Conserved Protein Domain Family
DGCR6
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pfam07324: DGCR6 (This model is not part of the current CDD release)
DiGeorge syndrome critical region 6 (DGCR6) protein
This family contains DiGeorge syndrome critical region 6 (DGCR6) proteins (approximately 200 residues long) of a number of vertebrates. DGCR6 is a candidate for involvement in the DiGeorge syndrome pathology by playing a role in neural crest cell migration into the third and fourth pharyngeal pouches, the structures from which derive the organs affected in DiGeorge syndrome. Also found in this family is the Drosophila melanogaster gonadal protein gdl.
Links
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Statistics
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PSSM-Id: 517665
Aligned: 7 rows
Threshold Bit Score: 252.46
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O73770         2 ERFGGAGYEvaAAELSR----------------QQERHYRLLSELQELVK-ALPSSCQQRLSYTTLSDLALALLDGTVFE 64  chicken
XP_002065323   8 SSTASITET--AADSESq--------------cLQRKIYFLVDNLRSYHA-ELPVTLQTRISYELLTELAHCVLNEGIFE 70 
4_pfamImport   1 TDITVSNEG--PTNGSEpvavaedpfqqpspefLQRKIYFLVDQLRTMHA-ELPENLQTRISYDLLTELANCVLNDSIFV 77 
2_pfamImport   1 ERYPGAFEE--AADGAR----------------QQERHYQLPSALQRAAQvHDRGSCQRRLSYTTLSDLALALLDGSVFE 62 
O35347         2 DRYAAAGDE--AADRAR----------------QQERHYQLLSALQSLVK-ELPSSFQQRLSYTTLSDLALALLDGTVFE 62  house mouse
XP_003974503   2 EGYPGTV----GGDSTK----------------QQERHYYLLSELQALVK-DLPSSFQQRLSYNTLSDLALALIDGTVYE 60  torafugu
XP_064424308   5 DDCLGMYEE--PADTTK----------------QQERHYYLLSELQNLIK-SLPSSCQQRLSYTMLSDLALALIDGTVFE 65  coelacanth

O73770        65 IVQGLLEIQHLTEKNLYSQRLKLHSEHRGLK----------QELFHRHKEAQQccRPHNLPLLRAAQQREMeaveqrire 134 chicken
XP_002065323  71 IVKALLELQHATEKHLLQMRLQVENEYEIEV----------TEWCSKIKDPKE--LAHLLDLLKAKHVNKL--------- 129
4_pfamImport  78 IVKALMELQHETERHLIKMRMQVENEYEIEV----------SDWRAKIKDPEE--LLHILGLMKLKHSKKL--------- 136
2_pfamImport  63 IVQGLLETQHLTEKRLYSQRLRLQDGHRVLR----------QALRQKHEEAQEacQPHNLPLLQEAALRCTrsgrqwihe 132
O35347        63 IVQGLLEIQHLTEKSLYNQRLRLQNEHRVLR----------QTLRQKHLEAQQscRPHNLPVLQAAQQRELeamehrire 132 house mouse
XP_003974503  61 IVQGLLDIQHLTEKNLYNQRQKLHCEHQALK----------QELTRKHKDALQtcKSHNLALLKTNQQAELealeirvke 130 torafugu
XP_064424308  66 IVQGLLEIQHLTEKNLYNQRLKLHSEHRGLKldllrkqkeaQQSC----------KSHNLSLLKTAQQRELealeqrikd 135 coelacanth

O73770       135 eqRMMDEKIVLELDQKVIDQQSTLEKAGVSGFYITTNPQELTLQMNLLELIRKLQQKESESEK 197 chicken
XP_002065323 130 --KDADKKIIEVLDQKVNDQQSTLHMAGVPGFYATQNAKEIKIQMFLLDFILRLSRLKYKPNK 190
4_pfamImport 137 --VESDKKIIEILDQKVNDQQSTLQKAGVPGFYVTENPKEIKIQMFLLDFILRLSRLNYEPNK 197
2_pfamImport 133 eqQTMDKKIILELDQMVADQQSTLEKAGVTGFYITTNLQELTLQMNLLKLIRKLQQRDCQMGK 195
O35347       133 eqQAMDRKIVLELDRKVADQQSTLEKAGVAGFYVTTNPQELTLQMNLLELIRKLQQRSCQVGK 195 house mouse
XP_003974503 131 eqRMMDKKIVAEMDQKVIDQQNTLEKAGVPGFYITTNPQELTMQMNLLELILKLQQKESQ--S 191 torafugu
XP_064424308 136 eqRMMDEKIVLELDQKVIDQQSTLEKAGVPGFYVTTNFQELTLQMNLLELILKLQQKETHLGG 198 coelacanth
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