pfam07140: IFNGR1_D2 (This model is not part of the current CDD release)
Interferon gamma receptor (IFNGR1), D2 domain
This entry consists of mammal and viral interferon gamma receptor proteins. Molecular interactions among cytokines and cytokine receptors in eukaryotes form the basis of many cell-signalling pathways relevant to immune function. Human interferon-gamma (IFN-gamma) signals through a multimeric receptor complex consisting of two different but structurally related transmembrane chains: the high-affinity receptor-binding subunit (IFN-gammaRalpha) and a species specific accessory factor (AF-1 or IFN-gammaRbeta). The vaccinia viral interferon gamma receptor has been shown to be secreted from infected cells during early infection. The structure has been halved such that the N-terminus of this family is now represented by Tissue_fac pfam01108 (which represents the D1 domain), and this domain represents the D2 domain, both of which adopt an Ig-like fold. This domain is mediates receptor-receptor contacts.
Jiyao W et al.(2023). "The conserved domain database in 2023.",