7ETW


Conserved Protein Domain Family
INSIG

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pfam07281: INSIG (This model is not part of the current CDD release)
Insulin-induced protein (INSIG)
This family contains a number of eukaryotic Insulin-induced proteins (INSIG-1 and INSIG-2) approximately 200 residues long. INSIG-1 and INSIG-2 are found in the endoplasmic reticulum and bind the sterol-sensing domain of SREBP cleavage-activating protein (SCAP), preventing it from escorting SREBPs to the Golgi. Their combined action permits feedback regulation of cholesterol synthesis over a wide range of sterol concentrations.
Statistics
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PSSM-Id: 517645
Aligned: 71 rows
Threshold Bit Score: 91.9173
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7ETW_A        30 IRGVVLFFIGVFLALVLNLLQIQRNVtlfpp-----dviasIFSSAWWVP----PCCGTASAVIGLLYPSIDR-----HL 95  human
XP_002172038 118 LGVIIVMFLGWSFTYLAEKLLLEARLpg-----------lrFTVHSQQYKphwsLLFGFAAILVGFSFPYADRls--hNG 184
XP_013025325 102 FKFLAIFGLGAIFTYMAEGIVQEAKLsl-----------ltVRYGNWVFKpnwsVTFGLVAIGLAVSYRLMDVrypsgSS 170
Q9Y7R5        95 CKLCVIFGLGFVFTYLAEQIVQDAKLpl-----------ltVNLKSWKFEppwpAIFGFVAVILGLSYRRMDTkyplgAA 163 Schizosaccharom...
XP_004995431   4 LSWLVLFGCGYVTAAVLYLLHMEHSVliirpti---------------stnalfVAAGLTTLFIGLLFPAVDKf------ 62 
XP_002115296   5 LRTLIVFVVGVLLSLALLILQIERNValfppg-----vlsdlSSIPWWVP----ISCGAGAATIGLSLPKMDEwf--qRK 73 
EEC19752      10 WRVAFLFLVGVFFSLMLDFFQIQYRLsafern----ligsmFMSSPWWVP----AICGTAAVSVGLLYPCVDHk------ 75 
XP_009024871   8 TRAVYLFSAGIIFSLVLNLLQLQRQAnffpa-----ffrdrDVQSSWWLP----VLCGVTAAVVGLLYPYLDE-----QL 73 
XP_001634527  33 VRGVVLFLIGGFLAMMLFVLsvlpeaqkrrwgsfpmeilakVYSTFWWIP----PSCGTLAAFVGLICPCLDT-----KL 103
XP_002111170  16 RIVIALFFIGVIFALVLNVLQVQRNVaafsrdvlsglalfgLSMSTWWML----PSYGTGAVLIGLAFPCADH-----HL 86  Trichoplax adha...
7ETW_A        96 GEPHKFKREWSSVMRCVAVFVGINHASAKVDFDNNIQLSLTLAALSIGLWWTFDRSRSGFGLGVGIAFLATVVtqLLVy- 174 human
XP_002172038 185 HRLVARPFEWNLIVRSIMALSFVLIGLKRCLGTDVKQTAIGFAVNALSVWFIFDHTKTGFVMSSFFSSLGTFL--YTAfv 262
XP_013025325 171 GTKTSNSSQFQVFSRYLAAFATLLLTMKRLLSTQSTHSFAALIASAITIWYVFDRSKNGFTVSCVMSIVGSIT--YYVfv 248
Q9Y7R5       164 PLRPSQSSKWQWISRYLAAFATLLLSMKKLLFISNSHSIVALVASSASIWYIFDRSRNGIILSTITSVLGSIL--YYNlv 241 Schizosaccharom...
XP_004995431  63 fNNKPRPQAWSLVLRSILALIGVAIAAVRFPSQRSHELNISLLIMASSMWWLVDGTAVGLGTAVAVTSFGITAsqYLSyl 142
XP_002115296  74 YDYHHDQVEWVGVLRCVGIFVGITYASTLAYNSVIAKFSVSLSLMAIGQWWLFDRSVSGFVLGVAVSFTATAVtqIIVhy 153
EEC19752      76 lGEETIPHRWSDVMKCIALFVGINQASAKIELQSDWQPSLSLVLLSVSLWWLCDRTHSGFGLSILTALIATLVahFLVyy 155
XP_009024871  74 GERRAEKQEWSSVMRCVAIFVGINHASAKIDFSSNLQLTLTLTALSVGLWWLFDGSRGGLMLGIIMAAIASVVchLLIyh 153
XP_001634527 104 GKPHNFQREWSSVARCVTMFVGISHAIAKLNFHSSHQLFLFVACTSFLLWWLFDRSQNGFSVAVLSALAAAIVvyMLAyl 183
XP_002111170  87 GESPKIKNEWTSIMRCTALWIGINHAAATLNFSTPAQLTFWVSAMSLCLWWLYDRTRTGLFLAMLSAVVATGFnqILVsn 166 Trichoplax adha...
7ETW_A       175 -----------nGVYQytspdfLYVRSWLPCIFFAGGITMGNIGRQLA 211 human
XP_002172038 263 evnl---sqgesIHIS------KSLRYWLPSIIFFACTVIGNVGR-LV 300
XP_013025325 249 dsapfslfetnpPEYQ--------FRYWIPMILFSASTIVGNAGRLLF 288
Q9Y7R5       242 dtskielngvefPEIQ--------FRLWIPMILFSASTIVGNAGRLLF 281 Schizosaccharomyces pombe 972h-
XP_004995431 143 gvl-----ewaqPDFF-------YVQATLIPILFLATMSFGLLGRQLA 178
XP_002115296 154 gif-----sfskPDFL-------SIRSWLPGVFFSATIAIGSLGRQLA 189
EEC19752     156 rig-----rcsdKDLT-------FVRSWLPCVFFSGGITVGNIGRLLA 191
XP_009024871 154 giy-----rytsPDFT-------YLQSWLPCIFFSGGVTIGNIGRQLA 189
XP_001634527 184 gvy-----------------ryrrIIAVVPGLFFAGAVTFSNIGRQLA 214
XP_002111170 167 gvf-----synePDLL-------SVKSWLPSIYFSGGLTIGNIGRQLV 202 Trichoplax adhaerens
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