9EH1,5XON,2DME


Conserved Protein Domain Family
TFIIS_M
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pfam07500: TFIIS_M (This model is not part of the current CDD release)
Transcription factor S-II (TFIIS), central domain
Transcription elongation by RNA polymerase II is regulated by the general elongation factor TFIIS. This factor stimulates RNA polymerase II to transcribe through regions of DNA that promote the formation of stalled ternary complexes. TFIIS is composed of three structural domains, termed I, II, and III. The two C-terminal domains (II and III), this domain and pfam01096 are required for transcription activity.
Links
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Statistics
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PSSM-Id: 517737
Aligned: 263 rows
Threshold Bit Score: 46.0585
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
9EH1_S         5 TSDSVRLKCREMLAAALRTGDdy-------iAi--------GADEEELGSQIEEAIYQeirntdmK-------------Y 56  human
Q6C9G1        28 SPMEVRNGTKKSLQKALAEAAde-------dEe-------dDEISTQVANEVEQRLFDl------Ygis--------peY 79  Yarrowia lipoly...
XP_013933250  30 VWKKTRAACKSTIEKTLsq----------iqAkr-----esVVDPGQLASEYECLLYEsrkh-------------nlenY 81 
XP_002490150  39 EVARVRSACSHKIEEALRTRItdaqkrlilkKenegslggvSYDITGIATAYERELYSkhnr-------------dlknY 105
XP_013933853 223 DRNKTRQSVVSQFAKKLQGHIped----hklLeqm----dvSSAAEEIASGLENALFEa------FpppnkrsesmspgY 288
CCE81276     157 YRNKTRSMVAKAFAAVFEKNIpst----yefPegl----dkSSLSSKWGIELENAIASiish-------------ndkkY 215
Q6BNY5       151 LKDKTRASVAKAFVNVFKRNIpes----yksPegm----dnEKLSSKWAIELEREIFIwcpk-------------kdkkY 209 Debaryomyces ha...
XP_006689404  83 LKDKVRANVAKAFMNVLKTQLpdd----ykdDgvs----skEDVALKWSMSIEAAIFNvfpq-------------kdrhY 141
XP_004995788 110 TGSQKRDGMRSVIIRRIVSLNp--------gRs--------QKSVADVACKVEEAIFNkfrn-------------dgdpY 160
EEQ37528     150 PKDKTRTNVCKALYNVILKNQta-------aGvs------kDEDAYHLAERMEEAIYVwsgt-------------tdkkY 203 Clavispora lusi...

9EH1_S        57 KNRVRSRISNLkdAKNPNLRKNVLCGNIPPDLFARMTAEEMASDELKEMRKNLTKEAIREH 117 human
Q6C9G1        80 KSAVRTRLVSLk-SKNSTIAVELLCGAIEPQAFAEYTVEQLKSDQRKKEEQALKDENLRQA 139 Yarrowia lipolytica
XP_013933250  82 KERFRKDLIALknQST-EFAQDLLRGNMSMKEFCRLKDSELLSKRQRTEDKQLLEKELKSK 141
XP_002490150 106 RTTFRKNLIAIknQDI-AFILDLLNGRICIKSFVNYSVEDLLSVKQKSIHKKLNQENLKHA 165
XP_013933853 289 LNKSRTLLFNL---DKSNLSDKVLSGQYTYEQIVHLTPEEMMRDDYKEFADAVRKQSINQS 346
CCE81276     216 TDKSRSLISLI---KKPNVMSQIIDGDLSFQKLVNSSPEEI-DNELKEYAEKVRQESIRRS 272
Q6BNY5       210 TDKSRSLMVLI---KKPNVMTRLIDGELSFTKLVNSPPEEI-DSELKEYAERVRSESIRRS 266 Debaryomyces hansenii CBS767
XP_006689404 142 TDKSRGIMTLL---KKPNVLQRLKEKTLTFEKLVASSPEEI-DDDLKKYAEKVRQESIRRS 198
XP_004995788 161 KKECRSRANYL---KN-EILDKLIAGELTPEQFATQAEQKLVSEEDRRETEQHLEQALRDK 217
EEQ37528     204 IDKSRSVMALV---KKPAVLAKAAQGSLAMSDLVSLPPEEI-DSELKDYAEKVRQESIRRS 260 Clavispora lusitaniae ATCC 42720
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