAFEPWYY-RKclaqggkPDP-----EARLPPMMIGCF 455 Schizosaccharomyces p... P0CU10 301 w------KSSYDFSpgi--sglMYISITLGLFSAVFIAMpinQKFYSYLV-KRng---geGEP-----EFRLPMGFIGIT 363 Schizosaccharomyces p... O93992 332 f-----tISEQGMS--------FLGLVVGMVSTCLISPY---FIDKGYVAlLRknn--gvAKP-----EFRFIPLMVGAF 388 Candida albicans Q8X5A4 242 f-----iINELHLPe-------KLAGVMMGTAAGLEIPT---MLIAGYFA-KR-------LGK-----RFLMRVAAVGGV 293 Escherichia coli O157:H7 Q961H2 337 -------QDKFNWT--------IKDFSLFNASRIVIQIV---GSIVGMLVlRR-----------------VLKMSIVTMA 381 fruit fly Q9VY22 354 -------RFRFNWSeve--fsfFSTY--AMFTGLIGVIF-----CVGILS-HK-------LNI-----DDALVGVLSSTS 404 fruit fly
O94019 458 IAPVGLILFAVG---TDQVWSWV------PTYIglgfIGF-GYGCA----GDVSMSYLMDSYPNAVIETMTVVAV-INNC 522 Candida albicans Q9Y7E0 356 LITLFAVLPAGT---LIYGWTLQed--kgGMVVpiiaAFFaGWGLMgs-fNCLNTYVAVEALPRNRSAVIAGKYM-IQYS 428 Aspergillus terreus O59833 402 FFPAGLFWFAFT---SDGRISWV------SPLIaggvLGV-GDPQL----WLAMINYITDSYP-SVAGSAIAAFTlPSFA 466 Schizosaccharomyces p... Q9URI1 435 AIVGGILLTSGL---FIFGWSANrtthwvGPLFgaatTAS-GAFLI----FQTLFNFMGASFKPHYIASVFASND-LFRS 505 Candida albicans O59699 456 MFPAGIFWLSWSghySYVNWVVP------ALSG----LAT-GCGILli-fLQCINYLIDAYL--FRAASAIAANT-IMRS 520 Schizosaccharomyces p... P0CU10 364 LFEIGILLFGWT---ARYKIFWF------VPTIgsaiMGG-GYIMT----SNPLNMYVVDSY--GIYSASASAGVkIFQL 427 Schizosaccharomyces p... O93992 389 VVPIGLFIIAWT---SYSHIHWI------APIIgsavYGS-GTILV----FNSIFAYTVEAY--RLYAASAMATNsLTRS 452 Candida albicans Q8X5A4 294 CFYAGMLMAHSP-----------------VILLglqlLNAiFIGIL----GGIGMLYFQDLMP-GQAGSATTLYT-NTSR 350 Escherichia coli O157:H7 Q961H2 382 MLSLACCVLEST---VRATAVYW------QELY----LGM-TLGMMrgvmGPMCRAILSHVAPATEVGKIFALTT-SMES 446 fruit fly Q9VY22 405 KILSSFVYAFAT-----LPWHMY------LGGL----VEI-FNGTA----FIAMRSIATKLVSKDELGKVNSLFG-VAEA 463 fruit fly
O94019 523 IGCVFTF 529 Candida albicans Q9Y7E0 429 FSAGSSA 435 Aspergillus terreus O59833 467 IAAVLVH 473 Schizosaccharomyces pombe 972h- Q9URI1 506 VIASVFP 512 Candida albicans O59699 521 AMAAGFP 527 Schizosaccharomyces pombe 972h- P0CU10 428 LLGAIFP 434 Schizosaccharomyces pombe 972h- O93992 453 VLSCIFP 459 Candida albicans Q8X5A4 351 VGWIIAG 357 Escherichia coli O157:H7 Q961H2 447 VSPLGAA 453 fruit fly Q9VY22 464 LMPMVFA 470 fruit fly
Lu S et al.(2020). "CDD/SPARCLE: the conserved domain database in 2020.",