Conserved Protein Domain Family
B9-C2

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pfam07162: B9-C2 
Ciliary basal body-associated, B9 protein
The B9-C2 domain is found in proteins associated with the ciliary basal body. B9 domains were identified as a specific family of C2 domains. There are three sub-families represented by this family, notably, Mks1-Xbx7, Stumpy-Tza1 and Tza2 groups of proteins. Mutations in human Mks1 result in the developmental disorder Mechler-Gruber syndrome; mutations in mouse Stumpy lead to perinatal hydrocephalus and severe polycystic kidney disease. All the three distinct types of B9-C2 proteins cooperatively localize to the basal body or centrosome of cilia.
Statistics
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PSSM-Id: 399858
View PSSM: pfam07162
Aligned: 127 rows
Threshold Bit Score: 97.9996
Threshold Setting Gi: 75033958
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFJ41998      602 LLLLGEIQSAADFPMDr----LYIEYVVRWd----pDVWELTTtsncqq----------tqpgiiQGVTHISRVTVYPPd 663  Volvox carter...
EAY21259      291 MFYRGEIARAI-MDTAp---gVAVEYQLRLp-----PGWANEEtgi-----------------pvQGCSQYSLCDENGVs 344  Trichomonas v...
A0CZW4         34 VNIFGEILEASNFDNSq----IFLQWKFKIp-----PGWDLDDnelleldqkeyediqleewnriQSITQQSKVNTIKNd 104  Paramecium te...
XP_004034955  164 INIIGEIMQAYDFDIEn----LYIEYEFVLq-----DNWKPDYedlqmiskkps-eetkrewnmlNSITQAASPTIQKYt 233  Ichthyophthir...
XP_002121395  317 LNVYGEVVSAQSFQQNd----LHVEFLLDVp-----RDWSCDPaq------------------llSGCTHTCRTTlvd-- 367  vase tunicate
AAI67339      313 VFINGEIVSAQEFEYDn----LYVHFFVELp-----KNWSSPGfq------------------elSGVTQTCRTKtra-- 363  tropical claw...
XP_001631460  190 LDLFGEIVSAKGFEYDg----LYVHFFLESp-----SEWTFEGsp------------------imSGVTHTCNVKayg-- 240  starlet sea a...
EDV20131      306 VNIFGEINMAKNFEYNd----IYIHYCLYLt-----TEWKTRDsd------------------viAGFTQISKCKgdk-- 356  Trichoplax ad...
EFX71541       25 hVVNVTIETAKEFHNCn---hLYVRYVVDAp-----ADWVLAEpk------------------nlHGVTHQSRAGNDSSn 78   common water ...
XP_002894860  178 mMISLEVAA---VDNPqttdsIFVEYELELpgraghsQWKLQPgny----------------trkRGKTPLSLHQRSEYp 238  Phytophthora ...
EFJ41998      664 patdtpprdVAH----FAHPLELEWVSRpaavpepvlgagggqgpgaagglapNAY-------------PCMFFQV--CT 724  Volvox carter...
EAY21259      345 ---------------aINLPIDLVARAE-------------------------TQTa------------PTLYLTLhsYT 372  Trichomonas v...
A0CZW4        105 d-------gTITakahFCFPFDLQLQVD-------------------------ENElnf-------gkfPQLLVQV--SS 143  Paramecium te...
XP_004034955  234 qngk-------qivtnYCFPFDIQLQTSseti------------------tecKKF-------------PFMFLIL--HS 273  Ichthyophthir...
XP_002121395  368 ------dveFAY----FCQPFHYHMFLDmenike-----------------------------feplewPRIFVHV--IS 406  vase tunicate
AAI67339      364 ------rdsVAY----FCYPFNFELFLSeeadse------------------------------ettqlPVLFFEV--LS 401  tropical claw...
XP_001631460  241 ------eddVAH----FCFPFEYSLVYDarhspd------------------------------afvkwPLLFVEV--MS 278  starlet sea a...
EDV20131      357 -------ekTAH----FGHPFEFEITYEkanfnq-----------------------------vgvsewPQLFIEV--VS 394  Trichoplax ad...
EFX71541       79 ---------------hFGHRFTLDVSKSwqhsssse--------------------------tpdliptPLLLLEV--YD 115  common water ...
XP_002894860  239 g-------cLTSvafgWHQHFNLKLVKD-------------------------EALngadegdddivpcPVLHLSV--YS 284  Phytophthora ...
EFJ41998      725 LDTLNRYTSQGYGWLAlgthhpVP---GSETHVVRTWKPLg-----TIRDRQAEFFVG--GS--PE--LADlay--lttP 788  Volvox carter...
EAY21259      373 PD--GARIVEGYGQCA------LPmsrGCHEIEVPVWRIRg-----RVSEELRLMFLD--SGleQQapVEQ--------T 429  Trichomonas v...
A0CZW4        144 MDSWERNYIQGYGFIE------IPhtpGFHEITMKTYRPNd-----DLYTRVYEFFLG--GG--TK--VKDld----siS 202  Paramecium te...
XP_004034955  274 LDSWGRKRLEGYGFCE------VPnkpGTHEIIVKTWTPCq-----SLYAKIHEFFLG--GQ--TK--LYDi-------K 329  Ichthyophthir...
XP_002121395  407 SDTWGRRRTEGYGYLT------IPstpGTHTYTVQCWRPLgnagypAIAAELRRFFIG--GN--PE--LEDisy--vavP 472  vase tunicate
AAI67339      402 LDFWQRYRVEGYGSVV------LPgtpGMHVLTAQTWRPVe----lGVLTELKRFFIG--GS--PE--LEDlty--vrvP 463  tropical claw...
XP_001631460  279 LDSWERHRTEGYGYTV------IPnkaGSHEIVINTWRPIg----nGPVPELRRFFIG--GS--PE--LEDpty--pqqP 340  starlet sea a...
EDV20131      395 CDSWQRYRIEGYGYTL------IPqapGMHKIEIQTWRPVa----pDLVSEMRRFFIG--GA--PE--LNDity--vshP 456  Trichoplax ad...
EFX71541      116 VNMWNRQKSVGYGFTH------VPltpGSYSIAIPTWRPYi----rETSLQLREYFLG--LA--PQ--IENiky--agiP 177  common water ...
XP_002894860  285 RDSWRRKRTQGHGEIK------LgncsGFYDSDVPIRKPIt-----SISDRMEELFLGidES------IEDveltrgqlR 347  Phytophthora ...
EFJ41998      789 -----TGFNGk-iLNKYGFKTET-IGAIKVRLHTV 816  Volvox carteri f. nagariensis
EAY21259      430 eddkfGALTAdtvYNRFGLRTVG-AGKVIVRFNLA 463  Trichomonas vaginalis G3
A0CZW4        203 nafyfDKQNQpkvLNRFPIDTES-SGDIKIRVNVS 236  Paramecium tetraurelia
XP_004034955  330 klhkqNVFSA---IDRFNIKTDS-RGSVKVRFNIg 360  Ichthyophthirius multifiliis
XP_002121395  473 -----STFEGn-rLNKYGVRTES-TGSVTIKFNSI 500  vase tunicate
AAI67339      464 -----ETFQGq-rLSRLGFRTKS-SGSLTVRLHCL 491  tropical clawed frog
XP_001631460  341 -----VATEEk-vLSKFYFRTAT-SGSVTIRLNVV 368  starlet sea anemone
EDV20131      457 -----AGSDGp-cLSKYGLKTAS-SGSVTVKMNVL 484  Trichoplax adhaerens
EFX71541      178 nd--nHNNESpsvLGRFPFGTET-SGSVQVRFDTM 209  common water flea
XP_002894860  348 evntdDSPLStmiTSRLGQKSEStGTTVRVrcniv 382  Phytophthora infestans T30-4
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