Conserved Protein Domain Family
SMC_Nse1

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pfam07574: SMC_Nse1 (This model is not part of the current CDD release)
Nse1 non-SMC component of SMC5-6 complex
S. cerevisiae Nse1 forms part of a complex with SMC5-SMC6. This non-structural maintenance of chromosomes (SMC) complex plays an essential role in genomic stability, being involved in DNA repair and DNA metabolism. It is conserved in eukaryotes from yeast to human. This domain lies immediately up-stream of the DNA-binding zinc-finger domain, zf-RING-like pfam08746.
Statistics
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PSSM-Id: 517784
Aligned: 76 rows
Threshold Bit Score: 141.597
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003688301  22 RYLLQYLLfCQGICNESFMLLALMRLHltdgsssddfyrlnMVELNAELDAIIDLVNVKLDKLKFKICKVSHPLGkdevs 101
XP_003062341  12 HVFLQAMM-SRCVMSETDARAMYAEIVga----------dvARADARGFDRFWGEIASQLGYLDLDLRRVKYQDD----- 75 
XP_005847453  36 HCFLQAIM-GRQYLKESDAKELYRQITga--------------aHDGNYLHFMADINQQLNFAQFELRRVKYPGD----- 95 
EEF40760       9 HTLIQSLM-SRGPLKEDDFHKIFSSVTgk-----------nPRTCGREFNDFLLKINKELSYVQMELRRCRNQND----- 71 
XP_006354180   9 HTLIQALL-SRGPLKEKDFQSIFTKITgk-----------sPGNHQSLFNEYLRKINGELAFVQLELRACRNQYD----- 71 
NP_001142328   9 HTLLQSLL-HRGPLSERDFHAIFAGVSgk-----------nPATHQQLFNDTLLKINKDLAYLQFELRACINQYD----- 71 
XP_006663780   9 HTLLQALL-SRGPLSERDFHALFTAISgg----------knPATHQQLFNDTLLKINKELSYLQFELRACIHQYD----- 72 
XP_003578992   9 HTLLQALL-SRGPLPEPDFHALFTDMTgg----------knPATHKQLFVDTLGKINNELKYLNFDLRAGINQYD----- 72 
XP_044985531   9 HTLLQALL-SRGPLSERDFHALFTAISgg----------knPATHQQLFSDTLMKINNELRYLQFDLRACINQYD----- 72 
CBI24358       9 HALIQALL-SRGPLIEDDFHAIFSGVTgk-----------nPGAHQQQFNDYLLKINKELSYVHLELRGCRNQYD----- 71 
XP_003688301 102 sytkddieklllainddsdedtlskdvilefasqvqaSNKyYVYVNLESDKETELATTYTVKE--------IECMKRLIK 173
XP_003062341  76 -------------------------------------DELyLGIVNKVASDSAKLATTMTPEQ--------IALFRVVLD 110
XP_005847453  96 -------------------------------------GEWyLGFVNREGDEPSKRATKYRGAKdgkpdtriTAYFRALLD 138
EEF40760      72 -------------------------------------GQLfYGLVNNVSDDQSKLGSKYSVPQ--------ITLFKAAIE 106
XP_006354180  72 -------------------------------------GHVhYGVVNNVSDESSKLGTKYSVPQ--------IAFYKGIIE 106
NP_001142328  72 -------------------------------------GMVyYGVVNNIADEESKLGTKYSVPQ--------IAFYKGLLE 106
XP_006663780  73 -------------------------------------GTVyYGVVNNIADEESKLGSKYSVPQ--------IAFYKGLLE 107
XP_003578992  73 -------------------------------------GTVyYGVINTIADEESKLGSKYSVPQ--------IAFYKGLLE 107
XP_044985531  73 -------------------------------------GTVyYGVVNNISDEESKLGSKYSVPQ--------IAFYKGLLE 107
CBI24358      72 -------------------------------------GKVyYGVVNNVSDEQSKLGTKYTVPQ--------LAFYKGIIE 106
XP_003688301 174 MMVNNsTRPREV-----DTTVRANPvfKEIKNmlsRYerdrggdteeevnvpmwtsyisyqigSTEAAsn---------- 238
XP_003062341 111 EILRE-DATCDAknggvDVISALNAtqIWTGAtqgAT--------------------------QGGEGgatqltqaqtes 163
XP_005847453 139 QMVA--SSAADQg---lGYLTSQQAlyIQISPda----------------------------aTQAEEeeaaavrqqade 185
EEF40760     107 AIVQDaTa--------qGSISWSGAlnIRLENqvyNS----------------------------AESqsqgsssqvppa 150
XP_006354180 107 AIVQDaAa--------qGFISTIDAlnIRLENqflAG----------------------------TESqtqggsthipaa 150
NP_001142328 107 AIVQEaGn--------dGSITSIDAlnVRLDNqvaVL----------------------------DGSqdsqsrl--pss 148
XP_006663780 108 AIVHEaGn--------dGSITNIDAlnTRIDNqvvIA----------------------------DGSqshdsqsrlpts 151
XP_003578992 108 AIVQEaGn--------dGTITTIDAfnVRIDNqviIA----------------------------DSTqdsqsrl--pss 149
XP_044985531 108 AIVHEaGn--------dGSITSIDAlnVRIDNqvvIA----------------------------DSTqdtqsrl--pss 149
CBI24358     107 AIVQDvTa--------qGSISDIDAlnIRLENqvlTG-----------------------------TShsqgippnvpaa 149
XP_003688301 239 -mvMTSTETQVFLNTLCADKWFYRTRN--GRYGLDLKGAFE 276
XP_003062341 164 vakMSKTEKEATLKRLCEEGWLRRGDDeaGKLTIGVRSFLE 204
XP_005847453 186 vrkLSMKERETVLAQLATDGWLAHMPSraGCYTLGPRSFLE 226
EEF40760     151 lrnFSLSQKEKTLDELVCDKWLCRTPD--GGIGLGVRSYLD 189
XP_006354180 151 frnFSMSQKERTLEELARDHWLSLT-D--GKVGLGVRSFLD 188
NP_001142328 149 iknFSMSQKEKTLDELIRDRWLSYTAT--GKIGLGTRSFLD 187
XP_006663780 152 itnFSLSQKEKTLNELIQDHWLSYTPT--GKIGLGIRSFLD 190
XP_003578992 150 itnFSFNQKEKTLDDLIQDRWLSYTSP--GNIGLGIRSFLD 188
XP_044985531 150 itnFSFSQKENTLNDLIQDRWLAYTSE--GKIGLGIRSFLD 188
CBI24358     150 fknFSISQKEKTLDELVQDQWLSSTPD--GKIRLGVRSFLD 188
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