Conserved Protein Domain Family
BofA
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pfam07441: BofA 
SigmaK-factor processing regulatory protein BofA
This family contains the sigmaK-factor processing regulatory protein BofA (Bypass-of-forespore protein A) (approximately 80 residues long). During sporulation in Bacillus subtilis, transcription is controlled in the developing sporangium by a cascade of sporulation-specific transcription factors (sigma factors). Following engulfment, processing of sigmaK is inhibited by BofA. It has been suggested that this effect is exerted by alteration of the level of the SpoIVFA protein.
Links
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Statistics
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PSSM-Id: 488960
Aligned: 102 rows
Threshold Bit Score: 28.9342
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CDA50869      11 VLAVIFIIFKIFnLSIKIFFKLLINALIGAALLFVFN-FVfAGLMNLSffyINITWLTALITGIFGVPGVVVLLIIG 86 
14_pfamImport  1 GIFGFIIIISMF-RTKKFLLSLFMTALQGIASLIAAN-FI-GGFFGVH---LSVNAFSLGVCGLGGLPGTVMLLITD 71 
7_pfamImport   2 AVLCGLLILLL--RNPRALGKWALGGVGGCVALWAVN-AA-GAFTGVS---VACNLWTVGAAIVLGLPGVVSLFFLK 71 
CDA89070       9 VCVVLLIPIITMfKKGSFLKCIFLSAFQGLAALLAVN-SL-GLLTGVS---LAVNWYTILACVCLGIPASISMLVLN 80 
22_pfamImport  2 GIFCALLVLHVAaGSKKPFRRALGSALNGLVALVLVN-IT-GGFTGVT---LPVSLLSLGVSAGLGIPGVTMLLLLN 73 
24_pfamImport  2 GVFLALVAIRKImKSKHPIRSTLLGLLLGPACMLVIN-II-SIFTSVS---IPISPLSLGISSTLGIPGVTAMLLLQ 73 
CDC82604      12 STVIFFAVIYAAkQSKKPLKRACGTVLTGLAALAAVN-IS-GIFTGVY---IPVSCLSVCASAVGGIPAVTAMLIID 83 
WP_022234209  12 GAFLLFAFAHYIsKSRHPFKRSLLSMAIGLLTLLAVN-LT-GSFTGVY---LPVSLVSVCCAAFGGVPGVTLMLGLN 83  Ruminococcus sp.
17_pfamImport  1 -ICVFLLWVGV--DAWKYILNFMVRCLSGLVIIYVVNcAIqYYGGNLA---VKINEIAMGFSGILGIWGVIFLYALQ 71 
15_pfamImport  2 AFLVVKVIGYGAlSWMQYLSEVLLRCLSGLIVLYVCNfFMcYLNENLI---VNINEISLTISAFFGLAGVFLLYCFR 75
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