Conserved Protein Domain Family
RCS1

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pfam07326: RCS1 (This model is not part of the current CDD release)
Regulator of chromosome segregation 1
This family consists of several mammalian proteins of around 240 residues in length. Family members include regulator of chromosome segregation 1 (RCS1), also known as FAM64A, CATS or PIMREG (PICALM-interacting mitotic regulator). It is a substrate of APC/C. It may control the metaphase to anaphase transition. It is also a substrate of the Kinase Interacting Stathmin (KIS). RCS1 is highly expressed in cancer cell lines in a cell cycle dependent manner and is induced by mitogens.
Statistics
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PSSM-Id: 517666
Aligned: 12 rows
Threshold Bit Score: 303.692
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003416906   1 MASRWQGVGASRRRRSLQDQEQLQENVVPQPAVGHLESSTSALGSLCRHFQRRLPLRAVNLNLGAGPSWKRLENPEPGQQ 80 
2_pfamImport   1 MASMLQNVKATMGWQRRLLLADFDENESPVPDKFKRKASFSSLHTICMSLRKRIPLKQVELNFHETPLWENMEARNKSQV 80 
XP_006100736   1 MASRWPGVSTSMRRRSLQDHQQLEESDELPPAAGHLEASGGALGSLCRQFQRRLPLRAVSLNLGAGPSWKRLETPEPEQQ 80 
XP_023099528   1 MASKWPGVGVSLRRGPLQEREQLAEKEAEQTAGGHPEPSSGALGSLCRHFQRRLPLRAVSRNLGAGPSWKRLENPEPSQQ 80 
1_pfamImport   1 MACRW-----SVRRRSLLEEEQP---EKPPAAAGQQDASAGALGSLRRQFQRRLPLRAVSLNLGAGPSWKRLGTPEPEQQ 72 
EHB13573       1 MASQWHGMRSSVRRRSLLKEEQMEE-EVVWSAAGHVEPSTGALGSLCRQFQRRLPLRAVSLNLGAGPSWKRLQTPEPQQQ 79 
Q8BFY7         1 MASQWQGMRTSVRRRSLLKEEQLEKKEVTRSAGGHPET--GPLGSLCRQFQRRLPLRAVSLNLGNGPSWKRLESPEPEQQ 78  house mouse
XP_003799078   1 MASRWQGMRSSVRRRSLRNQEQLEDSKALQSVVSHQETST--LGSLCRQFQRRLPLRAVSLNLGAGPSWKRLETPESGQQ 78 
Q9BSJ6         1 MASRWQNMGTSVRRRSLQHQEQLEDSKELQPVVSHQETSVGALGSLCRQFQRRLPLRAVNLNLRAGPSWKRLETPEPGQQ 80  human
XP_014346666   1 MASVFQSVGAAVGWRNHQVLEDFDENDSPKPDNLRKASSAGAFNSMRMSLRKRLPLKPVKTNISDNPTWESLQIKKSST- 79 
XP_005056615   1 MASVLQNVKATVTWRKHQLLADLNENESPVPDKFKRRASQSSLSTICMSLRKRAPLKRVELNFHKTPTRESLEPRQRGQT 80 
XP_040506112   1 MASMLQNVKATMGWQRRLLLADFdENESPVPDKFKRKASFSSLHTICMSLRKRIPLKQVELNFHETPLWENMEARNKSQV 80  chicken
XP_003416906  81 gLQAAARSAKNALGAMSQRIQESCQNGTKWLVETQVKARRRKRGAQKGG------SPP-----------------PRSLS 137
2_pfamImport  81 -FQSITKTARNAFGTVSQKIQKTCQSPVHSTVTFPAEDIGSSSATCFSKkrr-tvQTPclsv---------nsvtPAARS 149
XP_006100736  81 gLQAAARSAKNALGAVSQRIQESCQSGTKWLVETQVKARRRKRETQKGG------SPP-----------------ARSLS 137
XP_023099528  81 gLQAAARSAKNALGSVSQRIQESCQSGTKWLVGTQVKARKRRRGAQTGS------RPP-----------------AHTPG 137
1_pfamImport  73 gLQAAARSAKSALGAMSQRIQESCQSGTKWLVETQVKARRRRRGAQTGD------GSP-----------------PHTLS 129
EHB13573      80 gLQAAARSAKNALGVVSQRIQESCQSGTKWLVETQVKARRRKRGAQKGS------GSP-----------------PPTLS 136
Q8BFY7        79 gLQAAARSAKSALGAMSQRIQESCQSGTKWLMETQVKVRR-KRGAQKDR------GSP-----------------PPSLS 134 house mouse
XP_003799078  79 dVQGAARSAKSALGAMSQRIQESCQSGTKWLVETHVKARKGKRGAQKDN------SLP-----------------AHSLT 135
Q9BSJ6        81 gLQAAARSAKSALGAVSQRIQESCQSGTKWLVETQVKARRRKRGAQKGS------GSP-----------------THSLS 137 human
XP_014346666  80 -VQNLTRSAKGAFGSVSQKIQKTYQSPSNRLVTTPGKQRRSRVSASASK------RTPptqtpkrqadrrttkttPVSGV 152
XP_005056615  81 -LHAIKRRAKYAFGTMSQKIQKSCQSPVCSVVTLPAEPISSSCVISSTKkrsttpRTPcck-----------svtPAASS 148
XP_040506112  81 -FQSITKTARNAFGTVSQKIQKTCQSPVHSTVTFPAEDIGSSSATCFSKkrr-tvQTPclsv---------nsvtPAARS 149 chicken
XP_003416906 138 QKNTRLSGATPAYSALDSWKKEQHSLSAQRSPQTHPLRRSRRE-AAF-RSPYSSTEPLCSPS---ESDSDLEPVGMGIQR 212
2_pfamImport 150 KCTLRSSRRSLLGPTTASEHKELRGFPSWHGEDAVPLLKSRTAsAAL-KSLYSSPTPTCRRIe--EFDCELELVSSGIHQ 226
XP_006100736 138 QRSTRLSGTGPACSTLGPWGWERHRRSTQMGPRAHPLRRSRRE-AAF-RSPYSSTEPLCSPS---ESDSDLEPVGAGIQH 212
XP_023099528 138 QKSPRLCGAAPASSALGPRERPCRRLSGHVGPRAHPQWRSRRE-PTF-RSPYSSTEPLCSPS---ESDSDPEPVGAGLQH 212
1_pfamImport 130 QKSTRLSST--THPALGSRERGYRRLSAQTGPRAHLLRRPRRD-AAFqRSPYSSTEPLCSPS---ESDSDLEPAGAGIQL 203
EHB13573     137 QKSTRLCGA-----TLDPGKREYHRLSAQKDPRSHPRRRPRRN-AAF-QNPYSLTEPLCSPRqvvESESDLEPVGAGIQH 209
Q8BFY7       135 QKNTRLCRA-----NRDARVGGHLRLSGQMGPHAHRRQRLRRE-SAL-RSPCSSTEPLCSPS---ESDSDLEPVGAGIQH 204 house mouse
XP_003799078 136 QKSTRLSRATPVHSTTDSWERGHHYRSIQMGLRTPQLRRSRRE-AAF-QSPYSSTEPLCSPS---EPDGDLEPVGAGIQH 210
Q9BSJ6       138 QKSTRLSGAAPAHSAADPWEKEHHRLSVRMGSHAHPLRRSRRE-AAF-RSPYSSTEPLCSPS---ESDSDLEPVGAGIQH 212 human
XP_014346666 153 RRAPSFKTRCSPRVKPTSARTPKWRSYSLIDKDATLLRRSVRT-AVL-KSPYASPATINRRR---QFDRDLETVSTGIRQ 227
XP_005056615 149 KGTPRSSRRALLGPTRVSEHREWREFSSWLDKNAVSLRRSRRA-AAL-KSPYSSPAPSSRRI---EFDCELDLVSSGICQ 223
XP_040506112 150 KCTLRSSRRSLLGPTTASEHKELRGFPSWHGEDAVPLLKSRTAsAAL-KSLYSSPTPTCRRIe--EFDCELELVSSGIHQ 226 chicken
XP_003416906 213 LQKLSHKLDEAIVAEDSGDM 232
2_pfamImport 227 LKHLFWAPDDAIVHGDRQHA 246
XP_006100736 213 LQKLSQELDEAIAAEESADM 232
XP_023099528 213 LQKLSRQLDEAIVAEESGDM 232
1_pfamImport 204 LQKLSQKLDKAIVAEDSGDM 223
EHB13573     210 LQKPSQKLDKAIMAED---K 226
Q8BFY7       205 LQKLSQRLDRAIKAEESGDM 224 house mouse
XP_003799078 211 LQKLSQELDKAIMAEDSSDM 230
Q9BSJ6       213 LQKLSQELDEAIMAEERKQA 232 human
XP_014346666 228 LKHLSQVFDDVIVREERTHA 247
XP_005056615 224 LKCISQAFDDAIVKEERKEA 243
XP_040506112 227 LKHLFWAPDDAIVHGDSQqv 246 chicken
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