Conserved Protein Domain Family
EF-G-binding_N

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pfam07299: EF-G-binding_N 
Elongation factor G-binding protein, N-terminal
This domain can be found in the N-terminus of the FusB, FusC, and FusD proteins from Staphylococcus aureus. They are elongation factor G (EF-G) binding proteins that are linked to the fusidic acid (FA) resistance in S. aureus. The FusB proteins are two-domain metalloproteins, and this N-terminal domain forms a four-helical bundle whose helices help to stabilize the conformation of the treble-clef zinc-finger in the C-terminal domain. FA is an antibiotic that binds to EF-G, preventing its release from the ribosome, thus stalling bacterial protein synthesis. The FusB proteins provide FA resistance by preventing formation or facilitating dissociation of the FA-locked EF-G-ribosome complex during elongation and ribosome recycling.
Statistics
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PSSM-Id: 399938
View PSSM: pfam07299
Aligned: 29 rows
Threshold Bit Score: 71.4832
Threshold Setting Gi: 222119610
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9CDP5          1 MLKPYEYNRIKYLTFDLVNVYHSVNDKSTVEAVYAQVATEILQIaenadslvsENNLSVKVaiQEYLSAIDNPKlSREQA 80  Lactococcus la...
EQC80589        3 TIEPYQFHFIKHQVQQLVRTYQSVNDRHTIRTVEMLTEEAIQPF---------FSEEDKEA--QSLIRQFFDSSlTMSKS 71  Enterococcus s...
WP_015509634    1 MIEPYQFHSIKHQVYQLVRTYQSVNDPRTIKTVETMTKDAIEQF---------FPEEETAP--REILAAFFQPGmTISRS 69  Enterococcus
Q838Z6          4 TIQPYQFNIIKEQVAVLLNTYTSVNDATTVKTVQALCAEKINGL---------FPEEHPAV--TILLDKVMDRRlTRARA 72  Enterococcus f...
Q3XWW0          4 TIKPYQYFFIIREVEQLLNAYSSVNDPKTVQTVQALAAEKIRDI---------LDHELPEI--DTFLTTVLDVKlTKAQA 72  Enterococcus f...
BAO07464       13 TIKTYQYFFIKREIEQLLNVYHSVNDKKTVATVQALAKERINEVvendpqviaLVEP--------FVKQVMDTNlKKEKA 84  Enterococcus m...
EOU07131        4 TIKPYQYYFIKREVEQLISVYHSVNDSKTIETVQALAVERIEE----------LVEPSQRM--NLFLENILDTSlTKETA 71  Enterococcus h...
WKK:WKK_03235   6 qLQPFQFVQISQEVHHVISAYKSVNDSKVIGVLQLDLIKLLDEMg-----------IKTEAvvEKLLEIILAKDcTHERA 74  Weissella kore...
Q03TN9          4 TITAYEYSDIKQHVNALVSAYLAVNDRHMRSIIRAETIAYVTPF---------LPEGAPLT--QAFLAGLQPDRlSRKEA 72  Lactobacillus ...
WP_011100860    4 TITTYQYSYITQQVNQLISAELAVNDLQIRAVVRAQAIKRITPL---------LPSDNPIT--ANFLSHLQTDRlTRAKA 72  Lactobacillus ...
Q9CDP5         81 EKLLTELKTLVEAF 94  Lactococcus lactis subsp. lactis
EQC80589       72 LTILEALKKNVRPF 85  Enterococcus sp. HSIEG1
WP_015509634   70 NELLTELKEYVRPF 83  Enterococcus
Q838Z6         73 EKYLDELKETVLPF 86  Enterococcus faecalis
Q3XWW0         73 ERALEELKQIVQPF 86  Enterococcus faecium DO
BAO07464       85 TELLERLKEHVAPF 98  Enterococcus mundtii QU 25
EOU07131       72 ERLLEELKESVQPF 85  Enterococcus hirae ATCC 9790
WKK:WKK_03235  75 DKALQGLKSLVQPF 88  Weissella koreensis KACC 15510
Q03TN9         73 AKLLPLLEPAVIPF 86  Lactobacillus brevis ATCC 367
WP_011100860   73 PQLLETLIPLIIPF 86  Lactobacillus plantarum
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