7AJK


Conserved Protein Domain Family
CYRIA-B_Rac1-bd

?
pfam07159: CYRIA-B_Rac1-bd (This model is not part of the current CDD release)
CYRIA/CYRIB Rac1 binding domain
This domain has been annotated as Rac1-binding domain. It can be found in human CYRIA/CYRIB and at the N terminus of CYFIP1/2. CYFIP proteins are known RAC1 effectors that stimulate actin polymerization. In mice, CYRIB (also known as CYRI or FAM49B) negatively regulates RAC1-driven cytoskeletal remodelling and plays a role in restricting infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes.
Statistics
?
PSSM-Id: 517585
Aligned: 31 rows
Threshold Bit Score: 338.45
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
7AJK_CCC      18 NFFLDFENAQPTES-EKEIYNQVNVVL-KDAEGILEDLQSY-RGAGHEIREAIQHPA-DEkLQEKAWGAVVPLVGKLKKF 93  human
EFP07843      32 EIFVDFENAQPTNE-EREIYNMAEEVL-HDCDVVLADVSSYgNGCYIE-RSQLKNDSdTQ-ALKILMTKLEPFVARTCSY 107
XP_006677838  19 DIPIDF-NAQPTPE-EQQIYNSASEIL-SFAPNILQDLRNY-TGCGEAIRQAISTPG-RA-TEDAAWAVVCPAVVKLKEF 92 
EPB90899      19 ELGFDLENATPSSD-ELQLYNKLSSLLvKPGPALLHLLKSY-VPASDQIRDAIAKPT-PE-NESRAWDAVSPTVDILRDI 94 
XP_067515828  19 EIGFDIENAAPTTE-ESEIHDELYNLLiQPTTELLQSFRQY-EPASDMIREAIASPT-TE-NEDKAWEAVTPTVNMLRTF 94 
Q8T2H0        16 QIFIDFEHAQPSDD-ERELHKTVNEVL-IRGPAIIDKLLAY-AGCNEFIRRAITNPG-PE-TEDAAWEAVLPSVDQLQEF 90  Dictyostelium d...
XP_001325741  13 AVYIDLKNATPTNDvERKIVEDFQEKVlNPGKNLYDKFANY-KDGQEFVKIAMRDTS-QA-NKDAAWNAILPNVYTQMDG 89 
EPB83473      20 EINFDIENARPSSE-ELGIYNQLHALLvQPNSNLLKILKEY-KPASDEIRNAIATPN-QE-NEDKAWNAILPTVDALREF 95 
XP_654500     16 KIIIDFENVVPSPE-EQELYSSVEQCL-QKSSKILQEISEY-KGCEDLIRKAISQVS-PE-NEEECWKALIPRVDVLYEF 90  Entamoeba histo...
XP_655512      9 VAIPINFSATPSAA-EQEPFQTINEVA-SHINEMLQKMTNY-KAKETEIRAAIATPS-PE-TEEAAWKAIIPQVQTINSF 83  Entamoeba histo...
7AJK_CCC      94 YEFSQRLEAALRGLLGALTSTPYSPTQ-HLEREQALAKQFAEILHFTLRFDELKMTNPAIQNDFSYYRRTLS-R------ 165 human
EFP07843     108 YEHVAKIEKIVPILLWELSSGPLPLEE-QLANKQSIAKQFARLIGFVLDFDVVKMKTAQITNDYSYYRRAKH-------- 178
XP_006677838  93 YDFSSSIEQLVPRIWQFFG--KGDVSA-SFEKYQATARRLAEILDFATQFDGLKMSNPNVQNDFSYYRRSVS-R------ 162
EPB90899      95 YDYSADLQEGLPKLLGVLC--QGDVSK-NLERNQGLAKLFAELLDFVFEFDHLKMRSPTLQNDFSYYRRMLQ-Rg----- 165
XP_067515828  95 YSYSAQLEKGIPTLLNVLC--KDGTTK-DLDRHPGLTKLFADLLDFVFEFDYIKIRSPAIQNDFSFYRRTLQ-Rg----- 165
Q8T2H0        91 YDFSLELETCFPKLLVALC--KNDPKA-SLSNQQALAKQLADIFDFVLKFDDAKMVNPAIQNDFSYYRRTLN-R------ 160 Dictyostelium d...
XP_001325741  90 YYFSSTIATEFVNVMSSVLEIAGAAKVdFFTQYPALTKCFADCFDVCLKFDQIPIKNPFLLNDLAYFRRNCReHnhdgsf 169
EPB83473      96 YSYSSELERGIPMLLNVLCKDGGGTTK-DLDRHPGLTRLFAEILDFVFEFDYLKIRNPTIQNDFSFYRRTLQ-Rgra-te 172
XP_654500     91 YEFSNQLKDRFIEIIRVLS--QAEAKL-SLVNYQALSKQLGLVLDFVLQFDNKKLGNSSIQNDFSYYRRTLN-R------ 160 Entamoeba histo...
XP_655512     84 FEYSRSMKTEVVKSLRLIC--KLNGND-SVTQYQAVTVKLMELIDFAVQFDNKKLANPGLQNDFSYYRRSVG-K------ 153 Entamoeba histo...
7AJK_CCC     166 -MRINNVPAEG-----------EneVNNELAN-------RMSLFYAEATPM-LKTLSDATTKFVS--ENKNl-pIENTTD 222 human
EFP07843     179 ----------------------I--VYQDFEDqgvpelpQVQMFLCEGNPM-LKALCNGVDSYMH--THQSl-pINNTTD 230
XP_006677838 163 -MKMNNAQLVA-----------V--VSDDLAN-------KMSLFFAHSSPV-TKALIDATALTIS---SRAi-sQDAASD 216
EPB90899     166 -RYSSQDGRDGddssvsdlrsaM--IEDDQAN-------RISLFIAYPTPM-LKCIIDTTTKFVN--KNRL---QKSVGD 229
XP_067515828 166 ------rSLEDsdpnksnlrtaM--DEDDLAN-------RISLFIAYSTPM-LKCLIDTTVKYVQ--SNQS---TKSVSE 224
Q8T2H0       161 -MKLTKKDANI-----------K--IRDELAN-------RMSLFFAYPTPM-MKVLSETTVKFLS--QDTTv-pRDNVTT 215 Dictyostelium d...
XP_001325741 170 dNLLTD------------------------SN-------FSTVFWGSRMPFtMKVVSEVQDKYKS--NATQ---YANVIN 213
EPB83473     173 fTQTTPSSPEKeqrsqsdlrlaM--NEDDLAN-------RISLFIAYPTPM-LKCVIDTTTKYVQ--SNQL---SKCTSE 237
XP_654500    161 -MKGVKKDSDI-----------K--IRDETAN-------KMSMFFAYSSPM-MKVLTEAVNEFTKgvNEEI---KDNISG 215 Entamoeba histo...
XP_655512    154 -MKQKHREDV------------V--LRDEVTN-------QISMFFAFAAPM-ILCLCEALNE-----DIKNglsLDNLGD 205 Entamoeba histo...
7AJK_CCC     223 CLSTMASVCRVMLETPeyRSRFTNEETVSFCLRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKDQPPN------SV 296 human
EFP07843     231 VFVTIINVCRFMLANEdcLARLT-DSSKHLCCRVMTGLVILFDHVDQNGAFVSNSSIDMRDVVRLIKSNTTQe-----QS 304
XP_006677838 217 ILSTLAGIAYSTVAKNr------aGNDTGFYLRVMVISIVLYDHVDLAGAFIKTSKISIKSSVKVIQTYGGS------AC 284
EPB90899     230 WLAALWATCFNTVSK----KRNQNPEISAFCMKVMVVSIILYDHIDPNGAFYKNSPINIKHSVKIIQTITTVksn-eySA 304
XP_067515828 225 WLSSIWAVCYQTLSK----KKTNNDSISSFCFKVMVVTIILYDHVDPQGAFSKYSPINVKNSLKIIQTSNNnnn-eqsST 299
Q8T2H0       216 ALATMANVCHDMVEKK----KFTQDDLNMFCLRAMVGSIILFDHIHPQGAFVKKSPVNIKPCIVTLKDSNTQ------SS 285 Dictyostelium d...
XP_001325741 214 LIGLVADCCTSICTKSdnPS----QEICIIALRCLTAAIIIYDSLNPLGAFHHEVRYHYREAVDLLLNYTP-------KQ 282
EPB83473     238 WLASIWAVCYQTLNAN--YKKSSSSSVDTFCLKVMVVSIILYDHIDPSGAFAKNSPINVKSSLKTIQNVNQInrqeqsST 315
XP_654500    216 LLCTLANACNDMVFSN----TFSKVETNLFCLRVMTGSIILNDIISPLGSFHKKTPIRIKECIMQLKNYNQEdpliceTT 291 Entamoeba histo...
XP_655512    206 WLRTVAYSCCVEAQKH--------GSNGIQLLRIMTGCILLYDTVVPTGAFSTKGKFNVLECVRTLQTYQEE------EV 271 Entamoeba histo...
7AJK_CCC     297 EGLLNALRYTTKHLNDETTSKQIK 320 human
EFP07843     305 DCLLAGLRFTTKHYNDSSTPKSLR 328
XP_006677838 285 DTLLNSLRYSTRHLNDETTPKVTK 308
EPB90899     305 TNLLSALRYNSKHLNDDTTPKNVK 328
XP_067515828 300 ANLISALRYNSKHLNDESTPKAIK 323
Q8T2H0       286 PGLLNALRFTTIHLNDVDTPGAIK 309 Dictyostelium discoideum
XP_001325741 283 QDLIDIVKYCTTSLSKPTTDSKIK 306
EPB83473     316 SNLICALRYNSKHLNDESTPKGIK 339
XP_654500    292 KSLLDTLRFTSKHIQDPETPGYIK 315 Entamoeba histolytica HM-1:IMSS
XP_655512    272 ALLANSLKYSTKHFNDEDTPKNIK 295 Entamoeba histolytica HM-1:IMSS
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap