6RXV,7AJT,7MQ8


Conserved Protein Domain Family
UTP20_N

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pfam07539: UTP20_N (This model is not part of the current CDD release)
U3 small nucleolar RNA-associated protein 20, N-terminal
This domain is found towards the N-terminal of eukaryotic proteins including U3 small nucleolar RNA-associated protein 20 (UTP20) from yeast and the homologue from human, also known as DRIM (Down-Regulated In Metastasis), which is differentially expressed in metastatic and non-metastatic human breast carcinoma cells. Proteins of this entry are involved in processing of non-coding RNA as components of of the small-subunit (SSU) processome; SSU processome is involved in the biogenesis of the 18S rRNA. UTP20 is a huge alpha-solenoid structure that functions as a scaffold.
Statistics
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PSSM-Id: 517762
Aligned: 136 rows
Threshold Bit Score: 340.304
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6RXV_UT              895 WNLADRKDLIKVFSQFSNPRVLYLSQKVYQALLKLLANGDIELQKLALKAILTWKS-EGIKPYQEHLEYLLDEARFKNEL 973  Thermo...
26_pfamImport          2 GIHQVLLCYLKICTELTSKSVRKHADRLYETYETLVSSRNEEIQKVALNGIFTLGG-SQLTPYKDFISRLTSEKTLKQAL 80  
XP_002063362         844 FILQTLQLKLACFTIQPNPKALYRQTELKEFYLELLAGPNPQLQQLALDCLVKYKDpTALVQHKSTLSDLIDELKFKSTL 923 
WGS:AANI:GJ21931-PA  854 FILQTLQLKLACFVSQPNPKALHRESEMREFYLELLAGPNAQLQQLALDCLAAYKQpASLVQQKQQLAGLIDDAKFKATL 933 
XP_032525560         885 IIFKTLINIMQVLSQFKNPRALHKEPVFAEVYLEFLKNKNPGLQKYALDCILNYKN-KSVVPYKANLHNLIDENKFKDEL 963 
30_pfamImport          2 AITKTLLVHMRVLGKFRSPKNIYREADLHKIYIDFLSHKAAEVQKAALDCLMTYKH-KFLFPYREHLYGLIDDKTFKNEI 80  
XP_969008            843 SNLQVLLTCLPVFTKIRSPKSIYREPELAKLYFDFLQHKNSQVQKLALDCIMTYKH-KFLTPYKDHLYNLVDDKNFKNEL 921 
4_pfamImport           2 ERVKLLLAMLQVFGKFTNVRSLYREPEILRIYLDLLSSKNSEIQKAALHCLYTYRH-KYLTPYKEQLDNIVDEKNLKNEL 80  
7_pfamImport           2 YKTKLLIAQMEIFGRVLNPKVLYREAEMHQIYLDLLCSKNTDIQKAALNCLFIYKY-NYLLPYKESLYGLISEKNLKNEL 80  
XP_011256579         863 DKVEYLLAQLEVFEKVLNPRMLHREAEMYQIYLDLLSSKNANIQKTALNCLFAYKH-EYLLPYKESLYSLISEKNLKNEL 941 
6RXV_UT              974 TVLFQG-------------------DNkILPEHRSEVIPVLLHLLYGRAISRKG-AASGRhglhaTRLAIIR---QLDVE 1030 Thermo...
26_pfamImport         81 LSVFVPsdeqedeqedggftsasgrTK-VAEEHRPMVVQLVLKVLDGKIKQNLG----NGgpggqHKATLLTfigRLRIE 155 
XP_002063362         924 STWNLS--------------------N-LQTEERAQLLPYVLRLLYGKMLTKGS---QKQlsaqqRKTLILRflgQLEEL 979 
WGS:AANI:GJ21931-PA  934 TGLEIA--------------------S-LPTQQRSELMPYILRVLYGH-LTKAG---QRQlsgqqRKTLILRflgQLEEK 988 
XP_032525560         964 TQFKITdg----------------sPA-IQAEHREHVIPLILRILYGKMTSKLG--ADKKgggqaRRSLIMRyisGCNET 1024
30_pfamImport         81 TVFRIDte----------------sEV-LRPEHRSDLIPFVLRIVYSKMYTRTN--TVKGvnrqdRKASVIRflaGCSPE 141 
XP_969008            922 AAFQIDke----------------sGT-IQEEHRDDLVPLIIRIVFSKMSTKTGlRTGGKssgqlRRNLVLRflaGCQDK 984 
4_pfamImport          81 ARFQISvge-------------gieAV-VQEEHREGLIPVLMRILHSKMSQRVGmRTGGKtgglvRRKTILRflaGVKEE 146 
7_pfamImport          81 ARFKLDke----------------sNM-IQEEHRENLIPIIMRIIYAKMIMKTGmRTGGKaggfaRRKIILRflaGTQEN 143 
XP_011256579         942 AHFKLDre----------------sNV-IKEAHRENLMPIILRIIYAKMIMKTGmRTGGKasgseRRKMILRflsGTQED 1004
6RXV_UT             1031 DMGSFLDIGLGPLRAIRvv-----dEqgvrESVF---------------AHEPLPPRKQVGLLNMLEAVINELGTSV-EP 1089 Thermo...
26_pfamImport        156 ELDLLLERWFAPYLAQLkttpletvrc------------itaalaegveLVPTVPPVRVKTLLNFLAALQTEIAPMKkAS 223 
XP_002063362         980 EILNFLQMAFGRFNLYtdkpieelh----------------levikhydPSAVIAAKQLQRIVNLLELIRKEFAGKLsEK 1043
WGS:AANI:GJ21931-PA  989 EILDFLKMAFGRFEEYtnqpvella----------------ghvraqyvPTAVISARQLHRIVNLLELIRKEFAGRLsTA 1052
XP_032525560        1025 ELKIFIEMAFSYLKEYlimepkeiy----------------envqrnldLKSVTSPGKLHSMLNLFDVVREYFGGYMnDE 1088
30_pfamImport        142 ELICFFKMVFAAFHGKv--------------eKIgnilelaertiseleLECVIPPKKMQSQIYLLNTVLIYCGGLLgRD 207 
XP_969008            985 EMLAFVKMAFQYYSKFldddpqvm-----------------vkglesitLESYIPPKRLQSAINLLNVILDQFGGLMgNE 1047
4_pfamImport         147 EMMVFVRMAFKPFQNYLpilkldeaSy---AAGGvdlqqmvqdifkninLENVVPPKRLSSAVNLLAVIIEQFGGKMtEK 223 
7_pfamImport         144 EMITFVKMAFRSYmsl-------------emNQAfslkqhakkivdtidLSNIMPPKRMQSAVNLLAIVMEQFGGKMsTK 210 
XP_011256579        1005 EMIVFVQMAFRPFKSYisl---------emEDGAfdlkryiekimdtidLSNVIPPKRMQSTVKLLAIMMEEFGGKMsTR 1075
6RXV_UT             1090 YMDALVNSVLyCLVNAC-----RKlgvsaeepesGEggqienESLYRVIRTTALKSLSRLFQNAP-DF--NWVPYre-lM 1160 Thermo...
26_pfamImport        224 YAAKLMHLKI-CFDALLlpl---------------------dhSIYKKYKNQALVALVDLFDQYDaSYq--WTNDeldaV 279 
XP_002063362        1044 FQSYVLKLLL-LVGSVAqqvidGGegg----klmVA------Y---RNVKHAGLQTLVNYFQHLV-DMheLWQEPeiqaI 1108
WGS:AANI:GJ21931-PA 1053 FQVYVLKLLL-LAGSVSqqvigGNalea--sklmSA------Y---KNVRHAAIQTLVNYFGQLL-DMseLWNTKemqaI 1119
XP_032525560        1089 LLTYFLKIFY-AVSSNIanvlvNVekv-----hvSY------VKVMKNLRTLSIIILGKLFDQFE-KYp--WKRDelyvL 1153
30_pfamImport        208 HQNYLLRILI-SVSGHLagifqMRerv-----hpCY------LRTLRDIKNTSFEALIKFYEKFE-TYe--WTLEeteaV 272 
XP_969008           1048 LLTFILQIVL-IIggv----lkIAfgqig-nvhaGY------LAILRTLRTGAIKLVERFFGQFE-RYq--WTNKqinaI 1112
4_pfamImport         224 LLPHLLAILI-CILAQVagillKSsev-----hsGY------LTSLRNVRNNCINVLARFFAHFE-NYd--WTSSeinaL 288 
7_pfamImport         211 LLPHLFGILI-CILAEAtgilrRSeev-----yaGY------LPIIKNVRTNCIGVLARFFVHFE-EYd--WKQHeidaV 275 
XP_011256579        1076 LLPCLLRMLI-CILAEVtgilhKTdev-----ypGY------LPAIKNVRTSCIDILTRFFKHFE-DYn--WKRHeidaV 1140
6RXV_UT             1161 VKEIISPRIEKLPVESTQGVSATWRLMATWSSLPKAAPFLNV-------------------------DKRILPKIVETLS 1215 Thermo...
26_pfamImport        280 LHVHVWPQLQLLPSDSIHTPTPLLKLLLMWSQSERLYVLLQRhppverqtetegesepatgdettppSMTPLDAMICLLR 359 
XP_002063362        1109 CEVYVWPNLSRLSQDSIHNPTPLLKLLLLWGAEVNYQKWLKRqpe--------------------kgaDPIIQHLVALLL 1168
WGS:AANI:GJ21931-PA 1120 CDVFVWPCLERLPQDSIHTPTPLLKLLLMWGGEPSYQSWLQQrps--------------------pesPPIVHYLMALLL 1179
XP_032525560        1154 FQTLIWPLVPRLQIEGIHSPTALLKLFNIWCQNPRYYILLITcse-------------------ddsELSALPAIFKLLL 1214
30_pfamImport        273 F---------KLSLSGCARIVEYFKLI---CKIYRYFVLLGKyle-------------------ddkNLAPLRFIIELWL 321 
XP_969008           1113 FHIFVWPYLDKLNVEGIHSPTTLLKLFVQWGSNPRYFSLLVKhed-------------------grqDQYVLPHVIRLLL 1173
4_pfamImport         289 FQVAVFPWLNKLPVEGIHSPTPLLKMFAAWSHNPRYYPLFVKlde--------------------drkMTPLDSVIRLLL 348 
7_pfamImport         276 FDVAIFPWLPKLPVESIHSPTALLKLFIAWGQNPRYYPLFVKhqe-------------------dnkSVSPLPYIMQLIS 336 
XP_011256579        1141 CHVAIFPWLQKLPVEGIHSPTALLKLFMAWGENPRYHPLFAKhre-------------------ddeSITPLPYIVELLL 1201
6RXV_UT             1216 IEKAKDEVKVFALDILKNLINLAQAPETesq-----------------------------fneLIKTELLDPNTDLILKT 1266 Thermo...
26_pfamImport        360 GSQTKGNVCKQIFTALAAMLDGDERNSAeeqsrir---------------------eedsdrvGNRSRLLIPYVQDLLQY 418 
XP_002063362        1169 NEKAKPVVKRSLLQLIEQILEATALDEYke----------------------------------eaLSLIRPYIPEILKH 1214
WGS:AANI:GJ21931-PA 1180 NDKAKPVVRRALLQLVEQLLESANTEEYga----------------------------------qaLSILQPYIPDVLQL 1225
XP_032525560        1215 APKTSPGVVNMILDMIEKLLTLT-NEDEnevteiktfss-------------lpisgnvkndiNFGSKILLPHLPSILEV 1280
30_pfamImport        322 SPKIHGSVYNTILDLIENMFVLQ--QDDtsefkrievknppl--------lckeklstlkqslNYGSILLVPYIPDILEL 391 
XP_969008           1174 NPKSHITVVNAIEEMVEKLLTLQ--ADEedlqlvipvdnllpv------pqhildriklddklNYGSCILLPFVSSILEK 1245
4_pfamImport         349 GLKTHKSVLQMILDMVEKMLTLQDFEKEnpdqlmevdefkpksl---mptvtnklqvekndsiNYGSAILLPHVTDILVY 425 
7_pfamImport         337 NPKTHPSVINAVLETIEKMLTLQDYRKSnedtgemqidspflplipiltnlieveekifstgiNYGSAILLPHIPHILEF 416 
XP_011256579        1202 NSKSHQSVVNAILLIIENLLTLQDYDQSnedsmqvdvpllpipt----nlldvekkgvlpngiNYGSAVLLPHVPRILEF 1277
6RXV_UT             1267 IGGVLHgqsdiGRELLSSAVDTVVVFAPMIEVS-SHIQ---------DMLEIATWLLNQplRKVNPKVK----GAILLIL 1332 Thermo...
26_pfamImport        419 IRHQVrsk----ktISSDLLLILTRLAESGMIGsDQKDeeriekdrvSLLNLLFPILARkvHEVGDERSgediRRLHIII 494 
XP_002063362        1215 LQGNWqrk-tkKQMLDRRELNILTLITSHVDDA-STCD---------LLLQLVLPIFSKq-vAGAGP-Em--vIQLITTL 1279
WGS:AANI:GJ21931-PA 1226 LQASWRqkrtgKQTLDKRELNILSLLTVHVHEP-DTCE---------LLLQLLLPLFTKq-aASASA-Et--vIQLITTL 1291
XP_032525560        1281 MKRRIans-akSNTVNRRDLLILSRVTEMVTTP-EMCD---------ELLGLLLPILVKk-vCMNMA-Een-mEHAVNTI 1346
30_pfamImport        392 FQRKLs----tKQGLNRKEVEILSRMTELVTDP-DSAD---------KLLNLLIPRLIKk---sGSS-Edv-iIPLLSTA 452 
XP_969008           1246 IQRRLdg--knKN-LNQRVLFILSWISELVWEA-DISD---------TTLKLLLPLALKr-cSTPIG-Eei-vVQLLTTI 1309
4_pfamImport         426 IERKLkrq-arQG-ASRTELVILSRISEFVSDS-KTCD---------TLLTLVLPILQRk---sGDS-Eev-vMQLLTTV 488 
7_pfamImport         417 IKSRLkkr-snKG-VSRIELAILSRISEFVTDA-ETCD---------MLLALILPILIRk--aMHNN-Eea-vTELLTTV 480 
XP_011256579        1278 LKNKLqr--snRG-LNKTELLILSRISEYVTDA-ETCD---------TVLKLILPILVKk--aSGNN-Nei-iVELLTTV 1340
6RXV_UT             1333 KRFIELddlqSnqelqrKVYSTISALFGFFKDKQNRQTLAEVLDVFARREV--------------WAQEVSDICRGLNSY 1398 Thermo...
26_pfamImport        495 ARLLNDiddpL------QYLKQLALSLQNVKNRGARKILLQIFDRLACRSP--------------EMQLISTLVHGLNAM 554 
XP_002063362        1280 SNLLKRvkqpH------IYVNQLAPLFELVQVISARKMLCEILTDMAKQLHkavkdqpqlsaqatALREWARIVYLLNAW 1353
WGS:AANI:GJ21931-PA 1292 SNLVQRvpapH------NYVRQLAPLFEQVQALPARKLLCEMLADMAKRLFkqskeqpelaaastKLREWARFVLQLNAW 1365
XP_032525560        1347 INLLGHstkpE------NYIKNFAILFNKVGPVEVRKLLIKLLYSISENVSen----------keKYEKIAHVVSEMNAF 1410
30_pfamImport        453 YNLIKYvinpG------RYVRKLAPLYGSVEGPAARKLLFSIVIDLSKQEGse-------------sgLDEGLLGDLNAW 513 
XP_969008           1310 SNLVGNvanpC------AHLKQITPLFGEVSCASGRKILVKVLKICLKEFGp-------------------DLVDGLNAF 1364
4_pfamImport         489 TNLLKHvdepK------KHLRSIQHLLAQITAAPARKMLMQVLIGVARdd--------------eQMKKNQNLLAELNAY 548 
7_pfamImport         481 INLVKIvnrpE------IHLRAIAPLMGLTSDISIRRLLIQLYNTIAEKSTgen---------reTITRDCNVLIALNAW 545 
XP_011256579        1341 MNLIKMankpE------IYLRDLAPLMSVVSDVPTRKLLLQLYGAIVERSSeey---------reTMMHDRDVLLALNAW 1405
6RXV_UT             1399 vEQRLDEPDYNTRLAAFNSITKD---RDKPft---lDQWMPLVHNLLYfiqqPEEFGvLSSNSADGLCKFISAVESVWAT 1472 Thermo...
26_pfamImport        555 dRRWVDQPDNVARTTAFRSIDQMlseDAPNgqrmtgNVAIVFLSQAFHvlqsEKDFT-VRQNACEYVCKVVLHLASANEW 633 
XP_002063362        1354 dKRWIEQPDYDKRLEALKEVKEMvaeEEKKqql-dmQLAILVVYNCFYmlrhDNDLG-LRVNIGELLKGLLPQLTIQL-- 1429
WGS:AANI:GJ21931-PA 1366 dKRWLEQPDYDKRLQALTELKQLlerKEDSpvvldmELGLLVTYNCFYmlrhDSDLG-MRVNIGELLKLMLPQITRQLMH 1444
XP_032525560        1411 nKRWIEQPDFDRRLDAYKSIYQMleaNEid-----vDLAILIVNNCFYfiktEKDIG-LRDSAGLCLKKILPKLLIKY-R 1483
30_pfamImport        514 dVKWIDQPDFNRRLNAFKKLEEManeKNis-----vNLGIIVIYTCFFfvktEKDLS-LKENSKYCLQKICPALCHSLQD 587 
XP_969008           1365 dTKWLDQPDFQRRHDAFKEVHKAideGRid-----lDLGVLLAYNCYYllksEKDLS-MKENSTHCLKQLCPYLINKYPK 1438
4_pfamImport         549 dQRWIDQPDFQRRLDAFSEIDRLikeEEat-----lEFGVAVILNCFFflktENDLA-MRDRSGQCLKSIGLYLAKKYSD 622 
7_pfamImport         546 dHRWIDQPDFQKRLDAFGEINDMvekNTit-----lEFGVAVIYNCFYflkaESDLA-IRDYSGQCLKLVAPRLAKEHQN 619 
XP_011256579        1406 dRKWIDQPDFERRLDAFDEISKMterNAis-----lEFGVTVIHNCFFflktASDLA-IRDCAGQCLKLVGCRLAKEHCN 1479
6RXV_UT             1473 PdqaAwi--dvVANIILPAIYAGSRDPS 1498 Thermochaetoides thermophila DSM 1495
26_pfamImport        634 P---Aelh-ycLDRIVLHNIAAGFKHKG 657 
XP_002063362        1430 A---EkdrnfwLDDILMPLFQRYIRDEK 1454
WGS:AANI:GJ21931-PA 1445 S---KdelhfwLDECLLPLLQRCVRDER 1469
XP_032525560        1484 S---VpegtilVRDTVLSLISTGIRDAK 1508
30_pfamImport        588 N---NrdrnfvI-GTILYLVTKGLSDKQ 611 
XP_969008           1439 Q---Vdy---iLNDTIFNLVRNGMKSRN 1460
4_pfamImport         623 N---StdrkylIEDTILTMVRHGIRKQN 647 
7_pfamImport         620 N---AvnrrylMDDTILVLTRRGIVSKN 644 
XP_011256579        1480 N---SsnrrylMDDTILALTRKGIMSKN 1504
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