Conserved Protein Domain Family
Turandot

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pfam07240: Turandot 
Stress-inducible humoral factor Turandot
This family consists of several Drosophila species specific Turandot proteins. The Turandot A (TotA) gene encodes a humoral factor, which is secreted from the fat body and accumulates in the body fluids. TotA is strongly induced upon bacterial challenge, as well as by other types of stress such as high temperature, mechanical pressure, dehydration, UV irradiation, and oxidative agents. It is also up-regulated during metamorphosis and at high age. Flies that over-express TotA show prolonged survival and retain normal activity at otherwise lethal temperatures. Although TotA is only induced by severe stress, it responds to a much wider range of stimuli than heat shock genes such as hsp70 or immune genes such as Cecropin A1.
Statistics
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PSSM-Id: 399906
View PSSM: pfam07240
Aligned: 10 rows
Threshold Bit Score: 98.2335
Threshold Setting Gi: 74869302
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_523482     44 SVDEATKYRNIDSLVTFYDKYFTRLQLKPDLNTRAHDLLRRYKEenaRVVLVDGTPAQGGFWLPLVKLLIVQLGVEIASE 123 fruit fly
EDW24699      41 DVDQATKETNLGSLAKFYEDHSNSLQLPEDQKQRNDELLEKHKRinsSEVLIDGVPANGGWKSSLLRHIVVEGAIQAVGA 120 Drosophila pers...
Q9VIR2        43 EVDRYTKSRNLPALIEFYEKYSSRLPLTVQDRTYANNVIRRYRAhnnQQ--VDGVPAQGGVG--VVFALLLPFAVSIVEG 118 fruit fly
Q8IN42        43 SADANTQVDIAYEVIGIYDKYKGQGGSNVLREAQLNSQVNDFKR---KTMVIDGVPAQGGVW--GILGAIKKAADAVPDN 117 fruit fly
XP_002134305  42 PADDAQLLANIQTAIALYKECVHCAADEHQVDDDLDREVKKFED---ENRTVEGLPAQGGFW-----SCISAAADSVPDE 113 Drosophila pseu...
Q299E7        42 PADDAELLRNTQEAIALYKKHASRTLPGHQVELDLDRDIRAFET---EHLTVDGLPIQGGVW-----DLIKRGADKVPDE 113 Drosophila pseu...
B4R1P9        44 lVNDSIKEKNIPELIAFYQRYPTDVPLSDADRQQFERFIHDYREy--REVLVDGVPPQGGSFGNIFGHFLGRVGTRYISS 121 Drosophila simu...
Q9VDH4        41 SWDDNTKIKRIQELLTIYNRMAPS--LRPDERARMDRFISGYT----GEIMVDGVPSQGGARR-IFKKILSPAAKSVATG 113 fruit fly
Q8IN44        41 AQDDDSKINSTQELLDIYRRLYPS--LTPEERESIDKFVNEHT----DAIIIDGVPIQGGRKARIVGKIVSPGVKGLATG 114 fruit fly
Q8IN43        41 SNDAESKINRTQELLDIFRRLTPT--LSPEQREKIERSIQEHT----DEILIDGVPSQGGRKTKYVGKILSPVAQGLAVG 114 fruit fly
NP_523482    124 GVKR 127 fruit fly
EDW24699     121 AVEH 124 Drosophila persimilis
Q9VIR2       119 IAKA 122 fruit fly
Q8IN42       118 VKKD 121 fruit fly
XP_002134305 114 VKDQ 117 Drosophila pseudoobscura
Q299E7       114 VKDQ 117 Drosophila pseudoobscura pseudoobscura
B4R1P9       122 LFNK 125 Drosophila simulans
Q9VDH4       114 FFTe 117 fruit fly
Q8IN44       115 FFEe 118 fruit fly
Q8IN43       115 FFEe 118 fruit fly
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