Conserved Protein Domain Family
DMP1

?
pfam07263: DMP1 (This model is not part of the current CDD release)
Dentin matrix protein 1 (DMP1)
This family consists of several mammalian dentin matrix protein 1 (DMP1) sequences. The dentin matrix acidic phosphoprotein 1 (DMP1) gene has been mapped to human chromosome 4q21. DMP1 is a bone and teeth specific protein initially identified from mineralised dentin. DMP1 is primarily localised in the nuclear compartment of undifferentiated osteoblasts. In the nucleus, DMP1 acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the early phase of osteoblast maturation, Ca(2+) surges into the nucleus from the cytoplasm, triggering the phosphorylation of DMP1 by a nuclear isoform of casein kinase II. This phosphorylated DMP1 is then exported out into the extracellular matrix, where it regulates nucleation of hydroxyapatite. DMP1 is a unique molecule that initiates osteoblast differentiation by transcription in the nucleus and orchestrates mineralised matrix formation extracellularly, at later stages of osteoblast maturation. The DMP1 gene has been found to be ectopically expressed in lung cancer although the reason for this is unknown.
Statistics
?
PSSM-Id: 517639
Aligned: 12 rows
Threshold Bit Score: 194.005
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q13316         1 MKISILLMFLWGLSCALP-VTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSD 79  human
2_pfamImport   1 MKTSILLVFLWGLSCALP-VARYQNTESKSSEEWKGRLAKTPTLPSESSESSEESKDSSEEQENEDPSESSESEEGRGHD 79 
6_pfamImport   1 MKTSILLMFLLGLSSAFP-VARYQNNESESSEEWKGHLAQVSTPPLESGVSSERRSVNPKLQANEDPSDSTESEEELASD 79 
XP_017202907   1 MKTSILFMFLWGLTCALP-VARYENTETESSEEWKDPLAPPPTPPL-DSVSSEESKVSSEEQVSKDSRDTTDSEEALISD 78 
7_pfamImport   1 MKTSILLICFWGLSCALP-VARYQNTETESSEEWK---------------------------ANVDPSDSAELEDDLGSD 52 
O55188         1 MKTVILLVFLWGLSCALP-VARYHNTESESSEERTGDLAGSPPPPT-NSESSEESQASPEGQANSDHTDSSESGEELGYD 78  house mouse
XP_003469412   1 MKTVILLALLWGLACALP-VARYQDTASESSEEWTGHLVSSPTPSV-GNESSQESKVSSEEQANEDLSDSPETAEDLTSD 78 
EHB12356       1 MKTSILLMLLWGLSCALP-VARYQNTESESSDEWKGHLAPSPAPPVENSESSEESKVSSEEQANEDPSDSTETEEDLTSD 79 
4_pfamImport   1 MKTSILLMFLWGLSCALP-VARYQNTESESSEEWKGHLAQTPTPPLESSESSEESKVSSEEQASEDPSDSAESKEGL--N 77 
5_pfamImport   1 MKTSILLMFLSTSLSFLPhVARYQHTESESSEEWKGHLAQTPTPPLESSESSEESKVSSEEQVNEDPSDSAESEEGLSLA 80 
XP_028932379     --------------------------------------------------------------------------------     platypus
Q95120         1 MKTTILLMFLWGLSCALP-VARYQNTESKSSEEWKGHLAQTPTPPLESSESSEESKLSSEEQANEDPSDSTESEEVLGLD 79  domestic cattle
Q13316        80 DHQYIYRLAGGFSRSTGKggddkdddeddsGddtfgdddsGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQgQDSAQ 159 human
2_pfamImport  80 DRQYIYRPADGLSRRGGK------------G---------GLGPEEGHEGGNVRLQSDEDSADTTQSREDSTPQgEDSDQ 138
6_pfamImport  80 DRQDVHRPAGSLSSSAGIqgddkdddeddsGddtfgdddnGPLSEERQ-GGNSRLGSDEDSGDTTQSSEESVPQaEDSAQ 158
XP_017202907  79 DGQYLYRTAGGFSKSdkedd------eddsGddtfgdednGPGPKERQGGGNSELGSEEDSADNTQSREDSA-------Q 145
7_pfamImport  53 DRQYVYRPAGGLSRSTGKeedkdd-deddsGddtfadednGPWPEERTGGGISR-ADGDDSADATRSSEDSTSP-EDSAQ 129
O55188        79 RGQY--RPAGGLSKSTGTgadked-deddsGddtfgdednDLGPEEGQWGGPSKLDSDEDSTDTTQSSEDSTSQ-ENSAQ 154 house mouse
XP_003469412  79 DDHYVSRPAGGLARSAGRegddkeddeddsGddtfgdednSLGPRKDREGGISRLDSGEDSADTTQSREDSASR-EDSTE 157
EHB12356      80 DGHYVSGSDGGLSRSAGKeeddkeddeddsGddtfgdednGLGPKEGQEGGISRLGSEKDSAGTTQSREDSASR-EDSIQ 158
4_pfamImport  78 DHQYMHRPADGLPRNGGKggddkdddeddsGddtfgnddnGPGPEKRQ-GGNSRHKSNEDSADTTQSGEDSALQgEDSAQ 156
5_pfamImport  81 DHPYAHRPAGGFSRNGGKegddrdddeddsGddtfgdddnGPGPEETQ-GGNSRLSSNEDSADATESREDSASHgEDSGQ 159
XP_028932379   1 ---------MGPTKSIMKeadgkdddeddsGddtfgdeenGQASIQRQEEESPFVGAGDDNT-VGDDSEDYA----DTQR 66  platypus
Q95120        80 DQQHVHRPAGGLSRRGGSegdnkdddedesGddtfgdddgGPGPEERRSGGDSRLGSDEDSADTTRSREDSTPQgDEGAR 159 domestic cattle
Q13316       160 DTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKS 239 human
2_pfamImport 139 DTTIESREVDNEGEVNSRPEAGDFTHESESEERWVGGGSEGDSSHGDGFEFDDEEMQSDDPDSVRSDRNNSRMSSASIKS 218
6_pfamImport 159 DVTSESRDLDNE--VDSRPEGGDSTPDSESEEHWLGVGSDGGRSHGDGSEFDDEGMQSDDPDSIRSERGSSRIKGSTA-- 234
XP_017202907 146 DTTSDSRDLDHEGVVHSRP-------DSESEEHWVGGGSDGESSHGDGSEFDDEGMQSDDPDSIMSERVKARISSAGVRS 218
7_pfamImport 130 DTTSDSRDLDHEDDVGSRVEGRDFAQESESEEDWVGGGSEGESSHGDGSEFDDEGMQSDDPDSTRRDRGNSRMSSAGVKS 209
O55188       155 DTPSDSKDHDSEDEADSRPEAGDSTQDSESEEQRVGGGSEGESSHGDGSEFDDEGMQSDDPESTRSDRGHARMSSAGIRS 234 house mouse
XP_003469412 158 HLASDSRELDGEDGV-----------DSKSEEHWEGGDSEGDSSHGTGLEFHDNGMQNDDPDSTRREGGSSRMDSTSVKS 226
EHB12356     159 YPASDSRDLDGEDRV-----------DSESEEHWVGGGREGDSSHGDASEFHDDGMQSDDPDSTRSEGGSSRMDNVSVKS 227
4_pfamImport 157 DTTSESRDLDHEDEVNSRPERGDSAQESDSEELWVGGGSEGDSSHGDGSEFGDEEMQNDDPDIIRSDRGNSRMNSASVKS 236
5_pfamImport 160 DTTSESRDLDKE---------------SESKERWVGGGSEGDSSHGDGSEFDDEGMQSDDPDTIRSERSHSRMNSASVKS 224
XP_028932379  67 DYS--SQNLDEGEDVSHAADSGASDGDGQSRE-------NGEEHDSDSQEFDDDEMQGDDPDSFGSDNSNSSMSSDSLNS 137 platypus
Q95120       160 DTTSESRDLDREDEGNSRPEGGDSTPDSDSEEHWVGGGSEGDSSHGDGSEFDDEGMQSDDPGAYRSERGNSRISDAGLKS 239 domestic cattle
Q13316       240 KES-GENSEQANTQDSGGSQLLEHPSRKIFRKSRIS--EEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDsKGD 316 human
2_pfamImport 219 EESkGKSDEQASTQDSDGSQSAENPRRKFFRKSRLS--DEDDRSELVDSNTMEEFKSDSSENSSSKEIGLSQSREN-KSD 295
6_pfamImport 235 ------NSEQPSPEDSGESQAGPRPGRTAFRKSRLS--PE--------AAAPEEMQSDSAEDADAGEAGLRRSREDsRHE 298
XP_017202907 219 KESnG-DSRQASTPDAGQSRSVEYPRRRFFWKSRIS--QEDDRHELEDSNTQEEVE-DSTESPDSRDAGLSRSRE----- 289
7_pfamImport 210 KESkR-DNEQVSAQDSGESPLVEHSSRKFSRKSRIS--EEDGGGELNGGYTTEEVKSDS------------NSKEDsKSE 274
O55188       235 EESkG-DHEPTSTQDSDDSQSVEFSSRKSFRRSHVS--EEDYRGELTDSNSR-ETQSDSTEDTASK--------EEsRSE 302 house mouse
XP_003469412 227 KESqG-VLKQEGTQDSGDKQSVGSPSRKFFRKSRIS--EEDDRDDLEDSNTVEDLRSDLTDSTDSQEDSPGQ--EDsKSD 301
EHB12356     228 KEFqGDSKKE-GTEDSGDKQSAESPSRKFFRKSRIS--QEDDRGDLEDSDTMEDLKSGSTESTNSQEDSPDQSREDsKSD 304
4_pfamImport 237 EESkGNSDEQASTQDSGDSQSVEYPRRKIFRKSRIS--EEDDIGELDDNNTMEEIKSDSTENTNSKETGLSQSRENsESE 314
5_pfamImport 225 KESrGNSDGQANTQDSGESQSVENPGRKFFRKSRIS--VEDDTG--DRGNSQEEVKSDSTE--NTKEAGLSQSRENsKSE 298
XP_028932379 138 KESsQENSEQGSRQDSNDSQSVGQSSRKWLKKAGISeeEEDDSGEQNDSNSMEERDSHSTEDSSSREASPGQSEENsKSK 217 platypus
Q95120       240 TQSkGDDEEQASTQDSHESPAAAYPRRKFFRKSRLP--EEDGRGELDDSRTI-EVMSDSTENPDSKEAGLGQSREHsKSE 316 domestic cattle
Q13316       317 SQEDSKENLSQE--ESQNVDGPSSESSQEANLSSQEN-----SSESQEEV-VSESRGDNPD-PTTSYV-EDQEDSDSSEE 386 human
2_pfamImport 296 SREDSKENQSQE--DNQNVQDLSSESSQEADLPPQEN-----SSESQEEV-VSESRGDNPDqNTTNHSeEDQEDSDSSEE 367
6_pfamImport 299 SQEDREENESWE--DSRNEPEPSSESSQEADLPSEES-----SSESREEA-AGESRGDNPD---------DVANRDSSEE 361
XP_017202907 290 ---DSRESQSQE--DSNNEQDPSSESSQEADLPSQES-----SSESQEEG-LSESRGDNPD-ATTSST---EEDSDSSQE 354
7_pfamImport 275 SQEDSKESRSQE--DSENAQDPSSESSQEADLASQES-----SSESEEEV-ASESRGDNPD-NVSRAS--DQEDSDSSQE 343
O55188       303 SQEDTAESQSQE--DSPEGQDPSSESSEEAGEPSQES-----SSESQEGV-TSESRGDNPD-NTSQAG--DQEDSESSEE 371 house mouse
XP_003469412 302 SQEDTSESQSHE--D-EDEQDTSSESSQEVDTPSQES-----SSESQEEVmAAESRGDNPD-ATS------QPDSDSSEE 366
EHB12356     305 SQVDSSESQSQE--DGEDLQEPSSESSQEVDLPSQES-----SSESQEGV-VGESRGDNPD-ATS------QEDSDSSEE 369
4_pfamImport 315 SLEESEEKQSPE--DSQNVQDPSSESSQEIDQPSQEN-----SSESQEEV-VSESRGDNPD-NTTSHS-EDQEDSDSSEE 384
5_pfamImport 299 SQEDSEENQVQA--DSQNEQDPSSESSQEVDLPSQET-----SSESQEEV-LSKSRGDNPD-NTSTHS-EDQDSSDSSEE 368
XP_028932379 218 SHEDS-GSRSREgaDSRGSRDL-SSSKDHSKGSSQETvlkqkSSKSHEDS-EVTSRGDNPEpN----EdGDEVDSDSSQE 290 platypus
Q95120       317 SRQESEENRSPE--DSQDVQDPSSESSQEVDLPSQEN-----SSESQEEA-LHESRGDNPD-NATSHSrEHQADSESSEE 387 domestic cattle
Q13316       387 DSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQ-SEE------SHSEED-D-SDSQ 457 human
2_pfamImport 368 DNVSKPSNSESESREEQADSDSNESLKSSEESPESVEDENSSSQESLQSQSASTESQ-SEEsqseqdSQSVED-DdSDSQ 445
6_pfamImport 362 GGLTASSSSESESGEDQADGESSESLQSSEESPESAEEGNSSSQEGFRSHSASAESQ-SEE-----------D-RsSDSQ 428
XP_017202907 355 DNLSVPSSSESQSREEQADSDSNESLKSSEESPETTEEENSSSQEGLQSQSESAESP-SEEsqseqdSQSDEG-AgSDSQ 432
7_pfamImport 344 DSLNTFSSSESESREEQADSESNESLKLSEESPESTEDENSSSQEGLQSQSTSAESQ-SDEsrseqdSQSEEE-PdSDSQ 421
O55188       372 DSLNTFSSSESQSTEEQADSESNESLSLSEESQESAQDGDSSSQEGLQSQSASTESR-SQEsqseqdSRSEED---SDSQ 447 house mouse
XP_003469412 367 DSLNTFSSSESESREQQADSESNESLRLSEESQESSEDDHSSSQEDLQSWSTSTESQ-SQE------SSSRED-TdSNSQ 438
EHB12356     370 DSLNTFSSSESESREQQADSESNESLRFSEESQESPEDDSSSSQEGLQSQSRSTESH-SQE------SHSGED-TnSDSQ 441
4_pfamImport 385 NSLNKTSSSESESTEEQADSESNESLKDSEESPEFTEE-NSSSQEGLQSHSASAESQ-SEE------SQSEED-DaSDSQ 455
5_pfamImport 369 DSLSTPSSSESTSREEQADSESNESLKFSEESPESPED-NSSSQEGLQSHSASTESQ-SQEsqs-peSQSEED-DgSDSQ 444
XP_028932379 291 SSLSKSSQSESESRESQEHSKSSESSRQSEESRESSEEKSSSSHEGLLSHSRSSSKEdSAEssseqvGTKESDsEeSESQ 370 platypus
Q95120       388 DVLDKPSDSESTSTEEQADSESHESLRSSEESPESTEEQNSSSQEGAQTQSRSQESP-SEE-----------D-DgSDSQ 454 domestic cattle
Q13316       458 DSSRSKEDSNSTESKSSSEED-GQLKNIEIESRKLTVDAYHNKPIGDQDDNDCQDGY 513 human
2_pfamImport 446 DSSRSKEDSNSTESKSSSEED-GQSKNTEIESRKLTVDIYHNKPIGDQDDNDCQDGY 501
6_pfamImport 429 DSSRSKEDSDSTESTSSSEEH-GQSKTVEIESRKLTVDAYHNKPIGDQDDNDCQDGY 484
XP_017202907 433 ENSKSKEDSNSTESMSSSEED-GQARGMDMESRKLTVDTYNNKPIGDQDDNDCQDGY 488
7_pfamImport 422 DSSRSKEDSNSTESTSSSEED-GQPKNMEMDSRKLTVDAYHNKPIGDQDDNDCQDGY 477
O55188       448 DSSRSKEESNSTGSASSSEED-IRPKNMEADSRKLIVDAYHNKPIGDQDDNDCQDGY 503 house mouse
XP_003469412 439 DASWSKEDSNSTESTSSSEED-WLPKNMEAESRKLTVDLYHNKPIGDQDDNDCQDGY 494
EHB12356     442 DSSQSKEDSNSTESTSSSEEN-GQPKNMEVENRKLTVDSFHNKPIGDQDDNDCQDGY 497
4_pfamImport 456 DSSKSKEDSNSTESKSSSEED-GQSKNTEIESRKLTVDTYHNKPIGDQDDNDCQDGY 511
5_pfamImport 445 DSSKSQEDSNSTESNSSSEEA-GQSKNTEIESRKLTVDAYHNKPVGDQDDNDCQDGY 500
XP_028932379 371 ENSTSKRDSKSTESQSSSEEDaSLSKSIELESRKLMLDAYHNKPIGDHDDNDCQDGY 427 platypus
Q95120       455 DSSRSKEDSNSTESVSSSEEE-AQTKNTEVESRKLTVDAYHNKPIGDQDDNDCQDGY 510 domestic cattle
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap