8QY4


Conserved Protein Domain Family
IL11
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pfam07400: IL11 (This model is not part of the current CDD release)
Interleukin 11
This family contains interleukin 11 (approximately 200 residues long). This is a secreted protein that stimulates megakaryocytopoiesis, resulting in increased production of platelets, as well as activating osteoclasts, inhibiting epithelial cell proliferation and apoptosis, and inhibiting macrophage mediator production. These functions may be particularly important in mediating the hematopoietic, osseous and mucosal protective effects of interleukin 11. Family members seem to be restricted to mammals.
Links
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Statistics
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PSSM-Id: 517690
Aligned: 8 rows
Threshold Bit Score: 168.379
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8QY4_A        35 PRAELDSTVLLTRSLLADTRQL--AAQLRdkFPADGD-HNLDSLPTLAMSAGALGALQLPGVLTRLRADLLSYLRHVQWL 111 human
XP_007241275  84 SHADLDKLTNQTRHLQKLTHDL--INDHE--LDSVIDhHRFKSLPAINGRANDLSSLELKTTLSQLHTDLKSFEHHFEWL 159
XP_018591840  32 rQIAEAEITNQTRHLLKLTQEL--LKDHV--IGTDIE-HRFKTLPAMANRVADLSTLEVKSTLAQLHSDIQLFDLHFEWL 106
1_pfamImport   7 LCGMFRPMVLQLNSLNNMSKKLhhLTDHElvIFEGVE-HRLDDLPHIQHTAAHFSSLKVNESLSQLLRYTRSFRLHVDWL 85 
2_pfamImport   6 vDHELDTMVNLAKNILHDTKIA--FRQFKlkFPSEGE-HRLETLPVLSGSASDLGAIQVTNALSKIDSDLRSYEEHFEWL 82 
KFO36483      63 ARAEMDSTVLLTRSLLLDTQEL--FAQLKnqYPVAGG-FGLKSLPKLAMSAGALGALQLSSMLTRLRTDLLSYLRHMQWL 139
XP_031762208  26 PKVEFDDLLNMARHLLRDTKQS--YHNFKakYPSEGE-HKLDSLPVLSMNAVEISNVQIHTGLLKLSTDLFIYQKHFDWL 102
XP_021101408  35 PRAELDSAVLLTRSLLVDTRQL--AAQLRdkFPVDGD-HSLDSLPTLAMSASALGALQLPSVLTRLRTDLLSYLRHVQWL 111

8QY4_A       112 RRAGGSSLKTLEPELGTlQARLDRLLRRLQLLMSRLALPQPPPD-PPAPPLAPPSSAWGGIRAAHAILGGLHLTLDWAVR 190 human
XP_007241275 160 NKVTKKHQHSTAPKLGE-MISHIKSLINSLQRQMSRVDAQRNPV-PSPSLPPHPTSHWEMDQSSQELLQRFRLYCDWATR 237
XP_018591840 107 NKALKNRKHASFPKLGE-LIQHLKLLKFSLQRQMTKLQVLRPPT-PSPSLPSTDVNEWEVVQSSLELFQKFRLFCDWALR 184
1_pfamImport  86 KTAKENVSLSS-RSTGG-AGAHLLRLSDLLTASLLQMGEEVPPS-LSPPLAPI-STAFDVLRFSVEMSERLMVFCNWSKR 161
2_pfamImport  83 KKAEVISKAPLEQSITK-IHSKTQNLANHIEHLMNRHNIPKSNF-SPPQLPPQHATHWSAVHAGHAIFHHFKLFMDWTVR 160
KFO36483     140 RRVGGPSVKSLEPELGT-LQTQLDRLLRRLQLLMASLALPQVPPeLPAPPLPSSLKDWRSIQAAHAIIGGLHLTLDWAVR 218
XP_031762208 103 RKAAH-AIRPMDHEFNG-IHNRIEKLLKKIDLLMIKHHMPRVTEpVVPQF-PNSTTPWGVIQSGHAIFHHFHLFLDYATR 179
XP_021101408 112 RRVGGPSLRTLEPELGT-LQARLDRLLRRLQLLMSVLALPQVPPePPTPPLAPPASAWGGIRAAHAVLGGLHLTLDWAVR 190

8QY4_A       191 GLLLLKTRL 199 human
XP_007241275 238 AFLSLKSKT 246
XP_018591840 185 VFLSLKLRH 193
1_pfamImport 162 VLLRLQRLC 170
2_pfamImport 161 ALVVLQNKH 169
KFO36483     219 GLMLQKAQL 227
XP_031762208 180 VLVLMKNKW 188
XP_021101408 191 GLLLLKTRL 199
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