5L2A


Conserved Protein Domain Family
Gate

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pfam07670: Gate 
Nucleoside recognition
This region in the nucleoside transporter proteins are responsible for determining nucleoside specificity in the human CNT1 and CNT2 proteins. In the FeoB proteins, which are believed to be Fe2+ transporters, it includes the membrane pore region, so the function of this region is likely to be more general than just nucleoside specificity. This family may represent the pore and gate, with a wide potential range of specificity. Hence its name 'Gate'.
Statistics
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PSSM-Id: 400146
View PSSM: pfam07670
Aligned: 233 rows
Threshold Bit Score: 28.3723
Threshold Setting Gi: 81766407
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5L2A_A   104 ALRVLPMIVFFSSLMAVLYYIGVMQLLIKVIGGFLQKm-LgtSKAESMSAAASIFVGQT-E----APLV----VRPy--- 170
O34382   174 VLQLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLl-G-----MNKNTSMTMVTGLTiGlaygAGVM----IKA---- 239 Bacillus subtilis s...
EGI13017  87 ALELAPSVILSLGIISITDGLGGLRAAQQLMTPVLKPllGi-PGICSLALIANLQNTDA-AagmtKELAqegeITErdkv 164 Escherichia coli M605
Q8ENK2    16 TWKLGKIIFPITLIVTILQYTPVLPWFIKLISPMMGLl-G-----LSGEAAVPLVLGNAlNlyagIAAI----ISF---- 81  Oceanobacillus ihey...
O34382    16 TWTLGKVIFPVTLLVTLLQHTPVMDWLVRLITPVMGLf-G-----LSGEAAIPLVLGNMlNlyagIAGI----LTL---- 81  Bacillus subtilis s...
Q9K6Y6    15 TWTLGKVIFPVTLIVTILGHTPVLDWLAAFLAPAMGYi-G-----LRGEAAIPLVLGNAlNlyagIGAI----LTM---- 80  Bacillus halodurans
Q7VXK6    15 FLTLVKVMLPVMIAVQAAQAWGWIDILGQAFAPAMGLl-N-----LPAEAGMVWMTGAFvGiygaIAAL----ISLa--- 81  Bordetella pertussis
P0AEH8    25 TTNLLPNVVMAFVIIQALKITGLLDWVGHICEPVMALw-G-----LPGEAATVLLAALM-SmggaVGVA----ASLat-- 91  Escherichia coli K-12
Q7MCL3    27 TTSTVPNVLMAFVIIKALQITGTLDLMGSVFSPVMAVf-G-----LPGEAAAVLIGAWM-SmggaVGVV----ISLfd-- 93  Vibrio vulnificus Y...
Q7MCL2    84 ALTLIPTVMFALGMINVLEHYGALDAARKLLTPLLRP-----LMNIPGNTGLALIASLQ-StdagAAMT----RQL---- 149 Vibrio vulnificus Y...
5L2A_A   171 -----------IRRMTES-ELFAVMSGGLASVAGSVLAG--YVQMG 202
O34382   240 -----------VEDDGVS-KRDMTLAFIFLVACHAVVEDtlVFIPL 273 Bacillus subtilis subsp. subtilis str. 168
EGI13017 165 ifaayqtsgsaIITNYFSsGVAVFAFLGTSVIVPLAVIL--VFKFV 208 Escherichia coli M605
Q8ENK2    82 ------------DFSVKE-VFIMAIMLSFSH-NLFVESA--VATSV 111 Oceanobacillus iheyensis
O34382    82 ------------DLSVKE---VFILAVMLSF-CHNLIIEstVAAKV 111 Bacillus subtilis subsp. subtilis str. 168
Q9K6Y6    81 ------------ELTVKE---VFILAVMLSFSHNLFIESa-VATKV 110 Bacillus halodurans
Q7VXK6    82 ----------pALELTGG-QFSALCSMLLFAHALPVEQA--IVRRA 114 Bordetella pertussis
P0AEH8    92 ----------aGALTGHD---VTVLLPAMYL-MGNPVQN--VGRCL 121 Escherichia coli K-12
Q7MCL3    94 ----------qGILNGTH---IAILAPAIYL-MGSQVQY--VGRIL 123 Vibrio vulnificus YJ016
Q7MCL2   150 -----------KDEGHLT-KRETDVFTMFQFTAGATIVN--FFSSG 181 Vibrio vulnificus YJ016
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