6XP5


Conserved Protein Domain Family
Med9
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pfam07544: Med9 (This model is not part of the current CDD release)
RNA polymerase II transcription mediator complex subunit 9
This family of Med9 proteins is conserved in yeasts. It forms part of the middle region of Mediator. Med9 has two functional domains. The species-specific amino-terminal half (aa 1-63) plays a regulatory role in transcriptional regulation, whereas this well-conserved carboxy-terminal half (aa 64-149) has a more fundamental function involved in direct binding to the amino-terminal portions of Med4 and Med7 and the assembly of Med9 into the Middle module. Also, some unidentified factor(s) in med9 extracts may impact the binding of TFIID to the promoter.
Links
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Statistics
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PSSM-Id: 517767
Aligned: 57 rows
Threshold Bit Score: 46.8086
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6XP5_I        74 TSLPSSATTGPTP---SNAlHSVKELPATTDPIKHKLQRARAAVRLLGDMSRTMAQQEAELARLEERRRKQAAMLAKAQE 150 Thermochaetoide...
XP_002493820 120 ELLPLLLDLIEEL---KLGkIEPKDFDNAAGRIRAQISKIRGLLDNVEGLSESSESRINKLRELDEKITRKRQELLDFRE 196
XP_013933497  71 DLLPLLLDLIENL---KAGkISPKDFDNATGRIKTRLNKFRSLLNQIEGLDESTESRIQKMEEMKKRIGAKQELLKRFSE 147
XP_715214    131 EILPDLFNLLYDLnneENSkVTPKDFDKYLGSLRLKLSNLKNLMSEVEGINETLSYTLDKIESLKQNNIKKEAFLSNFKN 210
XP_002549720 136 EVLPDLFNLLYELnnsDNTkVTAKDFDKYLGSLRLKLSNFKDSMQQIDNINETLVNTFDKIEKLKQNNHNKQSFLLQLKQ 215
XP_036668445 151 QLLPELYNILFDF---TNGkIHPRDFDKHIGNLRSKLDNLKSYISEIDGIDVTPEIMMNEINRLKENNVKKQTLLNSFRN 227
XP_001383054  53 EILPDLFNLLHDL---QNGtISAKDFDNNAGSLRLKLTTLRQYLQEVEGINESIKSREAKIESLRVNNAKRYEFLSRFKE 129
EGV65747      68 ELIPELFGVLHDL---QSGiLSAKDFDNQVGGIRLKLANIKQYLRDFPGITESVDTRVERIETLRVNNESKLEVMKTFKE 144
Q6BSA8        77 ELLPDLYNLLNDL---QNGhILAKDFDNNAGSIRLKLSKMKQNLQDIPGISESVKFRETRIQNLKLSNEKKAHFLNKFKQ 153 Debaryomyces ha...
CCE84340      73 DLIPELFNLLYDL---QEGnVIPKDFDNNAGSIRVKLNHMRQVTRGIKGVDESIPYRQNQINSLEASNQKTLSFLSDFKK 149

6XP5_I       151 E 151 Thermochaetoides thermophila DSM 1495
XP_002493820 197 M 197
XP_013933497 148 E 148
XP_715214    211 S 211
XP_002549720 216 K 216
XP_036668445 228 K 228
XP_001383054 130 Q 130
EGV65747     145 K 145
Q6BSA8       154 R 154 Debaryomyces hansenii
CCE84340     150 R 150
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