4KG0


Conserved Protein Domain Family
Neuralized

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pfam07177: Neuralized 
Neuralized
This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.
Statistics
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PSSM-Id: 399869
View PSSM: pfam07177
Aligned: 127 rows
Threshold Bit Score: 102.237
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4KG0_A         18 FH-SVHGDNIRISRDGTLARRFESFCRAITFSARPVRINERICVKFAEISNNWNGGIRFGFTSNDPVTL---Egtlpkya 93 
EEN52841        3 FH-TVHGTAITLSGDRLTATRGDGFCNGITFSAAPMEVGEEISIEFVSTTSSWSGVLRFGATSVDPGTWkqeDlpr--ya 79  Florida lancelet
PDM62677       20 FH-SIHGQHIKREEGGSRVVRKGSFCNGIAFSNRPIAIDERVGIRQTTVTTKWSGVLRFGLTTVDPALHrslElpk--ya 96  Pristionchus p...
EFO97234      117 FH-RSKQNIQKLFSDGRMAKRKESFCKGLAFSSRPIEIDENICLRLCEVGTSWSGVLRFGVTNEDPEQYrsiPvpt--fa 193 Caenorhabditis...
38_pfamImport   1 FH-NIHGKNITLSEGNKVAQRINSFCYGIVFSSRPIRINEVAHLKLEQISHMWSGLVRFGVTCIRPEILgsqGlpr--fl 77 
EFX86111        5 FH-NTRGEHVRLSADRSTARRVDSFCKGIAFSQRTVRPNEKVYLRVAECSTSWNGVLRIGFTSCNPASFs-gVlpk--ya 80  common water flea
XP_015792381   31 FH-QVHGDNIRLSGNGAIAERLESFCEGIVFSSRPIKVGEHVSIKFMTSSTNWNGALRFGFTTTDPIKLkgql---pkya 106 two-spotted sp...
EEC10073        3 FH-EVHGENVRLEQGNKVARRAESFCKAIVFSSRPVQVNEKVVLRLTEISNSWSGALRLGFTAHDPATLegnl---pkya 78  black-legged tick
PDM66254       75 FH-SIHGTNVSLQKGGRLARRHESFCKGLAFSNRPIGIDENVCIKQCEVATNWSGVLRFGLTNIDPETYrntQvpk--fa 151 Pristionchus p...
XP_002601107    2 FHpTCHGNNISVSSDRQTARRAESFCNAIVFSDRPFRIQEKIRLKFTQTTDGWSGVIRFGFTTQDPNSIqaaSlpr--ya 79  Florida lancelet
4KG0_A         94 CPDLTNRPGFWAkaLheqyceKDNILYYYVNGAGDVIYGINNEEKG-VILTGIDTRslLWTVIDIYGNCTGIEFLD 168
EEN52841       80 VPDLTNKEGYWAkaMpenhcePGNLMTFHVDAQGNLRYSVNNDD-KgVFLSGLPTEvqLWALLDVYGVTTSIKFVS 154 Florida lancelet
PDM62677       97 CPTLSELPGYWIraLpdryakQGALVHFSVSRAGDLMYGIDGAAKG-IFIGGIDIArpLWVIVDVYGTATAVAFES 171 Pristionchus pacif...
EFO97234      194 CPDLTTKDGYWAkaLperystQGNILHFYVNQQGELFYGINGTQ-KgMFLTGINVRspIWLILDIYGNSVAVEIYD 268 Caenorhabditis rem...
38_pfamImport  78 CPDLTNQDGIWAkaLsdefanENTVISFHVNHSGELCYMVNGTS-QeSIISGIPTEqpLWVVMDVYGNSTALKFVG 152
EFX86111       81 CPDLTSRPGFWGkaLperyveSGVLFSFHFTASGDVMLNVNGQD-KgVFLTGVDARtpLWIMVDIYGNTTAVQFAD 155 common water flea
XP_015792381  107 CPELTSKSGFWAkaLsdrygvVENVLSYWVDESGKAHYSINGDD-KgVFLTEVDVSktIWALLDIYGSTTAIRFLD 181 two-spotted spider...
EEC10073       79 CPDLTNRPGNWAkaLgeryavEGTELHYYVNGVGEVFFGINGEE-KgLFLNGVDTRtpLWALVDIYGNTTTIQMVG 153 black-legged tick
PDM66254      152 CPDLSSKEGYWAkaLperysvEGNILHFYVNAEGELFYGVNGQQKG-LFLMGINTTlpLWVIVDIYGNSTAVEFID 226 Pristionchus pacif...
XP_002601107   80 CPDLTNLPGYWAkaLperyaeRNNILCYYVRRDGSVCYSVNNED-KgLFFAGVDTSspLWGLVDVYGNSTEIKIIE 154 Florida lancelet
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