7Q5Z,4XAM


Conserved Protein Domain Family
TED_complement

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pfam07678: TED_complement (This model is not part of the current CDD release)
A-macroglobulin TED domain
This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Statistics
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PSSM-Id: 517817
Aligned: 19 rows
Threshold Bit Score: 337.757
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7Q5Z_A        928 VTVLGDIMGTALQ----------NLDGLVQMPSGCGEQNMVLFAPIIYVLQYLEKAGLLT---E--E------IRSRAVG 986  human
Q8IZJ3       1120 ASIIGDVMGPTLN----------HLNNLLRLPFGCGEQNMIHFAPNVFVLKYLQKTQQLS---P--E------VERETTD 1178 human
Q9VLT3       1160 ISVVGDVVGPIFPtm------pvNASSLLSLPMESGEQNAFSFAANLYTIMYMRLINQRN---K--T------LEKNAFY 1222 fruit fly
2_pfamImport    1 VSVKGLLIGEVMSavl----sqeGIDILTHLPKGNAEAELMSIVPVFYVFHYLEAGNNWN---I--FssnslaQRQNLQK 71  
P01029        978 ASEPLETMGSEGAls------pgGVASLLRLPQGCAEQTMIYLAPTLTASNYLDRTEQWS---K--Lsp---eTKDHAVD 1043 house mouse
P0C0L4        982 ASDPLDTLGSEGAls------pgGVASLLRLPRGCGEQTMIYLAPTLAASRYLDKTEQWS---T--Lpp---eTKDHAVD 1047 human
Q7SZG2        965 ITAEED--GFTLPramsl-lspeKAAKLIVLPTGCLEQTMVKLAPTASAIRYLDLSNQWS---K--Lsv---nARDKALD 1033 torafugu
1_pfamImport    1 ISMEAN--GFCTSqvsnl-lnpeKVSNLIHLYKGCLEQTMSTFAPTTLAMRYLDLSQQWF---T--Lep---gARDVALS 69  
4XAM_C        226 ASDPLDTLGSEGAls------pgGVASLLRLPRGCGEQTMIYLAPTLAASRYLDKTEQWStlpP--E------TKDHAVD 291  human
XP_026691729 1134 IYAYASYMGPSIEvnqitqeprsIASIF-RQPYGCGEQNMLVTGPNVYAHMFLVTTGKMA---PgsI------RYEQSIR 1203 vase tunicate
7Q5Z_A        987 FLEIGYQKELMYK-HSNGS---YSAFGe----RDGNgnTWLTAFVTKCFGQ-----AQKFIF------------IDPKNI 1041 human
Q8IZJ3       1179 YLVQGYQRQLTYK-RQDGS---YSAFGer--dASGS--MWLTAFVLKSFAQ-----ARSFIF------------VDPREL 1233 human
Q9VLT3       1223 HMNIGYQRQLSFM-RPDGS---FSLFRsdwnnSDSS--VWLTSYCLRVFQEasfyeWENFIW------------IDATII 1284 fruit fly
2_pfamImport   72 KLREGVVSVMSFR-NADHS---YSMWKs----GSAS--TWLTAFALRVLGQ-----ASKYID------------QDLNSI 124 
P01029       1044 LIQKGYMRIQQFR-KNDGS---FGAWLh----RDSS--TWLTAFVLKILSL-----AQEQVG------------NSPEKL 1096 house mouse
P0C0L4       1048 LIQKGYMRIQQFR-KADGS---YAAWLs----RDSS--TWLTAFVLKVLSL-----AQEQVG------------GSPEKL 1100 human
Q7SZG2       1034 NLEKGYIHILGKKdKTSGA---YGTFPd----SPYS--NWMTALMVKVLSM-----IAERQGeaiglqgrktrfVPLEEI 1099 torafugu
1_pfamImport   70 EMEQGYLRILTFKnKATGA---YGAWSs----VPYS--TWVTALVVKMLSL-----VTERQStavgpssqrlkvVPQDEI 135 
4XAM_C        292 LIQKGYMRIQQFR-KADGS---YAAWLs----RDSS--TWLTAFVLKVLSL-----AQEQVG------------GSPEKL 344  human
XP_026691729 1204 RMEDGFNQQMRYR-SDLVGkraWSVFSh----YRPS--TWLNAYVDRVFIQ-----AQVYYTe-----------MDLTPV 1260 vase tunicate
7Q5Z_A       1042 QDALKWMA-GNQLPSGCYANVGNLLHT-AMKGGV-----DDE---VSLTAYVTAALLEM-----------GKDVDDPMVS 1100 human
Q8IZJ3       1234 AAAKSWII-QQQQADGSFLAVGRVLNK-DIQGGI-----HGT---VPLTAYVVVALLETg---------tASEEERGSTD 1294 human
Q9VLT3       1285 EKNMRWLL-QHQTPQGSFFEVTWLPDR-KMNRTn----fDKN---ITLTSHVLITLATVkdi-----sgtLGSRVALATQ 1350 fruit fly
2_pfamImport  125 CNSILWLVeKCQLGNGSFKENSEYQPI-KLQGTLpieaqENT---LYLTAFAVIGIRKAfd-------lcPLMKISMALT 193 
P01029       1097 QETASWLL-AQQLGDGSFHDPCPVIHR-AMQGGL-----VGSdetVALTAFVVIALHHGldvfqdddakqLKNRVEASIT 1169 house mouse
P0C0L4       1101 QETSNWLL-SQQQADGSFQDPCPVLDR-SMQGGL-----VGNdetVALTAFVTIALHHGlavfqdegaepLKQRVEASIS 1173 human
Q7SZG2       1100 RHSVRYLL-SVQKAFGSFGDPHPVKNIgVLHGE------NGK---ASMTAFIALALHRSrqfl----steDKDKVDVSIA 1165 torafugu
1_pfamImport  136 SQSVKFLL-SSQKTDGTFGDPHPMIHRdSMTGT------NKD---VAMTAFITLALNRSlpfl----pdeLQTNVKTSIS 201 
4XAM_C        345 QETSNWLL-SQQQADGSFQDPCPVLDR-SMQGGL-----VGNdetVALTAFVTIALHHGlavfqdegaepLKQRVEASIS 417  human
XP_026691729 1261 CRSLQWLV-GEQHQEGYFLERSSVIHR-EMHGAV-----GGR---YSLTAYVLVTLIEAqrin----csgVNQQIQQSRD 1326 vase tunicate
7Q5Z_A       1101 QGLRCLKn---SATSTTNLYTQALLAYIFSLAGEMDi-RNILLKQLDQQAIISGE---SIYWsqkPTPSSNASPW----- 1168 human
Q8IZJ3       1295 KARHFLEs---AAPLAMDPYSCALTTYALTLLRSPA--APEALRKLRSLAIMRDG---VTHW---SLSNSWDVDKgtfls 1363 human
Q9VLT3       1351 RALAYIErnmdFLRHQAQPFDVAITAYALQLCNSPI--AEEVFAILRRQARTIGD---FMYWgnqEIPQPPRKLEnqkwf 1425 fruit fly
2_pfamImport  194 KADTFLLe---NTRSTRSTFALAIAAYALSLGDKSHpqFRSIVSALKKEALVKGNppiYRFWkddLQKKDRSVP------ 264 
P01029       1170 KANSFLGq--kASAGLLGAHAAAITAYALTLTKASEdlRNVAHNSLMAMAEETGE---HLYWglvLGSQDKVVLRptapr 1244 house mouse
P0C0L4       1174 KANSFLGe--kASAGLLGAHAAAITAYALTLTKAPVdlLGVAHNNLMAMAQETGD---NLYWgsvTGSQSNAVSPtpapr 1248 human
Q7SZG2       1166 RATTYLLs---QMEKLNHPYAVAITVYSLAVCLPKEtdHSASWEKLTALAMRGENg--CYLWttdPSLDNQ--------- 1231 torafugu
1_pfamImport  202 KAIEYLQl---QLENITHPYAMAITSYCLSTCPSEErnRTAAWKKLQLMVKEARNd--RYFWsddPNMANQ--------- 267 
4XAM_C        418 KANSFLGe--kASAGLLGAHAAAITAYALSLTKAPVdlLGVAHNNLMAMAQETGD---NLYWgsvTGSQSNAVSPtpapr 492  human
XP_026691729 1327 KAINYLRnn-rNHPAFQRPYGLSILTYAMALHDQSSafTIELNQRLLGFQQLDDNs--YVHWqahSHSDIQGTDThdy-- 1401 vase tunicate
7Q5Z_A       1169 ------SEPAAVDVELTAYA-LLAQltk----psLT-QKEIAKATSIVAWLAKQHNAYGGFSSTQDTVVALQALAKY 1233 human
Q8IZJ3       1364 fsdrvsQSVVSAEVEMTAYA-LLTY---------TL-LGDVAAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEY 1429 human
Q9VLT3       1426 slprlpYEYDSLNIETTAYA-LLVY---------VA-RRE-FFVDPIVRWLNSQRLNDGGWASTQDTSAALKALVEY 1490 fruit fly
2_pfamImport  265 ------NTGTARMVETTAYA-LLTS---------LN-LKDMNYVNPIIKWLSEEQRYGGGFYSTQDTINAIEGLTEY 324 
P01029       1245 sptepvPQAPALWIETTAYA-LLHL---------LLrEGKGKMADKAASWLTHQGSFHGAFRSTQDTVVTLDALSAY 1311 house mouse
P0C0L4       1249 npsdpmPQAPALWIETTAYA-LLHL---------LLhEGKAEMADQASAWLTRQGSFQGGFRSTQDTVIALDALSAY 1315 human
Q7SZG2       1232 ------KAATAITVDSTSYA-LLAA---------VK-LGKIEFSDQIACWLTTQENYLGGFKSSQDTLNALDALAEY 1291 torafugu
1_pfamImport  268 ------ERADGVTIQTTAYA-LLTA---------VQ-VKNGEWADKIAHWLISQENYNGGFLSTHDTILALEALSEY 327 
4XAM_C        493 npsdpmPQAPALWIETTAYAlLHLL---------LH-EGKAEMADQASAWLTRQGSFQGGFRSTQDTVIALDALSAY 559  human
XP_026691729 1402 ---wyvRRPQAIDVETSAYA-LLAQvklassnnnVQ-QSDLDTTRSIALWLISQRNEAGAFRSTQDTVVGLQALAEY 1473 vase tunicate
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