2YMO,6H5N,2YMO,4YS4


Conserved Protein Domain Family
s48_45

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pfam07422: s48_45 
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Sexual stage antigen s48/45 domain
This family contains sexual stage s48/45 antigens from Plasmodium (approximately 450 residues long). These are surface proteins expressed by Plasmodium male and female gametes that have been shown to play a conserved and important role in fertilisation. This domain contains 6 conserved cysteines suggesting 3 disulphide bridges.
Statistics
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PSSM-Id: 400003
View PSSM: pfam07422
Aligned: 77 rows
Threshold Bit Score: 48.629
Threshold Setting Gi: 959586836
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2YMO_A       154 VKGCD------FTt------------------------------------------------SESTIFSKGYSINeISnK 179  Plasmodium fal...
6H5N_D         3 IHGCN------FS---------------------------------------------------------------SNvS 13   Plasmodium fal...
XP_001614246 298 IHGCN------FS---------------------------------------------------------------SD-K 307  malaria parasi...
Q7RGY9       303 IHGCN------FS---------------------------------------------------------------KD-L 312  Plasmodium yoe...
C6KSX1       170 lYGCD------FDhdeklmknktaftnfydkqkilplignnnndddnndddnnndnnnndnnNNNNNNNNNNNNN-NN-N 241  Plasmodium fal...
Q7RK06       170 IFGCD------FNydtnepkhsngk------------------------------------safarfydkkiiVN-SN-K 205  Plasmodium yoe...
ALR73004     472 IKGCDshqtpiFD------------------------------------------------------------------P 485  Babesia bovis
ALR73017     176 aYGCEtgnnmlFK----------------------------------------------------NSRPIIPNILnLQiA 203  Babesia bovis
XP_001610180 178 aYGCEtgnnmlFK----------------------------------------------------NTAPFVPGFKvSDvD 205  Babesia bovis ...
XP_001610179 177 aYGCEtgnnmlFK----------------------------------------------------NTIPKLDWLNhDDvE 204  Babesia bovis ...
2YMO_A       180 SSnnq------------qdiVCTVKAHa---NDLIGFKCPSNYSVEPHDCFVSAFnlsgknenleNKLKLTNIIM----- 239  Plasmodium fal...
6H5N_D        14 SKhtftdsldislvddsahiSCNVHLSepkyNHLVGLNCPG--DIIP-DCFFQVYqpeseelepsNIVYLDSQINigdie 90   Plasmodium fal...
XP_001614246 308 SThnftnhvdmaelgenaqiTCSIELVdtsyNHLIGMSCPG--EVLP-ECFFQVYqrespelepsKIVYLDAQLNignve 384  malaria parasi...
Q7RGY9       313 SIrtftnnmnllkytentdiNCNVEISqpfyDHLIGISCPG--TIIP-DCFFQIYkpltnelkssEITYLDSQLNignie 389  Plasmodium yoe...
C6KSX1       242 NI------------------TCNVTIKk--sQVYLGIICPDGYTLYPNDCFKNVIyd------nnIIIPLKKIIPhdily 295  Plasmodium fal...
Q7RK06       206 NI------------------ICNTQVNs--kEVYLGLVCPEGYEIYPENCFENILfe-------nKVIKISELIKhdikl 258  Plasmodium yoe...
ALR73004     486 SLvakdcvwkkyeyingflhKCVLENAy--gAIKAGIFCKDGESLMPNNCLENLYdyslg-kttrLPQSVKSLTY----- 557  Babesia bovis
ALR73017     204 --------------------SCSVDIEp---GMIFGIYCKAGERLDPGECFsd-----------eELSDYNGAITpyipk 249  Babesia bovis
XP_001610180 206 RV------------------DCSLTLEp---GMIFGIYCKPGEQLMPDHCFpg-----------kRLQELNGDITpyane 253  Babesia bovis ...
XP_001610179 205 E-------------------ECLITLEp---NMLFGIFCEKGERIWPKNCInd-----------dDYKKMNHAISsyslp 251  Babesia bovis ...
2YMO_A       240 ----------DHYNNTFYSRLp------sL-ISDNWKFFCVCS 265  Plasmodium falciparum 3D7
6H5N_D        91 -----yyedaEGDDKIKLFGIv-------GsIPKTTSFTCICK 121  Plasmodium falciparum 3D7
XP_001614246 385 -----yfedsKGENIVKIFGLv-------GsIPKTTSFTCICR 415  malaria parasite P. vivax
Q7RGY9       390 -----yyediHENNEIRIFSIv-------GaIPQSASFTCMCK 420  Plasmodium yoelii yoelii
C6KSX1       296 ------hqdkNKRITFASFTLnine-nppG-------FTCYCI 324  Plasmodium falciparum 3D7
Q7RK06       259 ------hiekNKNISFASFILnsne-npkS-------FSCHSQ 287  Plasmodium yoelii yoelii
ALR73004     558 ----------AKVSGMRILQLsynntrplS-------VGCSCV 583  Babesia bovis
ALR73017     250 fa-ananpasTLSTRFRLFKVh------dGqLPNSVDLSCACV 285  Babesia bovis
XP_001610180 254 te--fydsrrKINSRFQLFVVs------dKgVRTHFYHHCYCQ 288  Babesia bovis T2Bo
XP_001610179 252 wsptvyrsmsRLSPRFKLFQVs------pNeIVKNINIHCYCQ 288  Babesia bovis T2Bo
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