8TZ1,4PB1


Conserved Protein Domain Family
Nucleos_tra2_C
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pfam07662: Nucleos_tra2_C (This model is not part of the current CDD release)
Na+ dependent nucleoside transporter C-terminus
This family consists of nucleoside transport proteins. Rat Slc28a2 is a purine-specific Na+-nucleoside cotransporter localised to the bile canalicular membrane. Rat Slc28a1 is a a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine it also transports the anti-viral nucleoside analogues AZT and ddC. This alignment covers the C-terminus of this family of transporters.
Links
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Statistics
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PSSM-Id: 517811
Aligned: 283 rows
Threshold Bit Score: 125.62
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8TZ1_A       409 HLLTASVMSAPAALAISKLFWPETETP---------------KinlknamkmesgdsRN------------LLEAATQGA 461 domestic cattle
WP_015912389 193 FVVTAIVLNLFGGFIIASIINPYRVSAeeedavi--mtedekK--------------QS------------FFEMLGEYI 244 Macrococcoides ...
WP_013125819 199 YVVAAIVLNLFGAFIIVSLLNPYEVAPeddvfa----apeqkK--------------QS------------FFEMLGEYI 248 Tsukamurella pa...
Q5NIF7       194 YVCVAIVMNMFGAFFVLNIINPYEKTKevtyefltdqvedyeR--------------QR------------FFEMLSEYI 247 Francisella tul...
Q5NIF6       196 YVCTAIVLNMLSTFFVLHIINPYDKDPslnydtl-hadyetgR--------------QS------------FFEMLSEYL 248 Francisella tul...
Q2G162       192 FVVTAVMLNIFSALIIASVINPYKSDDtdveidn--ltksteT--------------KTlngktgkpkkvaFFQMIGDSA 255 Staphylococcus ...
Q38Z16       193 FVVVAVFLNIFSALIISCIVNPYEPEVedqktie--ahlsteK--------------EP------------FFQVLGNYI 244 Lactobacillus s...
Q04FN0       193 FVVVAVFLNILSALIISSIVNPYIPEKedklve----iskgnA--------------EP------------FFQVLGNYI 242 Oenococcus oeni...
WP_013773270 193 YVVVAVFLNILSALIVSCIINPYDIDAndtlve----iqeekT--------------GS------------FFQILGNYI 242 Melissococcus p...
BAK22225     138 FVVPAVFLNIFSALMVSCIINPYNASNydtmpms--kneeknH--------------ES------------FFQVLGDYI 189

8TZ1_A       462 SSSISLVANIAVNLIAFLALLSFMNSALSWLgnmfdYPQL------SFEVICSYVFMPFAFMMGVDwQDSFMVAKLIGYK 535 domestic cattle
WP_015912389 245 LDGFKVAIIVAAMLIGYIALIAMLNGIV----------DAftpgemNFQTILGYLFAPLAFLTGIAwDDAVRAGSIMATK 314 Macrococcoides ...
WP_013125819 249 LDGAKVALTVAAMLIGFVALIALVNGIFAAI-----FNGT------TFQEVLGHVFAPLAWLTGVPwSECVQAGQIMATK 317 Tsukamurella pa...
Q5NIF7       248 LDGFKVAIIVCVMIMGYIAFLNLADGIFSSL-----V-GI------SLRDILGYIFYPIAWILNIHgNEIFLSSQIMGTK 315 Francisella tul...
Q5NIF6       249 LDGFKIAVIVCAMLVGFIALLNLVDGIFQEI-----L-GI------TFRQILGYIFYPIAWVLNIHgNEIFLSSQIMGTK 316 Francisella tul...
Q2G162       256 MDGFKIAVVVAVMLLAFISLMEAINIMFGSV-------GL------NFKQLIGYVFAPIAFLMGIPwSEAVPAGSLMATK 322 Staphylococcus ...
Q38Z16       245 VDGFQLALTVAAMLIGFVSLVTFLNNTFGFF-----F-NV------TFTDIIGWVFAPVAFVIGVPaDDIVKVGSLMATK 312 Lactobacillus s...
Q04FN0       243 VDGFQLAITVAAMLIGFVALVTFLNNSFLAV-----I-NI------SFTSLIGYIFAPIAFLMGVPtSDILKVGSLMATK 310 Oenococcus oeni...
WP_013773270 243 TDGFKLAITVGAMLIGFIALVTFLNNSFLAI-----I-HV------SFTTILGYIFSPIAWIMGVPaHDIIKVGSLMATK 310 Melissococcus p...
BAK22225     190 LDGFKLAVTVAAMLIGFVALVNFLNSIFVAI-----F-NI------SFTTILGYIFSPIAFLMGVPtKDSIKVGSLMATK 257

8TZ1_A       536 TFFNEFVAYQQLSKLIslrqvggpkfvdgvqQYMSMRSEAISTYALCGFANFGSLGIVIGGLTSMaPSRKRDITAGAMRA 615 domestic cattle
WP_015912389 315 LVSNEFVAMLDIQSIVkg-----------ktGELSEHAVGIVSVFLVSFANFSSIGIIAGAIKSLnDKQGDVVARFGLKL 383 Macrococcoides ...
WP_013125819 318 LVSNEFVAMLSFTSQNpg-----------gaVVMSERATAIVQTFLVSFANFSSIGIIAGAAKSLaPDQGDQIAKFGLKL 386 Tsukamurella pa...
Q5NIF7       316 IVTNEFVAMQELANHS---------------TQLSQHTKAVVSVFLVSFANFSSIGIIIGAIQALsREASVKVARFSLKI 380 Francisella tul...
Q5NIF6       317 IVTNEFVAMQELAKNS---------------QQLSEHTKAVVSVFLVSFANFSSIGIIVGAVQALnKEASIKVARFSLKI 381 Francisella tul...
Q2G162       323 LITNEFVAMLDFKNVL---------------GDVSARTQGIISVYLVSFANFGTVGIIVGSIKGIsDKQGEKVASFAMRL 387 Staphylococcus ...
Q38Z16       313 LITNEFVAMGNLSQIA---------------HSLSPKATAIISTYLVSFANFGTIGIISGSIKAIdKKQGAVVAKFTMKL 377 Lactobacillus s...
Q04FN0       311 LITNEFVAMGTLHGIA---------------GTLSTKANAIISAYLVSFANFGTIGIITGSIKSIsAKQGSYVAKFSIRL 375 Oenococcus oeni...
WP_013773270 311 LLTNEFVAMGDLHNLT----------------GLSTKSHAIISAYLVSFANFGTIGIITGSIKSIsEKQGSYVAKFSMKL 374 Melissococcus p...
BAK22225     258 LLTNEFVAMSSLHNMS---------------STLSLKANAIISAYLVSFANFSVVGIITGSIKSIsSKQGITVANFSMKL 322

8TZ1_A       616 LIAGTIACFLTACIAG 631 domestic cattle
WP_015912389 384 LYGATLVSFISATIAG 399 Macrococcoides caseolyticum
WP_013125819 387 LYGATLVSFLSATVVG 402 Tsukamurella paurometabola
Q5NIF7       381 LYGAVLVSFLSANIVG 396 Francisella tularensis subsp. tularensis
Q5NIF6       382 LYGAVLVSILSACVVG 397 Francisella tularensis subsp. tularensis
Q2G162       388 LLGSTLASIISGSIIG 403 Staphylococcus aureus subsp. aureus NCTC 8325
Q38Z16       378 LLGATMASMLTGTIVG 393 Lactobacillus sakei subsp. sakei 23K
Q04FN0       376 LAGATLASILTGTIVG 391 Oenococcus oeni PSU-1
WP_013773270 375 LLGATLASVLTGTIVG 390 Melissococcus plutonius
BAK22225     323 LLGATLASILTGTIVG 338
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