Conserved Protein Domain Family
Prenylcys_lyase

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pfam07156: Prenylcys_lyase 
Prenylcysteine lyase
This family contains prenylcysteine lyases (EC:1.8.3.5) that are approximately 500 residues long. Prenylcysteine lyase is a FAD-dependent thioether oxidase that degrades a variety of prenylcysteines, producing free cysteine, an isoprenoid aldehyde and hydrogen peroxide as products of the reaction. It has been noted that this enzyme has considerable homology with ClP55, a 55 kDa protein that is associated with chloride ion pumps.
Statistics
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PSSM-Id: 399853
View PSSM: pfam07156
Aligned: 29 rows
Threshold Bit Score: 388.157
Threshold Setting Gi: 549051220
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ENH85803     141 QDDTSWEWWNLAKLFWKYGLA-PYKAQKLV-QATVATFLKLYE--EPYFPFRSLTQRAFEL---DLLKATSVTGDQFLAN 213 Colletotrichum ...
XP_006631780 129 LEETDWYLLDLFRLWWRYGFS-FIRLQMWV-EEIMEKFMRIYKyqAHGYAFSSVEELLHSLggsSFINMTRRSVSESLLE 206 spotted gar
EGD74936     141 FQTSEYDWVTILKMLLRYGLS-PYRMDGVV-KELLDKFDGIYEaqHQRLVFDTVDSLLSHVg---LYDLTQQDLRSYLRD 215 Salpingoeca ros...
P57681       149 FLDTIVSWVNDLYLFLRYGLS-LLRMSSFI-ENTVDNFLKYYEslESRPIFDNVEGMLKWSg---LYNLTKLTLQEKLSE 223 thale cress
EMD96863     133 IVHSGDSWWTIGKMLWKYGAA-PYWTDRLM-KSAVGKFLTMYD--EPVFPWKSLSAAVESVg---LLEVTGVTGEQYLKA 205 Bipolaris maydi...
ELA27822     142 QDDSSWQWWNLAKLFWKYGLA-PYKAQKLV-QSTVDTFLQLYE--APHFPFRSLTQRAFEL---DLLKATSVTGKEFLAN 214 Colletotrichum ...
CAK48605     156 VMKEASSWWNIAKLVWRYGWT-PVRTYRLM-KSTVNNFLKLYD--EPIFPFSSLTSASEAVg---LVNVTAVPGEAFLQQ 228 Aspergillus niger
CCX09801     180 FTYPEGRWWSLMKLVYRYGATaPWRTRGLT-QSVVGKFLSLYK--APIFPFKSLTAAIEEVg---LKETVSLTGEQLLES 253 Pyronema omphal...
EFN70532      90 FEESTWYVISLAKLVHRYGFQ-VYKLKRYV-DDIVEEFENIYHlqDEGKSFLNVTALLSAMn-kEFPSLLQSSVKDHLLH 166 Florida carpent...
EKC31236     293 ISSSQYSVVTMAKLFWRYGMD-IYNIDSWInEKLLSKFMRIYDiqSAGHAYTTVPDLIGAMd-pSFISYMKNSIKFVMKT 370 Pacific oyster
ENH85803     214 NEIGELFSQQIIQAATRVNYAsNLKYIHGLETMVSMA--PEGAKQVVGGNWQIFDTMLRNTN-ATLnRNTSVTSITV--K 288 Colletotrichum ...
XP_006631780 207 LGVSQRFIDEVIAAVMRANYG-QPVSIPAFVGAVSLAgaQANMWSVEGGNKLVCSGLLNLAR-ASL-IHAKVTAVAP--H 281 spotted gar
EGD74936     216 QGIGDLLADELVVGIMRTNYG-QDLNMNAFGGAVSLAgaSEHLWAIEEGNNRMCARLLDNPS-THVhLNTHVDRIVT--Q 291 Salpingoeca ros...
P57681       224 AQLSPLLVNELVTVITRINYG-QSVLISGLAGAVSLAgsGGGLWSVEGGNWQMAAKLINHSD-VTLhLNEKIESISY--- 298 thale cress
EMD96863     206 NGIGQAFSKDIIQASTRVNYAsNLPYIHGLETMVCMA--TNGAMQIEGGNWQIFAHMLKTSG-GNVhLNTSVSHISK--Q 280 Bipolaris maydi...
ELA27822     215 NDIGELFSDHIIQAATRVNYAsNLKYIHGLETMVSMA--PEGAKQVIGGNWQIFDTMLQKTN-ATVnRNTTVTSMEV--K 289 Colletotrichum ...
CAK48605     229 NQVSAKFSREVIQASTRVNYGqNLALIHGLETMVCMA--TEGAMAVEGGNWLIFDGMLKLSH-ADLrLNHTVTSLDWd-A 304 Aspergillus niger
CCX09801     254 AGISGAFATELIQASTRVNYGqNLGLIHGVETMVCMA--TDGAVSIAGGNWKIFQGMLNKSR-ADVkLRTPVTSIMR--R 328 Pyronema omphal...
EFN70532     167 MGFTERLINEIVQATVVVNYG-QDVNIQSFVGLISIAgaDANLWSVKGGNKAVPEHLIYRNKyVNI-IPSRVTKIRNi-V 243 Florida carpent...
EKC31236     371 SGFGDTFIDEMVMGALRTNYG-QNTDIPGFVGAVSIAgvQPGLWAVKGGNKQVPEKLVSEAQ-VQV-IQGTVVSVQLlqY 447 Pacific oyster
ENH85803     289 SGPSSSKYLLTTKSlnseteggGEaDQHPVAFDNVVIATPWQYSD-INVAEDLFQHKIDH---I-PYTKLHVTLFASpfR 363 Colletotrichum ...
XP_006631780 282 ATAEGTQYQLSSVN--------EKeEKGAEIYDIVVLATPLQQDGsAGLAFDGFDPPLPGi-tG-SYHHTVASIVHG--Y 349 spotted gar
EGD74936     292 SGGNPTITTTTNEG-----------ETHTREYDAVVIATPLETGS-IELS-EDMQSRVAA---R-KMHTTVATFVEG--T 352 Salpingoeca ros...
P57681       299 ---LENHYELKSTK-----------GNSYK-CDVTVVATPLD--E-VDIQF---SPTISIp-kR-ELQHTHTTFVRG--L 353 thale cress
EMD96863     281 ADGS---YKITTS------------GGETSSFDEVILASPLQY---SDLIIDPAPKHIPDe---iPYTKLYTTLFATpfQ 339 Bipolaris maydi...
ELA27822     290 TGPTSSKYFISAKDsha--daaAEaDQYPVAFDNVVIATPWQYSD-ISVAEDLFQHKIDE---I-PYVKLHVTLFASpfR 362 Colletotrichum ...
CAK48605     305 NGPSTLTFTTATN------------SEEKLEFDEVVIAGPWQ------FSNITVTPPLKKtpdEiPFVTLYVTLFATphR 366 Aspergillus niger
CCX09801     329 DGE----WAVTYAT--------DGeKSQTEVFDEVVIAAPMQYAG------LDIAPGLESkpdTiPYVTLHVTLFASprK 390 Pyronema omphal...
EFN70532     244 DSSDSSQYEVTYKNk-------DSvDTMTSTYDIVIIAAPLTHDQeFPIKFVDFPDNLVf--pG-DYQTTYATFING--D 311 Florida carpent...
EKC31236     448 QGKN---YRVGFFD--------AEkKEQFKDYDIVIVATPLHDEV-SEIDFEDFPSSIENf-pQ-QFHKVTATFVEG--V 511 Pacific oyster
ENH85803     364 LSPEYFGLP-AGSKAPDTVLTTLPKTEEAkvgaegagkAGFYSISTLRTATNPE-T--LKDEFIYKIFSPDKVAAEFLSS 439 Colletotrichum ...
XP_006631780 350 LNCSYFGFPdPKLFPFASMLTTDTPGLFF---------NSVGSVCPVNISASFR-RkqPQEAAVYKVFSQQLLGKKELKT 419 spotted gar
EGD74936     353 LNSSYFGLReDHRVP-AVILTVEKDTIPI---------NCIANVAT-------D-ErkQNNAGLFKIFSRRRLAREELDL 414 Salpingoeca ros...
P57681       354 LNPGYFGMKsLSDVP-ALVGTLEDPLIPF---------SCISIL-----------RkySKTDMTYKIFTRQPASDSLLDE 412 thale cress
EMD96863     340 LSQAAFNLDvKSPVP-TTILTTLPPSEQVvdg---agsPNFYSISITGTGVNKR-AspARHEYIYKIFSPSRVNATFLSH 414 Bipolaris maydi...
ELA27822     363 LSPEYFGME-PGSKAPDTVLTTLNPADEAkagaegagkAGFYSISTLRTATNPE-T--LKDEFIYKIFSPKQVTAEFLSQ 438 Colletotrichum ...
CAK48605     367 LSPKYFGLTePNAYTPETILTTLPPETDIgkseagvgpAGFWSISTLRTVDAPD-PseGKH-YVYKIFSPERPTAEFIES 444 Aspergillus niger
CCX09801     391 LDPLYFGLPeDAAVPQSVLTTLNATEQQDplftrgegrNAAGSVGFFSVSTLRSvErgNRTEYIYKVFSPDHYGDDKVRK 470 Pyronema omphal...
EFN70532     312 LNPKYFGLQ----ETVDIILSCNPNKTKI---------SSIAKATSVDGSFDIN-Sq------nWKIFSREPLGTKLLKN 371 Florida carpent...
EKC31236     512 PDPKYFGVDnTDDLP-NSILTCNDSIL-------------------VNSQDKKA-DvfGNPTDVYKFFSNTPPSEDDVKQ 570 Pacific oyster
ENH85803     440 LLgvev---------pstiVSTdenaaQTVKPISWYHphvfnsYPIEYPRVT-FQDPILRDG-LYYLSGIESFISCMETS 508 Colletotrichum ...
XP_006631780 420 LF-----------------KSY-----YSVQATDWQA------YPQYGSSQA-LPPLVLHDG-LYYLNGIEWAASAMEMS 469 spotted gar
EGD74936     415 FL-----------------LDIk---eDSIREVDWKA------YPKFAPPEQ-FTPFVLGEG-VFYPNAIENSASAMEMS 466 Salpingoeca ros...
P57681       413 LF-----------------SRR-----TETVRIDWGA------YPKYHAPEV-FAPFILDDHhLYYVNAFENAASTMETS 463 thale cress
EMD96863     415 ILgaevsdeeaehgeangnVSW-------IHHKIWHS------YPREYPRVT-FEEIELDDG-LWYTSGIESFISTMETS 479 Bipolaris maydi...
ELA27822     439 LLgvkv---------petiVSKdk--tEAVDPISWYHphvfhsYPIEYPRVT-FQDPILRDG-LYYLSGMESFISCMETS 505 Colletotrichum ...
CAK48605     445 ILgl-------------ehKSW-------FHEKIWRP------YPFEYPRVT-FEEPLLAPH-VWYTGGIESFISTMETS 496 Aspergillus niger
CCX09801     471 ILgvapg-------seeevTTW-------SYRHTWKS------YPYEYPRVT-FEEVKLASG-VWYTAGIESFISTMETS 528 Pyronema omphal...
EFN70532     372 MF-----------------SHV-----TEKKEIAWKA------YPHYSSTNVhFDQFKLHDA-LYHINAIEWAGSAMEMS 422 Florida carpent...
EKC31236     571 MF-----------------TSK-----KDIRMATFMA------YPKYSTVGEdLPPFVLHDQ-LYYVNGIELAASAMEMS 621 Pacific oyster
ENH85803     509 ALMGKNIAKLITQDFaSLDTNEAgDE 534 Colletotrichum orbiculare MAFF 240422
XP_006631780 470 AVAAKNIALLAYHRW-NRQQEMI-DQ 493 spotted gar
EGD74936     467 AIAAKNAALLVEKHM-RRKCLQAtDE 491 Salpingoeca rosetta
P57681       464 AVAGENIARLIISRFmTKESLSSsDK 489 thale cress
EMD96863     480 ALSGKNVAKLIANRW-AAGSEASqEE 504 Bipolaris maydis C5
ELA27822     506 ALMGKNVAKLIAEDF-AVSTEAVkEE 530 Colletotrichum fructicola Nara gc5
CAK48605     497 ALMGRNVAALMSREW-QAQA----DG 517 Aspergillus niger
CCX09801     529 ALMGMNVAKLVIGEW--EEAKEVeDE 552 Pyronema omphalodes CBS 100304
EFN70532     423 AVAGRNIAILAHDNF-VQKYNLVlNK 447 Florida carpenter ant
EKC31236     622 SIAGKNVALLAYNHW-HGNLDKI-DE 645 Pacific oyster
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