4FXG


Conserved Protein Domain Family
A2M_comp

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pfam07678: A2M_comp 
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A-macroglobulin complement component
This family includes the complement components region of the alpha-2-macroglobulin family.
Statistics
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PSSM-Id: 400150
View PSSM: pfam07678
Aligned: 23 rows
Threshold Bit Score: 335.411
Threshold Setting Gi: 47209714
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4FXG_E        303 ASDPLDTLGSEGAls------pgGVASLLRLPRGCGEQTMIYLAPTLAASRYLDKTEQWST--Lpp---eTKDHAVDLIQ 371  human
Q29PC6        972 FGLVGDLLGPVIK----------NLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKKLTP--A------IETRIKRNLQ 1033 Drosophila ps...
Q16ML5       1183 ISVVGDVVGAIFPtm------pvNATSLLSLPMDSAEQNMFSFAANFYTIQYMRAIKQRNK--K------TEKLAFHYMN 1248 yellow fever ...
XP_002612866  343 LPTERDIMGPTITtt------igGLGTLLRLPTGCGEQTMIKLAPNVYVLSYLHCTDQITK--D------VEEKAYDFIR 408  Florida lancelet
Q6VPV1        977 VSVKGLLIGEVMSavl----sqeGIDILTHLPKGNAEAELMSIVPVFYVFHYLEAGNNWNI--FssnslaQRQNLQKKLR 1050 pig
P01029        978 ASEPLETMGSEGAls------pgGVASLLRLPQGCAEQTMIYLAPTLTASNYLDRTEQWSK--Lsp---eTKDHAVDLIQ 1046 house mouse
Q8WPD8        980 LYAYMDFMGPAIEvdpvt-qeanNVNSLIRQPYGCGEQTMIYAGPTVFALQYLVTTGTITP--Ns----pEYNSAVNKIE 1052 vase tunicate
XP_011604050  965 ITAEED--GFTLPramsl-lspeKAAKLIVLPTGCLEQTMVKLAPTASAIRYLDLSNQWSK--Lsv---nARDKALDNLE 1036 torafugu
NP_001098167  968 ISMEAN--GFCTSqvsnl-lnpeKVSNLIHLYKGCLEQTMSTFAPTTLAMRYLDLSQQWFT--Lep---gARDVALSEME 1039 Japanese medaka
XP_026691720 1135 IYAYASYMGPSIEvnqitqeprsIASIF-RQPYGCGEQNMLVTGPNVYAHMFLVTTGKMAPgsI------RYEQSIRRME 1207 vase tunicate
4FXG_E        372 KGYMRI--QQFR-KADGS---YAAWLs---------RDSSTWLTAFVLKVLSL-----AQEQVG------------GSPE 419  human
Q29PC6       1034 EGYQNM--LHYR-HDDGS---FSSFGpgkwreedpeRNGSTWLTSYVLRSFSK-----IKDIID------------LDEK 1090 Drosophila ps...
Q16ML5       1249 IGYQKQ--LSYL-NDDGS---FSLFRadw-----nqSASSVWLTAYCARIFSEasfyeYENFIY------------IDPL 1305 yellow fever ...
XP_002612866  409 QGYNRQ--LGHR-RPEGC---FSVWGqn------nrYPCSTWLTAFVNKVFCQ-----AKKFVSs-----------IDEE 460  Florida lancelet
Q6VPV1       1051 EGVVSV--MSFR-NADHS---YSMWKs---------GSASTWLTAFALRVLGQ-----ASKYID------------QDLN 1098 pig
P01029       1047 KGYMRI--QQFR-KNDGS---FGAWLh---------RDSSTWLTAFVLKILSL-----AQEQVG------------NSPE 1094 house mouse
Q8WPD8       1053 AAFQRE--MTYR-TTHTNprvWSVFTh---------YLPSTWLNAFVDKVFYH-----GRRYDTd-----------MNVG 1104 vase tunicate
XP_011604050 1037 KGYIHI--LGKKdKTSGA---YGTFPd---------SPYSNWMTALMVKVLSM-----IAERQGeaiglqgrktrfVPLE 1097 torafugu
NP_001098167 1040 QGYLRIriLTFKnKATGA---YGAWSs---------VPYSTWVTALVVKMLSL-----VTERQStavgpssqrlkvVPQD 1102 Japanese medaka
XP_026691720 1208 DGFNQQ--MRYR-SDLVGkraWSVFSh---------YRPSTWLNAYVDRVFIQ-----AQVYYTe-----------MDLT 1259 vase tunicate
4FXG_E        420 KLQETSNWLL-SQQQADGSFQDPCPVLDR-SMQGG-------L-----VGNdetVALTAFVTIALHHGLAvfqdegaepL 485  human
Q29PC6       1091 SLESGYEFLL-SRQVENGSFTDAGEYFYG-SQRSS-------------------LTLTANALLALLE------------Q 1137 Drosophila ps...
Q16ML5       1306 VIQKNIHYIL-QHQKDDGSFWEVTWLPDR-KVNQSsehprneIv---rSKN---ITLTAHVLITLVSVKDls-----grL 1372 yellow fever ...
XP_002612866  461 AVCTAMEWLL-STQREDGAFKEVYKVHHR-EMTGG-------I-----QGD---ASMTAFVLISLLENCEc--------P 515  Florida lancelet
Q6VPV1       1099 SICNSILWLVeKCQLGNGSFKENSEYQPI-KLQGT-------LpieaqENT---LYLTAFAVIGIRKAFDl-------cP 1160 pig
P01029       1095 KLQETASWLL-AQQLGDGSFHDPCPVIHR-AMQGG-------L-----VGSdetVALTAFVVIALHHGLDvfqdddakqL 1160 house mouse
Q8WPD8       1105 PICNSLNFLI-GEQMAGEHFRERRPPLHR-EMHGA-------V-----KGP---MTLTAHVAISMGEINSicl----peL 1163 vase tunicate
XP_011604050 1098 EIRHSVRYLL-SVQKAFGSFGDPHPVKNIgVLHGE-------------NGK---ASMTAFIALALHRSRQfls----teD 1156 torafugu
NP_001098167 1103 EISQSVKFLL-SSQKTDGTFGDPHPMIHRdTMTGT-------------NKD---VAMTAFITLALNRSLPflp----deL 1161 Japanese medaka
XP_026691720 1260 PVCRSLQWLV-GEQHQEGYFLERSSVIHR-EMHGA-------V-----GGR---YSLTAYVLVTLIEAQRinc----sgV 1318 vase tunicate
4FXG_E        486 KQRVEASISKANSFLGEk--ASAGLLGAHAAAITAYALSLTKAPVdlLGVAHNNLMAMAQETGD---NLYWgs----vTG 556  human
Q29PC6       1138 DKKNQTAIDKAVAYLSA---HTEESEELLPKSIAVYALQKSKAPD--AAKHVASLKALAQQEDD---RTWWtedteklRA 1209 Drosophila ps...
Q16ML5       1373 GSSVALAEQRASRYIERnigLIKDYGSPYEIAVVSYALAQAKAPQ--AEHAFKILASKMRSIAD---LNYWgn----dEV 1443 yellow fever ...
XP_002612866  516 IAERSIAIERATRFLER---QLDQLQRPYVIAIVTYALHLADSPV--KGAANEKLRSIAKYDEGt-nSRYWea----dAS 585  Florida lancelet
Q6VPV1       1161 LMKISMALTKADTFLLE---NTRSTRSTFALAIAAYALSLGDKSHpqFRSIVSALKKEALVKGNppiYRFWkd----dLQ 1233 pig
P01029       1161 KNRVEASITKANSFLGQk--ASAGLLGAHAAAITAYALTLTKASEdlRNVAHNSLMAMAEETGE---HLYWgl----vLG 1231 house mouse
Q8WPD8       1164 NQRVIASRVSAMNYLEQh-kDHATFQRPYPLSLLAYAAALHNPRSqlAIEMNARLMAMKQTSGNg-aYVFWra----kTL 1237 vase tunicate
XP_011604050 1157 KDKVDVSIARATTYLLS---QMEKLNHPYAVAITVYSLAVCLPKEtdHSASWEKLTALAMRGENg--CYLWtt----dPS 1227 torafugu
NP_001098167 1162 QTNVKTSISKAIEYLQL---QLENITHPYAMAITSYCLSTCPSEErnRTAAWKKLQLMVKEARNd--RYFWsd----dPN 1232 Japanese medaka
XP_026691720 1319 NQQIQQSRDKAINYLRNn-rNHPAFQRPYGLSILTYAMALHDQSSafTIELNQRLLGFQQLDDNs--YVHWqa----hSH 1391 vase tunicate
4FXG_E        557 SQSNAVSPtpaprnpsdPMPQAPALWIETTAYALLHL---------LLh--------EGKAEMADQASAWLTRQGSFQGG 619  human
Q29PC6       1210 SKGCRRWWcw-----------vwSHDVEITSYALLTL---------LEt-------eQETPDSVLNTIRWLVAQRNSFGG 1262 Drosophila ps...
Q16ML5       1444 PQPPSKLEnqkyfnlprLPYKYDSLNIETTAYALLTY---------VS---------RQETFTVEPIVRWLNSQRLMDGG 1505 yellow fever ...
XP_002612866  586 SIADGQKPyw-------ytRKPSAIAVETTAYALLTQ---------MH---------LGDIQYSNPIVVWLTLQRNSAGG 640  Florida lancelet
Q6VPV1       1234 KKDRSVP------------NTGTARMVETTAYALLTS---------LN---------LKDMNYVNPIIKWLSEEQRYGGG 1283 pig
P01029       1232 SQDKVVLRptaprsptePVPQAPALWIETTAYALLHL---------LLr--------EGKGKMADKAASWLTHQGSFHGA 1294 house mouse
Q8WPD8       1238 AEISGTNAha-----ywYRTRPLALDIETTSYALLAQ---------VAmskakdplvQADLDLGRKISLWLISQRNSNGG 1303 vase tunicate
XP_011604050 1228 LDNQ---------------KAATAITVDSTSYALLAA---------VK---------LGKIEFSDQIACWLTTQENYLGG 1274 torafugu
NP_001098167 1233 MANQ---------------ERADGVTIQTTAYALLTA---------VQ---------VKNGEWADKIAHWLISQENYNGG 1279 Japanese medaka
XP_026691720 1392 SDIQGTDThd-----ywYVRRPQAIDVETSAYALLAQvklassnnnVQ---------QSDLDTTRSIALWLISQRNEAGA 1457 vase tunicate
4FXG_E        620 FRSTQDTVIALDALSAY 636  human
Q29PC6       1263 FASSQDTVVGLQALIKF 1279 Drosophila pseudoobscura
Q16ML5       1506 WASSQDTGIAMKALTEY 1522 yellow fever mosquito
XP_002612866  641 FVSTQDTVVALQALSSY 657  Florida lancelet
Q6VPV1       1284 FYSTQDTINAIEGLTEY 1300 pig
P01029       1295 FRSTQDTVVTLDALSAY 1311 house mouse
Q8WPD8       1304 FRSTQDTVIGLQALSTI 1320 vase tunicate
XP_011604050 1275 FKSSQDTLNALDALAEY 1291 torafugu
NP_001098167 1280 FLSTHDTILALEALSEY 1296 Japanese medaka
XP_026691720 1458 FRSTQDTVVGLQALAEY 1474 vase tunicate
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