2YUE,2E63


Conserved Protein Domain Family
Neuralized
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pfam07177: Neuralized (This model is not part of the current CDD release)
Neuralized
This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.
Links
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Statistics
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PSSM-Id: 517596
Aligned: 96 rows
Threshold Bit Score: 110.333
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2YUE_A        11 FH-SVHGDNIRISRDGTLARRF-ESFCRAITFSARPVRINERICVKFAEISNNWNGGIRFGFTSNDPvtleGTL-----P 83  fruit fly
XP_008120017  24 FHpYVKGSQIVMDESHRTARRA-ATFRDGLVFSNRPVRVYEKVALRISKDDGKWHGGLRVGFTWEDP----SCLkprdlP 98 
XP_007476594  23 FHpKAKGNQILLNDCFSRAERI-STFHDGIVFTNRPIQPYEIITLRILEMEDKWNGGLRVGFSCLDP----SNInpcslP 97 
8_pfamImport   1 FHaKAKGAQVRLDAEGSVARRC-ATFCDGIVFSQRPVRPGERVVLRVLEHEDRWHGGLRVGFTRLDP----ARVpaaslP 75 
XP_004770982  20 FHaKAKGVQVHLDARRCTAQRC-ATFHDGIVFSQRPVPPGEPVALRVLWHETRWYGGLRVGFTRLDP----AQVsapslP 94 
XP_005212439  27 FHaQAVGAQVRLDAERSTAYRR-ATFHDGIVFSQRPVRLGERVALRLLWHEHGWLGGLRVGFTRLDP----ARVsapslP 101
XP_002811706  20 FHaEAKGAQVRLDTRGCIAHRR-ATFHDGIVFSQRPVRPGERVALRVLREESGWCGGLRVGFTRLDP----ACVsvpslP 94 
Q4H355       124 FH-PVHGSNVVLSCDRQVASRKpDSFCNGLVFGHRPVKFGEAIHLRFNKVRPDWRGCIRLGFTPYNP----ARCnsaslP 198 vase tunicate
XP_029703290  73 FHpHAKGKNIRLDGQFRRATRK-NSFCNGITFSHRPVHLYEKVRLRLSGVHTGWSGALRFGFTSLDP----SELvatdiP 147 torafugu
XP_064421785  36 FHpTTKGSLIQLSEDFCHARRR-STFCNGITFTQRPIRIQEKVCLCITREAKKWTGVLRVGFTTVNP----SFIdlaflP 110 coelacanth

2YUE_A        84 kyaCPDLTNRPGFWAkaLheqyceKDNILYYYVNGAGDVIYGINNEEKG-VILTGIDTRslLWTVIDIYGNCTGIEFLD 161 fruit fly
XP_008120017  99 pfaCPNLIRRGKTRArlLpdeyceEGTVVSFWVDTRGRVLYSINGEPEQfLLLDKVLVTspLWAVMDIYGRTKAIQLLd 177
XP_007476594  98 pfiCPDLIAQSPTWAavLpdqfikVGDIIHFWVNNSGKVFLRTNEVKKF-PLLGRVAVSspLWAVLDVYGTTKAIELLT 175
8_pfamImport  76 pfvCPDLEEQSSTWAavLpegcalAGDVVRFWVSRHGRLFAAVNAGPWF-LLRTGVLLGapLWAVMDVYGTTKTIQLLD 153
XP_004770982  95 pfvCPDLEQQSPTWAamLpegsalLGDVIHFWVNCRGRLYARVNAGP-RlLLRKGVPLDapLWAVMDVYGTTKAIELLD 172
XP_005212439 102 pflCPDLEQQSQTWAamLpdgrasPGDVVRFWVNRRGQIFAQVNSGPQR-RLREGVLMGapLWAVMDLYGTTKAIELLD 179
XP_002811706  95 pfvCPDLEEQSPTWAavLpegcalTGDVVRFWVDRRGRLFAKVNAGCRL-LLREGVPVGtpLWAVMDVYGTTKAIELLD 172
Q4H355       199 syaVPDLSRRSRFWAipIpekyatKYNIFSFVCKDDGSVSFMINNEG-KgIFATGLSTKisLWPMLDLYGKVEELAIVD 276 vase tunicate
XP_029703290 148 kyaCPDLVTRPGYWAkaLperlalKDNVLSFWADRHGRVFYSINEGEPI-LFHCGLSIScpLWAIIDIYGITQEV-TLL 224 torafugu
XP_064421785 111 qfvCPDLSQQPGFWAacLpeecaqEGDILKFWVGRKGEVFFKMNGKQ-SyFLFDGVPTNmlLWAIIDVYGNTEAVQLLG 188 coelacanth
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