Conserved Protein Domain Family
A-2_8-polyST

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pfam07388: A-2_8-polyST 
Alpha-2,8-polysialyltransferase (POLYST)
This family contains the bacterial enzyme alpha-2,8-polysialyltransferase (EC:2.4.99.-) (approximately 500 residues long). This catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA).
Statistics
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PSSM-Id: 399987
View PSSM: pfam07388
Aligned: 23 rows
Threshold Bit Score: 126.124
Threshold Setting Gi: 738936824
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_034632117   2 NLFIVSNLGQLIQAQNVIKQNDLIDNV---LVVLWTKRN---TVVRDNI---------INNVDn-------QFFSNVDTL 59  Bacillus okhensis
KKK38900       3 ILYLCFTPYHI-KVSNYLSKTEYKSDEnhmILSSCSGINe-------------------------------nTLKKFVKI 50  Bacillus campis...
CDF82554       2 SLFIIGSPWHAALANAIIEREE--------------------IKNPSII---------VEEISs-------SSLEQILGI 45  Pseudomonas kna...
WP_068400361   1 MLIIVGSPWQALLAKSYILKEN--------------------ITDPQYL---------IEKSSp-------KSFAEIIKI 44  Pedobacter cryo...
EDM34775       1 MLIIVGSPWQALLAKSYILKEK--------------------IEHPQYV---------IEKSSp-------KSYAEIIKI 44  Pedobacter sp. ...
WP_044664276  26 FIASSTSHWHALGIDAEINSNEELKQSggiIFISPHPKDgflIDSNDFI---------CSRSPk----------IKIAMV 86  Syntrophaceticu...
CDC04958      24 VVAFCITPWHSVGIEVALEKLNSLEKQlngHLFICKHPKtglALSPTSVnlssygnfkTEIYNipaasplkKLFDHIYHF 103 Clostridium lep...
RAU82220       6 KILFIGDYCRTDYVSLLKDA----KNDiylYFLFYTSPKeetNHGYQAY---------GQAIYw-------KNFKDVFAL 65  Pontibacter sp....
WP_116023844   3 QIFVSSRLFGAMSLAAAIDAGHFGPSGrrrILLISHDAQ-----IPELT---------PPPNErpgyapllSRFDEVISL 68  Actinomadura um...
WP_103942705   3 QIFVSSRLFGAMSLAAAVDAGLFGPPGrrrILLVSHDAE-----IPELT---------PPPNErpgyrpllSRFDEVISL 68  Actinomadura ec...
WP_034632117  60 -QLPNFPNKF-------HVNN------LMKIRKDYNHLIENY------PFTDVFVCN---YNSHYNFLYDIAKAKNININ 116 Bacillus okhensis
KKK38900      51 tQYKTLNYTDielslreGVKLga--syFKKYKSSIEHFIKTIke---qEYDKIVYFSdnpIAYQLLFNDIKQNSVNTKLM 125 Bacillus campis...
CDF82554      46 lKHPTLAIFQhentrfeSIKKlgifrfIRNMHLEFERIENSCkylnqsQTRKVYYFNfysPITRKIIKSLPKALSKREVI 125 Pseudomonas kna...
WP_068400361  45 lDADENSIRMiiewsklSVLSka---kANIASDYIDAIIQTL---------------------------KQDYFKTVETI 94  Pedobacter cryo...
EDM34775      45 lNVGEADIRItiewgrlSVLSfd---kAKKASAYIDEILTNL---------------------------KEEYFQKVETV 94  Pedobacter sp. ...
WP_044664276  87 nPIQTRPHELirltiklIINKiknktnTFYLLSPMTPKLLSL---------------------RLFTETFLVNSCQLNYI 145 Syntrophaceticu...
CDC04958     104 fHIIKSPNFSadkpscyVISP---------LNPDYKTISDAM---------------------------KLRPDENIIAV 147 Clostridium lep...
RAU82220      66 lHQIR------------PHKV------VFLYIESYNHVILNL----------------------------ACRQLNIPTY 99  Pontibacter sp....
WP_116023844  69 nELIDPLHPLawspaavDQPM-------------IERLLRRVwn---lGDEPIELAVe--AIQSNPARSLASIFHDATVT 130 Actinomadura um...
WP_103942705  69 nEVIAPQHPLswnprpeDLPM-------------LERLLRQVwg---lGADPVELAVe--AIQSSPAKTLAAIFHEATVT 130 Actinomadura ec...
WP_034632117 117 IF------------------------EEGL-GTYKFkvvldkmqennkikfierftiaqnfaikdfkq--------aikq 163 Bacillus okhensis
KKK38900     126 FV------------------------EEGT-GIYlknyrypf-------------------------------------- 142 Bacillus campis...
CDF82554     126 RV------------------------EDGI-CDY---------------------------------------------- 134 Pseudomonas kna...
WP_068400361  95 LVfseqtvlfkiiynlfgasktyiksEDGI-LDYLPglkhhsll------------------------------------ 137 Pedobacter cryo...
EDM34775      95 LVfseqtvffkifydvfgdtktylksEDGI-LDYLSklkhhgvt------------------------------------ 137 Pedobacter sp. ...
WP_044664276 146 LI------------------------DEGI-GTYLSssiwkrvqkddksnydifgniiiqlkngifrvfnsfiiykcisv 200 Syntrophaceticu...
CDC04958     148 VV------------------------DEGLggrs---------------------------------------------- 157 Clostridium lep...
RAU82220     100 LL------------------------EHGLrADYvfgfdanis------------------------------------- 118 Pontibacter sp....
WP_116023844 131 VY------------------------SDGL-ATYgatrat---------------------------------------- 145 Actinomadura um...
WP_103942705 131 VY------------------------SDGL-ATYgatrat---------------------------------------- 145 Actinomadura ec...
WP_034632117 164 tdlfkwlvflllfiknnlfnplfillkgMARICLSFFPIefVnkikki-------ktpkelRSFDGTIPMFDKAYFTFP- 235 Bacillus okhensis
KKK38900     143 ---------------------rykilifLAKILFNNNNIrvFmhgkggfe-----------------------------d 172 Bacillus campis...
CDF82554     135 -------------------------------FEFNFINHkkPllliknilatlliksdlyrRRNSKLENKTSSYYCFFP- 182 Pseudomonas kna...
WP_068400361 138 --------------------------------------------------------kqiagylFIRSKVKYYIYKNYYPv 161 Pedobacter cryo...
EDM34775     138 --------------------------------------------------------kkiagylLMGAKTKYYVYKSYFPi 161 Pedobacter sp. ...
WP_044664276 201 enrflfnnvknnlrvnatvrdnynklllAnan------------------------------------------------ 232 Syntrophaceticu...
CDC04958     158 -----------------------------------------------------------rfsWFISRIHDGINPLKSFIt 178 Clostridium lep...
RAU82220     119 -------------------paskknfiaKIKTYYKLTHNfiAriksrlfllnsikllppedKAFAKHFIKIRSKHNYLDt 179 Pontibacter sp....
WP_116023844 146 --------------------------------------------------------pptgvGSRLSRLLYLDLMPGLVP- 168 Actinomadura um...
WP_103942705 146 --------------------------------------------------------pprgvGSRLSRLVHLDLVPGLTP- 168 Actinomadura ec...
WP_034632117 236 -------DQGSELfkakq------ynelKLDYQLKKEVEYYLKNSQTLSL-----------LDRKSVIFLDQVYN----- 286 Bacillus okhensis
KKK38900     173 evllrepELIESK-----------------------------GKKIKLSKdefreilinndCTENFVLEKGSLFCpsfii 223 Bacillus campis...
CDF82554     183 -------EKITQRwkskkl---ialleyATEIRKNFSITee------------------aiVDDSESLIIGQTLfed-gi 233 Pseudomonas kna...
WP_068400361 162 fsqvimfSRVEAV-----------------SEERYVPLTILRQELLSVLKtayqitegadtFKGKDVLLLCQSLsed-kv 223 Pedobacter cryo...
EDM34775     162 frkvimfRKMTEV-----------------SGDQYVPLTSLKKEFLTVLKeayalggaevgFKDKDVLLITQSLsed-kv 223 Pedobacter sp. ...
WP_044664276 233 ----------------------------------------------------------qypLQGPVALFVTNPYsey-ny 253 Syntrophaceticu...
CDC04958     179 flqeitlDKISYSqlvkkgclidqtlfvKKHGNFFVQNKLAEKYRSILETrnladdkqnfsIYENAIIINTQPFeet-gq 257 Clostridium lep...
RAU82220     180 frsitseKRLAENyigfss---kiydafVTHEAPYFSKKATFIGIPYFDAlakqnpaqqikI----ILFIDQPLaeh-sl 251 Pontibacter sp....
WP_116023844 169 -------HLLAEYdapa--------eelSGEAFLKVIEEVTAEVEPILAGhge--------fgDNVALIVGQYFsel-ei 224 Actinomadura um...
WP_103942705 169 -------HLLSEYgapg--------qelPGEAFLKVLDEVCAEIDPLISRygt------lgEHDNAALIVGQYFsel-gi 226 Actinomadura ec...
WP_034632117 287 VPPEKHTEIIMK-YLNEFYPQR--NIFIKMHPRSKT-EVRKSFEDKIKK-----YNNIRLIe-lDVEMPFEAILVE--KK 354 Bacillus okhensis
KKK38900     224 NDPKVRNKAFNE--IFLCYYQKreFLYVKLHPSEREvDSLQKLVESYDG---------YIIilnRDDLTSEDIIVN--PN 290 Bacillus campis...
CDF82554     234 ATLEQEVRLYKT-----ASDTLpgPVKLKAHPRTTR-----------LKrdairAAGIEIL---ETKFPAENLIAT--RP 292 Pseudomonas kna...
WP_068400361 224 IPLHEELKLYEK--FIQRCNDLklTVIIKPHPRSCP-EKIEALSKLTSSqveffE---------DYGIPAESMLLN--GK 289 Pedobacter cryo...
EDM34775     224 MSLEEEMKLYEK--FIQRCNDLnlSVIIKPHPRSYP-EKIQALTTLTSQhvqffE---------DYGIPAESMLLS--GK 289 Pedobacter sp. ...
WP_044664276 254 VDVIDEYNNIVK-KIVQLLIKNgfKVIIKPHPREDP-NKYQKLINKNNN------GNIKIL---NKNKPIEKEIVL--IK 320 Syntrophaceticu...
CDC04958     258 LQNNADIYSLKK--IIQSLQNCgeKVIIKPHPREKNlDRYKDLGCTIEK---------------RKGIAQEEILSTlkTK 320 Clostridium lep...
RAU82220     252 LQWNNEIKKTFNtDLSDLCQKHnyQLYVKLHPKQET-AGWEELQNQRKC-----------------LIINEETLINlaPS 313 Pontibacter sp....
WP_116023844 225 LTDEEENRLHLE-MLQGVVARGhdTVLFKPHPHSPP-RLFELLVDEAKRl----DARLVVI---DDPVPAETWCAR--VR 293 Actinomadura um...
WP_103942705 227 LEPDEEDQMHLE-MLQGVVARGhsTVLFKPHPHSPP-RLFELLTDEAKRl----GARLVII---DDPVPAEAWFAR--AR 295 Actinomadura ec...
WP_034632117 355 PKTIVSLTSTSLVYGPKLISGTEVVSCA 382 Bacillus okhensis
KKK38900     291 IKEVISDVSSSLINAYYLRDDIKIISYQ 318 Bacillus campisalis
CDF82554     293 YHSIVGMWSNTVIYSAPLFHIRSFTMNH 320 Pseudomonas knackmussii B13
WP_068400361 290 FKEVVGVYSNTIIYAHQFFGVKGISLLT 317 Pedobacter cryoconitis
EDM34775     290 FKEVVGIYSNTIIYANEFFGVKGISLLT 317 Pedobacter sp. BAL39
WP_044664276 321 PSVIVGFMSTALLTAKVIFNIPAFTAVK 348 Syntrophaceticus schinkii
CDC04958     321 PKAVIGFCSTTLVTAKIFWDIPTYSCIH 348 Clostridium leptum CAG:27
RAU82220     314 IPIVIGFYSTYLMPFAAFPHTTVITYVK 341 Pontibacter sp. 2b14
WP_116023844 294 PALIVGICSTAMMTAYRYYGVPAATVGT 321 Actinomadura umbrina
WP_103942705 296 PALVVGICSTAMMTARCYFGIPTVTLGV 323 Actinomadura echinospora
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