Conserved Protein Domain Family
SMC_Nse1

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pfam07574: SMC_Nse1 
Nse1 non-SMC component of SMC5-6 complex
S. cerevisiae Nse1 forms part of a complex with SMC5-SMC6. This non-structural maintenance of chromosomes (SMC) complex plays an essential role in genomic stability, being involved in DNA repair and DNA metabolism. It is conserved in eukaryotes from yeast to human. This domain lies immediatley up-stream of the DNA-binding zinc-finger domain, zf-RING-like pfam08746.
Statistics
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PSSM-Id: 400112
View PSSM: pfam07574
Aligned: 81 rows
Threshold Bit Score: 139.269
Threshold Setting Gi: 307107107
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003688301       22 RYLLQYLLfCQGICNESFMLLALMRLHltdgsssddfyrlnMVELNAELDAIIDLVNVKLDKLKFKICKVSHPLGkdevs 101 Tetrapisis...
ACF88202            9 HTLLQSLL-HRGPLSERDFHAIFAGVSgk-----------nPATHQQLFNDTLLKINKDLAYLQFELRACINQYD----- 71  Zea mays
XP_006663780        9 HTLLQALL-SRGPLSERDFHALFTAISgg----------knPATHQQLFNDTLLKINKELSYLQFELRACIHQYD----- 72  malo sina
XP_003578992        9 HTLLQALL-SRGPLPEPDFHALFTDMTgg----------knPATHKQLFVDTLGKINNELKYLNFDLRAGINQYD----- 72  stiff brome
XP_020157732        9 HTLLQALL-SRGPLSERDFHALFTAISgg----------knPATHQQLFSDTLMKINNELGYLQFDLRACINQYD----- 72  Aegilops t...
KRG89848           10 HVVIQSLL-SRGPLSEKDLHAMFQDLTkr-----------nPGTERQLFDSFILKINKALSCANFELRACIDQYD----- 72  soybean
EEF40760            9 HTLIQSLM-SRGPLKEDDFHKIFSSVTgk-----------nPRTCGREFNDFLLKINKELSYVQMELRRCRNQND----- 71  castor bean
EFN55351           36 HCFLQAIM-GRQYLKESDAKELYRQITga--------------aHDGNYLHFMADINQQLNFAQFELRRVKYPGD----- 95  Chlorella ...
XP_001418712       46 QCFLQALL-SRGIVESEDAEALYREIV--------------EDDAANEFTRFWGEIAVALKFLDLDIRTGKFEGD----- 105 Ostreococc...
jgi:MICPUN_108045  13 HAFLQALM-AKGAMPEKSAKRLYAEIAsm-----------dPAEANKTFSRFWNPIASALGYLDLDIRVIRYQED----- 75  Micromonas...
XP_003688301      102 sytkddieklllainddsdedtlskdvilefasqvqaSNKyYVYVNLESDKETELATTYTVKE--------IECMKRLIK 173 Tetrapisis...
ACF88202           72 -------------------------------------GMVyYGVVNNIADEESKLGTKYSVPQ--------IAFYKGLLE 106 Zea mays
XP_006663780       73 -------------------------------------GTVyYGVVNNIADEESKLGSKYSVPQ--------IAFYKGLLE 107 malo sina
XP_003578992       73 -------------------------------------GTVyYGVINTIADEESKLGSKYSVPQ--------IAFYKGLLE 107 stiff brome
XP_020157732       73 -------------------------------------GTVyYGVVNNISDEESKLGSKYSVPQ--------IAFYKGLLE 107 Aegilops t...
KRG89848           73 -------------------------------------GQVyYGVVNTVSDEHSKLGTKYTVPQ--------IAFYKAIIE 107 soybean
EEF40760           72 -------------------------------------GQLfYGLVNNVSDDQSKLGSKYSVPQ--------ITLFKAAIE 106 castor bean
EFN55351           96 -------------------------------------GEWyLGFVNREGDEPSKRATKYRGAKdgkpdtriTAYFRALLD 138 Chlorella ...
XP_001418712      106 -------------------------------------GKTyMAVVNQGTTEVAKLATRMTPAE--------IALFRVAML 140 Ostreococc...
jgi:MICPUN_108045  76 -------------------------------------QQLyIGVVNKTGGEAAKLATRLTPEQ--------IALFRVVLD 110 Micromonas...
XP_003688301      174 MMVNNsTRPREV--DTTVRANPvfKEIKNmlsRYerdrggdteeevnvpmwtsyisyqigSTEAasn-----------mv 240 Tetrapisis...
ACF88202          107 AIVQEaGn-----dGSITSIDAlnVRLDNqvaVL----------------------------DGsqdsqsr--lpssikn 151 Zea mays
XP_006663780      108 AIVHEaGn-----dGSITNIDAlnTRIDNqvvIA----------------------------DGsqshdsqsrlptsitn 154 malo sina
XP_003578992      108 AIVQEaGn-----dGTITTIDAfnVRIDNqviIA----------------------------DStqdsqsr--lpssitn 152 stiff brome
XP_020157732      108 AIVHEaGn-----dGSITSIEAlhVRIDNqvvIA----------------------------DGtqdtqsr--lpssitn 152 Aegilops t...
KRG89848          108 AIVQDaSa-----nAAIFSIHAlnLSLDSqvtIV----------------------------TDsqsqgsqpnvptalkn 154 soybean
EEF40760          107 AIVQDaTa-----qGSISWSGAlnIRLENqvyNS----------------------------AEsqsqgsssqvppalrn 153 castor bean
EFN55351          139 QMVA--SSAADQglGYLTSQQAlyIQISPda----------------------------aTQAEeeeaaavrqqadevrk 188 Chlorella ...
XP_001418712      141 EILRD-DSSAERgiDFMSALNSteLQLTQda----------------------------sTQDGatqmtqlekqtqtvqk 191 Ostreococc...
jgi:MICPUN_108045 111 EIMRD-DGTVERgvDVITALNA--TQVAPt------------------------------QGETqgdgglsqaqtqsvak 157 Micromonas...
XP_003688301      241 MTSTETQVFLNTLCADKWFYRTRN--G-RYGLDLKGAFE 276 Tetrapisispora phaffii CBS 4417
ACF88202          152 FSMSQKEKTLDELIRDRWLSYTAT--G-KIGLGTRSFLD 187 Zea mays
XP_006663780      155 FSLSQKEKTLNELIQDHWLSYTPT--G-KIGLGIRSFLD 190 malo sina
XP_003578992      153 FSFNQKEKTLDDLIQDRWLSYTSP--G-NIGLGIRSFLD 188 stiff brome
XP_020157732      153 FLFSQKEKTLTELIQDRWLAYTSE--G-KIGLGIRSFLD 188 Aegilops tauschii subsp. tauschii
KRG89848          155 FSLSQKEKTLHELVRDQWLDLTTD--G-VIRLGLKSFLD 190 soybean
EEF40760          154 FSLSQKEKTLDELVCDKWLCRTPD--G-GIGLGVRSYLD 189 castor bean
EFN55351          189 LSMKERETVLAQLATDGWLAHMPSraG-CYTLGPRSFLE 226 Chlorella variabilis
XP_001418712      192 MSKVVKDAALNDLVAERWLERVDD--GrRLTLGPRSFLE 228 Ostreococcus lucimarinus CCE9901
jgi:MICPUN_108045 158 MSKMEKEATLKQLCKDGWLTQADDeaG-FLKLGVRAFLE 195 Micromonas commoda
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