Conserved Protein Domain Family
P19Arf_N
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pfam07392: P19Arf_N 
Cyclin-dependent kinase inhibitor 2a p19Arf N-terminus
This family represents the N-terminus (approximately 50 residues) of cyclin-dependent kinase inhibitor 2a p19Arf, which seems to be restricted to mammals. This is a tumour-suppressor protein that has been shown to inhibit the growth of human tumour cells lacking functional p53 by inducing a transient G2 arrest and subsequently apoptosis.
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Statistics
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PSSM-Id: 488936
Aligned: 6 rows
Threshold Bit Score: 37.5276
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O77618         4 RVRVTVRVSRACRPHHVRIFVAKIVQALCRASASINQGtpfQVLLIVRKKR 54  gray short-tailed opossum
XP_003407379   4 RFLVTVRIRRACGPPRVRSFVVHVARPAREWAAPGPRA---LVLRLVRSQR 51 
Q8QZZ9         4 RFVVTVRIRRTGRSPQVRVFLVQFLGSSRPRSANGTRGfvaLVLRPERIAR 54  Norway rat
Q64364         4 RFLVTVRIQRAGRPLQERVFLVKFVRSRRPRTASCALAfvnMLLRLERILR 54  house mouse
1_pfamImport   1 RFSITVRIPRAGGPPRV---TVHIARPAGEWAAPSVSAavaLVLMLVRRQR 48 
ELK15813       4 tFLVTVRIRRSRGPPQVRAFVVQFPRPAGEWASPGVRAaaaLVLTLVRSQR 54
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