5H7V


Conserved Protein Domain Family
MANEC

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pfam07502: MANEC (This model is not part of the current CDD release)
MANEC domain
This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins. Although formerly called MANSC (for motif at N terminus with seven cysteines) it has now been renamed by MANEC (motif at N terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors.
Statistics
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PSSM-Id: 517739
Aligned: 44 rows
Threshold Bit Score: 74.6328
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5H7V_A         19 DCLNS----FTaGVPGFVLDTNASVSNGATFLE-SPTVRRGWDCVRACCTT------QNCNLALVELQPdrG---EDAIA 84  human
Q0VC64         28 NCLTE-------SLEDVVIDIQLSLSKGIRGNE-PIHTLTPQDCINSCCSTknisgdKACNLMIFDTQK------KFKLP 93  cattle
XP_005010093   24 GCSAE-------KEENAIVDISFALPAGIRGAE-PVYASAPEACMRACCLGkglpgdKKCNFMIFDARG------TKTHP 89 
Q9CR33         27 NCLTK-------SLEDVVIDIQSSLSKGIRGNE-PIHLATQEDCIGACCSTkdiagdKACNLMIFDTRK------TDRQP 92  house mouse
EDO43585       29 GCPKIq------VKKNQILRTKEALNNGAKYLK-RAVISTARECYNLCCRH------SSCNLAMISYTN--StsgSDAVR 93 
XP_004084003   61 SCVVD----FS-ASKERIIRTKVSTQHGAAFLLaPDRVHSWRDCVHACCAQ------PHCTVAVLQEEPr----kAGDSL 125
10_pfamImport   2 SCVGD----FS-SVGDSIIQAKASIEQGATFLLaPKRVYTWRDCVHACCSQ------PHCTVAVIQEEQ--Gl--PGADL 66 
XP_006626311   76 ECLNS----YN-AIEDYIIRARDSIELGATFLTaPARVYSWRDCLHACCSD------PHCTVAVAEQER--Gr--SEESL 140
Q5VYB9         88 DCPGPgsggYS-AMPDAIIRTKDSLAAGASFLRaPAAVRGWRQCVAACCSE------PRCSVAVVELPR--RpapPAAVL 158 human
XP_005988730   59 HCFTD-------QMEDVIIDIKAALPLGVRSRE-PLYTAAAEVCTNLCCDGvki-neKKCNLVIFDFRK------HPQQD 123 coelacanth
5H7V_A         85 ACFLINCLYEQNFVCKFAPREGFIN 109 human
Q0VC64         94 NCYLFFC--PSEEACPLKPAKGLMS 116 cattle
XP_005010093   90 NCYLFYC--PSTEACPMKPATGFVS 112
Q9CR33         93 NCYLFFC--PSEDACPLKPAKGLVT 115 house mouse
EDO43585       94 MCYLFDC--GSPSKCMYAPYSHYAT 116
XP_004084003  126 GCYLFNCTYRNTNVCSFSPQRGFTT 150
10_pfamImport  67 DCYLFNCTYRGQHVCSFAPQPGFSA 91 
XP_006626311  141 SCFLFNCTYRGRNICKFSLQEGYNS 165
Q5VYB9        159 GCYLFNCTARGRNVCKFALHSGYSS 183 human
XP_005988730  124 NCYLFHC--PSAEACPMKTLKGLKS 146 coelacanth
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