Conserved Protein Domain Family
IgaA

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pfam07095: IgaA 
Intracellular growth attenuator protein IgaA
This family consists of several bacterial intracellular growth attenuator (IgaA) proteins. IgaA is involved in negative control of bacterial proliferation within fibroblasts. IgaA is homologous to the E. coli YrfF and P. mirabilis UmoB proteins. Whereas the biological function of YrfF is currently unknown, UmoB has been shown elsewhere to act as a positive regulator of FlhDC, the master regulator of flagella and swarming. FlhDC has been shown to repress cell division during P. mirabilis swarming, suggesting that UmoB could repress cell division via FlhDC. This biological function, if maintained in S. enterica, could sustain a putative negative control of cell division and growth exerted by IgaA in intracellular bacteria.
Statistics
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PSSM-Id: 429290
Aligned: 11 rows
Threshold Bit Score: 1125.5
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:Rahaq2_0280   3 LVLLCIAIIATASYFWLVLRRRQRDESVVRFSTPSQRKLSQKERDAVERYLRQNEG----LGQTp--iTHRNNLIILRDK 76 
ADD78843          8 LAVVLTCSILAGIGFWYAMRRRPPLAKPLPFISPPCRKLSERERKAVEQYLAALEK----QPRI----LSPGETRRRHEK 79 
WP_002444787      8 VATVLATVTLALSLLWRSQQQSARLP-AVNFPGATFRKLSADERKAAENYLETFNR----SRQL----VGLSAASNAPQP 78  Shimwellia b...
P45800            8 LAALLACSLLAGWLIKVRSRRR-QLPWTNAFADAQTRKLTPEERSAVENYLESLTQ----VLQV----PGPTGASAAPIS 78  Escherichia ...
wugsc:KPN_03769  10 LTALLICVLLIGWWYRAHARRR-RLPLLHAFSDATTRQLPADERQAIEKYVAELSH----AQQV----PA-SGATSAPVA 79 
P58722            8 LALLLTSLIAVGLLWWLRFRRPHPITAALPFVKLTHRKLTPEERVSIENYLRNQQNkhgfNTQPafdsHALAASTSSTPM 87  Yersinia pestis
AHG19970          8 LALVLICLIAAGIYFWFVFREQSTLAYSLPFIKPTHRKLTTAERAAVESYLNQQNR----FSTR----LLPASPMLPSAR 79 
Q7NA48            8 LAILIISLIVMASFLIFKWKLHDNDRYLPSVAAPTYRKLNADEYQAIECYLNRVLP------------PVVTNRINKTSW 75  Photorhabdus...
WP_015422356      8 TAALVIGCLIMVSVISHRRRQRRAGYVLPSLASLTHHRPGAGEIQAIEHHLT----------------CAARQAVSNDLH 71  Morganella m...
WP_013319764      8 LAVLFACLIAVGGIIGYLMYRRLLFAKRLPVTPSGHRQLTASERIAIERYLAMSHL----DG------PVSSSVSVASPR 77  Dickeya dada...
Q6CZP9            8 LAILLACLIVIGGLVGYRMRRRFLSAPPLPVSQSLPRRLTEDERIAVERYLAQENS----QQ------TTPLDTPNTQPK 77  Pectobacteri...
jgi:Rahaq2_0280  77 LTLTT---KSENVYSLTRAITRYGVASEDPNKWRYFLDSTEIHLPPFWEQYIAQENQVELIKTQTLPLVISLNGHTLTEH 153
ADD78843         80 LVLTA---QSNNVYPVTRAITRYGLSTDDPHKWRYYLDEVEVHLPPLWEQYITDENYVELIRTQSIPLIISLNGHSLVDY 156
WP_002444787     79 LTLSP---RSTKVICVTRAITRYGLSTDEANKWRYYLDSVEVHLPPFWEPYISNDNRIELVRTETMPLVISLNGHTLQDY 155 Shimwellia b...
P45800           79 LALNA---ESNNVMMLTHAITRYGISTDDPNKWRYYLDSVEVHLPPFWEQYINDENTVELIHTDSLPLVISLNGHTLQEY 155 Escherichia ...
wugsc:KPN_03769  80 LALNE---QSDTVYAVTRAITRYGITTDAPNKWRYFLDSVEVHLPPFWEQHINDENSVELIPTDSLPLVITLNGHSLSDY 156
P58722           88 LVLTP---QSDNVYSVTRAITRYGVASDEPNKWRYYLDSIEVHLPSAWEQYITQDNDVELIQTQTIPLVISLNGHTLNNH 164 Yersinia pestis
AHG19970         80 LALTS---QSDNVYPITRAITRYGLASDEPNNWRYYLDSEEVHLPPFWEQYISADNHVEVIKTQTLPLVISLNGHSLLDH 156
Q7NA48           76 PILMG---KNDMVYTICHSITRFSVASDERHSWRYYIDMAEIHLPFFLEPFIKQQNIIDVIHTATIPLVISINGHFLKDF 152 Photorhabdus...
WP_015422356     72 FTLPAfpkKSDHVYRLCNRITRYAIPEKNGQQWHYYIEGNEVYLPAVLDEFIQATNVIDVMFTDGIPMIVGLNGHDLREF 151 Morganella m...
WP_013319764     78 LPRLL---PGNRVYPITHSITRYGLSTDAPNKWRYYIDTQEIHLPARWEQYITQNNEIELIKTRSIPLVVSLNGHSLTEF 154 Dickeya dada...
Q6CZP9           78 LPRSL---QSNRVYPITHTITRYGLSTDVQNKWRYYIDTQEIHLPPSWEQFITENNTVELIKTRSIPLVISLNGHSLTEC 154 Pectobacteri...
jgi:Rahaq2_0280 154 VYEGP-APVSAVMPsqPQNASIRHEESEHIELVKVRRETREEHALTRSNGVKEALAVSAILLVLFITLQSPVIFLPWLLL 232
ADD78843        157 AIDQQsLPNLIRPS--STNASIRKAESENVELVRVRKETLEEYRLSRPDGTREAVIISFALLLFFIGLLLPASLMIWLSV 234
WP_002444787    156 VNEAA-GFALENTS--QGHSFIRGEESEQVELRHVRQETPEEYALSQAENLRDPLFIVAALVLAFLCLVTPGFLIPWLAG 232 Shimwellia b...
P45800          156 MQETR-SYALQPVP--STQASIRGEESEQIELLNIRKETHEEYALSRPRGLREALLIVASFLMFFFCLITPDVFVPWLAG 232 Escherichia ...
wugsc:KPN_03769 157 RQEAQ-SYALERAS--ATQASIRGEESEQVELRQIRRETPEEHALNRPDGLREAILIVASFLFFYFSLIGPAVFTPWLVA 233
P58722          165 QSENT-YQPILPSV--SKNASIRKEDSEHIELLNIRKETPEEYALHGPNGLKEACAICIALLLLFFALSGPTVTLPWLVI 241 Yersinia pestis
AHG19970        157 IYDRP-PTPVVTTTipEKNASIRQKESEHVELVNIRKETYQENSLNRPNGIKEATSISAALLLLFFSLISPIMVIPWMIF 235
Q7NA48          153 QQDFPsAPVIADIS--HQQASIQKNGETSVKLQNIRKETLEEYRLNHSSGIWEGGFLCFGFFIWFFALLSPALLLPWLML 230 Photorhabdus...
WP_015422356    152 TDDHAlARPMTKNNnvPVQAAILTNSNADIEFLGTRRESRQEYNLQHSHGFISGTLIVCGVLTALTAVFMPPFLFYWMMA 231 Morganella m...
WP_013319764    155 INEMD-SSAGVDIP--GEQASIRPEVHEHTELVAIRRETLEEHAVHRSRGLRETGVLSLAFLLLVFSLTSPLAMLPWLAG 231 Dickeya dada...
Q6CZP9          155 IDDRPlAPLPAEIP--VPNASIHQEGSEHAELVTIRKETREEHAMHHSRGLKETAVLCLSFLLLFISLNSPIALLPWLIG 232 Pectobacteri...
jgi:Rahaq2_0280 233 ISAGLAAWVIWRLVSERL-GKNRKEIHCLRGLPKRWGLFGESKQGDiSNISLGAVDLIYPPHWQPYIGRDLGQPTDVEVY 311
ADD78843        235 LAGMMIVASLWLMYRVPG-ENGLREIHCLRGAPKRWGLFGESNQEQ-SNITLGIIDLAYPAHWQPYVAHDLGQVTDVDIY 312
WP_002444787    233 AGLILCAVGCLGMFAPPA-RRSLREIHCLRGTPKRWGLFGESDQDPlNNISLGVIDLIYPKHWKPFVSHNLGRQTDIDVY 311 Shimwellia b...
P45800          233 GALLLLGAGLWGLFAPPA-KSSLREIHCLRGTPRRWGLFGENDQEQiNNISLGIIDLVYPAHWQPYIAQDLGQQTDIDIY 311 Escherichia ...
wugsc:KPN_03769 234 AGLLLLAAGLWGIYAPPR-RAALREIHCLRGVPKRWGLFGENDQEQiNNISLGIIDLIYPRHWQPWIAQDLGQQTDIDIY 312
P58722          242 VAVSLTCWACWYLFRPLS-EKDLREVHCLNGTPKRWGLFGESNQGQiNNISLGIVDLIYPAHWGPYFVHDLGKKTHIDIY 320 Yersinia pestis
AHG19970        236 VAVLMIVWGCWNLLRHPA-ESELKEVHCLRGTPKRWGLFGEPEQGQiSNISLGMIDLTYPPHWQPYLTADLGKITNVDIY 314
Q7NA48          231 IAGSLVVVSFWPLLCPLS-ICRRQDIHCFTGIPKRWGLFGEFEQGQmSNISLGGIDLIYPPHWEPYVAYYFDQKTSIDIY 309 Photorhabdus...
WP_015422356    232 AGAGLLLPGIILSLIPISnRRRLRDIQCYRGIPKRWGLFGDFDHSQkHSISLGGIDLIYPRHWEPWLHQDLGSVTQIEMY 311 Morganella m...
WP_013319764    232 AACLMAGWGCWQLFRPPS-QKELREVHCLHGTPQCMGLFSDASQSQiGNVSLGNIDLIYPPHWQPYIGYDLGRKTDVDIY 310 Dickeya dada...
Q6CZP9          233 TASLLAGWSLWQLFRSPS-AQELRDVHCLHGTPQGLGLFGESNQGPlGNISLGNIDLIYPPHWQPYITQDLGLKTDVDIY 311 Pectobacteri...
jgi:Rahaq2_0280 312 MNSHVVRQGSYLTLHDEVKKFPLQLWGRNLVLATSAFLLLLALLVYVPLGLPLKLSVAWLQGAQSSQVNSVQELEKAALR 391
ADD78843        313 LNRQVVRQGRFLSLQDEVRNFPLQRWRKNVVLAVGSLIVLALLITWIPLSMPIKLSLAWAKGTESLDVNSVNQLSREDLK 392
WP_002444787    312 LDRRVVRQGPFLSLEDEVKHFPLQRWSRSLVLATGSLLVLVMMAIWVPLDMPLKLTLSWLKGAQTISAQHVRQLESAGVK 391 Shimwellia b...
P45800          312 LDRHVVRQGRYLSLHDEVKNFPLQHWLRSTIIAAGSLLVLFMLLFWIPLDMPLKFTLSWMKGAQTIEATSVKQLADAGVR 391 Escherichia ...
wugsc:KPN_03769 313 LNRHVARQGRYLSLHDEVKNFPLQYWLRSAIIAAGALVVVIMLWASVPLNMPFKFTLSWLKGAQTIEATTVSQLEKAHVR 392
P58722          321 LNRQVVRQGAFLSLHDEMKMFPLQRWGKNLTLIVGSLLVLVLLLIYVPLGLPLKLSVAWLQGAQSQQVTSVAALDKMPLR 400 Yersinia pestis
AHG19970        315 LNRQVVRQGHYLSLHDEVKHFPLQQWGKNAVLAASALVTILLLLTYVPLSLPVKLSSAWLQGAQKTEVTNVQALEAIPLH 394
Q7NA48          310 TNGQVVRQGHYLSLHDEEKNYPYRRYGKNLMMIASCLLIMLLLYFYQPVSVPMKLSFAWLHGSSTKVITDANMMEGMELR 389 Photorhabdus...
WP_015422356    312 EDQQVVRQGKYLSLREESTRFPYRRYGKNLLIALTSAFALLVLACNQPVNLPVKLALNWLTGTETKVTTNFSELQNMPLY 391 Morganella m...
WP_013319764    311 LTRQVVRQGHYLSLHNEVKFFPLQQWGKNAVLAVGALLSLILLLTSVPLDLPLKLSLAWVQGTSSVKVTQVEDLERMPLH 390 Dickeya dada...
Q6CZP9          312 LNRQVIRQGEHLSLHDEVKNFPLQRWGRNLLLAAGSLLSLILLVTNVQLELPLKLSLAWLQGAQRIEVTQVSDLEKAQLR 391 Pectobacteri...
jgi:Rahaq2_0280 392 VGDTLKVQGTGMCYV--PP----AASRSASGFMPFDCSAIYWNTATPLPVPQSEIIDAATALQTTVNNQLHPGQNqmpEQ 465
ADD78843        393 VGDSLKVTGTGMCAV--PDn---YQSNRTYTYMPFDCSQIYWNNATPLPLPHSDIIEKASALLDTTTRQLHPETNt--DP 465
WP_002444787    392 VGDTLKIQGTGTCNI---Gs---FSPRNHSPFAPFDCSQIIWNTARALPFPESETVAKASALLASVNQQLHPQPG---ES 462 Shimwellia b...
P45800          392 VGDTLRISGTGMCNIrtSGt---WSAKTNSPFLPFDCSQIIWNDARSLPLPESELVNKATALTEAVNRQLHPKPEd--ES 466 Escherichia ...
wugsc:KPN_03769 393 IGDTLRLTGTGMCNIrtPGs---WSAKEDSPFLPFDCSQIVWNDAPPLPLPESDIVSKATALMQSVQRQLHPETDd--DS 467
P58722          401 IGDMLKAQGNGMCYV--PPn---IQNTRGFVFTPFDCSGIYWNTASPLPQPESETIEKAAALVETINKQLHPQGS---DA 472 Yersinia pestis
AHG19970        395 IGDTLKIQGYGMCYL--PPd---EGNSTTAGFMPFDCSRIYWNNADPLPPPESEVIDKAAALLATVNKQLHPSGT---QQ 466
Q7NA48          390 VGDILKAKGVGMCYM--PPn--nMNGKGDTYFSPFDCSGIYWNRVNPLPIPESEIIENAAKLIATVNKQLRLQEN---ND 462 Photorhabdus...
WP_015422356    392 VGDFLEAKGVGMCYM--PPn---LSAQDKPNFRAFDCSGIYWNNTSPLPVPESEQVDRAAALLAELNNQLHPDAG---AR 463 Morganella m...
WP_013319764    391 IGDKLQVRGAGMCYV--PPinlnPTSSRASAFAPFDCAAIYWNKAAPLPLPESDTIEKTTALQKTVNEQLHPAAS---DN 465 Dickeya dada...
Q6CZP9          392 IGDTLAVRSSGMCYV--PAgihpVSAPSSYAFSPFDCSAIYWNKAAPLPLPESETIEKASALLKSVNSQLHPQADk--EG 467 Pectobacteri...
jgi:Rahaq2_0280 466 NINPQLATAIEKSGMILLDDFADIVLKTETLCGNS-NDCVRLKNALVNLGNSSNWNSLVKRAKAGTLQGINVLLRPVSAQ 544
ADD78843        466 KLNPQLASAIQKSGMILLDDFSDLVLKTQALCNQA-QDCMRLKNALVNLGNAKDWDTLVSRADSGQLNGMNVLLRPVSAE 544
WP_002444787    463 EVNPQLASAIQRSGMILLSDFADIVRKTQALCTGR-DECVRLKNALTNLGNTRDWATLTRRASTGKLDGTNLLLRPVSAE 541 Shimwellia b...
P45800          467 RVSASLRSAIQKSGMVLLDDFGDIVLKTADLCSAK-DDCVRLKNALVNLGNSKDWDALVKRANAGKLDGVNVLLRPVSAE 545 Escherichia ...
wugsc:KPN_03769 468 RVSPALRSAIQKSGMVLLDDFGDIVQKTNDLCSAK-DDCLRLKNALVNLGNTRNWETLTKRATAGKLDGVNVLLRPVSAE 546
P58722          473 SVNPKLATAIEKSGMILLDDFSDIVLKTQALCSEN-TDCIRLKNALVNLGNAKNWSALVKRAQSGNLEGMNVLLRPISAD 551 Yersinia pestis
AHG19970        467 KLNPQLASAIEKSGMILLDDFSDIVLKTQELCSLE-SDCIRLKNALVNLGNAKNWASLVKRAKSGALQGVNVLLRPVSAE 545
Q7NA48          463 VINPDLPQEIFKSGMILLDNFSDIVLKTKELCEKE-ADCLRLKNALVNLGSAIDWLTLLKNAESGKLDGTHVLLRPAGAE 541 Photorhabdus...
WP_015422356    464 KVNDSLRNVITRSGMSLLDDFSSLVLKTQALCEFEnSDCVRLKNALVNLGNSPNWENLLARAKAGKLEQSNVLLRPASAE 543 Morganella m...
WP_013319764    466 QVSSQLADAIQKSGMILLNNFSDIVLKTDALCEKE-EDCTRLKNALINLGNAKNWELLVKRARSGALKGMSVVLRPVSAE 544 Dickeya dada...
Q6CZP9          468 QVNSQLASTIQKSGLILMKNFAEVVLRTQDLCKQE-NDCSRLKNALVNLSDVKNWSTLVKDADSGKLKGMNVVLPAVSAE 546 Pectobacteri...
jgi:Rahaq2_0280 545 SLSELVNNATSSFFVQETRRAADSLNSPPPGGFLISNDEGRQLIEMPAPPV------GVFANPPQEQWKQLQQLSTLLLH 618
ADD78843        545 ALENLVHTATSTFFFRETRRAAENLNSPPPGGFVIASDEGHQLVNQPQPAV------PLFDLDAGSQWQELQRLSSLLLH 618
WP_002444787    542 SLDNLVTTSTNPFFLRETERAAQALNSPAPGGFVIISDEGNSLVNLPGPAT------PLDDYPPAERWSALRHLAGQLMN 615 Shimwellia b...
P45800          546 SLDNLVATSTAPFITHETARAAQSLNSPAPGGFLIVSDEGSDFVDQPWPSA------SLYDYPPQEQWNAFQKLAQMLMH 619 Escherichia ...
wugsc:KPN_03769 547 SLENLVTTSTAPFVIRETSRAAQALNSPAPGGFLIASDEGSVLVNQPWPAV------SLYDYPAHEQWGELRRLAGMLMH 620
P58722          552 VLENLINTAASSFVYRETHLATEALNSPPPGGFLITSDEGKQLVNHPAPTL------PLFDYSALEQWRELQRLSALLLD 625 Yersinia pestis
AHG19970        546 SLENLSNTAASSFVTEEIRQATATLNSPPPGGFLITSDEGKPLVDHPKPNS------PLNENNALEQWNELQRLTNLLLR 619
Q7NA48          542 ALGKLVDATTSSFIYREIDKVAMLLNSPSPGGVLLISDEGKQLVEYITPAIisydhsVLEDHSALEQWRELQRLSDMVLQ 621 Photorhabdus...
WP_015422356    544 ALEKLVIATTSTAINKEVENAAMRLNSPPPGGVLLISDEGKSLVENAPVNE------QTEEMTPLAHWQSLQKLSNMLLH 617 Morganella m...
WP_013319764    545 SLDSLVKNATDEFYSREIITASNSLNSPPPGGFLIRSDEGRQFVNHQMPTT------PLRDFPPQEQWQELQRLSSMLLH 618 Dickeya dada...
Q6CZP9          547 TLESLVNSSTDQFFYQEINNAAESLNSPPPGGFLIRSDEGRQFVNHPLPPI------PLNEYRPSDQWQELQRLSAMLLH 620 Pectobacteri...
jgi:Rahaq2_0280 619 TPFSAQGVITSISIDANGTRHISLHSEPDISTLWRYLGTSLLLLLLIGVLAVNTVLFIRRFIKDKRRIDDIQQYYNSCFH 698
ADD78843        619 TPFSATGIITGIYTDANGTRHIALHNEPDAMAKWRYLGAALLLIVLLTCAITNGLLALRRIHLNRQRMLAIQQYYDKCFN 698
WP_002444787    616 TPFTAEGIVTGIQTDANGTRHVTLHAIPDSAGIWRNTGTTLLLLLLLGCTLWNGVMAVRRYQHNQMRTVAIQRYYEDCLP 695 Shimwellia b...
P45800          620 TPFNAEGIVTKIFTDANGTQHIGLHPIPDRSGLWRYLSTTLLLLTMLGSAIYNGVQAWRRYQRHRTRMMEIQAYYESCLN 699 Escherichia ...
wugsc:KPN_03769 621 TPFHAEGIVTNLFTDANGTQHINLHRIPDRSGLWRYLGITLLLLSMVGCMAYHAVQALRRYQRHRQRMEEIQKYYESCLN 700
P58722          626 TPFKAEGIITNITTDANGTRHIALHSEPDIVTLGRYLATSLLLLVLIFCLVVNMVLLIQRAMKNRRRMDNIQRYYDDCFN 705 Yersinia pestis
AHG19970        620 APFQAQGVITNISVDANGTRHIALHSEPDMITLWRYLGTSLLLLALVASLGYNAWRLLQRWRKNQHRLADIQRYYDSCFN 699
Q7NA48          622 TPFETTGIVTELSVDSHGTRRIVLHSELDAMTLARCIGTTILFLALFTTLIINFVLVVKKNRQNKQRLNKIKQYYDNCFN 701 Photorhabdus...
WP_015422356    618 TPFEVQGIVTDVSVDANGTRHILLHFQPDSVMLARFIGSCILLVVFSLLAIINGIYTFIRWRQRRRRMTDIRRYYDNCFR 697 Morganella m...
WP_013319764    619 TPFEANGVITQLSIDANGTRHISLHSEPDAVTMWRSLGACLLLLAFSVILILNLVLLLVKRRRSQQRIANIQQYYARHLV 698 Dickeya dada...
Q6CZP9          621 TPFNAAGVITQLNTDANGTQHISLHSEPDVITVWRYLGSCLLLLLFSATFIINAVLTGIKMRKSQKRVTDIQRYYASRFN 700 Pectobacteri...
jgi:Rahaq2_0280 699 PTLM-P 703
ADD78843        699 PSLN-T 703
WP_002444787    696 KNLL-P 700 Shimwellia blattae
P45800          700 PQLItP 705 Escherichia coli K-12
wugsc:KPN_03769 701 PVLL-P 705
P58722          706 QTLT-P 710 Yersinia pestis
AHG19970        700 PQLT-S 704
Q7NA48          702 TLFP-P 706 Photorhabdus laumondii subsp. laumondii
WP_015422356    698 HDY--P 701 Morganella morganii
WP_013319764    699 PEtpva 704 Dickeya dadantii
Q6CZP9          701 MMTN-S 705 Pectobacterium atrosepticum
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