Conserved Protein Domain Family
Med9

?
pfam07544: Med9 
RNA polymerase II transcription mediator complex subunit 9
This family of Med9 proteins is conserved in yeasts. It forms part of the middle region of Mediator. Med9 has two functional domains. The species-specific amino-terminal half (aa 1-63) plays a regulatory role in transcriptional regulation, whereas this well-conserved carboxy-terminal half (aa 64-149) has a more fundamental function involved in direct binding to the amino-terminal portions of Med4 and Med7 and the assembly of Med9 into the Middle module. Also, some unidentified factor(s) in med9 extracts may impact the binding of TFIID to the promoter.
Statistics
?
PSSM-Id: 400090
View PSSM: pfam07544
Aligned: 61 rows
Threshold Bit Score: 46.0112
Threshold Setting Gi: 734680729
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_015790672    25 EFLPLIYDIIRsieKELnegssvgqkaihREQTEIPAKMQLLNDKFKKCREQLMKIEG----IDITKEQQLKQLENLSKQ 100 two-spotted s...
XP_003957821    40 EFIPHIFYSLHnimKNPn-----------QSLNQMENATGFIKHRLKNSKSLIQNNEQlinlLSYDIDYWENYLQNKENE 108 Kazachstania ...
CCH62112        57 EFIPHIFYSLYqitKDPn-----------NSANQLETTTSSIKNKLKNCKKFIENDVNsinlLSKSIDEWEIYLKQRDQE 125 Tetrapisispor...
XP_002551711    30 EFIPQLYYALHqvkKDPn-----------SSVNSLETATSSIRHRLKQCKSHIAESEEcralLSKTPEEWEAALRQRQKD 98  Lachancea the...
ybcl:Ecym_2117  32 EFIPQIFYALHqfkEDSk-----------SGGNSLETATSSIRHRIKLCKSYLREDPHcielLSRPYEDWPQVVEQKQQE 100 Eremothecium ...
Q755Q2          32 EFIPHIFYALHqlkNDN------------GHTNTFETATSNIRHRLKLCKAAIAGDAHavemLSRPCDEWPAVVCQKEQE 99  Eremothecium ...
EDO19486        63 EFIPHIFYSMYqikKDPn-----------NSSNQLETSTGFIKHRLKSCKTLIESDEDcrklLSKSTDEWDDYIKQRELE 131 Vanderwaltozy...
Q6FQJ5          64 EFIPSIFFSLHkirKDPn-----------NVSSQLETSTGFIRHRIKRCKALLQENEEvrnlLANSIEEWENIIADKEQQ 132 [Candida] gla...
CCK69810        44 EFIPHIFYALNqitRDPn-----------NVSNHLESSTGFIRHRLRTCKELIAENSEcmelLSRTPEEWEQELAFKEQE 112 Kazachstania ...
XP_003686852    63 EFIPYLFYCLHqirKDQs-----------NSANKFELQVGFIKHRLRSCKTFIETDQVfkdlMSKSIEDWNEEIQNRECE 131 Tetrapisispor...
XP_015790672   101 LDMKRQLLTQYKNFS 115 two-spotted spider mite
XP_003957821   109 AQIKKNLFAKLSERI 123 Kazachstania africana CBS 2517
CCH62112       126 IAVRQKLLSNLNLQI 140 Tetrapisispora blattae CBS 6284
XP_002551711    99 LAVKQQVFARLERQI 113 Lachancea thermotolerans CBS 6340
ybcl:Ecym_2117 101 IETKKLVHKQLGERI 115 Eremothecium cymbalariae DBVPG#7215
Q755Q2         100 IEAKKRVHRQLRQRV 114 Eremothecium gossypii ATCC 10895
EDO19486       132 IEGKRNVLKSLNNKI 146 Vanderwaltozyma polyspora DSM 70294
Q6FQJ5         133 LRVKAKVLRDLDARI 147 [Candida] glabrata CBS 138
CCK69810       113 LRIKGALLETLRERI 127 Kazachstania naganishii CBS 8797
XP_003686852   132 LQRKKEVINNLRSTI 146 Tetrapisispora phaffii CBS 4417
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap