4P3Z,1XKP


Conserved Protein Domain Family
HrpJ

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pfam07201: HrpJ 
HrpJ-like domain
This family represents a conserved region approximately 200 residues long within a number of bacterial hypersensitivity response secretion protein HrpJ and similar proteins. HrpJ forms part of a type III secretion system through which, in phytopathogenic bacterial species, virulence factors are thought to be delivered to plant cells. This family also includes the InvE invasion protein from Salmonella. This protein is involved in host parasite interactions and mutations in the InvE gene render Salmonella typhimurium non-invasive. InvE S. typhimurium mutants fail to elicit a rapid Ca2+ increase in cultured cells, an important event in the infection procedure and internalisation of S. typhimurium into epithelial cells. This family includes bacterial SepL and SsaL proteins. SepL plays an essential role in the infection process of enterohemorrhagic Escherichia coli and is thought to be responsible for the secretion of EspA, EspD, and EspB. SsaL of Salmonella typhimurium is thought to be a component of the type III secretion system.
Statistics
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PSSM-Id: 399881
View PSSM: pfam07201
Aligned: 35 rows
Threshold Bit Score: 59.6762
Threshold Setting Gi: 160860903
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4P3Z_A            84 TRTKKKEEKFQTLESRKKg----eAgkaeKKSESTEEKPDTDLADKYASGNSEisgQ---ELRGLRDAIGDD---A-SPE 152
wugsc:SPA1441     45 ALYETMEEIGMALSGKLRe----sN----KFIDAEKLERRQQALLRLIKQIQE---DngaTLRPLTEE-------N-SDP 105 Salmonella ...
Q5WMC5            55 SLSETIEGLSLGYRKGSA------R----KEEEGATIEKQLNDMQELLTLTDS---D---KIKELSLKn-----sG-LLE 112 Escherichia...
jgi:Sbal195_2269  46 ALEETMEGLSLGLSSHLK------K----LTSGKEPTDPRFTALEQLLQQLGD---T---QASTVNKLAEQFaslG-DGD 108 Shewanella ...
Q7NUV7            64 SCAETLENMSFALGTQARermrglS----SSADRARPRSMMQRLAKQVSATAP---D---HLEELRQRVPGIeavE-EVD 132 Chromobacte...
Q2SC37            73 L---FKERAEKTLARREMst--gkK----ENNQQILIEKIREMMDQVPDLLKN---V---KMKVLIERMASNf-pS-TPQ 135 Hahella che...
WP_012127547      59 L---GSEKAEKDLTKRKVk----dG----SIRVNEAHELVSDYLRKVPDLEKN---Q---KIKDLATKMASGn-lS-TIA 119 Vibrio
ABP51924          58 V---FSERAELSLAKRKLs----dS----HARISEIEALVGDYLDKVPELERQ---Q---KIKEMVSHLGSGr-lA-NLS 118 Aeromonas v...
Q7N0W3            56 A---FSERKDMPLSKRKVs----dG----HARVREIEALVGEYLQKVPDLERQ---Q---KVKALISHLNSAq-lT-NIA 116 Photorhabdu...
1XKP_A            25 vtfvFSERXELSLDXRXLs----dS----QARVSDVEEQVNQYLSXVPELEQX---Q---NVSELLSLLSNSp--NiSLS 88 
4P3Z_A           153 DILALVQEKIKDPALQSTAL-DYLVQTt---PPSQGKLKEALIqARNTHTE--QFGRTAIGAKNILFASQEYa-dQLNVS 225
wugsc:SPA1441    106 DLQN---------AYQIIAL-AMALTA----GGLSKKKKRDLQsQLDTLTA--EEGWEL------AVFSLLElgeVDTAT 163 Salmonella ...
Q5WMC5           113 QHDPTLAMFGNMPKGEIVALiSSLLQS----KFVKIELKKKYArLLLDLLG--EDDWEL------ALLSWLGvgeLNQEG 180 Escherichia...
jgi:Sbal195_2269 109 EILLQLKQLGLDSGNMMLLM-MALVMS----GKLGQSAHNKLRkLLTELLS--QEGAEI------ALFAALEgvaLDHAG 175 Shewanella ...
Q7NUV7           133 DLLNSLRQHQFDAGEMALLL-AAMLGK----DGLSPTRRRRLEeALDRVMD--DEDWAL------QLFSHLEfgaVGKSG 199 Chromobacte...
Q2SC37           136 QLMRRLEEFSKDPTLQFVAL-QVLEQEaksgGADKTERLKLIQsAAAELMN--TKGEAVRAGLNVSLTASEFa-eRLKTD 211 Hahella che...
WP_012127547     120 QLQAYLNGFSEEKSHQYLAL--QAVKKflgaNPESKNLLALIDqAILTFEQnpDSWAQIDTEIRVSSFADEYsqeQGFSS 197 Vibrio
ABP51924         119 QLLAYLESYSGEVSEQFEAL--CQARKalagRPEMQGTLALVEqALAKLAD--EQGSAIVLGARITGPAAEAa-kAGVGA 193 Aeromonas v...
Q7N0W3           117 QLQAYLESFSGEVSEQFYAL--SQARDalagRPEAHAILTLVEqELSRLAQ--EQGIAIELGARITPDATAAa-rNGVGN 191 Photorhabdu...
1XKP_A            89 QLXAYLEGXSEEPSEQFXML--CGLRDalxgRPELAHLSHLVEqALVSMAE--EQGETIVLGARITPEAYREs-qSGVNP 163
4P3Z_A           226 PSGLRSLYLEVT---GDT-HTCDQLLSMLQDRY 254
wugsc:SPA1441    164 LSSLKRFMQQAI---DNDeMPLSQWFRRVADWP 193 Salmonella enterica subsp. enterica serovar Paratyphi A st...
Q5WMC5           181 IQKIKKLYEKAKdedSENgASLLDWFMEIKDLP 213 Escherichia coli
jgi:Sbal195_2269 176 LQALQQLYQQAV---RGD-AGLAKWFELLQHLP 204 Shewanella baltica OS195
Q7NUV7           200 LAELRRLYQRAA---SRQ-SGLVYWFGQFRQMD 228 Chromobacterium violaceum
Q2SC37           212 VQMLRDAYRDAV---LNY-GGITQTYRSIVERH 240 Hahella chejuensis KCTC 2396
WP_012127547     198 LHQLRGFYRDTV---HSY-QGLGSAYKDVVERF 226 Vibrio
ABP51924         194 EQDLRDLYRDAV---QDY-RALSAAWRDIHSRF 222 Aeromonas veronii bv. sobria
Q7N0W3           192 LQALRNIYRDAV---MDY-QGLSAAWRDIQSNF 220 Photorhabdus laumondii subsp. laumondii
1XKP_A           164 LQPLRDTYRDAV---MGY-QGIYAIWSDLQXRF 192
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