2RGK


Conserved Protein Domain Family
GlcNAc_2-epim

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pfam07221: GlcNAc_2-epim 
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N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)
This family contains a number of eukaryotic and bacterial N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) enzymes (EC:5.3.1.8) approximately 500 residues long. This converts N-acyl-D-glucosamine to N-acyl-D-mannosamine.
Statistics
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PSSM-Id: 399891
View PSSM: pfam07221
Aligned: 14 rows
Threshold Bit Score: 299.698
Threshold Setting Gi: 81735911
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2RGK_B    32 G-FG---W-LGNKGQIKEEMGTHLWITARMLHVYSVAAA-MG-RPG-AYS-LVDHGIKAMNGALR--DKKYG---GWYAC 97  Escherichia coli
Q931B8    34 GgYY---NeYRDDGFITDRKTQHLVSTTRFIFNYATAAVlFE-RPD-FAE-AAAHGVRYLDEVHR--DPEHG---GYYWL 102 Sinorhizobium meliloti
Q8PAH3    39 GfFQ---Y-FRDDGSIYDAGHRHLVSSTRFVFNYAMAYReFG-NAD-YLD-AVRHGLAYLRNVHR--NAATG---GYAWT 106 Xanthomonas campest...
Q8AAL1    33 GyFS---C-LDREGKVFDTDK-FIWLQGREVWMFSMLYNkVEkRQE-WLD-CAVQGGEFLKKYGH--DGNYN---WYFSL 100 Bacteroides thetaio...
Q92VN8   397 GgFHealS-FEAAPLIKPKRMRTM---ARQVYAFSVAKL-RG-WDG-DADgLIGHGIAFMEKGR----TQRG---GWARV 462 Sinorhizobium meliloti
Q89HM2    56 GfID---R-LHRDGTADAAAPRRVFVQARQIYCYAKAAQ-MGwYPE-GRA-IALKGLEHL--LAR--AKAPDgrpGYVHR 124 Bradyrhizobium japo...
Q9A2E8    38 GfFE---K-IDLDGQAVDGPRRGRVL-PRQIYAYAIAGD-LG-WRGpWRA-AVEHGLAYFLSAYR----RSD---GQFRT 102 Caulobacter vibrioides
P29954    34 GgFV---EtIDMKGEPTRDDRRSRVQ-PRQVYCFAAAGR-RG-WDGdWRT-AAEGGLLYFDRVY----GQPG---GFYGA 99  Sinorhizobium melil...
Q8G4P1    58 GgSG---W-LNADGTLDPSHGVETWITSRMAHVYSIGAM-LG-YPG-AGE-LADAALKGLTGILH--DDEHG---GWYPQ 124 Bifidobacterium longum
KJX86773  68 GfYE---R-LSQDAKPIFSDDRRARVQPRQAYCFAAAGQ-HG-WQGpWKD-ALSHGLSWFEKVYRleNGLYG---NLA-- 135 Agrobacterium tumef...
2RGK_B    98 V--NDEG-V-VDASKQGYQHFFALLGAAS-AVTTGHPEA--RKLL---D----YTIEII------EKYFWSEEEQMCLES 157 Escherichia coli
Q931B8   103 M--RGRD-A-VDATKHCYGHAFVLLAYAT-AMKAGIPGT--GARV---S----QTWDLL------ENRFWEPDRELYKDE 162 Sinorhizobium meliloti
Q8PAH3   107 L--RDGV-V-EDDMNHCYGVAFVLLAYSC-GLKAGVDEA--RAWM---D----ETWQLL------EKHFWEPGFGLYRDE 166 Xanthomonas campest...
Q8AAL1   101 D--RSGR-P-LVEPYNIFSYTFATMAFGQlSLATGNQEY--ADIA---K----KTFKIIlskvdnPKSKWNKLHPGTRNL 167 Bacteroides thetaio...
Q92VN8   463 L--QEDG-TiADACEDAYDHACVLLMLAH-AYQAGNPDA--LRLG---Q----ETFAFL------DEHLEDDRLTGFLET 523 Sinorhizobium meliloti
Q89HM2   125 L--TPEGaV-MDGRRDAYDHAFILFALAT--VYALDKDAqvRAEI---D----ALLAFL------DGHLRSP-HGGVHEG 185 Bradyrhizobium japo...
Q9A2E8   103 LvgPNGE-S-LDDTADLYDQAFALFALAA-VAKALPDRA--DDAR---T----LALVVR------ERLIAERKHPVAGFH 164 Caulobacter vibrioides
P29954   100 LanADGK-L-IDASFDLYNQAFALLAFAH-LAEVLPERG--AEMVgrsD----KLRRQL------EARCKHPLAGF--EE 162 Sinorhizobium melil...
Q8G4P1   125 V--FADG-T-HAPRKVCYAHAFVILAASS-ALLAGRPGA--KELL---D----EALATY------DKHFWDDEIGLAVDT 184 Bifidobacterium longum
KJX86773 136 D--QTGR-L-IDPSFDLYNQAFALFAAAQ-A-AASLPER--KDEM---RvralDILAIL------ERDYRHPVAGF--EE 196 Agrobacterium tumef...
2RGK_B   158 WDEAFSKTeeYRGGNAN--MHAVEAFLIVYDVTH--DKK--WLDRAIRVASVIIHDVAR-----NNHYRVNEHFDTQWNP 226 Escherichia coli
Q931B8   163 VSRDWGATspYRGQNAN--MHMTEAMLAAYEATG--EIR--YLDRAETLARRICVELAA-----NTQDVVWEHYRQDWSV 231 Sinorhizobium meliloti
Q8PAH3   167 ADAQFNFTt-YRGQNAN--MHMCEAMIAAYEASG--EQR--YLDRALLLADNMTRRQAA-----KADGLVWEHYDLQWNI 234 Xanthomonas campest...
Q8AAL1   168 --KNFALP-----------MILCN--LAL-EIEHllDPG--YLEQTM---ETCIHEVMDvfyrpELGGIIVE------NV 220 Bacteroides thetaio...
Q92VN8   524 SDG--TEL---RRSNPH--MHLLEAFLAWYAATG--ERG--YLRRAARIIDLFRSHFFD-----TESWTLGEYFDEAWNP 587 Sinorhizobium meliloti
Q89HM2   186 LPV--SLP---RRQNPH--MHLFEAMIACFDATH--DLS--FQNRAGEFFALFLANLYD-----KQKHVLSEYFEEDWSK 249 Bradyrhizobium japo...
Q9A2E8   165 QTNPPSAP-----LQSNphMHLFEAMLAWNEIDK--DPI--WRTLADEIAELALSRFIH-----APSGQIREFFDLDWNP 230 Caulobacter vibrioides
P29954   163 DDPPRLPL----GSNPH--MHLFEACLASEEVEG--FDRvaWANLADEIAHLAMDRFID-----AESGALREFFDHDWAP 229 Sinorhizobium melil...
Q8G4P1   185 WNTEFTELdpYRGLNAN--MHTTEAFLAVADATG--NNT--YRVRAGRIIDHVI-EWAE-----HNGWRIPEHFKSDWSV 252 Bifidobacterium longum
KJX86773 197 ENPPRTPL----CSNPH--MHLFEAMLAWEAQDP--QGP--WSALADEIAGLALTRFID-----GNNGGLREFFAHDWTP 261 Agrobacterium tumef...
2RGK_B   227 LPDYNKDnpaHRFRAFGGTPGHWIEWGRLMLHI-Haal-earCEQPPAWLlEDAKGLFNATVRDAWAPDGAdGIVYT-VD 303 Escherichia coli
Q931B8   232 DWDYNKDdpkHLFRPYGYQPGHMTEWTKLLLIL-E-------RYRPQDWLlPKALLLYETALAKSADLEFG-GMHYS-YG 301 Sinorhizobium meliloti
Q8PAH3   235 DWDYNRDnpkHLFRPWGFQPGHQTEWAKLLMLL-D-------RYAPADWLlPTAQHLFDVAVERSWDAQRG-GLYYG-FD 304 Xanthomonas campest...
Q8AAL1   221 DMDGNLV---DCFEGRQVTPGHAIEAMWFIMDL-Gk------RLNRPKLI-EKAKDVTLTMLDYGWDKQYG-GIYYF-MD 287 Bacteroides thetaio...
Q92VN8   588 AVGPKGQ--------W-TEPGHHFEWASLLVEF-Aa------KSRQTDLI-AFARKLYASAIATGLNRSTG--LAYGaVS 648 Sinorhizobium meliloti
Q89HM2   250 IEPVSVE------------PGHQAEWVWLLKGF-EritgcptGQRRAELL---ATALRYRDEATGCLIDEG--------D 305 Bradyrhizobium japo...
Q9A2E8   231 APGVAGR---------ICEPGHQFEWGWLLMRWgQlag-radATAAALRMiDDAE-------THGVDLSRGvAINAL-LD 292 Caulobacter vibrioides
P29954   230 FPGEKGR---------IVEPGHLFEWAWLLLRW-Ae------RRGNAQAI-VKARRLFEIGEKDGTCPDRD-VVVMT-LF 290 Sinorhizobium melil...
Q8G4P1   253 DLECNADkkdDQFKPYGATPGHGIEWARLIVQW-Alss-fanRDGARPYI-DAAEHLFARAVDDAWNVDGAqGLVYT-TD 328 Bifidobacterium longum
KJX86773 262 -----HEgekGRI----MEPGHQFEWAWLLVRW-Gs------lRGNDEAI-TKARRLFEIGEEHGICPRRK---VAI-MS 320 Agrobacterium tumef...
2RGK_B   304 WEGKPVV----RERV--RWPIVEAMGTA---YALYTV-TGD--RQYETWYQTWWEYCIKYLMDY-E-NGSWWQELDADNK 369 Escherichia coli
Q931B8   302 PEGKLYD----LDKY--HWVHCETIAAA---AALAGR-TGR--ERYWQDYDRLWRYSWRHLIDH-E-YGCWFRILSPDGV 367 Sinorhizobium meliloti
Q8PAH3   305 PDGKVCD----DDKY--FWVQAESLAAA---ALLAQR-SGE--ARYWQWYDKLWDYSWTHMIDH-R-YGAWYRILDADNR 370 Xanthomonas campest...
Q8AAL1   288 RNGCPPQqlewDQKL--WWVHIESLISL---LKGYQL-TGD--RKCLEWFEKVHDYTWSHFKDP-E-YPEWYGYLNRRGE 357 Bacteroides thetaio...
Q92VN8   649 RAALPLD----LISR--SWPQAEAVKAA---LALEGT-GGP--DLKPEIEARVGRLFRWH-IDP-ApLGMWIDRVDEKGS 714 Sinorhizobium meliloti
Q89HM2   306 ATGNIRR----STRR--LWPQTE-IAKA---WIAQAE-SGE--AGAADEARAALVRLERHYLSHpV-RGGWYDQFDRDGK 371 Bradyrhizobium japo...
Q9A2E8   293 DFSTHDD----GARL---WPQTERIKAA---VLAAEI-TGQ--ARYWDMAAAAAEGLMAYLRTA-I-PGLWRDKYQPDET 357 Caulobacter vibrioides
P29954   291 DDFSVADp---TARL---WPQTEWLKAAirfAALTEG-AER--ERYLASAGRAAAALQRFLNVP-V-RGLWRDKQKADGS 359 Sinorhizobium melil...
Q8G4P1   329 WNGMPVV----TDRM--HWTAAESLNTA---ATLHAA-TGE--ARYADWYATFARYVDEHVIDH-E-GGSWFHQLDGGNH 394 Bifidobacterium longum
KJX86773 321 LYDDFSV----HDGLarLWPQTEWLKAA---VRLASVtSGEerQRYLTSGLRAIGALQPFLDTP-V-KGLWFDKWPAD-R 390 Agrobacterium tumef...
2RGK_B   370 --VTTKVWDGKQDiYHLLHC 387 Escherichia coli
Q931B8   368 kqSDIKSPSGKTD-YHPFGA 386 Sinorhizobium meliloti
Q8PAH3   371 kySDEKSPAGKTD-YHTMGA 389 Xanthomonas campestris pv. campestris
Q8AAL1   358 --VLLPLKGGKWK-----GC 370 Bacteroides thetaiotaomicron
Q92VN8   715 a-VATEVPA--SIfYHLVTA 731 Sinorhizobium meliloti
Q89HM2   372 s-LVDTIPA--SSfYHVLCA 388 Bradyrhizobium japonicum
Q9A2E8   358 f-IEEPVPA--SSfYHIALA 374 Caulobacter vibrioides
P29954   360 f-VEEPAPA--STfYHILCA 376 Sinorhizobium meliloti 1021
Q8G4P1   395 --VIGTVWPGKSDlYHAFQS 412 Bifidobacterium longum
KJX86773 391 --PMLDEPAPASTfYHIVCA 408 Agrobacterium tumefaciens
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