Conserved Protein Domain Family
SKA1

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pfam07160: SKA1 (This model is not part of the current CDD release)
Spindle and kinetochore-associated protein 1
Spindle and kinetochore-associated protein 1 (SKA1) is a component of the SKA1 complex (consists of Ska1, Ska2, and Ska3/Rama1), a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. It is required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint.
Statistics
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PSSM-Id: 517586
Aligned: 30 rows
Threshold Bit Score: 195.169
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002952784   2 DSLADLGAALSERIAELQRLSSLRl--dDQTKEYYHQDLLGLEANVQALEEQVAALKAFVQSELSVMPKVE-ALIEASRI 78 
XP_006683095  22 TLDTLITSTFSDRIQLLRELVSVHaaatSSQPTALSHILSDLSHQISTLESQAADLQQALDTETTLLGHGRsNILPKLKQ 101
A8WS92         3 AFMVSFERQKDAKFCMYRENI-----------PNFESTLSSITKSTNSIKILLEDIS---NVQKVITDPCEqSCSSCSPN 68  Caenorhabditis ...
EFP12701       3 SFMDSLNTENIEKFSMFRENI-----------PNFDATLTPITKSMNNIKVLLEDIT---NTRKKLVDPCEeTCTSCSID 68 
EGT56085       3 SFADTFAAENDEKLATYRENI-----------PNFDPTIAHLAGSIQNIRSTLQDIS---KANENLKECCEaTCANCLPL 68 
Q9XWS0         3 SFIDRITEETDENFRICRENI-----------PNFETTISPLLNTMKNIKLLLDDAA---FDQQKLENNCEeTCMNCTKS 68  Caenorhabditis ...
Q9CPV1         3 SELEDLCSYVNEKIGNIKKILSIRn---LGQDPALKTTLSKIGDEIIAVNELLNKFELEIQYQEQTNSSLK-ELCESLRE 78  house mouse
XP_003474094   3 SELEQLYSHVNEKIGNIKKTLSLRn---LGQDPTLKTVLNKIGDEIIIVNELLNKFELEIRYQEQISSSLK-ELSDLLEE 78 
1_pfamImport   1 SSLEDLCLYISLKISNIKKSILLRd---LGKDDCLKHFLRKVYNEGILIHELLQAMEIQVKKQEELKKSLK-EIQKAAES 76 
XP_008118662  20 SDLNGLCTYLNTKISNIKKSLQLRk---IVQEPSLKTVVGKIVQEMFLLNNILNELELECHHQESQQNKLK-ELQESLEK 95 
XP_002952784  79 QSERTNIVAKNLPARL---PRQVACSVQGVSLAPSRPGAVGagqld-----alqtgSKLAaggtaagtgvtvnggeDAGR 150
XP_006683095 102 QESVLIQMLDKV------------NAGGTHATSTEHTADVSdtltfmkvasasdtnGEPDadpt--------shapKKEK 161
A8WS92        69 VLNKFLGIEEKLVNNVe-iPDSVPQKSTRPCLDDEKE---Gss--------------------------------vVQPP 112 Caenorhabditis ...
EFP12701      69 ELYKFLGIEVTPVTNQ---MESCAQSSEKSNTTDKEEVKNKde--------------------------------lSKNV 113
EGT56085      69 NLNSLLGIKTENNRNEe-aPTKIIHGDEKTEVAKQND-KTNle--------------------------------tEKTE 114
Q9XWS0        69 QLNDFLGIKVEASTIVdvkSQLVPQSKESSALVETNEPNEQgl--------------------------------sSKPK 116 Caenorhabditis ...
Q9CPV1        79 ECEDVEHLKEHVPPHL---PQVTATQSLVHKPEPDPKESDKa--------------EEPGl--------------pKKPP 127 house mouse
XP_003474094  79 DYKDVEHLNENIPPHL---PQVTVTQNPVNGAHLDSEEPVKa--------------EESKs--------------tKKPL 127
1_pfamImport  77 AQKEAWHLLQHVPRYL---PKPL--QVCNVESTVKHEEETKa--------------VEPKc--------------eKKPA 123
XP_008118662  96 DYSEAQHLRDNVPIHL---PRAV--PNSEMGFVAKNEEPRKe--------------SDVAd--------------aKKPS 142
XP_002952784 151 R--RKEAPRWYVTEREFEAASSYLRGRLQTDKVNAALDELAGHALNNSKLIAAVKgggTKLAPADRKRATELLhSVAMKD 228
XP_006683095 162 PsaKPCRSIRLLTDDEYNHIPQYIVGRITLEKINQAITDLNLLISDKYKIFKLPQ---QKMSKLQRSIYWEHK-QLATAE 237
A8WS92       113 E--SGNRHVQLISEQEFKSIPKYQLGRLTLDNLNEIVGKMDEFLTKKNAILGKTN---KQITRQDREVLDNWR-ELEIKA 186 Caenorhabditis ...
EFP12701     114 E--KEIRIVAQISEQEFKTIPKYQLGRLTLDNLNEIVGKMDEFLTKKNNILSKTN---RQLTRIDREMLDSWR-ELEIKA 187
EGT56085     115 D--NEVRFVAQVSDQEFKTIPKYQLGRLTRDNLNEIVQKMDEFLMKKNQIFGKSN---KQLTRIDRELLDNWK-ELELKA 188
Q9XWS0       117 E--NDIRIVPQITDEEFKTIPKYQLGRLTLEMMNEIVSKMDDFLMKKSKILGKTN---KQLTRSDREVLDNWR-ELEMKA 190 Caenorhabditis ...
Q9CPV1       128 ReqRIIKEMQFITMDEFSDVPAYMKSRLTYCQINDIIKEINKAVVSKYKIMHQPK---ASMSSVKRNLYQRFI-NEETKD 203 house mouse
XP_003474094 128 KeqKIIKEMLFISTDEFNEIPSYMKSRLTYCQINDVIKEINKAVVSKYKIVHQPK---KSMNSVTRNLYQRFV-DEEIKD 203
1_pfamImport 124 Ke-RAIKEIALITTEEFENVPAYMKGRITYDQINAVVEEINKAVVGKYKILYQPL---RSMSAPVRNLYHRFI-EEETKD 198
XP_008118662 143 KktRSIKEVAFIMAEEFESIPAYMRGRITYNQVNAVIQEINKAVVSKYKIMNQPF---RKMSSAARNLYSRFL-DEETKD 218
XP_002952784 229 GiKGH----YWFLESDLRe------GTAIKLDKTGKSMLTLLRHLGRLQEAAICH 273
XP_006683095 238 T-KSR----VFVTEKDLKdksggwtESGFKFDAVGRNVVAILRHLGRIKEVRGGG 287
A8WS92       187 --KGRlpttLFFIENDIRp------LLTERLRLSFAKAIPCLRHIRRVREERCGP 233 Caenorhabditis briggsae
EFP12701     188 --KGRlpttLFFIENDIRp------LLQERLRPSFAKAIPCLRHIRRVREERCGP 234
EGT56085     189 --RGRlqttLFFVEADIRp------LLQERLRPTFSKAIPCLRHIRRIREERCGP 235
Q9XWS0       191 --RKRlpttLFFIETDIRp------MLQDRLRPSFAKAIPCLRHIRRIREERCGP 237 Caenorhabditis elegans
Q9CPV1       204 T-KGH----HFIVEADIKe------FTALKVDKRFYVIMHILRHCHRLSEVRGGG 247 house mouse
XP_003474094 204 T-KGR----YFIVEADIKe------FTTLKADKRFYGILNILRHCRRLSEVRGGG 247
1_pfamImport 199 T-NGV----FFIVEDDIKe------FTKLKLDKRFYVMLSILRHCQRLREIRSSG 242
XP_008118662 219 T-KGE----FFIVEADIEe------FTQLKADKRFHSILTILRHCQRLREIRGSR 262
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