5OFB,5OFB,2L7P,4O62


Conserved Protein Domain Family
zf-CW

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pfam07496: zf-CW (This model is not part of the current CDD release)
CW-type Zinc Finger
This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialised mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions . Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteristic of vertebrates, higher plants and other animals in which these domain is found.
Statistics
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PSSM-Id: 517733
Aligned: 135 rows
Threshold Bit Score: 36.5312
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5OFB_B         498 TTIQCDLCLKWRTLPFQLSSVEKdyPDTWVCSMNP-D-PEQDRCEASEQK 545  human
Q8GY51         418 YWAQCESCEKWRLLPYDLNTEKL--PDKWLCSMQTwL-PGMNHCGVSEEE 464  thale cress
XP_009146794   412 SWAECDTCKKWRLLPFSENPDKL--PDKWVCSMQTwL-PGMNHCRISQEE 458 
XP_006577130   662 NWVQCDQCHKWRLLPVGTNPDNL--PEKWLCSMLDwL-PDMNRCSFSEDE 708 
10_pfamImport    1 NWVCCDKCQKWRLLPIGINPDHL--PEKWLCSMLSwL-PGMNRCSISEEE 47  
XP_018510418   523 NWVACDQCGKWRLLPYGVLPKDL--PKKWMCTMLNwL-PDANYCHVPEDE 569 
EFH54744       572 HWVACDKCGKWRLLPFGVVPEDL--PEKWMCTMLNwL-PGVNYCNVPEDE 618 
3_pfamImport     1 DWIQCSTCRKRRLLPYGTKPNQL--SQSWVCTMLDwL-PGMNCCDISEDD 47  
XP_020529848   654 DWVCCDKCETWRILPFGMNPQLL--PKKWLCSMQTwLrPGLNKCSVSEEE 701 
XP_003534849   622 DWVCCDSCQKWRLLPNGMKPEHL--PEKWLCSMLNwL-PGMNSCDFSEDE 668  soybean
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