Conserved Protein Domain Family
CHRD
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pfam07452: CHRD (This model is not part of the current CDD release)
CHRD domain
CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in chordin, an inhibitor of bone morphogenetic proteins. This family includes bacterial homologues. It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made. Its most conserved feature is a GE[I/L]RCG[V/I/L] motif towards its C-terminal end Most bacterial proteins in this family have only one CHRD domain, whereas it is found repeated in many eukaryotic proteins such as human chordin and Drosophila SOG.
Links
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Statistics
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PSSM-Id: 517709
Aligned: 148 rows
Threshold Bit Score: 35.1455
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_015121615   241 ITSNLDGSQevTAGDSD----AQG-TSVLTL-NDTGDSLEYSLTVSGLDfganglvaggaqtpddtsdDVTRL-----H- 308  Rivularia sp...
27_pfamImport    1 FSAILTLEGp-PQANT------GG-IALLTL-SDTEDSLHFLLLSQGL-------------------------------- 39  
36_pfamImport    1 FSATLTLEG--P-QQQG----AGA-IAVLTL-SDTEDALHFLLLFRGL-------------------------------- 39  
Q63148         286 FSAILTl---eDPLQRG----VGG-IALLTL-SDTEDALHFLLLFRGLLgglah----------vplkLQILHqgqllRe 346  Norway rat
13_pfamImport    1 FSSLLEPAV---GTMTG----AGG-TAIVSIsTSVSTSIYLAIVFNGL-------------------------------- 40  
EDW27057       382 FSSLLEPPQsqPGGKFDpmltGAGgTAIVSTssgaASSMHLTLVFNGI-------------------------------- 429 
XP_064418140   291 FSSVLTs---sDPTLPG----LGG-IAMLTL-SDVENNLHFILMFEGLLqkkdrdy------plvpirVQMLHhhralRe 355  coelacanth
XP_018119027   283 FSALLTp---eDSDVTG----GGG-LAMFTL-SDVDDNLHFILMLRGLRggerd---------wipilLQISHqnhviRe 344  African claw...
XP_007663441   290 FSAILTl---eGPPRPG----TGG-IALLTL-SDTEDSLHFLLLSRGLLehedvgp------fqvplkLQILHegqllRe 354 
XP_011511556   283 FSAILTl---eGPPQQG----VGG-ITLLTL-SDTEDSLHFLLLFRGLLeprsggl------tqvplrLQILHqgqllRe 347  human

WP_015121615   309 IHNASRG----ENGGVVFSLFDTVAPELgnqlniqgnqdedlnvtlnengsvtlagiweetdsanddlsELVAEI----- 379  Rivularia sp...
27_pfamImport   40 LDSKSGGs---FHTPLRLQIQHQDQLLRelqanvs----------------------------ahepgfAEVLPD----- 83  
36_pfamImport   40 ---AVAGp---AQVPVRLQILREGQLLRelqants----------------------------aqdpgfAEVLPS----- 80  
Q63148         347 LQAN-----------------------------------------------------------------ASAQEPgfaev 361  Norway rat
13_pfamImport   41 FTEE-DV----ADVPINVTLSLDEKKYIlqevvrvkkphy-----------------elnmvevrspvtPADLRL----- 93  
EDW27057       430 -----FGaeeyADAALSVKIELPERKEIifdevprvr--------------------------------------kpsae 466 
XP_064418140   356 ICAN-----------------------------------------------------------------VTAHDPdfaev 370  coelacanth
XP_018119027   345 IYAN-----------------------------------------------------------------ISAQEQdfaev 359  African claw...
XP_007663441   355 LRAN-----------------------------------------------------------------ISAQEPgfaev 369 
XP_011511556   348 LQAN-----------------------------------------------------------------VSAQEPgfaev 362  human

WP_015121615   380 ---RDTqes---------edlDLYFNVHTEEFPG-GAIRGQL 408  Rivularia sp. PCC 7116
27_pfamImport   84 ---LTAqemqw------lalgELQISLERKEGPG-PRISGHI 115 
36_pfamImport   81 ---LTAqemdw------lvlgELQMALERADRPE-LRLRGYI 112 
Q63148         362 lpsLTDqemdw------lvlgELQMVLEKMGGPE-LRISGYI 396  Norway rat
13_pfamImport   94 ---LTRg--------------RLVLTVSSVSKPEaLRLSGSV 118 
EDW27057       467 invLELsspisiqnlrlmsrgKLLLTVESKKYPQ-LRIQGHI 507 
XP_064418140   371 ltdLSNremlw------lsqgQLEIAVETEGKNA-RQISGFI 405  coelacanth
XP_018119027   360 lpdLSSremlw------laqgQLEISVQTEGRRQ-QSMSGII 394  African clawed frog
XP_007663441   370 lpgLTPqemqw------laqgKLQIAMEREGGPG-HRISGLI 404 
XP_011511556   363 lpnLTVqemdw------lvlgELQMALEWAGRPG-LRISGHI 397  human
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