6URG


Conserved Protein Domain Family
RMMBL
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pfam07521: RMMBL (This model is not part of the current CDD release)
Zn-dependent metallo-hydrolase RNA specificity domain
The metallo-beta-lactamase fold contains five sequence motifs. The first four motifs are found in pfam00753 and are common to all metallo-beta-lactamases. This, the fifth motif, appears to be specific to Zn-dependent metallohydrolases such as ribonuclease J 2 which are involved in the processing of mRNA. This domain adds essential structural elements to the CASP-domain and is unique to RNA/DNA-processing nucleases, showing that they are pre-mRNA 3'-end-processing endonucleases.
Links
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Statistics
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PSSM-Id: 517746
Aligned: 82 rows
Threshold Bit Score: 44.9017
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6URG_F       528 SIEIKARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAECCR-----------AFG-GkdIKVYM-P 591  human
O17403       562 RVEVSCRIEFIEYEGISDGESTKKLLAGLLPRQIIVVHGSRDDTRDLVAYF------------ADS-GfdTTMLKaP 625  Caenorhabditis el...
XP_001415490 496 EINIRATIITVDFEGKADGKSVRTLITQAAPRRVVLVHGDAKETKTLKDALT-----------AGLpG--VQIDA-P 558 
Q2GQR7       706 TVSVQLRIAFVDFSGLHDKRSLNMLIPLIQPRKLILVAGAEEETLALAADCKkllsaqlasgsSQS-A--IDVFT-P 778  Chaetomium globos...
Q81SC3       350 RIGKECRVKRVPYKVHQSIRDVKEMLNTLLPEHTVLVHALKEDTDRLQKKL------------STA-G--YENVY-S 410  Bacillus anthracis
Q8IL83       431 VVKRKCRFEQISFSAHSDFNQTKTFIEKLKCPNVVLVHGDKNELNRLKNKLI-----------EEKqY--LSVFT-P 493  Plasmodium falcip...
XP_001310348 383 IIPRKISIDYVSFSGHADFNQTSRFITELKPKRIVLIHGVCGLMMQLKEKLlq--------mfVED-G--LEVYT-P 447 
Q503E1       377 TLDVKLQVEYMSFSAHADAKGIMQLIRMAEPRNMLLVHGEAKKMEFLKDKIE-----------QEF-S--ISCFM-P 438  zebrafish
Q8SUC3       371 SREIRLEVKNLAFSAHADAPGILNVVEQCSPRNVMLVHGEKSRMKVLKRSIE-----------ERF-G--IPTFL-P 432  Encephalitozoon c...
EDK34926     382 VIPVNCKVKNVGLSAHSDKSEIKSLINFLSPRNIFIVHGNEDVIENFCMQLS-----------SEV-K--GKVYA-P 443
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