2EYX,6B29,3LH5,4Z88


Conserved Protein Domain Family
SH3_2

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pfam07653: SH3_2 
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Variant SH3 domain
SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.
Statistics
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PSSM-Id: 400139
View PSSM: pfam07653
Aligned: 28 rows
Threshold Bit Score: 37.0507
Threshold Setting Gi: 81482133
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2EYX_A    8 YARVIQKRVPnaYDKTA-------LALEVGE---LVKVT----------KINV---------SGqWEG-ECn--GKR--- 52   human
Q91X43  418 HGIANEDIVS--RNPTE-------LSCKRGD---VLVILk---------QAEN---------NY-LEC-QRg--EGT--- 460  house mouse
Q921I6  657 FGKLLKTVVR--QNKSHy-----lLEYKKGD---VVALLs---------EERIrlkgqlwtkEW-YIG-YYq--GKV--- 710  house mouse
Q81B28    2 KYIVIKSHVS--NYPNP-------IRLEEGD---VVKMIesy----agpENWE---------NW-MFChEEk-yNRK--- 51   Bacillus cereus ATC...
Q8A5A0    6 KYIVVCKWVE--SYKNP-------IILKKDE---KVVVNlai-----keTDPEw-------vNW-VWC-IAg-nGMT--- 55   Bacteroides thetaio...
Q8RBE1   35 VGKVTGNYVN--VRTEGslsgsviTQVSKDE---VVTVL----------EKQG---------DW-YRI-RLs-dGRE--- 84   Caldanaerobacter su...
O35601  503 HAKACCDVKG---GKNE-------LSFKQGEdieIIRIT-----------DNP---------EGkWLG-RTa-rGSY--- 547  house mouse
Q8MQQ3  502 HIKTHFHCDN--PSKGE-------MAFKAGD---VFRVIdtl------hngVV---------GS-WQV-LKigrGHQem- 551  fruit fly
3LH5_A    5 YIRTHFEYEK--ESPYG-------LSFNKGE---VFRVVd---------TLYNgk------lGS-WLA-IRigkNHKev- 54   human
O62683  468 YIRTHFELEA--SPPSG-------LGFTRGD---VFHVLdtlcpgpgpsGARG---------TH-WLA-VRm--GRDlre 522  dog
2EYX_A   53 ---GHFPFTHVR 61   human
Q91X43  461 ---GRVHPSQMK 469  house mouse
Q921I6  711 ---GLVHTKNVL 719  house mouse
Q81B28   52 ---GWVPEQIIR 60   Bacillus cereus ATCC 14579
Q8A5A0   56 ---GWVPIQILN 64   Bacteroides thetaiotaomicron
Q8RBE1   85 ---GWIYGEYLS 93   Caldanaerobacter subterraneus subsp. tengcongensis
O35601  548 ---GYIKTTAVE 556  house mouse
Q8MQQ3  552 -qrGVIPNKSRA 562  fruit fly
3LH5_A   55 -erGIIPNKNRA 65   human
O62683  523 qerGIIPNQSRA 534  dog
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