Conserved Protein Domain Family
ProSAAS

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pfam07259: ProSAAS (This model is not part of the current CDD release)
ProSAAS precursor
This family consists of several mammalian proSAAS precursor proteins. ProSAAS mRNA is expressed primarily in brain and other neuroendocrine tissues (pituitary, adrenal, pancreas); within brain, the mRNA is broadly distributed among neurons. ProSAAS is thought to be an endogenous inhibitor of prohormone convertase 1 and may function as a neuropeptide. N-terminal fragments of ProSAAS in intracellular Pick Bodies (PBs) may cause a functional disturbance of neurons in Pick's disease. This protein is also associated with Alzheimer's and Parkinson's disease.
Statistics
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PSSM-Id: 517635
Aligned: 10 rows
Threshold Bit Score: 49.3375
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_045548794  33 AKPLSAARGVEGRGl-DATGGGVRRLRRDLRDSLPYEAGM-TAYPGesadVLTRRGDNKLLYKP----EEWRGQGLGQ-- 104
XP_013881602  17 AQTLPAAREGGRGQ--DVSVGGVRRQRRELGEQLPYEDQV-MSYSS----LQPGGGANDLYYQS----EDWRGRGIDT-- 83 
XP_014037316  32 AKSLSAAPGVGGRGl-DATGGGVRRLRRDLRDSLPYEAGM-MSYPGesadVLTRRGGNELLYQP----EEWRGQGLSH-- 103
XP_069039802  28 KPLSSG--GPRSGWgtEEVGGAGRMRRDLRDSLPYEAQMVmSYPPPgaglGSEGRNNEIFYQPGtgleGWKGRGVGEA-- 103
XP_018084823  22 AKPLGSVP--------RDDVGMSHRFRRSLPAGIPYDTDM-MSYLP------SESLQEEASYPDinpaLLSRLATYPQeq 86 
XP_007529458  34 ARPVKEARSLGAPSppVVEASGARRFRRALPRAE-AAGAVq---------------------------------eLAR-- 77 
1_pfamImport   1 TRPVKEPRGLGAPSppMAETGASRRFRRAVPGGE-AAGAVq---------------------------------eLAR-- 44 
XP_003462608  34 ARPIKDPRSLSAASpaIAEAGSQRRFRRAAPRGEAAAGAVq---------------------------------eLAR-- 78 
XP_004396898  34 ARPVKSARP-GSAGlgVRVCGARLAATPCPPLAP-GAGPAs---------------------------------pRRS-- 76 
NP_001159601  25 AKPLSAMRGGVRS------YDVPVRLRRELRDSVPYEAQM-ISYPS----ADFKSRSND-YYPS----EVLRAQGLGQ-- 86 
XP_045548794 105 ---------------------ALQQLVENDQRR---------EQE----TAYLAGLLRLLSEA-D---------VQEGGE 140
XP_013881602  84 ---------------------ALQRLVEREERR---------EQReeqrAAYLAALLRLLSEA-EstglvgpadVEVVEE 132
XP_014037316 104 ---------------------AVQQLVENDERH---------EQD----AAYLAGLLRLLSEA-Egt------aGEDGGV 142
XP_069039802 104 ---------------------LQQLVDDDRRRD---------QEA----IYLAGLLRLLSESY-Gapqk---------lg 139
XP_018084823  87 llaamekfglnhraealqdsiALQQLAEEGQRR---------DKE----AMYLANLLHLWNQIsQsrgypeqlqALR--- 150
XP_007529458  78 ---------------------ALAHLLEAERQErar---aeaQEAedqqARVLAQLLRSWGAP----------------- 116
1_pfamImport  45 ---------------------ALAHLLEAERQErar---aeaQQAedqqARILAQLLRLWGSP----------------- 83 
XP_003462608  79 ---------------------ALAHLLEAERQErar---aeaQEAedqqARVLAQLLRVWGSP----------------- 117
XP_004396898  77 ---------------------PVALSTGLARMKeggartglcPRGddwgAPVRPQLLRAWSTP----------------- 118
NP_001159601  87 ---------------------ALQRLVESDQRR---------EQE----AAYLASMLRLLNEA-Qgt-----gqGRAGDQ 126
XP_045548794 141 EIQg----PGDFQAPYPPDYDETEQGMRMRMPQTAapWQGLLDPQLTQALLNRyrqerlq---------qqqaglpGLPT 207
XP_013881602 133 EDEedqepPQDFQGPAGVDYDETGRGMSMGRPSAA--RWGLVEPQMAQVLLDR-----------------------LDPR 187
XP_014037316 143 EDQg----PADFQGHYTRDYDETEQGMRMGKPQAAapWQGLLDPQLTQALLNRyrqerlq----------qqaglpGLPA 208
XP_069039802 140 leEt----GDFQGPYPPDYDETEQGLSMDKPQAAW--QGLLDPQLTQALLNRYrqerl--------------rqasLPPT 199
XP_018084823 151 ---------RELPRSYQ-DYDDTGLASRSIRAQLP-------RNQLAQATQSHyrqdgg--------------------- 192
XP_007529458 117 ------------------RTPEPPPAL-DDDPDAP-------AAQLARALL-Rarldpaalaaq-llpaqapaplrPRPP 168
1_pfamImport  84 ------------------RPSDLSLGQ-DDDPDAP-------ATQLARALL-Ltrldpaalaaq--llpvpasvlrTRPS 134
XP_003462608 118 ------------------RASDAPLGL-DDDPDAP-------AAQLARALL-RarldpaalaaqlvpapvpaaahrPRPP 170
XP_004396898 119 ------------------RTNDPALGL-EDDPDAP-------AAQLARALL-RarldpaalaaqlvpgpapaaalrPRPP 171
NP_001159601 127 EEE-----GGDFQGPYPPDYDETEQAVSMAKPQAS--WQGLLDPQLTQALLNRykqer--------------lvqaGLAP 185
XP_045548794 208 AINRL--ANSRLETGSQDR---DEEAL--RYLV--AKVLSNISPTKPQGSsg-rrARRDLVSAsgdg-grvRASSSPVLH 276
XP_013881602 188 LVQSLlqRARQVGRAPSEP---TRDQDtlRRMI--TKVLSSIGPNEAQPIr----TRRDLSVKa-------ADSGSSAHR 251
XP_014037316 209 TINRL--TDDRLETGSQDR---DQEAL--RYLV--TKILSSIGPNNPQGSsg-rrARRDLVSVsggggggvRAASEPVFH 278
XP_069039802 200 SRLLTadSRSGGPGGEEGE---EEVLR--YLVG--RVLSSLASETPQQTPsr-laKRDLAAAG--------DRPTPPLKR 263
XP_018084823 193 --ykatgPHQQQEEVSEDGipmDEGML--RFLV--TRVLSAMSEAEMP-----------------------QRLSTPPSR 243
XP_007529458 169 VYDDGppAGPEPEDAGDETsdvDPELL--RYLL--GRILAGNSE---------------------------PEPAAA-PR 216
1_pfamImport 135 AYDDRp-TGQGAEDAGDWTpdvDPELL--RYVRagGGSFTGSPD---------------------------PETWALCVL 184
XP_003462608 171 VYDDGp-TGSDAEETGDETpdvDPELL--RYLL--GRILTGSAE---------------------------PEAGTT-PR 217
XP_004396898 172 VYDDGp-TGPEAEDAGDETpdvDPELL--RYLL--GRILAGSAD---------------------------PEAVAV-PR 218
NP_001159601 186 AANRI--PERE-----QDK---DQEML--RYLV--EKILSSLASGGNQGSssnprAKRDLSAVss-----iERPIKPALK 246
XP_045548794 277 RSRRSLDSP-PSPSLNREHSvgLLRVKRLgdmegmvvegpcgPGEEVEGHRTPDhMVELQRMKKIDN----ELqpQPGGR 351
XP_013881602 252 RTRRSLDDTsAPPSPNNQPS--LLRVKRL-------------EDEEEEEEKLRPqVTALQRMKRIDTmataDAaeLNHGS 316
XP_014037316 279 RSRRSLVSP-PTPSPSREPSpgLLRVKRLgymee----gpgwLGGEREGHKTQNhAVGLQRMKRIDT----ELqaQPGGR 349
XP_069039802 264 PRRSLDDGA-PPSPRVEPSL--LRVKRLGdee-------eeeEEERAAAAGGAR-AGLQRMKRIDSE----LQ--GGGRP 326
XP_018084823 244 RLRRSLPENpPGTASSN-----LLRIKRIddlldp-----------------dyvanGLLRRKRIDG----DLeaRP--- 294
XP_007529458 217 RLRRAADQNpTPDVLPEGVLgaLLRVKRL--------------------------------------------------- 245
1_pfamImport 185 VVRQTRS---GPDVPLKRAGgaA-AVKRL--------------------------------------------------- 209
XP_003462608 218 RLRRSANQDlAPDVPPEGVLgaLLRVKRL--------------------------------------------------- 246
XP_004396898 219 RLRRAADQDlGPEVPPEGVLgaLLRVKRL--------------------------------------------------- 247
NP_001159601 247 RSRRSLDSA---PGPQAEAS--LLRVKRLddd-------ddvDEDAVAGQSNGTpHIGLQRMKRIDT----DL--PPPKK 308
XP_045548794 352 PSRRRRAlny--dpITYDPELLVQHILHY 378
XP_013881602 317 RRRRRRAa------PTFDPQVLMDQILEY 339
XP_014037316 350 PSRRRRAlnydpqaLTHDPELLVQHILHY 378
XP_069039802 327 ARKRRAV-------TYDPDLLAQRILQYL 348
XP_018084823 295 --------------GHY-----TDQLLKY 304
XP_007529458 246 --------------ETPAPQAPARRLLPP 260
1_pfamImport 210 --------------ESPPPQAPMRRLLRP 224
XP_003462608 247 --------------ENPPPPAPARRLLPP 261
XP_004396898 248 --------------ETPSPQAPVRRLLPP 262
NP_001159601 309 HSRKRRA-------LSYDPALIAQHILQY 330
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