6VBU


Conserved Protein Domain Family
BBL5

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pfam07289: BBL5 (This model is not part of the current CDD release)
Bardet-Biedl syndrome 5 protein
BBS5 is part of the BBSome complex that may function as a coat complex required for sorting of specific membrane proteins to the primary cilia. Mutations in the BBS5 gene cause Bardet-Biedl syndrome 5.
Statistics
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PSSM-Id: 517649
Aligned: 36 rows
Threshold Bit Score: 365.365
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6VBU_5         8 WEDRDVRFD--VSSQQMKTRPG-EVLIDCLDSVEDTKGNNGDRGRLLVTNLRIVWHSLALPRVNLSIGYNCILNITTRTA 84  domestic cattle
XP_001746720  13 WRDREVHFD--IGNKLIALTRG-EFVIDHLDQVEDTKGNNGISGTLTVTNLRLIWTNKKRSNINLSIGLRNVVSIQVKPV 89 
XP_004997572  18 WRDHEVRFD--SIATHMQPGPG-EVIIDSLSNVEDTQGNNGVRGKLVVTNLRIMWHAIKKPSVNLSIGLFCISQISVKMV 94 
Q4GYG4        19 LLDRTIRFDtsLSELQEQTSRG-ERILMRLSPVEDTKGNSGKEGVLYVTNLRFMWHSSHRVRNNLSVGYYGVYNMSVQMV 97  Trypanosoma brucei
XP_821922     19 WFDREFRYNlpDEGLVVQTARG-EVLLSKLSPVEDTKGNNGEEGVLYVTNLRCIWQSKVNPHKNLSVGYYGIQGIEVREA 97 
EFO86825      13 WQDREIRFD--VDHKLLRMAKG-EFAVAKVEHVEDTKGNNGDKGIMKVTNLRLIWYAMNMPRINISIGWNTITGTQSKTS 89 
XP_009029001   7 WQDRETRFD--VNPSLLNLVRG-EKVILELNAVEDSKGNTGVLGSAILSNLRFIWHSQKFPKVNISLGHNCILSVNCIHS 83 
Q3SCX0         6 LYDRCIHFD--IAAAKLNMQKG-EKTLFLWKDVEDIKGNPDQLGSLVISNTRILWWSERNNSVNLSIGLGTIFHIEQKVT 82  Paramecium tetr...
Q4QGM5        26 WQDREIHFD--AATPVLKLRENtEHVYATFDNVEDTKGNNGCPGTLLVTNLRLIWRCKQRPNVNLSIGYYCVHKLTVQEA 103 Leishmania major
XP_001011463   6 FYDREIKFD--LQTKKLSPCSG-EFEMSSQNYIEDFKGNADCDGVLVLTNLRLIWYQNDDKRINLSIGLDTINSSDIKT- 81  Tetrahymena the...
6VBU_5        85 NS---KLR-GQT-EALYVLT--KCNSTRFEFIFT----------------------------------NLV--P-GSPRL 120 domestic cattle
XP_001746720  90 ES---KLL-GNV-KALWIMC--KHKQSKYQFIFT----------------------------------HLV--P-GSPRL 125
XP_004997572  95 ES---KLKgGRT-QALTLVC--KFKKMRFSFVFT----------------------------------YLV--P-SSPRL 131
Q4GYG4        98 ET---RLR-GHA-EALRITA--RYGSNRFEFFFT-----------------------------------------HPSED 129 Trypanosoma brucei
XP_821922     98 NL---RLR-GTT-EVLYITS--RFGSSRYEFVFT----------------------------------QLMrkNcQ---- 132
EFO86825      90 TSlaaRNR-GGTnEAIYILAklSSTTTKFEFIFT----------------------------------ATS--PnSHSKL 132
XP_009029001  84 QS---KIK-SSS-DSVIISA--ECSGEKYEFVFS----------------------------------NLI--V-DGPSL 119
Q3SCX0        83 NN-------NRTfGTLFRTK--LATGQKYEFHFS---------------------------------------S-QDKKL 113 Paramecium tetr...
Q4QGM5       104 ES---KLA-GRMtECITLGS--KCGASRFQFIFSvahdvgdigsgsaaststsggaaaqrdcenrsrrRPSkgTgGHQRL 177 Leishmania major
XP_001011463  82 ER---NLKiGLE-LTLSIKA--KLNKNKFEFIFK-----------------------------------------TKNGE 114 Tetrahymena the...
6VBU_5       121 ----YTSLIAVHRAYETSKMYRDFKLRS-ALIQNK-QLRLLPQENVYNKINGVWNLSSD---------------QGNL-G 178 domestic cattle
XP_001746720 126 ----FTTVPAVHRAYASSTLYRDVKIRApALIRDG-AIEPLPQEEVYDALEGVSNLSGE---------------KGEL-G 184
XP_004997572 132 ----FTIIQAVHRAYDSTRLYREVVVRSsTLVSDD-RVAVLPDEEIFDTLDGVWNLSGD---------------KGEL-G 190
Q4GYG4       130 rrsrLSAVRLVWRAYDTTRIYREVRLRS-CAVRDG-ELLLLKGERLVTRVKGVSNVSSE---------------QGHI-G 191 Trypanosoma brucei
XP_821922    133 ----LFIVPTVWRAYESSRAYRELRMRS-SLVRDG-DVILLPGEQLFTRLEGVTNVSED---------------KGII-G 190
EFO86825     133 ----FNTISSINRAYETTKMYRELKMRG-IFIREDgTLRILPQEYIVEIVAGAWNLSTEtvclrldfliyikliQGSL-G 206
XP_009029001 120 ----YTSLNSVLRAYVSSKMYREVKLRG-SLFKDD-ALKTYPHEEIFREIHGVLNLSND---------------QGNI-G 177
Q3SCX0       114 ----YESLINIQRLYTQTMLHREIKVQF-AMISQK-KLNTSEKEQIINQYANTISVAND---------------QQDVsG 172 Paramecium tetr...
Q4QGM5       178 ----YATIRAVWNAYESTRVYRELRVRS-AVVQHG-NLILLDGENVISRTSGVSSVSKD---------------EGHL-G 235 Leishmania major
XP_001011463 115 ptniFNLFQQVCRGYQATKIYRDLK-RG-AIIQDK-TLQILPNEKVISKYPNVRSVGNE---------------IGII-G 175 Tetrahymena the...
6VBU_5       179 TFFITNVRIVWHANMnDSFNVSIPYLQIRSVKIRDSKFGLALVIESSQQSGGYVLGFK-IDPVEKLQESVKEINSLHKVY 257 domestic cattle
XP_001746720 185 RFIVTNIRFIWYSEQnPLYNVSCPYYTVSHIGGRQSKFGSAVVVKLAGAAGALNLGFR-CDPPKRMAKLLKMMQRLHRVY 263
XP_004997572 191 TMVVSNIRCIWYSDLdPRFNVTIPYCMMSRIAIRNSKFGKALVVKTAKAARSLTIGFR-IDPADRLQRVAQKMERLHRVY 269
Q4GYG4       192 TFFTTNLRLLWCSDTsAEFNISIPFLQIAAMRIQDTEFGLSLMVETTASVDSYVIGFR-VDPVARLDQLFKECTSLLNAF 270 Trypanosoma brucei
XP_821922    191 VFFTTNVRIVWFAQHaPHINISIPILQLTALRMRPTKYGAAILLETSSYAGSCLIGFR-VDPVDRLRGLFRECVSLWKAW 269
EFO86825     207 VFVITNIRIVWYAELnTGYNVSVPYLTLYSARVRESKFGMALVLETTASSGEYVLGFK-VDPPERLQNLVKTIQTLHKAQ 285
XP_009029001 178 VMIVTNVRVVWYALSnQIYNVSIPYLQIIDVKVKDSKFGRAIVFEITKQGGGYILGFR-IDPVEKLQAVFREVRKLYKMF 256
Q3SCX0       173 TLIFTNVRFVWYSATnDLFNISIPWIAVKKISKKTTKGLYTMIIETYQEFGGYYVGYRnID----MDSMIKECNKLHAFH 248 Paramecium tetr...
Q4QGM5       236 TFIVTNIRVVWFAAA-EFFNVSVPYLQFVGLRSQMSKFGQALVIETSSYASNFVLGFR-VDPEEKLNEMYAEISSLWRTW 313 Leishmania major
XP_001011463 176 NLFLTNIRIAWFATNnESQNISIPWIQISSITKQNIKAGTSLLIEINKFTGGYILGYQ----TDQIDHCLKECNQLKEYY 251 Tetrahymena the...
6VBU_5       258 SANPIFGVDYEMEEKPQPLEALTV-----------------------------------KqIQDDVe----------iDS 292 domestic cattle
XP_001746720 264 HITPLLGIEAEVEEQPTEDLMPEN-----------------------------------V-PDDDVe----------iVQ 297
XP_004997572 270 HASPIYGVHVDVETAEGEGEGAGEm---------------------------------eT-EDDDIe----------iIQ 305
Q4GYG4       271 KTHPNLGVAVTLQDVTAGNDDEVSamlgaaega------------------svgpqpreL-DGENV------------VQ 319 Trypanosoma brucei
XP_821922    270 SARPVLGIAVTLEDAPPREEGDANmkhinddggdg-------------pfsllssqhrkL-DGENV------------VT 323
EFO86825     286 SMKPIFGVTFIKEKSEKTERKEVT-----------------------------------K-EDEEIdiidtneddveiEK 329
XP_009029001 257 THNPNYGIECSVENSMAESKQNSS-----------------------------------K-FSDDAev--------yeDH 292
Q3SCX0       249 TENPIYGIEIQEKQQPTVQ----------------------------------------R-FDEKVqv--------vqSI 279 Paramecium tetr...
Q4QGM5       314 TARPLLGMKVELHDDTAKAMVPESlgvggggpggksgsaehphsgripgaagdaqherqM-EGQSV------------LQ 380 Leishmania major
XP_001011463 252 CQNPDFGIPKIGDEYDSSYKSKLVk----------------------------------R-EEDNIei--------igTI 288 Tetrahymena the...
6VBU_5       293 DDHTDA-----FVAYF---ADGnkq------qdREP--VFSEELGLAIEKLKDGFTLQGLWEV 339 domestic cattle
XP_001746720 298 QDKVDT-----MAAYFssdSSGtt--------gRDP--VFSAELGLAIEPLPAGVSLQDLWRV 345
XP_004997572 306 RDDFDV-----LAAY----ANGrlgqe-asednKMP--VYSEELGLAIEPLLPGFTLDALANI 356
Q4GYG4       320 EVATDA-----FAAYYvgigq--------kgadRKP--EYNASIGLAVEKLRNGVTLQDLWNV 367 Trypanosoma brucei
XP_821922    324 QVETDA-----FAAYYadvgq--------kgtdRRP--EYDASIGLAVERLRTGVTLRELWTV 371
EFO86825     330 NIRPDP-----FAAYFdgqhs-------ttdekKLP--VLNQEIGLSMEPIRNGFTLQDLWAI 378
XP_009029001 293 GEHSDV-----FALYC---VDGgra------tnREP--VYNEELGLLIEKLPDGYTLSDLWDV 339
Q3SCX0       280 YN---------QAARYqane----------nndIQNdiAYSPELGLAIQKLPADAKLSEFWNI 323 Paramecium tetraurelia
Q4QGM5       381 EAPTDA-----LAAYY---AAGgrk-----gedRRP--VYEPSIGLAVEKLRKGTTIQSLWDT 428 Leishmania major
XP_001011463 289 INERKNisrnyMTSQI---TTSanipdqsqdqsQQGdiIFSSELGLAIEKPPQGCKVEDLWRI 348 Tetrahymena thermophila SB210
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