6H5N,7KJ7,2YMO,4YS4,2YMO,7KJ7


Conserved Protein Domain Family
s48_45

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pfam07422: s48_45 
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Sexual stage antigen s48/45 domain
This family contains sexual stage s48/45 antigens from Plasmodium (approximately 450 residues long). These are surface proteins expressed by Plasmodium male and female gametes that have been shown to play a conserved and important role in fertilization. This domain contains 6 conserved cysteines suggesting 3 disulphide bridges.
Statistics
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PSSM-Id: 429455
Aligned: 74 rows
Threshold Bit Score: 50.9668
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6H5N_D          3 IHGCnf-----------------sSNvSSKhtftdsldislvddsahiSCNVHLSep----------kyNHLVGLNCPG- 54   Plasmodium fa...
Q4UEY5        517 TYGCgtrndifrkelldfrselinNK-PAS------------------ICRVDGK--------------NSPIGFYCPKp 563  Theileria ann...
Q4UCH0       1021 VHGCgvngpsedf--fkdtekiieNG-SET------------------GCRVDIRe-------------KEYAGFYCPEp 1066 Theileria ann...
Q4N083       1029 VHGCgvnepsedf--fkdtekiieNG-EEI------------------GCTVDLRd-------------KQIAGFYCPEp 1074 Theileria parva
Q7RGZ1        279 IDGCdf------------------tQpKGKglykngfvl-seinnveeICTVHIGsg----------qnSNVAGLKCPY- 328  Plasmodium yo...
Q8IDN0        284 IDGCdf------------------tKpKGKgiykngfiindipneeerICTVHLWnk----------knQTIAGIKCPY- 334  Plasmodium fa...
XP_002259881  310 IDGCdf------------------tKpTGEgdyqhgfpl-gdiqskekICSIHIKsrsnssnggkgegsKIAAGIKCPY- 369 
XP_001616144  194 IDGCdftkntspl--ftkgydanfYKtIENkd--------------dvICKVKATe-------------GKLIGFKCPAd 244 
2YMO_A        154 VKGCdfttsesti--fskgysineISnKSSnnq------------qdiVCTVKAHa-------------NDLIGFKCPSn 206  Plasmodium fa...
XP_001609645  799 VHGCglgfkgetlfrdd-------------------tityteptsgikSCVIDLNv-------------NDEGGFYCPPp 846  Babesia bovis...
6H5N_D         55 -DIIP-DCFFQVYqpese--elepsNIVYLDSQINigdieyyedAEGDDKIKLFGIv--------------------GsI 110  Plasmodium fa...
Q4UEY5        564 fLLEPrDCFKSVLvstd-----egeKSVDLVKVDK---------HARHFTTKNLVVldtysngghvgpaqnegganyEdD 629  Theileria ann...
Q4UCH0       1067 yRVDPpGCFKYAYtge------ysrAVMMKDEILDd-------lWQETNGFRYLKLk-------------------rN-L 1113 Theileria ann...
Q4N083       1075 yKVDPpSCFKYMYveg------ysmPVALRDELLDg-------iWRETNGFKYIKLr-------------------rN-I 1121 Theileria parva
Q7RGZ1        329 -KLTPvYCFKHVLyekkykngnntfQTFLLDDVLRtvdi--eyyYNAKLSAHIVGIp-------------------tLpE 386  Plasmodium yo...
Q8IDN0        335 -KLIPpYCFKHVLyekeid-sqktyKTFLLSDVLDtpni--eyyGNNKEGMYMLALp-------------------tKpE 391  Plasmodium fa...
XP_002259881  370 -KLTPtYCFRHVLheknmk-gvkdyQPFLMTDVLGttdm--efySNVKEGSYIIGLp-------------------tGiQ 426 
XP_001616144  245 yAIEPeECFLQGFnlsgk--keqlrTKIELTDLVM----------DHYNKIFYARVp-------------------qR-I 292 
2YMO_A        207 ySVEPhDCFVSAFnlsgk--nenleNKLKLTNIIM----------DHYNNTFYSRLp-------------------sL-I 254  Plasmodium fa...
XP_001609645  847 yIMEPpECFHDVFvg---------dVVTKLNRISSdlf---afrSSHFSLIRLDRLannakes----------------- 897  Babesia bovis...
6H5N_D        111 PKTTS---F--------TCICKK 122  Plasmodium falciparum 3D7
Q4UEY5        630 NEYVNaseI--------MCKCVD 644  Theileria annulata
Q4UCH0       1114 RSQVL---MtflkrrpyVCFCRT 1133 Theileria annulata
Q4N083       1122 KTQVL---LtflrrkayTCYCRT 1141 Theileria parva
Q7RGZ1        387 KSETI------------RCVCEQ 397  Plasmodium yoelii yoelii
Q8IDN0        392 KTNKI------------RCICEQ 402  Plasmodium falciparum 3D7
XP_002259881  427 KYSVV------------RCLCEY 437 
XP_001616144  293 YQNMH---F--------FCACVl 304 
2YMO_A        255 SDNWK---F--------FCVCSK 266  Plasmodium falciparum 3D7
XP_001609645  898 --rktypaL--------RCRCVt 910  Babesia bovis T2Bo
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