6SXH


Conserved Protein Domain Family
SecA_DEAD
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pfam07517: SecA_DEAD (This model is not part of the current CDD release)
SecA DEAD-like domain
SecA protein binds to the plasma membrane where it interacts with proOmpA to support translocation of proOmpA through the membrane. SecA protein achieves this translocation, in association with SecY protein, in an ATP dependent manner. This domain represents the N-terminal ATP-dependent helicase domain, which is related to the pfam00270.
Links
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Statistics
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PSSM-Id: 517744
Aligned: 80 rows
Threshold Bit Score: 297.875
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6SXH_A         9 IDSIL----D----KADEQE---IKKL--NVIVDKIDALEDSMKNLSYEELKDMT--AIFKNRL---K----KG-E-T-- 62  Clostridioides ...
Q2YAJ4        30 LDRFLgsslGqarlWASHLR---LKRL--RSFADKVVHRSNALSALSEAELAACV--DDLRVKLa--R----QG---L-- 91  Nitrosospira mu...
A0L9N3        24 drmgervrlA----WMRHKQ---VNGWvlGRMAKRVLKAQTERESMTPEALREDL--QRLTLAL---R----RD-G---- 82  Magnetococcus m...
Q2L0B4        32 VLRWL----S----RKRRQP---LWRT--RRILKQVHAEAALLAGLDLAGVRARA--DEVAFEL---Rc---DG------ 84  Bordetella aviu...
Q0FWT8        36 GRKLI----G----LGVARTa-gLRRHglSAILTETAQHEAALRPLTDAELRAAA--EALRAPL---RlaiaQGlPdA-- 99  Salipiger bermu...
Q2CHH2        47 LRRRL---------TRPRRW-----RY--HRLTRRCARRAPALAALDEAGLAAET--LRVRRAL---R----RRaGrA-- 99  Oceanicola gran...
Q2CEY2        34 AERWL----G----WAEARWplhRRRL--ARRAARIAALEPRYAALRSHQLVALA--HTLARQTlrhT----PG-R---- 92  Oceanicola gran...
WP_009807420  43 LAH-----------APFTRI-----RL--RLAAWRVLRLQPTFEDWEDDALRNEA--QRLRPAL---L----RN-E---- 90  Pseudooceanicol...
Q5LPY3        33 YTTL----------PRRRRR---ARPS--RFFAWRVLRRGKAFAQMSDDRLQGEVraAAYGMRAaraH----PG-E---- 88  Ruegeria pomero...
Q7UZ71        30 LGRFT------------DRP---AVDI--ETVLQSACDQISNRSANSKQDLQDRW--QTLRYKL---L----EAtSdQtr 83  Pirellula sp.

6SXH_A        63 -----LD----DI-LPEAFAVVREVSKRKLGMRQYRVQLIGGIVI------HQGKIAEMKTGEGKTLVEVAPVYLNALTG 126 Clostridioides ...
Q2YAJ4        92 -----TE----DL-TIEVFSLVREVCGRKLGLRHFPVQLIGGRVI------LAGKLAEMQTGEGKSLTAVLPAIAVALSG 155 Nitrosospira mu...
A0L9N3        83 -----LE----DAlVEQAFAHVRLTAQRVLGMAHFPVQLKGGYIM------LMGYLAEMDTGEGKTLTATLPAATAALAG 147 Magnetococcus m...
Q2L0B4        85 -----IT----QAsAARAFALVRQAGKLALGKAHFDVQLLGGWAM------LQGMVAEMNTGEGKTLTATLPAATAALAG 149 Bordetella aviu...
Q0FWT8       100 -----------KM-LGPAFALLREAAERTLGMRHYDVQLLGAFAM------LRGAVAEMRTGEGKTLCATLASCTMALAG 161 Salipiger bermu...
Q2CHH2       100 -----------DA-RLAAVALVRELCGRTLGMTPYDVQVFAALAL------LDGHLAEMETGEGKSLVAAMGAAAAALGG 161 Oceanicola gran...
Q2CEY2        93 -----------DP-LAHLLAVLAELLFRTLGKRPYPVQLMGAMAL------LEGRLVEMATGEGKTITGMPAALAAALRG 154 Oceanicola gran...
WP_009807420  91 -----MA----EPeLSRAFALVREVSWRTLGKRHYPVQIMGARAL------FEGRMVEMATGEGKTLTATPAAVVAALAG 155 Pseudooceanicol...
Q5LPY3        89 -----------AL-LVRSFALIRECAGRELGQRHYATQILGARAV------LNGAVAEMQTGEGKTLAITLAAGTAALAG 150 Ruegeria pomero...
Q7UZ71        84 dssnqLDaiwrEC-LADALILAADAIRATHDIELFEVQLRAGLIVssgwisRRGGVAEMQTGEGKTYALFVSSLIAALPG 162 Pirellula sp.

6SXH_A       127 KGVHVITVNDYLAERDKELMSPVYESLGMTVGVIISNQDPNIRKQQYKCDITYGTNSEFGFDYLRDNMVPDLSHK----- 201 Clostridioides ...
Q2YAJ4       156 LPVHVITVNEYLVRRDARFMRPVYEFFGLDVGMVVPDQDPETRRNAYGCDVTYCVNKDLVFDYLRDRIDSNRDVSdarra 235 Nitrosospira mu...
A0L9N3       148 FTVHVVTVNEYLARRDAQLMTPLYRALGVTTGVVTESMDSDEKQLGYRANVVYCTSKTLVFDYLRDRIQLGERMKpmama 227 Magnetococcus m...
Q2L0B4       150 LPVHVITTNDYLVERDAQIMSPLYEALGLTVRWVSMDMEPAQRRLAYQADIVYCSNKTLVFDYLRDLIVLDDDKDedrlr 229 Bordetella aviu...
Q0FWT8       162 VPVHVITVNDYLALRDRDLMRPLYDFLGLSTGVVQAGQQEPERAAIYRADIVFGANKEIAFDYLRDRMVLRRNPGnlrrk 241 Salipiger bermu...
Q2CHH2       162 EPVHVVTVNDYLGARDAESFAPLFDALGLRHGSIVHETTPAERRVLYGHDIVYISNKELAFDHLRDRVRMGGAPDrlrlk 241 Oceanicola gran...
Q2CEY2       155 EPVHVVTVNDYLAGRDGAEIAPLAERLGLSVGIVETEMDPAARAAAYACDLTYVSNANVTFDYLRDRVALGQARGparar 234 Oceanicola gran...
WP_009807420 156 LPVHVVTVNDYLAARDAEENTPIFDFFGLSVGIIDSDMDPQARKEAYGCHITYVSNKNLTFDYLRDRISLQHRRAaarrr 235 Pseudooceanicol...
Q5LPY3       151 RRVHVITANDYLAGRDADTMRGLYARLGLTCAAVEPGCTPEERRAAFAADIVYASGKEVAFTFLRDRVAMGGRAGdiglr 230 Ruegeria pomero...
Q7UZ71       163 RGVHIATPNAYLAQRDHEQLRETWSLLGVKSSCLPEDSSADAAHAAYRADVTYGPGHAFGFDYLRDQLAMDTAARqrpgs 242 Pirellula sp.

6SXH_A       202 --------------VQ-RELNFAIVDEVDSILIDEARTPLIIAG--D-GDE-DLK--LYELANSFVkTVKE-EDFELDRK 259 Clostridioides ...
Q2YAJ4       236 varl-frgdensraYL-RGLFFGIVDEADSVLIDEARTPLIISS--SvSDKqGVD--DYRRALDFCrQLRDgLHFRIFAA 309 Nitrosospira mu...
A0L9N3       228 fda---lvgggrgqVMlQGLQYAIVDEADSIFVDEARTPLIISA--PsKDAsELA--FLHTAWSLSqQLQQgQDYTL-SG 299 Magnetococcus m...
Q2L0B4       230 lerl-rggsgrlseLFlRGLCFAIVDEADSVLVDEARTPLIISG--SqKED-GGA--VTGQALALAqAMQa-GHYRVQPA 302 Bordetella aviu...
Q0FWT8       242 verl--saegpgavLRmRGLHFALIDEADSVLIDEARTPLVISGstDvARNqDPG--FLRRALRAArQLDEgKDYRIHPN 317 Salipiger bermu...
Q2CHH2       242 ldrlggaaaggeapVM-AGLAFAIVDEADSVLIDEARTPLILSQ----ETDaAAEeaTARQSFALLdALEEgRDYKVDLR 316 Oceanicola gran...
Q2CEY2       235 lasl--iggragagLTlRGLGFAIVDEADSVFIDEARTPLILSS--SgDEAdAAR--LYNTGLRLArALRAgADFELDEM 308 Oceanicola gran...
WP_009807420 236 mley--lsggqggdLMlRGLAFAIVDEADSVFVDEARTPLILSS----TADdPEAdaIYGQALDMVrQLETpRHYKIDHM 309 Pseudooceanicol...
Q5LPY3       231 tr-----affdgtgLLlPGLQFAIVDEIDSVMIDEARTPLILSV--P-PADaEVEaeAARAAHAIAaELKEgRDYRLDRL 302 Ruegeria pomero...
Q7UZ71       243 tllrrlnsesstprLQ-RGLAVALVDEIDHVLIDDALSPLLLSGtlPgEAD-DAA--VHRHALKTAtSLHGeEDF--LAT 316 Pirellula sp.

6SXH_A       260 DKTIALTASGISKAESFFGiTN-LTDIKNI--ELYHHINQALRGHKLMEKDVDYVISNGEVMIVDEFTGRVMDGRRYTDG 336 Clostridioides ...
Q2YAJ4       310 DKLIQLTPAGRDHITNICGnLPgVWQVAR---ARFELIEQALAAQLLYMRDKHYIVKDEKVQIVDEYTGRVMSDRTWESG 386 Nitrosospira mu...
A0L9N3       300 EEPPRITEAGSAQLAQLCVdLPpVWQGQH---RREEAVAQALTAQHSFDRDVHYIIRDDKVMVVDETTGRVMPDRAWERG 376 Magnetococcus m...
Q2L0B4       303 ARRVVLTEAGRAYLREACAaWPaPWSIPF---RREELILSALTVLHLYKRDEQYIVRDGKVMVVDEFTGRVMPDRSWGQG 379 Bordetella aviu...
Q0FWT8       318 EHRIEITPKGAERLEIMGEyGSgPFRVGV---IRDHAVVQALSALHLFHRDNDYVVRDGKVQIVDENTGRIQEDRSWSEG 394 Salipiger bermu...
Q2CHH2       317 ERRTTITPRGRARLEGLAEgLAaEWQNRI---RREEAVRNAVHARRFLTLGDQYVIRDGEIVIVDEYTGRLMPERSWSGG 393 Oceanicola gran...
Q2CEY2       309 RRSVTLTEAGKERLAAEAAgLDgQWRVRL---AREELVVQALSALHLFELGRDYIVDDGGVQIVDEYSGRVMPDRTWQGG 385 Oceanicola gran...
WP_009807420 310 NRQITLEEAGKARITQLAQdLQgIWQIRK---AREELARQALSALCLFEHGKDYIIVDDTIQIVDEYTGRVMADRSWQGG 386 Pseudooceanicol...
Q5LPY3       303 RHAVELSRNGCDRLADLAErMPpAWRPAP---IREDAVRTAISAIRLHQRDEHYILRDGKVEIVDEFTGRIMPDRSWSAG 379 Ruegeria pomero...
Q7UZ71       317 GQQIELTDTGLNRAYEAv--ED--WSDASLrrPWHEYVELALQATHLLRRDIDYVIEDESVRIVDQSTGRIYEDRTWSGG 392 Pirellula sp.

6SXH_A       337 LHQAIEAKEGVEIKNESKTMATVTYQNFFRLYEKLSGMTGTAKTEEGEF 385 Clostridioides difficile 630
Q2YAJ4       387 LHQMIEVKEGCALTDRRKTISRITYQRFFRRYLRLGGMTGTAAEVVGEL 435 Nitrosospira multiformis ATCC 25196
A0L9N3       377 LQQLIEIKEGVAVTPPKETLAKISFQLFFRRFLRLSGMSGTCREVGGEI 425 Magnetococcus marinus MC-1
Q2L0B4       380 VHQMIEHKEGLELSDPRVTLKSISYQRFFKHYLRLAGMTGTAAEIRGEL 428 Bordetella avium 197N
Q0FWT8       395 LHQMIELKEDVELTEPRATLSRISYQRVFRRYQRLAGMTGTASDAAWEL 443 Salipiger bermudensis HTCC2601
Q2CHH2       394 IHQLVEVKEEVTVTSRKLTIARLTYQRFFARYRRLAGMTGTAREVAGEL 442 Oceanicola granulosus HTCC2516
Q2CEY2       386 LHQMIEAKEGVEVTGRKVTLASITYQRFFRRYVRLAGMTGTGMELAGEF 434 Oceanicola granulosus HTCC2516
WP_009807420 387 LHQMIEAKEGVEISGQKHTLARITYQRFFRRYVRLAGMTGTGTELAGEF 435 Pseudooceanicola batsensis
Q5LPY3       380 LHQAVEAKEGVEITSRRVTLAQITFQRFFRRYIHLGGMTGTATEAADEF 428 Ruegeria pomeroyi DSS-3
Q7UZ71       393 LQQAIEAKEELPIQRESESLAKITRQRFYRSYDYLAGVTGTAGDCREEL 441 Pirellula sp.
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