4F55


Conserved Protein Domain Family
Hydrolase_2

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pfam07486: Hydrolase_2 (This model is not part of the current CDD release)
Cell Wall Hydrolase
These enzymes have been implicated in cell wall hydrolyzis, most extensively in Bacillus subtilis. For instance Bacillus subtilis SleB is expressed during sporulation as an inactive form and then deposited on the cell outer cortex. During germination the the enzyme is activated and hydrolyzes the cortex. A similar role is carried out by the partially redundant Bacillus subtilis CwlJ. It is not clear whether these enzymes are amidases or peptidases.
Statistics
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PSSM-Id: 517727
Aligned: 324 rows
Threshold Bit Score: 57.1303
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4F55_A                           29 GEPYLGQVAVAAVILNRVTSaSFPNTVSGVIFEPR-------AFTAVadgQiyltPNET------AKKAVLDAI--NGW- 92  Bacillus cereus ATCC 14579...
Q2RV49                           61 GETLQGRVAVAQVVLNRARDpRFPGSICDVVQENRsgmgrgcQFSWYcdgKa--dAPIEedawrsSVLLAMSVLrrDNAi 138 Rhodospirillum rubrum ATCC 11170...
WP_012971379                     56 SEPESGQIAVARVTLNRVESeAFPESICGVVKQGSqkr-hrcQFSWWcdgKp--dDPKEqkawkrSLEISRRVL--ADEv 130 Allochromatium vinosum...
ESQ15725                        146 SEPRLGQEAVAAVTINRVAStKFPNSVCGVVQQGGtkr-nrcQFSWWcdrRs--dRPQEadawarAQALSREAL--DGKl 220
WP_245538977                     62 SEPAIGRLAVAAVTMNRVQSgDYPNSICAVVHQGGekh-nqcQFSWWcdgRd--dTPTDtrawklAQQTARRSL--LGLa 136 Thioflavicoccus mobilis...
WP_012567122                     75 GEPEKAQAAVAAVVLNRVEDpQFPDTPCDVVRQGGetp--pcQFSWWcdgRs--dRPRDqdswrqALRIADLVG--SGTv 148 Rhodospirillum centenum...
WP_015773359                     91 GEEAAGIEAIANVVMNRLGHeGFPETICEVVKQGLeqg--acQFSWWcdgLp--dDAQEeeaysaAKEIARKAL--NKQv 164 Desulfomicrobium baculatum...
Q88H03                          101 GADAKDMTAVASVVLNRLGHdGFPDTICAVVKQGVetk--acQFSWWcdgRp--dQVEEpqrydvAKEIARKAL--NQQl 174 Pseudomonas putida KT2440...
dbos:1099484000104_PB2503_09259 107 AEPDAGLWAVGHVILNRMEAaRYPDTACGVTKDGGsdp--pcQFSWWcds--lpdTPREadawenARVLARKLL--LGEi 180
WP_013032914                     45 SEGREGMVAVGWVVLNRMDDsRYPATVCSIVYQGGesp--pcEWNWWcdgRs--dRPREkeawkkAQKVAQLLL--THPp 118 Nitrosococcus halophilus...
4F55_A                           93 -DPTGNALYYFNPDTatskWIWTr--PqIKKIGKHIF 126 Bacillus cereus ATCC 14579
Q2RV49                          139 nDPTRGALWYHNGTVap-sW--AdrlDrTVRIGTHVF 172 Rhodospirillum rubrum ATCC 11170
WP_012971379                    131 pDPTDGALYYHTDYVsp-kW--SrhlErTTRIGRHLF 164 Allochromatium vinosum
ESQ15725                        221 sDPTNGALYYHANYVep-rW--SrvfHkTSRIGRHLF 254
WP_245538977                    137 aDPTNGATHYHATYVhp-gW--AkafEqTTRIGRHRF 170 Thioflavicoccus mobilis
WP_012567122                    149 eDPTGGALYFHHTRVsp-sW--SavfEqVAEIGAHIY 182 Rhodospirillum centenum
WP_015773359                    165 qDRTGGALYFHRKDLtp-qW--AaeyVkTVVIGEHVF 198 Desulfomicrobium baculatum
Q88H03                          175 kDPTGGALYFHDRTVrp-dW--AkayRkTAQTTHFLF 208 Pseudomonas putida KT2440
dbos:1099484000104_PB2503_09259 181 eDPTNGATSFHAKRVsp-yWAEk--mTrTVTLGNHHF 214
WP_013032914                    119 pDPTQGALWYHHTSTktppW--LrkrKrTALIGKHVF 153 Nitrosococcus halophilus
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