Conserved Protein Domain Family
INSIG

?
pfam07281: INSIG 
Insulin-induced protein (INSIG)
This family contains a number of eukaryotic Insulin-induced proteins (INSIG-1 and INSIG-2) approximately 200 residues long. INSIG-1 and INSIG-2 are found in the endoplasmic reticulum and bind the sterol-sensing domain of SREBP cleavage-activating protein (SCAP), preventing it from escorting SREBPs to the Golgi. Their combined action permits feedback regulation of cholesterol synthesis over a wide range of sterol concentrations.
Statistics
?
PSSM-Id: 399925
View PSSM: pfam07281
Aligned: 75 rows
Threshold Bit Score: 88.4445
Threshold Setting Gi: 366995381
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
EMR68480     249 RALLLSALGVLYGVLVARVLDRFRPimg---------aptTSTYDWRYMAFWGVSGVALGGLLPWFDGvwegafgasggd 319 Eutypa lata UCREL1
XP_797011     56 RGVVLFLIGIVMALVLNLLQVQNNVtlfpp-----etldsISSSAWWVAPFCGSAAVLVGLLYPCIDD------------ 118 purple sea urchin
XP_005815553  43 RGGMLFFVGVFLALVLNLLQVQRNVtlfpp-----dvissIFSSVWWVPPSCGIASAMIGVLYPCIDR------------ 105 southern platyfish
1_pfamImport   2 RGVVLFSIGVFLALVLNLLQVQRNVtlfpp-----dviasIFSSAWWVPLCCGTASVTVGLLQLAADT------------ 64 
Q08755        69 RSLVLFSFGVVLALVLNLLQIQRNVtlfpd-----eviatIFSSAWWVPPCCGTAAAVVGLLYPCIDS------------ 131 Norway rat
2_pfamImport   2 RSVVLFVVGAFMALVLNLLQIQRNVtlfpd-----evistLFSSAWWVPPCCGTAAGERGGGAECVTR------------ 64 
EDO42464      15 RGVVLFLIGGFLAMMLFVLsvlpeaqkrrwgsfpmeilakVYSTFWWIPPSCGTLAAFVGLICPCLDT------------ 82  starlet sea ane...
XP_002416085  11 RVAFLFLVGVFFSLMLDFFQIQYRLsafern----ligsmFMSSPWWVPAICGTAAVSVGLLYPCVDH------------ 74  black-legged tick
XP_009025028   7 RVVSLFFAGVLFSLVLNLLQFQRQItifpd------lvdnVFSSTWWVPPSCGFAAALLGMFYPYTDR------------ 68  Helobdella robusta
XP_009024871   9 RAVYLFSAGIIFSLVLNLLQLQRQAnffpa-----ffrdrDVQSSWWLPVLCGVTAAVVGLLYPYLDE------------ 71  Helobdella robusta
EMR68480     320 grlhdesavvveqpqqrrqrrrpgrrsvggglsgkgqqqqqqqEGVGEGAAVPGPDWSLAVRGIGAFAGIAFAIRKLAWD 399 Eutypa lata UCREL1
XP_797011    119 ---------------------------------------------KLGETPYYKREWSHVMRCLAVFVGINHACAKIEFA 153 purple sea urchin
XP_005815553 106 ---------------------------------------------RLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFA 140 southern platyfish
1_pfamImport  65 ---------------------------------------------HCLFNQSFLLHFSSNFMCVCVCVSVNTGPKKVDFA 99 
Q08755       132 ---------------------------------------------HLGEPHKFKREWASVMRCIAVFVGINHASAKLDFA 166 Norway rat
2_pfamImport  65 --------------------------------------------AHFQPTASDADIWEDARPALSPRTVLNIFFQKLDFA 100
EDO42464      83 ---------------------------------------------KLGKPHNFQREWSSVARCVTMFVGISHAIAKLNFH 117 starlet sea ane...
XP_002416085  75 -------------------------------------------KL---GEETIPHRWSDVMKCIALFVGINQASAKIELQ 108 black-legged tick
XP_009025028  69 -------------------------------------------HF---GLFNEKQEWSGVMRCVAVFVGINQASAKIDFS 102 Helobdella robusta
XP_009024871  72 ---------------------------------------------QLGERRAEKQEWSSVMRCVAIFVGINHASAKIDFS 106 Helobdella robusta
EMR68480     400 STTQVSVTLALVNPVLWYLIDRSVPGLLMAGAVGIAGSAI--FMA---------PLASpsvpfattlspwayllnngged 468 Eutypa lata UCREL1
XP_797011    154 NNLQFSLTLAAMSLGLWWLFDRSRSGFGLALTIAFLATLItqLLVykgvyrytePDFL---------------------- 211 purple sea urchin
XP_005815553 141 NNVQLSLTLAALSIGLWWTFDRSRSGFGLGISIALLATLTtqILVy-------nGVFQy--------------------- 192 southern platyfish
1_pfamImport 100 NNIQLSLTLAALSIGLWWTFDRSRSGFGLGIGIAFLATVVtqLLVyngvyqytsPDFL---------------------- 157
Q08755       167 NNVQLSLTLAALSLGLWWTFDRSRSGLGLGITIAFLATLItqFLVyngvyqytsPDFL---------------------- 224 Norway rat
2_pfamImport 101 NNVQLSLTLAALSLGLWWTFDRSRSGLGLGITIAFVATLItqFLVyngvyqytsPDFL---------------------- 158
EDO42464     118 SSHQLFLFVACTSFLLWWLFDRSQNGFSVAVLSALAAAIVvyMLAylgvy------------------------------ 167 starlet sea ane...
XP_002416085 109 SDWQPSLSLVLLSVSLWWLCDRTHSGFGLSILTALIATLVahFLVyyrigrcsdKDLT---------------------- 166 black-legged tick
XP_009025028 103 NSLQFSLTLLIMSFGLWWLFDKSMVGLLLGVLFSFVATFMtqLLVywelfkysnPDFV---------------------- 160 Helobdella robusta
XP_009024871 107 SNLQLTLTLTALSVGLWWLFDGSRGGLMLGIIMAAIASVVchLLIyhgiyrytsPDFT---------------------- 164 Helobdella robusta
EMR68480     469 wnrqqqqqsfnesssssyhddnsplrlfngggglggasaggggsgsgRHH-LESAVWMLSVLFCCCVCFGNIGRWLA 544 Eutypa lata UCREL1
XP_797011    212 ----------------------------------------------------YVRSWLPCVFFSGGVTIGNIGRQLA 236 purple sea urchin
XP_005815553 193 ----------------------------------------------tNPDfLYIRSWLPCIFFAGVITMGNIGRQLA 223 southern platyfish
1_pfamImport 158 ----------------------------------------------------YVRSWLPCIFFAGGITMGNIGRQLA 182
Q08755       225 ----------------------------------------------------YIRSWLPCIFFSGGVTVGNIGRQLA 249 Norway rat
2_pfamImport 159 ----------------------------------------------------YIRSWLPCIFFSGGVTVGNIGRQLA 183
EDO42464     168 -------------------------------------------------ryrrIIAVVPGLFFAGAVTFSNIGRQLA 195 starlet sea anemone
XP_002416085 167 ----------------------------------------------------FVRSWLPCVFFSGGITVGNIGRLLA 191 black-legged tick
XP_009025028 161 ----------------------------------------------------FVRSWLPCIFFSASVTMGLIGRQLA 185 Helobdella robusta
XP_009024871 165 ----------------------------------------------------YLQSWLPCIFFSGGVTIGNIGRQLA 189 Helobdella robusta
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap